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Literature for peptidase C01.032: cathepsin L

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(References are filtered for relevance to Knockout. To remove the filter click here. See explanation.)

    2025
  1. Chen,Y., Shi,Y., Zuo,X., Dong,X., Xiao,X., Chen,L., Xiang,Z., Ren,L., Zhou,Z., Wei,W., Lei,X. and Wang,J.<br>UNC0638 inhibits SARS-CoV-2 entry by blocking cathepsin L maturation<br>J Virol (2025) , e0074125-e0074125. PubMed  Europe PubMed DOI  K
    2. 2024
  2. Bestle,D., Bittel,L., Werner,A.D., Kamper,L., Dolnik,O., Krahling,V., Steinmetzer,T. and Bottcher-Friebertshauser,E.<br>Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage<br>Virus Res (2024) 347, 199430-199430. PubMed  Europe PubMed DOI  K
  3. Zhang,K., Xu,R., Zheng,L., Zhang,H., Qian,Z., Li,C., Xue,M., He,Z., Ma,J., Li,Z., Chen,L., Ma,R. and Yao,B.<br>Elevated N-glycosylated cathepsin L impairs oocyte function and contributes to oocyte senescence during reproductive aging<br>Aging Cell (2024) , e14397-e14397. PubMed  Europe PubMed DOI  K
    4. 2022
  4. Mondal,S., Chen,Y., Lockbaum,G.J., Sen,S., Chaudhuri,S., Reyes,A.C., Lee,J.M., Kaur,A.N., Sultana,N., Cameron,M.D., Shaffer,S.A., Schiffer,C.A., Fitzgerald,K.A. and Thompson,P.R.<br>Dual Inhibitors of Main Protease (M(Pro)) and Cathepsin L as Potent Antivirals against SARS-CoV2<br>J Am Chem Soc (2022) 144, 21035-21045. PubMed  Europe PubMed DOI  PMC  EPMC  K  I
    5. 2021
  5. Zhao,M.M., Yang,W.L., Yang,F.Y., Zhang,L., Huang,W.J., Hou,W., Fan,C.F., Jin,R.H., Feng,Y.M., Wang,Y.C. and Yang,J.K.<br>Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development<br>Signal Transduct Target Ther (2021) 6, 134-134. PubMed  Europe PubMed DOI  PMC  EPMC  K
    6. 2020
  6. Parigiani,M.A., Ketscher,A., Timme,S., Bronsert,P., Schlimpert,M., Kammerer,B., Jacquel,A., Chaintreuil,P. and Reinheckel,T.<br>Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression<br>Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI  K
    7. 2016
  7. Zhang,H., Zhang,L., Wei,L., Gao,X., Tang,L., Gong,W., Min,N., Zhang,L. and Yuan,Y.<br>Knockdown of cathepsin L sensitizes ovarian cancer cells to chemotherapy<br>Oncol Lett (2016) 11, 4235-4239. PubMed  Europe PubMed DOI  K
    8. 2015
  8. Brindle,N.R., Joyce,J.A., Rostker,F., Lawlor,E.R., Swigart-Brown,L., Evan,G., Hanahan,D. and Shchors,K.<br>Deficiency for the cysteine protease cathepsin L impairs myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer<br>PLoS ONE (2015) 10, e0120348- PubMed  Europe PubMed DOI  PMC  EPMC  K
    9. 2014
  9. Tholen,S., Biniossek,M.L., Gansz,M., Ahrens,T.D., Schlimpert,M., Kizhakkedathu,J.N., Reinheckel,T. and Schilling,O.<br>Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis<br>Cell Mol Life Sci (2014) 71, 899-916. PubMed  Europe PubMed DOI  K
    10. 2013
  10. Tholen,S., Biniossek,M.L., Gansz,M., Gomez-Auli,A., Bengsch,F., Noel,A., Kizhakkedathu,J.N., Boerries,M., Busch,H., Reinheckel,T. and Schilling,O.<br>Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome<br>Mol Cell Proteomics (2013) 12, 611-625. PubMed  Europe PubMed DOI  K
