Literature for peptidase A22.001: presenilin 1

(References are filtered for relevance to Specificity. To remove the filter click here. See explanation.)

2017
1. Langosch,D. and Steiner,H.
   Substrate processing in intramembrane proteolysis by gamma-secretase - the role of protein dynamics
   Biol Chem398, 441-453. PubMed  Europe PubMed DOI  P
2. Yan,Y., Xu,T.H., Melcher,K. and Xu,H.E.
   Defining the minimum substrate and charge recognition model of gamma-secretase
   Acta Pharmacol Sin38, 1412-1424. PubMed  Europe PubMed DOI  P
2016
3. Bolduc,D.M., Montagna,D.R., Seghers,M.C., Wolfe,M.S. and Selkoe,D.J.
   The amyloid-beta forming tripeptide cleavage mechanism of gamma-secretase
   elife5, PubMed  Europe PubMed DOI  P
4. Fleck,D., Voss,M., Brankatschk,B., Giudici,C., Hampel,H., Schwenk,B., Edbauer,D., Fukumori,A., Steiner,H., Kremmer,E., Haug-Kroper,M., Rossner,M.J., Fluhrer,R., Willem,M. and Haass,C.
   Proteolytic processing of neuregulin 1 type III by three intramembrane-cleaving proteases
   J Biol Chem291, 318-333. PubMed  Europe PubMed DOI  P
2014
5. Jung,J.I., Ran,Y., Cruz,P.E., Rosario,A.M., Ladd,T.B., Kukar,T.L., Koo,E.H., Felsenstein,K.M. and Golde,T.E.
   Complex relationships between substrate sequence and sensitivity to alterations in gamma-secretase processivity induced by gamma-secretase modulators
   Biochemistry53, 1947-1957. PubMed  Europe PubMed DOI  P
6. Vahidi,A., Glenn,G. and van der Geer,P.
   Identification and mutagenesis of the TACE and gamma-secretase cleavage sites in the colony-stimulating factor 1 receptor
   Biochem Biophys Res Commun450, 782-787. PubMed  Europe PubMed DOI  P
2013
7. Funamoto,S., Sasaki,T., Ishihara,S., Nobuhara,M., Nakano,M., Watanabe-Takahashi,M., Saito,T., Kakuda,N., Miyasaka,T., Nishikawa,K., Saido,T.C. and Ihara,Y.
   Substrate ectodomain is critical for substrate preference and inhibition of gamma-secretase
   Nat Commun4, 2529-2529. PubMed  Europe PubMed DOI  P
8. Ousson,S., Saric,A., Baguet,A., Losberger,C., Genoud,S., Vilbois,F., Permanne,B., Hussain,I. and Beher,D.
   Substrate determinants in the C99 juxtamembrane domains differentially affect gamma-secretase cleavage specificity and modulator pharmacology
   J Neurochem125, 610-619. PubMed  Europe PubMed DOI  P
9. Piao,Y., Kimura,A., Urano,S., Saito,Y., Taru,H., Yamamoto,T., Hata,S. and Suzuki,T.
   Mechanism of intramembrane cleavage of alcadeins by gamma-secretase
   PLoS ONE8, e62431-e62431. PubMed  Europe PubMed DOI  P
2012
10. Takami,M. and Funamoto,S.
    gamma-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid beta-Protein Production
    Int J Alzheimers Dis2012, 591392-591392. PubMed  Europe PubMed DOI  P
2010
11. Perez-Revuelta,B.I., Fukumori,A., Lammich,S., Yamasaki,A., Haass,C. and Steiner,H.
    Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage
    J Neurochem112, 940-950. PubMed  Europe PubMed DOI  P
2008
12. Beel,A.J. and Sanders,C.R.
    Substrate specificity of gamma-secretase and other intramembrane proteases
    Cell Mol Life Sci65, 1311-1334. PubMed  Europe PubMed DOI  V  P
13. Hemming,M.L., Elias,J.E., Gygi,S.P. and Selkoe,D.J.
    Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements
    PLoS Biol6, e257-e257. PubMed  Europe PubMed DOI  P
2003
14. Ikeuchi,T. and Sisodia,S.S.
    The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage
    J Biol Chem278, 7751-7754. PubMed  Europe PubMed DOI  P