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Literature for peptidase C14.003: caspase-3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(References are filtered for relevance to Inhibitor. To remove the filter click here. See explanation.)

    2024
  1. Berthenet,K., Aimontche,E., El Mrini,S., Briere,J., Pion,N., Iacono,I., Brejon,S., Monier,K., Catez,F., Ichim,G., Combaret,V., Mertani,H.C., Diaz,J.J. and Albaret,M.A.
    Spatial sequestration of activated-caspase 3 in aggresomes mediates resistance of neuroblastoma cell to bortezomib treatment
    Sci Rep14, 3768-3768. PubMed  Europe PubMed DOI  I
    2. 2022
  2. Bresinsky,M., Strasser,J.M., Vallaster,B., Liu,P., McCue,W.M., Fuller,J., Hubmann,A., Singh,G., Nelson,K.M., Cuellar,M.E., Wilmot,C.M., Finzel,B.C., Ashe,K.H., Walters,M.A. and Pockes,S.
    Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314
    ACS Pharmacol Transl Sci5, 20-40. PubMed  Europe PubMed DOI  I
    3. 2020
  3. Corrigan,T.S., Lotti Diaz,L.M., Border,S.E., Ratigan,S.C., Kasper,K.Q., Sojka,D., Fajtova,P., Caffrey,C.R., Salvesen,G.S., McElroy,C.A., Hadad,C.M. and Dogan Ekici,O.
    Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors
    J Enzyme Inhib Med Chem35, 1387-1402. PubMed  Europe PubMed DOI  I
  4. Cui,X.Y., Park,S.H. and Park,W.H.
    Auranofin inhibits the proliferation of lung cancer cells via necrosis and caspasedependent apoptosis
    Oncol Rep44, 2715-2724. PubMed  Europe PubMed DOI  I
  5. Firoozpour,L., Gao,L., Moghimi,S., Pasalar,P., Davoodi,J., Wang,M.W., Rezaei,Z., Dadgar,A., Yahyavi,H., Amanlou,M. and Foroumadi,A.
    Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors
    J Enzyme Inhib Med Chem35, 1674-1684. PubMed  Europe PubMed DOI  I
  6. Fu,S., Ding,M., Wang,J., Yin,X., Zhou,E., Kong,L., Tu,X., Guo,Z., Wang,A., Huang,Y. and Ye,J.
    Identification and functional characterization of three caspases in Takifugu obscurus in response to bacterial infection
    Fish Shellfish Immunol PubMed  Europe PubMed DOI  I
  7. Guo,X., Bai,X., Zhang,F., Zheng,L., Ding,W. and Yang,S.
    Resveratrol protects against apoptosis induced by interleukin-1beta in nucleus pulposus cells via activating mTOR/caspase-3 and GSK-3beta/caspase-3 pathways
    Biosci Rep40, PubMed  Europe PubMed DOI  I
  8. Huo,W., Yu,J., Liu,C., Wu,T., Wang,Y., Meng,X., Song,F., Zhang,S., Su,Y., Liu,Y., Liu,J., Yu,X. and Hua,S.
    Caspase-3 inhibitor inhibits enterovirus D68 production
    J Microbiol58, 812-820. PubMed  Europe PubMed DOI  I
  9. Liang,H., Li,F., Li,H., Wang,R. and Du,M.
    Overexpression of lncRNA HULC Attenuates Myocardial Ischemia/reperfusion Injury in Rat Models and Apoptosis of Hypoxia/reoxygenation Cardiomyocytes via Targeting miR-377-5p through NLRP3/Caspase1/IL1beta Signaling Pathway Inhibition
    Immunol Invest1-14. PubMed  Europe PubMed DOI  I
  10. Salama,R.M., Mohamed,A.M., Hamed,N.S., Ata,R.M., NourelDeen,A.S. and Hassan,M.A.
    Alogliptin: a novel approach against cyclophosphamide-induced hepatic injury via modulating SIRT1/FoxO1 pathway
    Toxicol Res (Camb)9, 561-568. PubMed  Europe PubMed DOI  I
  11. Yardim,A., Kandemir,F.M., Ozdemir,S., Kucukler,S., Comakli,S., Gur,C. and Celik,H.
    Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-kappaB, ATF-6 pathways and activating Nrf2, Akt pathways
