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Literature for peptidase M01.018: endoplasmic reticulum aminopeptidase 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(References are filtered for relevance to Mutation. To remove the filter click here. See explanation.)

    2025
  1. Su,S.H., Cai,X.Q., Li,Y.H., Xu,A.H., Huang,Q., Niu,H., You,Q.H. and Sun,G.Y.
    The important roles of ERAP1, ERAP2 genes polymorphisms and their DNA methylation levels in pulmonary tuberculosis
    BMC Infect Dis25, 178-178. PubMed  Europe PubMed DOI  M
    2. 2023
  2. Tedeschi,V., Paldino,G., Alba,J., Molteni,E., Paladini,F., Scrivo,R., Congia,M., Cauli,A., Caccavale,R., Paroli,M., Di Franco,M., Tuosto,L., Sorrentino,R., D'Abramo,M. and Fiorillo,M.T.
    ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-Epitopes
    Int J Mol Sci24, PubMed  Europe PubMed DOI  M
    3. 2022
  3. Cavers,A., Kugler,M.C., Ozguler,Y., Al-Obeidi,A.F., Hatemi,G., Ueberheide,B.M., Ucar,D., Manches,O. and Nowatzky,J.
    Behcet's disease risk-variant HLA-B51/ERAP1-Hap10 alters human CD8 T cell immunity
    Ann Rheum Dis81, 1603-1611. PubMed  Europe PubMed DOI  M
  4. Mattorre,B., Tedeschi,V., Paldino,G., Fiorillo,M.T., Paladini,F. and Sorrentino,R.
    The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation
    Front Immunol13, 1002375-1002375. PubMed  Europe PubMed DOI  M
    5. 2020
  5. Gao,S., Xu,T., Liang,W., Xun,C., Deng,Q., Guo,H. and Sheng,W.
    Association of rs27044 and rs30187 polymorphisms in endoplasmic reticulum aminopeptidase 1 gene and ankylosing spondylitis susceptibility: A meta-analysis
    Int J Rheum Dis23, 499-510. PubMed  Europe PubMed DOI  M
  6. Joob,B. and Wiwanitkit,V.
    Endoplasmic reticulum aminopeptidase protein 1 and Behcet's syndrome
    Intern Emerg Med15, 733-733. PubMed  Europe PubMed DOI  M
  7. Li,C., Li,Y., Yan,Z., Dai,S., Liu,S., Wang,X., Wang,J., Zhang,X., Shi,L. and Yao,Y.
    Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population
    BMC Cancer20, 341-341. PubMed  Europe PubMed DOI  M
  8. Zavattaro,E., Ramezani,M. and Sadeghi,M.
    Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms and psoriasis susceptibility: a systematic review and meta-analysis
    Gene736, 144416-144416. PubMed  Europe PubMed DOI  M
    9. 2019
  9. Niepieklo-Miniewska,W., Mpakali,A., Stratikos,E., Matusiak,L., Narbutt,J., Lesiak,A., Kuna,P., Wilczynska,K., Nowak,I., Wisniewski,A., Zwolinska,K., Poninska,J., Ploski,R., Szepietowski,J.C. and Kusnierczyk,P.
    Endoplasmic reticulum aminopeptidase 1 polymorphism Ile276Met is associated with atopic dermatitis and affects the generation of an HLA-C associated antigenic epitope in vitro
    J Eur Acad Dermatol Venereol33, 906-911. PubMed  Europe PubMed DOI  M
    10. 2017
  10. Guasp,P., Barnea,E., Gonzalez-Escribano,M.F., Jimenez-Reinoso,A., Regueiro,J.R., Admon,A. and Lopez de Castro,J.A.
    The Behcet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing
    J Biol Chem292, 9680-9689. PubMed  Europe PubMed DOI  M  P
  11. Romania,P., Cifaldi,L., Pignoloni,B., Starc,N., D'Alicandro,V., Melaiu,O., Pira,G.L., Giorda,E., Carrozzo,R., Bergvall,M., Bergstrom,T., Alfredsson,L., Olsson,T., Kockum,I., Seppala,I., Lehtimaki,T., Hurme,M.A., Hengel,H., Santoni,A., Cerboni,C., Locatelli,F., D'Amato,M. and Fruci,D.
    Identification of a genetic variation in ERAP1 aminopeptidase that prevents human cytomegalovirus miR-UL112-5p-mediated immunoevasion
    Cell Rep20, 846-853. PubMed  Europe PubMed DOI  M
  12. Wang,X., Ma,J., Ma,J., Wen,Y., Meng,L., Yang,H., Zhang,R. and Hao,D.
    Bioinformatics analysis of genetic variants of endoplasmic reticulum aminopeptidase 1 in ankylosing spondylitis
    Mol Med Rep16, 6532-6543. PubMed  Europe PubMed DOI  M
    13. 2016
  13. Pedersen,N.C., Dhanota,J.K. and Liu,H.
    Polymorphisms in ERAP1 and ERAP2 are shared by Caninae and segregate within and between random- and pure-breeds of dogs
    Vet Immunol Immunopathol179, 46-57. PubMed  Europe PubMed DOI  M
  14. Sezgin,G., Dabak,R., Kaya,F.O., Kotevoglu,N., Uygur-Bayramicli,O. and Nalbant,S.
    The association of endoplasmic reticulum aminopeptidase-1 (ERAP-1) with Familial Mediterranean Fever (FMF)
    United European Gastroenterol J4, 92-96. PubMed  Europe PubMed DOI  M
  15. Takeuchi,M., Ombrello,M.J., Kirino,Y., Erer,B., Tugal-Tutkun,I., Seyahi,E., Ozyazgan,Y., Watts,N.R., Gul,A., Kastner,D.L. and Remmers,E.F.