    11. 2011
  11. Sun,J., Sukhova,G.K., Zhang,J., Chen,H., Sjoberg,S., Libby,P., Xiang,M., Wang,J., Peters,C., Reinheckel,T. and Shi,G.P.<br>Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice<br>Arterioscler Thromb Vasc Biol (2011) 31, 2500-2508. PubMed  Europe PubMed DOI  K
  12. Sun,M., Chen,M., Liu,Y., Fukuoka,M., Zhou,K., Li,G., Dawood,F., Gramolini,A. and Liu,P.P.<br>Cathepsin-L contributes to cardiac repair and remodelling post-infarction<br>Cardiovasc Res (2011) 89, 374-383. PubMed  Europe PubMed DOI  K
  13. Tholen,S., Biniossek,M.L., Gessler,A.L., Muller,S., Weisser,J., Kizhakkedathu,J.N., Reinheckel,T. and Schilling,O.<br>Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts<br>Biol Chem (2011) 392, 961-971. PubMed  Europe PubMed DOI  K
    14. 2010
  14. Dennemarker,J., Lohmuller,T., Mayerle,J., Tacke,M., Lerch,M.M., Coussens,L.M., Peters,C. and Reinheckel,T.<br>Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis<br>Oncogene (2010) 29, 1611-1621. PubMed  Europe PubMed DOI  K
  15. Dennemarker,J., Lohmuller,T., Muller,S., Aguilar,S.V., Tobin,D.J., Peters,C. and Reinheckel,T.<br>Impaired turnover of autophagolysosomes in cathepsin L deficiency<br>Biol Chem (2010) 391, 913-922. PubMed  Europe PubMed DOI  K
  16. Minokadeh,A., Funkelstein,L., Toneff,T., Hwang,S.R., Beinfeld,M., Reinheckel,T., Peters,C., Zadina,J. and Hook,V.<br>Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression<br>Mol Cell Neurosci (2010) 43, 98-107. PubMed  Europe PubMed DOI  K
  17. Zeeuwen,P.L., van Vlijmen-Willems,I.M., Cheng,T., Rodijk-Olthuis,D., Hitomi,K., Hara-Nishimura,I., John,S., Smyth,N., Reinheckel,T., Hendriks,W.J. and Schalkwijk,J.<br>The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea<br>FASEB J (2010) 24, 3744-3755. PubMed  Europe PubMed DOI  K
    18. 2009
  18. Beinfeld,M.C., Funkelstein,L., Foulon,T., Cadel,S., Kitagawa,K., Toneff,T., Reinheckel,T., Peters,C. and Hook,V.<br>Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies<br>Peptides (2009) 30, 1882-1891. PubMed  Europe PubMed DOI  PMC  EPMC  K  I
  19. Luft,F.C.<br>From furless to heartless - unraveling the diverse functions of cathepsin L<br>J Mol Med (Berl) (2009) 87, 225-227. PubMed  Europe PubMed DOI  K
    20. 2008
  20. Funkelstein,L., Toneff,T., Hwang,S.R., Reinheckel,T., Peters,C. and Hook,V.<br>Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression<br>J Neurochem (2008) 106, 384-391. PubMed  Europe PubMed DOI  PMC  EPMC  K
    21. 2007
  21. Boudreau,F., Lussier,C.R., Mongrain,S., Darsigny,M., Drouin,J.L., Doyon,G., Suh,E.R., Beaulieu,J.F., Rivard,N. and Perreault,N.<br>Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia<br>FASEB J (2007) 21, 3853-3865. PubMed  Europe PubMed DOI  K
  22. Stahl,S., Reinders,Y., Asan,E., Mothes,W., Conzelmann,E., Sickmann,A. and Felbor,U.<br>Proteomic analysis of cathepsin B- and L-deficient mouse brain lysosomes<br>Biochim Biophys Acta (2007) 1774, 1237-1246. PubMed  Europe PubMed DOI  K
