Literature for peptidase M10.003: matrix metallopeptidase-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

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    2025
  1. Conde-Tella,S.O., Gerlach,R.F. and Tanus-Santos,J.E.
    Using Zymography to Assess Circulating Matrix Metalloproteinase (MMP)-2 and MMP-9 in Clinical Samples
    Methods Mol Biol2918, 177-186. PubMed  Europe PubMed DOI  L
  2. George,J.
    Zymography: A Simple and Powerful Tool for the Assessment of MMP-2 and MMP-9 in Pathological Conditions
    Methods Mol Biol2918, 187-199. PubMed  Europe PubMed DOI  L
  3. Veilleux,C., Roy,M.E. and Annabi,B.
    Assessing MMP-2/9 Proteolytic Activity and Activation Status by Zymography in Preclinical and Clinical Tissue Samples
    Methods Mol Biol2918, 165-176. PubMed  Europe PubMed DOI  L
  4. 2024
  5. Blascke de Mello,M.M., Neves,V.G.O., Parente,J.M., Pernomian,L., de Oliveira,I.S., Pedersoli,C.A., Awata,W.M.C., Tirapelli,C.R., Arantes,E.C., Tostes,R.C.A., Schulz,R. and Castro,M.M.
    Sarcoplasmic reticulum calcium ATPase (SERCA) proteolysis by matrix metalloproteinase-2 contributes to vascular dysfunction in early hypertension
    Eur J Pharmacol983, 176981-176981. PubMed  Europe PubMed DOI  L
  6. Cavalcante,G.L., Bonifacio,L.P., Sanches-Lopes,J.M., Puga,F.G., de Carvalho,F.S., Bellissimo-Rodrigues,F. and Tanus-Santos,J.E.
    Matrix metalloproteinases are associated with severity of disease among COVID-19 patients: A possible pharmacological target
    Basic Clin Pharmacol Toxicol134, 727-736. PubMed  Europe PubMed DOI  L
  7. Kamarajan,P., Timm,J.C., Goetting-Minesky,M.P., Malone,E.T., Ganther,S., Radaic,A., Tafolla,C., Fenno,J.C. and Kapila,Y.L.
    Purification of Native Dentilisin Complex from Treponema denticola by Preparative Continuous Polyacrylamide Gel Electrophoresis and Functional Analysis by Gelatin Zymography
    Bio Protoc14, e4970-e4970. PubMed  Europe PubMed DOI  L
  8. 2023
  9. Bassiouni,W., Valencia,R., Mahmud,Z., Seubert,J.M. and Schulz,R.
    Matrix metalloproteinase-2 proteolyzes mitofusin-2 and impairs mitochondrial function during myocardial ischemia-reperfusion injury
    Basic Res Cardiol118, 29-29. PubMed  Europe PubMed DOI  L
  10. Zhang,Y.N., Liu,J.J., Zhang,W., Qin,H.Y., Wang,L.T., Chen,Y.Y., Yuan,L., Yang,F., Cao,R.Y. and Wang,X.J.
    Expression, purification and refolding of pro-MMP-2 from inclusion bodies of E. coli
    Protein Expr Purif208-209, 106278-106278. PubMed  Europe PubMed DOI  L
  11. 2022
  12. Morales-Hernandez,F.V., Bautista-Bautista,G., Acuna-Gonzalez,R.J., Vazquez-Cardenas,P., Lopez-Canales,J.S., Lozano-Cuenca,J., Osorio-Caballero,M. and Flores-Herrera,H.
    Differential proMMP-2 and proMMP-9 secretion in human pre-implantation embryos at day 5 of development
    Acta Biochim Pol69, 683-689. PubMed  Europe PubMed DOI  L
  13. 2021
  14. Buttacavoli,M., Di Cara,G., Roz,E., Pucci-Minafra,I., Feo,S. and Cancemi,P.
    Integrated Multi-Omics Investigations of Metalloproteinases in Colon Cancer: Focus on MMP2 and MMP9
    Int J Mol Sci22, PubMed  Europe PubMed DOI  L
  15. 2020
  16. Dong,Z., Guo,S., Wang,Y., Zhang,J., Luo,H., Zheng,G., Yang,D., Zhang,T., Yan,L., Song,L., Liu,K., Sun,Z., Meng,X., Zheng,Z., Zhang,J. and Zhao,Y.
    USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer
    Onco Targets Ther13, 8495-8510. PubMed  Europe PubMed DOI  L
  17. Gou,X., Xue,Y., Zheng,H., Yang,G., Chen,S., Chen,Z. and Yuan,G.
    Gelatinases Cleave Dentin Sialoprotein Intracellularly
    Front Physiol11, 686-686. PubMed  Europe PubMed DOI  L
  18. Lee,H., Kim,S.J., Shin,H. and Kim,Y.P.
    Collagen-immobilized extracellular FRET reporter for visualizing protease activity secreted by living cells
    ACS Sens5, 655-664. PubMed  Europe PubMed DOI  L
  19. Zhang,L., Cui,Y., Yang,Y., Wei,J., Liu,W., Cai,L., Wang,L., Zhang,D., Xie,J. and Cheng,L.
    The virulence factor GroEL promotes gelatinase secretion from cells in the osteoblast lineage: Implication for direct crosstalk between bacteria and adult cells
    Arch Oral Biol122, 104991-104991. PubMed  Europe PubMed DOI  L
  20. 2019
  21. Yin,L., Sun,H., Zhang,H., He,L., Qiu,L., Lin,J., Xia,H., Zhang,Y., Ji,S., Shi,H. and Gao,M.
    Quantitatively visualizing tumor-related protease activity in vivo using a ratiometric photoacoustic probe
    J Am Chem Soc141, 3265-3273. PubMed  Europe PubMed DOI  L
  22. Yin,L., Sun,H., Zhao,M., Wang,A., Qiu,S., Gao,Y., Ding,J., Ji,S.J., Shi,H. and Gao,M.
    Rational design and synthesis of a metalloproteinase-activatable probe for dual-modality imaging of metastatic lymph nodes in vivo
    J Org Chem84, 6126-6133. PubMed  Europe PubMed DOI  L
  23. 2018
  24. Cao,S., Li,Z., Zhao,J., Chen,M. and Ma,N.
    Rational engineering a multichannel upconversion sensor for multiplex detection of matrix metalloproteinase activities
    ACS Sens3, 1522-1530. PubMed  Europe PubMed DOI  L
  25. Cowell,S., Carroll,L., Lavdas,I., Aboagye,E.O. and Vilar,R.
    Towards an MMP-2-activated molecular agent for cancer imaging
    Dalton Trans47, 1530-1534. PubMed  Europe PubMed DOI  L
  26. Liu,C., Li,S., Gu,Y., Xiong,H., Wong,W.T. and Sun,L.
    Multispectral photoacoustic imaging of tumor protease activity with a gold nanocage-based activatable probe
    Mol Imaging Biol20, 919-929. PubMed  Europe PubMed DOI  A  L
  27. Nadolski,G.J., Hunt,S.J., Weber,C.N., Mohammed,M., Pulido,S., Noji,M., Chisholm,A. and Gade,T.P.F.
    Near-infrared fluorescence imaging of matrix metalloproteinase 2 activity as a biomarker of vascular remodeling in hemodialysis access
    J Vasc Interv Radiol29, 1268-1275. PubMed  Europe PubMed DOI  L
  28. 2017
  29. Cheng,H., Li,S.Y., Zheng,H.R., Li,C.X., Xie,B.R., Chen,K.W., Li,B. and Zhang,X.Z.
    Multi-Forster resonance energy transfer-based fluorescent probe for spatiotemporal matrix metalloproteinase-2 and caspase-3 imaging
    Anal Chem89, 4349-4354. PubMed  Europe PubMed DOI  L
  30. Pillai,S.S., Yukawa,H., Onoshima,D., Biju,V. and Baba,Y.
    Forster resonance energy transfer mediated photoluminescence quenching in stoichiometrically assembled CdSe/ZnS quantum dot-peptide labeled black hole quencher conjugates for matrix metalloproteinase-2 sensing
    Anal Sci33, 137-142. PubMed  Europe PubMed DOI  L
  31. Zhu,X., Lin,H., Wang,L., Tang,X., Ma,L., Chen,Z. and Gao,J.
    Activatable T1 relaxivity recovery nanoconjugates for kinetic and sensitive analysis of matrix metalloprotease 2
    ACS Appl Mater Interfaces9, 21688-21696. PubMed  Europe PubMed DOI  L
  32. 2016
  33. Bourguet,E., Brazhnik,K., Sukhanova,A., Moroy,G., Brassart-Pasco,S., Martin,A.P., Villena,I., Bellon,G., Sapi,J. and Nabiev,I.