    Neurotoxicology81, 137-146. PubMed  Europe PubMed DOI  I
  12. Yossef,R.R., Al-Yamany,M.F., Saad,M.A. and El-Sahar,A.E.
    Neuroprotective effects of vildagliptin on drug induced Alzheimer's disease in rats with metabolic syndrome: Role of hippocampal klotho and AKT signaling pathways
    Eur J Pharmacol889, 173612-173612. PubMed  Europe PubMed DOI  I
  13. Zhang,J.W., Long,T.Y., Pan,W., Zhong,Q.Q., Qian,Z.X. and Jing,R.
    MiR-808 inhibits cardiomyocyte apoptosis and expressions of caspase-3 and caspase-9 in rats with myocardial infarction by regulating TGF-beta1 signaling pathway
    Eur Rev Med Pharmacol Sci24, 6955-6960. PubMed  Europe PubMed DOI  I
    14. 2019
  14. Checker,R., Pal,D., Patwardhan,R.S., Basu,B., Sharma,D. and Sandur,S.K.
    Modulation of caspase-3 activity using a redox active vitamin K3 analogue, plumbagin, as a novel strategy for radioprotection
    Free Radic Biol Med143, 560-572. PubMed  Europe PubMed DOI  I
  15. Eda,S.R., Veeramachaneni,G.K., Bondili,J.S. and Jinka,R.
    Screening of caspase-3 inhibitors from natural molecule database using e-pharmacophore and docking studies
    Bioinformation15, 240-245. PubMed  Europe PubMed DOI  I
  16. Solania,A., Gonzalez-Paez,G.E. and Wolan,D.W.
    Selective and rapid cell-permeable inhibitor of human caspase-3
    ACS Chem Biol14, 2463-2470. PubMed  Europe PubMed DOI  I
  17. Van Kersavond,T., Konopatzki,R., Chakrabarty,S., Blank-Landeshammer,B., Sickmann,A. and Verhelst,S.H.L.
    Short peptides with uncleavable peptide bond mimetics as photoactivatable caspase-3 inhibitors
    Molecules24, PubMed  Europe PubMed DOI  I
    18. 2017
  18. Poreba,M., Salvesen,G.S. and Drag,M.
    Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity
    Nat Protoc12, 2189-2214. PubMed  Europe PubMed DOI  P  I
    19. 2016
  19. Hajimahdi,Z., Safizadeh,F. and Zarghi,A.
    Qsar analysis for some 1, 2-benzisothiazol-3-one derivatives as caspase-3 inhibitors by stepwise mlr method
    Iran J Pharm Res15, 439-448. PubMed  Europe PubMed  I
    20. 2015
  20. Chen,B., Ning,J.L., Gu,J.T., Cui,J., Yang,Y., Wang,Z., Zeng,J., Yi,B. and Lu,K.Z.
    Caspase-3 inhibition prevents the development of hepatopulmonary syndrome in common bile duct ligation rats by alleviating pulmonary injury
    Liver Int35, 1373-1382. PubMed  Europe PubMed DOI  I
  21. Ferrucci,A., Leboffe,L., Agamennone,M., Di Pizio,A., Fiocchetti,M., Marino,M., Ascenzi,P. and Luisi,G.
    Ac-tLeu-Asp-H is the minimal and highly effective human caspase-3 inhibitor: biological and in silico studies
    Amino Acids47, 153-162. PubMed  Europe PubMed DOI  I
  22. Limpachayaporn,P., Schafers,M. and Haufe,G.
    Isatin sulfonamides: potent caspases-3 and -7 inhibitors, and promising PET and SPECT radiotracers for apoptosis imaging
    Future Med Chem7, 1173-1196. PubMed  Europe PubMed DOI  L  I
    23. 2014
  23. Ahmad,K., Balaramnavar,V.M., Baig,M.H., Srivastava,A.K., Khan,S. and Kamal,M.A.
    Identification of potent caspase-3 inhibitors for treatment of multi-neurodegenerative diseases using pharmacophore modeling and docking approaches
    CNS Neurol Disord Drug Targets13, 1346-1353. PubMed  Europe PubMed  I
  24. Guo,Z., Yan,Z., Zhou,X., Wang,Q., Lu,M., Liu,W., Zhou,H., Yang,C. and McClain,E.J.
    Synthesis and biological evaluation of novel 1,2-benzisothiazol-3-one-derived 1,2,3-triazoles as caspase-3 inhibitors