  23. Yang,M., Zhang,Y., Pan,J., Sun,J., Liu,J., Libby,P., Sukhova,G.K., Doria,A., Katunuma,N., Peroni,O.D., Guerre-Millo,M., Kahn,B.B., Clement,K. and Shi,G.P.<br>Cathepsin L activity controls adipogenesis and glucose tolerance<br>Nat Cell Biol (2007) 9, 970-977. PubMed  Europe PubMed DOI  K  I
    24. 2006
  24. Petermann,I., Mayer,C., Stypmann,J., Biniossek,M.L., Tobin,D.J., Engelen,M.A., Dandekar,T., Grune,T., Schild,L., Peters,C. and Reinheckel,T.<br>Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice<br>FASEB J (2006) 20, 1266-1268. PubMed  Europe PubMed DOI  K
  25. Sevenich,L., Pennacchio,L.A., Peters,C. and Reinheckel,T.<br>Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice<br>Biol Chem (2006) 387, 885-891. PubMed  Europe PubMed DOI  K
    26. 2005
  26. Koike,M., Shibata,M., Waguri,S., Yoshimura,K., Tanida,I., Kominami,E., Gotow,T., Peters,C., von Figura,K., Mizushima,N., Saftig,P. and Uchiyama,Y.<br>Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease)<br>Am J Pathol (2005) 167, 1713-1728. PubMed  Europe PubMed DOI  PMC  EPMC  K
    27. 2003
  27. Levicar,N., Dewey,R.A., Daley,E., Bates,T.E., Davies,D., Kos,J., Pilkington,G.J. and Lah,T.T.<br>Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis<br>Cancer Gene Ther (2003) 10, 141-151. PubMed  Europe PubMed DOI  K
    28. 2002
  28. Benavides,F., Starost,M.F., Flores,M., Gimenez-Conti,I.B., Guenet,J.L. and Conti,C.J.<br>Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation<br>Am J Pathol (2002) 161, 693-703. PubMed  Europe PubMed DOI  PMC  EPMC  K  M
  29. [YEAR:11-6-2002]Felbor,U., Kessler,B., Mothes,W., Goebel,H.H., Ploegh,H.L., Bronson,R.T. and Olsen,B.R.<br>Neuronal loss and brain atrophy in mice lacking cathepsins B and L<br>Proc Natl Acad Sci U S A (11-6-2002) 99, 7883-7888. PubMed  Europe PubMed DOI  PMC  EPMC  K
  30. [YEAR:30-4-2002]Stypmann,J., Glaser,K., Roth,W., Tobin,D.J., Petermann,I., Matthias,R., Monnig,G., Haverkamp,W., Breithardt,G., Schmahl,W., Peters,C. and Reinheckel,T.<br>Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L<br>Proc Natl Acad Sci U S A (30-4-2002) 99, 6234-6239. PubMed  Europe PubMed DOI  PMC  EPMC  K
    31. 2001
  31. [YEAR:22-6-2001]Honey,K., Duff,M., Beers,C., Brissette,W.H., Elliott,E.A., Peters,C., Maric,M., Cresswell,P. and Rudensky,A.<br>Cathepsin S regulates the expression of cathepsin L and the turnover of gamma-interferon-inducible lysosomal thiol reductase in B lymphocytes<br>J Biol Chem (22-6-2001) 276, 22573-22578. PubMed  Europe PubMed DOI  K
  32. Reinheckel,T., Deussing,J., Roth,W. and Peters,C.<br>Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L<br>Biol Chem (2001) 382, 735-741. PubMed  Europe PubMed DOI  K
    33. 2000
  33. Roth,W., Deussing,J., Botchkarev,V.A., Pauly-Evers,M., Saftig,P., Hafner,A., Schmidt,P., Schmahl,W., Scherer,J., Anton-Lamprecht,I., von Figura,K., Paus,R. and Peters,C.<br>Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling<br>FASEB J (2000) 14, 2075-2086. PubMed  Europe PubMed DOI  K  M

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