    Design, synthesis, and use of MMP-2 inhibitor-conjugated quantum dots in functional biochemical assays
    Bioconjug Chem27, 1067-1081. PubMed  Europe PubMed DOI  L  I
  34. Dang,Q., Gao,H., Li,Z., Qi,H., Gao,Q. and Zhang,C.
    Simple and sensitive electrogenerated chemiluminescence peptide-based biosensor for detection of matrix metalloproteinase 2 released from living cells
    Anal Bioanal Chem408, 7067-7075. PubMed  Europe PubMed DOI  A  L
  35. Gerwien,H., Hermann,S., Zhang,X., Korpos,E., Song,J., Kopka,K., Faust,A., Wenning,C., Gross,C.C., Honold,L., Melzer,N., Opdenakker,G., Wiendl,H., Schafers,M. and Sorokin,L.
    Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier
    Sci Transl Med8, 364ra152-364ra. PubMed  Europe PubMed DOI  L
  36. 2015
  37. Liu,Q., Pan,D., Cheng,C., Zhang,A., Ma,C., Wang,L., Zhang,D., Liu,H., Jiang,H., Wang,T., Xu,Y., Yang,R., Chen,F., Yang,M. and Zuo,C.
    Targeting of MMP2 activity in malignant tumors with a 68Ga-labeled gelatinase inhibitor cyclic peptide
    Nucl Med Biol42, 939-944. PubMed  Europe PubMed DOI  L
  38. 2014
  39. Fan,G.C., Han,L., Zhu,H., Zhang,J.R. and Zhu,J.J.
    Ultrasensitive photoelectrochemical immunoassay for matrix metalloproteinase-2 detection based on CdS:Mn/CdTe cosensitized TiO2 nanotubes and signal amplification of SiO2@Ab2 conjugates
    Anal Chem86, 12398-12405. PubMed  Europe PubMed DOI  A  L
  40. van Duijnhoven,S.M., Robillard,M.S., Hermann,S., Kuhlmann,M.T., Schafers,M., Nicolay,K. and Grull,H.
    Imaging of MMP activity in postischemic cardiac remodeling using radiolabeled MMP-2/9 activatable peptide probes
    Mol Pharm11, 1415-1423. PubMed  Europe PubMed DOI  L
  41. Wang,Z., Li,X., Feng,D., Li,L., Shi,W. and Ma,H.
    Poly(m-phenylenediamine)-based fluorescent nanoprobe for ultrasensitive detection of matrix metalloproteinase 2
    Anal Chem86, 7719-7725. PubMed  Europe PubMed DOI  A  L
  42. Yue,X., Wang,Z., Zhu,L., Wang,Y., Qian,C., Ma,Y., Kiesewetter,D.O., Niu,G. and Chen,X.
    Novel 19F activatable probe for the detection of matrix metalloprotease-2 activity by MRI/MRS
    Mol Pharm11, 4208-4217. PubMed  Europe PubMed DOI  L
  43. Zhang,X., Bresee,J., Fields,G.B. and Edwards,W.B.
    Near-infrared triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity in vivo
    Bioorg Med Chem Lett24, 3786-3790. PubMed  Europe PubMed DOI  L
  44. Zhang,X., Bresee,J., Cheney,P.P., Xu,B., Bhowmick,M., Cudic,M., Fields,G.B. and Edwards,W.B.
    Evaluation of a triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity
    Molecules19, 8571-8588. PubMed  Europe PubMed DOI  L
  45. 2013
  46. Casalini,F., Fugazza,L., Esposito,G., Cabella,C., Brioschi,C., Cordaro,A., D'Angeli,L., Bartoli,A., Filannino,A.M., Gringeri,C.V., Longo,D.L., Muzio,V., Nuti,E., Orlandini,E., Figlia,G., Quattrini,A., Tei,L., Digilio,G., Rossello,A. and Maiocchi,A.