    A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Behcet's disease in HLA-B*51 carriers
    Ann Rheum Dis75, 2208-2211. PubMed  Europe PubMed DOI  M
    16. 2015
  16. Aldhamen,Y.A., Pepelyayeva,Y., Rastall,D.P., Seregin,S.S., Zervoudi,E., Koumantou,D., Aylsworth,C.F., Quiroga,D., Godbehere,S., Georgiadis,D., Stratikos,E. and Amalfitano,A.
    Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells
    J Innate Immun7, 275-289. PubMed  Europe PubMed DOI  M
  17. Ombrello,M.J., Kastner,D.L. and Remmers,E.F.
    Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease: genetics
    Curr Opin Rheumatol27, 349-356. PubMed  Europe PubMed DOI  M
  18. Stamogiannos,A., Koumantou,D., Papakyriakou,A. and Stratikos,E.
    Effects of polymorphic variation on the mechanism of endoplasmic reticulum aminopeptidase 1
    Mol Immunol67, 426-435. PubMed  Europe PubMed DOI  M
  19. Tran,T.M. and Colbert,R.A.
    Endoplasmic reticulum aminopeptidase 1 and rheumatic disease: functional variation
    Curr Opin Rheumatol27, 357-363. PubMed  Europe PubMed DOI  M
  20. Wang,J., Li,H., Wang,J. and Gao,X.
    Association between ERAP1 gene polymorphisms and ankylosing spondylitis susceptibility in Han population
    Int J Clin Exp Pathol8, 11641-11646. PubMed  Europe PubMed  M
  21. Yousaf,N., Low,W.Y., Onipinla,A., Mein,C., Caulfield,M., Munroe,P.B. and Chernajovsky,Y.
    Differences between disease-associated endoplasmic reticulum aminopeptidase 1 (ERAP1) isoforms in cellular expression, interactions with tumour necrosis factor receptor 1 (TNF-R1) and regulation by cytokines
    Clin Exp Immunol180, 289-304. PubMed  Europe PubMed DOI  M  R
    22. 2013
  22. Seregin,S.S., Rastall,D.P., Evnouchidou,I., Aylsworth,C.F., Quiroga,D., Kamal,R.P., Godbehere-Roosa,S., Blum,C.F., York,I.A., Stratikos,E. and Amalfitano,A.
    Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens
    Autoimmunity46, 497-508. PubMed  Europe PubMed DOI  M
    23. 2012
  23. Garcia-Medel,N., Sanz-Bravo,A., Van Nguyen,D., Galocha,B., Gomez-Molina,P., Martin-Esteban,A., Alvarez-Navarro,C. and de Castro,J.A.
    Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo
    Mol Cell Proteomics11, 1416-1429. PubMed  Europe PubMed DOI  M
  24. Mahmoudi,M., Jamshidi,A.R., Amirzargar,A.A., Farhadi,E., Nourijelyani,K., Fallahi,S., Oraei,M., Noori,S. and Nicknam,M.H.
    Association between endoplasmic reticulum aminopeptidase-1 (ERAP-1) and susceptibility to ankylosing spondylitis in Iran
    Iran J Allergy Asthma Immunol11, 294-300. PubMed  Europe PubMed DOI  M
    25. 2011
  25. Evnouchidou,I., Kamal,R.P., Seregin,S.S., Goto,Y., Tsujimoto,M., Hattori,A., Voulgari,P.V., Drosos,A.A., Amalfitano,A., York,I.A. and Stratikos,E.
    Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme
    J Immunol186, 1909-1913. PubMed  Europe PubMed DOI  M
    26. 2010
  26. Cagliani,R., Riva,S., Biasin,M., Fumagalli,M., Pozzoli,U., Lo Caputo,S., Mazzotta,F., Piacentini,L., Bresolin,N., Clerici,M. and Sironi,M.
    Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection
    Hum Mol Genet19, 4705-4714. PubMed  Europe PubMed DOI  M
  27. Haroon,N., Tsui,F.W., Chiu,B., Tsui,H.W. and Inman,R.D.
    Serum cytokine receptors in ankylosing spondylitis: relationship to inflammatory markers and endoplasmic reticulum aminopeptidase polymorphisms
    J Rheumatol37, 1907-1910. PubMed  Europe PubMed DOI  M
  28. Tsui,F.W., Haroon,N., Reveille,J.D., Rahman,P., Chiu,B., Tsui,H.W. and Inman,R.D.
    Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis
    Ann Rheum Dis69, 733-736. PubMed  Europe PubMed DOI  M
    29. 2009
  29. Fung,E.Y., Smyth,D.J., Howson,J.M., Cooper,J.D., Walker,N.M., Stevens,H., Wicker,L.S. and Todd,J.A.
    Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus
    Genes Immun10, 188-191. PubMed  Europe PubMed DOI  M
  30. Mehta,A.M., Jordanova,E.S., Corver,W.E., van Wezel,T., Uh,H.W., Kenter,G.G. and Jan Fleuren,G.
    Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma
    Genes Chromosomes Cancer48, 410-418. PubMed  Europe PubMed DOI  M
    31. 2006
  31. Goto,Y., Hattori,A., Ishii,Y. and Tsujimoto,M.
    Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1
    FEBS Lett580, 1833-1838. PubMed  Europe PubMed DOI  M
    32. 2002
  32. Yamamoto,N., Nakayama,J., Yamakawa-Kobayashi,K., Hamaguchi,H., Miyazaki,R. and Arinami,T.
    Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension
    Hum Mutat19, 251-257. PubMed  Europe PubMed DOI  M

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