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Literature for peptidase C14.005: caspase-6

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(References are filtered for relevance to Inhibitor. To remove the filter click here. See explanation.)

    2021
  1. Zhu,Y., Zhou,J., Niu,P., Chen,H. and Shi,D.
    Cardamonin inhibits cell proliferation by caspase-mediated cleavage of Raptor
    Naunyn Schmiedebergs Arch Pharmacol394, 809-817. PubMed  Europe PubMed DOI  I
    2. 2020
  2. Corrigan,T.S., Lotti Diaz,L.M., Border,S.E., Ratigan,S.C., Kasper,K.Q., Sojka,D., Fajtova,P., Caffrey,C.R., Salvesen,G.S., McElroy,C.A., Hadad,C.M. and Dogan Ekici,O.
    Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors
    J Enzyme Inhib Med Chem35, 1387-1402. PubMed  Europe PubMed DOI  I
    3. 2019
  3. Tubeleviciute-Aydin,A., Beautrait,A., Lynham,J., Sharma,G., Gorelik,A., Deny,L.J., Soya,N., Lukacs,G.L., Nagar,B., Marinier,A. and LeBlanc,A.C.
    Identification of allosteric inhibitors against active caspase-6
    Sci Rep9, 5504-5504. PubMed  Europe PubMed DOI  I
  4. Zhou,L., Flores,J., Noel,A., Beauchet,O., Sjostrom,P.J. and LeBlanc,A.C.
    Methylene blue inhibits caspase-6 activity, and reverses caspase-6-induced cognitive impairment and neuroinflammation in aged mice
    Acta Neuropathol Commun7, 210-210. PubMed  Europe PubMed DOI  I
    5. 2017
  5. Pakavathkumar,P., Noel,A., Lecrux,C., Tubeleviciute-Aydin,A., Hamel,E., Ahlfors,J.E. and LeBlanc,A.C.
    Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in caspase-6-overexpressing mice
    Mol Neurodegener12, 22-22. PubMed  Europe PubMed DOI  I
  6. Suita,H., Shinomiya,T. and Nagahara,Y.
    Caspase-6 induces 7A6 antigen localization to mitochondria during FAS-induced apoptosis of Jurkat cells
    Anticancer Res37, 1697-1704. PubMed  Europe PubMed DOI  I
    7. 2015
  7. Aharony,I., Ehrnhoefer,D.E., Shruster,A., Qiu,X., Franciosi,S., Hayden,M.R. and Offen,D.
    A huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits
    Hum Mol Genet24, 2604-2614. PubMed  Europe PubMed DOI  I
    8. 2014
  8. Flygare,J.A. and Arkin,M.R.
    Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases
    Curr Top Med Chem14, 319-325. PubMed  Europe PubMed DOI  I
  9. Murray,J., Giannetti,A.M., Steffek,M., Gibbons,P., Hearn,B.R., Cohen,F., Tam,C., Pozniak,C., Bravo,B., Lewcock,J., Jaishankar,P., Ly,C.Q., Zhao,X., Tang,Y., Chugha,P., Arkin,M.R., Flygare,J. and Renslo,A.R.
    Tailoring small molecules for an allosteric site on procaspase-6
    ChemMedChem9, 73-77. PubMed  Europe PubMed DOI  I
    10. 2013
  10. Murray,J. and Renslo,A.R.
    Modulating caspase activity: beyond the active site
    Curr Opin Struct Biol23, 812-819. PubMed  Europe PubMed DOI  I
    11. 2012
  11. Heise,C.E., Murray,J., Augustyn,K.E., Bravo,B., Chugha,P., Cohen,F., Giannetti,A.M., Gibbons,P., Hannoush,R.N., Hearn,B.R., Jaishankar,P., Ly,C.Q., Shah,K., Stanger,K., Steffek,M., Tang,Y., Zhao,X., Lewcock,J.W., Renslo,A.R., Flygare,J. and Arkin,M.R.
    Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6
    PLoS ONE7, e50864-e50864. PubMed  Europe PubMed DOI  S  I
  12. Stanger,K., Steffek,M., Zhou,L., Pozniak,C.D., Quan,C., Franke,Y., Tom,J., Tam,C., Krylova,I., Elliott,J.M., Lewcock,J.W., Zhang,Y., Murray,J. and Hannoush,R.N.
    Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization
    Nat Chem Biol8, 655-660. PubMed  Europe PubMed DOI  I
    13. 2011
  13. Muller,I., Lamers,M.B., Ritchie,A.J., Dominguez,C., Munoz-Sanjuan,I. and Kiselyov,A.
    Structure of human caspase-6 in complex with Z-VAD-FMK: new peptide binding mode observed for the non-canonical caspase conformation
    Bioorg Med Chem Lett21, 5244-5247. PubMed  Europe PubMed DOI  I
    14. 2009
  14. Chu,W., Rothfuss,J., Chu,Y., Zhou,D. and Mach,R.H.
    Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6
    J Med Chem52, 2188-2191. PubMed  Europe PubMed DOI  I
    15. 2008
  15. Pereira,N.A. and Song,Z.
    Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity
    Biochem Biophys Res Commun377, 873-877. PubMed  Europe PubMed DOI  P  I
    16. 2006
  16. [YEAR:21-9-2006]Ekici,O.D., Li,Z.Z., Campbell,A.J., James,K.E., Asgian,J.L., Mikolajczyk,J., Salvesen,G.S., Ganesan,R., Jelakovic,S., Grutter,M.G. and Powers,J.C.
    Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10
    J Med Chem49, 5728-5749. PubMed  Europe PubMed DOI  I
  17. [YEAR:8-5-2006]Wu,X., Simone,J., Hewgill,D., Siegel,R., Lipsky,P.E. and He,L.
    Measurement of two caspase activities simultaneously in living cells by a novel dual FRET fluorescent indicator probe
    Cytometry A69, 477-486. PubMed  Europe PubMed DOI  I
    18. 1996
  18. Fernandes-Alnemri,T., Armstrong,R.C., Krebs,J., Srinivasula,S.M., Wang,L., Bullrich,F., Fritz,L.C., Trapani,J.A., Tomaselli,K.J., Litwack,G. and Alnemri,E.S.
    In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
    Proc Natl Acad Sci U S A93, 7464-7469. PubMed  Europe PubMed DOI  I

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