    Synthesis and preliminary evaluation in tumor bearing mice of new (18)F-labeled arylsulfone matrix metalloproteinase inhibitors as tracers for positron emission tomography
    J Med Chem56, 2676-2689. PubMed  Europe PubMed DOI  L  I
  47. Freskos,J.N., Asmelash,B., Gaston,K.R., Karwa,A., Marzan,T.A., Nickols,M.A., Rogers,T.E., Schoenstein,T., Sympson,C.J. and Vu,B.
    Design and synthesis of MMP inhibitors with appended fluorescent tags for imaging and visualization of matrix metalloproteinase enzymes
    Bioorg Med Chem Lett23, 5566-5570. PubMed  Europe PubMed DOI  L  I
  48. Ryu,J.H., Shin,J.Y., Kim,S.A., Kang,S.W., Kim,H., Kang,S., Choi,K., Kwon,I.C., Kim,B.S. and Kim,K.
    Non-invasive optical imaging of matrix metalloproteinase activity with albumin-based fluorogenic nanoprobes during angiogenesis in a mouse hindlimb ischemia model
    Biomaterials34, 6871-6881. PubMed  Europe PubMed DOI  L
  49. 2012
  50. Chuang,C.H., Chuang,K.H., Wang,H.E., Roffler,S.R., Shiea,J.T., Tzou,S.C., Cheng,T.C., Kao,C.H., Wu,S.Y., Tseng,W.L., Cheng,C.M., Hou,M.F., Wang,J.M. and Cheng,T.L.
    In vivo positron emission tomography imaging of protease activity by generation of a hydrophobic product from a noninhibitory protease substrate
    Clin Cancer Res18, 238-247. PubMed  Europe PubMed DOI  L
  51. 2009
  52. Jastrzebska,B., Lebel,R., Therriault,H., McIntyre,J.O., Escher,E., Guerin,B., Paquette,B., Neugebauer,W.A. and Lepage,M.
    New enzyme-activated solubility-switchable contrast agent for magnetic resonance imaging: from synthesis to in vivo imaging
    J Med Chem52, 1576-1581. PubMed  Europe PubMed DOI  L
  53. Wang,W., Shao,R., Wu,Q., Ke,S., McMurray,J., Lang,F.F., Jr., Charnsangavej,C., Gelovani,J.G. and Li,C.
    Targeting gelatinases with a near-infrared fluorescent cyclic His-Try-Gly-Phe peptide
    Mol Imaging Biol11, 424-433. PubMed  Europe PubMed DOI  L  I
  54. 2008
  55. Lebel,R., Jastrzebska,B., Therriault,H., Cournoyer,M.M., McIntyre,J.O., Escher,E., Neugebauer,W., Paquette,B. and Lepage,M.
    Novel solubility-switchable MRI agent allows the noninvasive detection of matrix metalloproteinase-2 activity in vivo in a mouse model
    Magn Reson Med60, 1056-1065. PubMed  Europe PubMed DOI  L
  56. Mukai,T., Suganuma,N., Soejima,K., Sasaki,J., Yamamoto,F. and Maeda,M.
    Synthesis of a beta-tetrapeptide analog as a mother compound for the development of matrix metalloproteinase-2-imaging agents
    Chem Pharm Bull (Tokyo)56, 260-265. PubMed  Europe PubMed DOI  L  I
  57. 2007
  58. Hanaoka,H., Mukai,T., Habashita,S., Asano,D., Ogawa,K., Kuroda,Y., Akizawa,H., Iida,Y., Endo,K., Saga,T. and Saji,H.
    Chemical design of a radiolabeled gelatinase inhibitor peptide for the imaging of gelatinase activity in tumors
    Nucl Med Biol34, 503-510. PubMed  Europe PubMed DOI  L  I