    Med Chem Res24, 1814-1829. DOI  I
  25. Holland-Nell,K., Fernandez-Bachiller,M.I., Ahsanullah and Rademann,J.
    Chemoselective Wittig and Michael ligations of unprotected peptidyl phosphoranes in water furnish potent inhibitors of caspase-3
    Org Lett16, 4428-4431. PubMed  Europe PubMed DOI  I
  26. Ishimoto,T., Jigawa,K., Henares,T.G., Sueyoshi,K., Endo,T. and Hisamoto,H.
    Efficient immobilization of the enzyme and substrate for a single-step caspase-3 inhibitor assay using a combinable PDMS capillary sensor array
    RSC Adv4, 7682-7687. DOI  A  I
  27. Kelotra,S., Jain,M., Kelotra,A., Jain,I., Bandaru,S., Nayarisseri,A. and Bidwai,A.
    An in silico appraisal to identify high affinity anti-apoptotic synthetic tetrapeptide inhibitors targeting the mammalian caspase 3 enzyme
    Asian Pac J Cancer Prev15, 10137-10142. PubMed  Europe PubMed DOI  I
  28. Li,B., Blanc,J.M., Sun,Y., Yang,L., Zaorsky,N.G., Giacalone,N.J., Torossian,A. and Lu,B.
    Assessment of M867, a selective caspase-3 inhibitor, in an orthotopic mouse model for non-small cell lung carcinoma
    Am J Cancer Res4, 161-171. PubMed  Europe PubMed  I
  29. Li,Z., Pan,Y., Zhong,W., Zhu,Y., Zhao,Y., Li,L., Liu,W., Zhou,H. and Yang,C.
    Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors
    Bioorg Med Chem22, 6735-6745. PubMed  Europe PubMed DOI  I
  30. Wu,L., Lu,M., Yan,Z., Tang,X., Sun,B., Liu,W., Zhou,H. and Yang,C.
    1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors
    Bioorg Med Chem22, 2416-2426. PubMed  Europe PubMed DOI  I
    31. 2013
  31. Krause-Heuer,A.M., Howell,N.R., Matesic,L., Dhand,G., Young,E.L., Burgess,L., Jiang,C.D., Lengkeek,N.A., Fookes,C.J.R., Pham,T.Q., Sobrio,F., Greguric,I. and Fraser,B.H.
    A new class of fluorinated 5-pyrrolidinylsulfonyl isatin caspase inhibitors for PET imaging of apoptosis
    MedChemComm4, 347-352. DOI  L  I
  32. Limpachayaporn,P., Riemann,B., Kopka,K., Schober,O., Schafers,M. and Haufe,G.
    Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7
    Eur J Med Chem64, 562-578. PubMed  Europe PubMed DOI  I
  33. Limpachayaporn,P., Schafers,M., Schober,O., Kopka,K. and Haufe,G.
    Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: Nonradioactive counterparts of putative PET-compatible apoptosis imaging agents
    Bioorg Med Chem21, 2025-2036. PubMed  Europe PubMed DOI  I
  34. Liu,D., Tian,Z., Yan,Z., Wu,L., Ma,Y., Wang,Q., Liu,W., Zhou,H. and Yang,C.
    Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors
    Bioorg Med Chem21, 2960-2967. PubMed  Europe PubMed DOI  I
  35. Sharma,S., Basu,A. and Agrawal,R.K.
    Pharmacophore modeling and docking studies on some nonpeptide-based caspase-3 inhibitors
    Biomed Res Int2013, 306081-306081. PubMed  Europe PubMed DOI  I
  36. Vickers,C.J., Gonzalez-Paez,G.E. and Wolan,D.W.
    Selective detection of caspase-3 versus caspase-7 using activity-based probes with key unnatural amino acids
    ACS Chem Biol8, 1558-1566. PubMed  Europe PubMed DOI  I
    37. 2012
  37. Firoozpour,L., Sadatnezhad,K., Dehghani,S., Pourbasheer,E., Foroumadi,A., Shafiee,A. and Amanlou,M.
    An efficient piecewise linear model for predicting activity of caspase-3 inhibitors
    Daru20, 31-31. PubMed  Europe PubMed DOI  I
  38. Samiulla,D.S., Naidu,A., Rao,G.V. and Ramachandra,M.
    Discovery of indole tetrafluorophenoxymethylketone-based potent novel small molecule inhibitors of caspase-3
