Literature for peptidase A01.004: BACE1 g.p. (Homo sapiens)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

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    2020
  1. Rudan Njavro,J., Klotz,J., Dislich,B., Wanngren,J., Shmueli,M.D., Herber,J., Kuhn,P.H., Kumar,R., Koeglsperger,T., Conrad,M., Wurst,W., Feederle,R., Vlachos,A., Michalakis,S., Jedlicka,P., Muller,S.A. and Lichtenthaler,S.F.
    Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1
    FASEB J34, 2465-2482. PubMed  Europe PubMed DOI  P
  2. 2016
  3. Ben Halima,S., Mishra,S., Raja,K.M., Willem,M., Baici,A., Simons,K., Brustle,O., Koch,P., Haass,C., Caflisch,A. and Rajendran,L.
    Specific inhibition of beta-secretase processing of the Alzheimer disease amyloid precursor protein
    Cell Rep14, 2127-2141. PubMed  Europe PubMed DOI  P  I
  4. Fleck,D., Voss,M., Brankatschk,B., Giudici,C., Hampel,H., Schwenk,B., Edbauer,D., Fukumori,A., Steiner,H., Kremmer,E., Haug-Kroper,M., Rossner,M.J., Fluhrer,R., Willem,M. and Haass,C.
    Proteolytic processing of neuregulin 1 type III by three intramembrane-cleaving proteases
    J Biol Chem291, 318-333. PubMed  Europe PubMed DOI  P
  5. 2013
  6. Deng,Y., Wang,Z., Wang,R., Zhang,X., Zhang,S., Wu,Y., Staufenbiel,M., Cai,F. and Song,W.
    Amyloid-beta protein (Abeta) Glu11 is the major beta-secretase site of beta-site amyloid-beta precursor protein-cleaving enzyme 1 (BACE1), and shifting the cleavage site to Abeta Asp1 contributes to Alzheimer pathogenesis
    Eur J Neurosci37, 1962-1969. PubMed  Europe PubMed DOI  P
  7. Hogl,S., van Bebber,F., Dislich,B., Kuhn,P.H., Haass,C., Schmid,B. and Lichtenthaler,S.F.
    Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains
    Proteomics13, 1519-1527. PubMed  Europe PubMed DOI  K  P
  8. Li,X., Hong,L., Coughlan,K., Wang,L., Cao,L. and Tang,J.
    Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease
    Acta Biochim Biophys Sin (Shanghai)45, 613-621. PubMed  Europe PubMed DOI  P
  9. Stutzer,I., Selevsek,N., Esterhazy,D., Schmidt,A., Aebersold,R. and Stoffel,M.
    Systematic proteomic analysis identifies beta-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic beta-cells
    J Biol Chem288, 10536-10547. PubMed  Europe PubMed DOI  P
  10. 2011
  11. Hogl,S., Kuhn,P.H., Colombo,A. and Lichtenthaler,S.F.
    Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase
    PLoS ONE6, e21337-e21337. PubMed  Europe PubMed DOI  P
  12. 2010
  13. Kihara,T., Shimmyo,Y., Akaike,A., Niidome,T. and Sugimoto,H.
    Abeta-induced BACE-1 cleaves N-terminal sequence of mPGES-2
    Biochem Biophys Res Commun393, 728-733. PubMed  Europe PubMed DOI  P
  14. Li,X., Bo,H., Zhang,X.C., Hartsuck,J.A. and Tang,J.
    Predicting memapsin 2 (beta-secretase) hydrolytic activity
    Protein Sci19, 2175-2185. PubMed  Europe PubMed DOI  P
  15. 2009
  16. Hemming,M.L., Elias,J.E., Gygi,S.P. and Selkoe,D.J.
    Identification of beta-secretase (BACE1) substrates using quantitative proteomics
    PLoS ONE4, e8477-e8477. PubMed  Europe PubMed DOI  P
  17. 2002
  18. [YEAR:15-2-2002]Gruninger-Leitch,F., Schlatter,D., Kung,E., Nelbock,P. and Dobeli,H.
    Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases
    J Biol Chem277, 4687-4693. PubMed  Europe PubMed DOI  P  I
  19. [YEAR:9-7-2002]Turner,R.T., III, Loy,J.A., Nguyen,C., Devasamudram,T., Ghosh,A.K., Koelsch,G. and Tang,J.
    Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity
    Biochemistry41, 8742-8746. PubMed  Europe PubMed DOI  P  I