    Org Med Chem Lett2, 27-27. PubMed  Europe PubMed DOI  I
  39. Vuojola,J., Riuttamaki,T., Kulta,E., Arppe,R. and Soukka,T.
    Fluorescence-quenching-based homogeneous caspase-3 activity assay using photon upconversion
    Anal Chim Acta725, 67-73. PubMed  Europe PubMed DOI  A  I
  40. Zhu,Q., Gao,L., Chen,Z., Zheng,S., Shu,H., Li,J., Jiang,H. and Liu,S.
    A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions
    Eur J Med Chem54, 232-238. PubMed  Europe PubMed DOI  I
    41. 2011
  41. Ganesan,R., Jelakovic,S., Mittl,P.R., Caflisch,A. and Grutter,M.G.
    In silico identification and crystal structure validation of caspase-3 inhibitors without a P1 aspartic acid moiety
    Acta Crystallogr Sect F Struct Biol Cryst Commun67, 842-850. PubMed  Europe PubMed DOI  S  I
  42. Gao,Y.Y., Liu,B.Q., Niu,X.F., Zhuang,Y. and Wang,H.Q.
    Caspase-dependent cleavage of BAG3 associated with pancreatic cancer cell apoptosis
    Chin J Cancer Prev Treat18, 81-84.  I
  43. Gloria,P.M., Coutinho,I., Goncalves,L.M., Baptista,C., Soares,J., Newton,A.S., Moreira,R., Saraiva,L. and Santos,M.M.
    Aspartic vinyl sulfones: inhibitors of a caspase-3-dependent pathway
    Eur J Med Chem46, 2141-2146. PubMed  Europe PubMed DOI  I
  44. Jiang,Y. and Hansen,T.V.
    Isatin 1,2,3-triazoles as potent inhibitors against caspase-3
    Bioorg Med Chem Lett21, 1626-1629. PubMed  Europe PubMed DOI  I
  45. Liu,M.C., Kobeissy,F., Zheng,W., Zhang,Z., Hayes,R.L. and Wang,K.K.
    Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions
    ASN Neuro3, e00051-e00051. PubMed  Europe PubMed DOI  P  I
  46. Sengupta,S., Rao,G.V. and Dubey,P.K.
    Synthesis and evaluation of indole aspartyl ketones as novel caspase-3 inhibitors
    Asian J Chem23, 5517-5520.  I
  47. Sengupta,S., Rao,G.V. and Dubey,P.K.
    Synthesis and biological evaluation of novel oxalamido derivatives as caspase-3 inhibitors
    Indian J Chem Sect B Org Med Chem50, 901-905.  I
    48. 2010
  48. Murphy,D.J., Walker,B., Ryan,C.A. and Martin,S.L.
    The inhibitor profiling of the caspase family of proteases using substrate-derived peptide glyoxals
    Biochem Biophys Res Commun402, 483-488. PubMed  Europe PubMed DOI  I
  49. Newton,A.S., Gloria,P.M., Goncalves,L.M., Dos Santos,D.J., Moreira,R., Guedes,R.C. and Santos,M.M.
    Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study
    Eur J Med Chem45, 3858-3863. PubMed  Europe PubMed DOI  I
    50. 2009
  50. Fang,B., Fu,G., Agniswamy,J., Harrison,R.W. and Weber,I.T.
    Caspase-3 binds diverse P4 residues in peptides as revealed by crystallography and structural modeling
    Apoptosis14, 741-752. PubMed  Europe PubMed DOI  P  S  I
  51. Havran,L.M., Chong,D.C., Childers,W.E., Dollings,P.J., Dietrich,A., Harrison,B.L., Marathias,V., Tawa,G., Aulabaugh,A., Cowling,R., Kapoor,B., Xu,W., Mosyak,L., Moy,F., Hum,W.T., Wood,A. and Robichaud,A.J.
    3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3
    Bioorg Med Chem17, 7755-7768. PubMed  Europe PubMed DOI  I
  52. Podichetty,A.K., Faust,A., Kopka,K., Wagner,S., Schober,O., Schafers,M. and Haufe,G.
    Fluorinated isatin derivatives. Part 1: Synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors
    Bioorg Med Chem17, 2680-2688. PubMed  Europe PubMed DOI  I
  53. Schmidt,M.F., El-Dahshan,A., Keller,S. and Rademann,J.
    Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase-3 inhibitor
    Angew Chem Int Ed Engl48, 6346-6349. PubMed  Europe PubMed DOI  I
  54. Wang,Q., Mach,R.H. and Reichert,D.E.
    Docking and 3D-QSAR studies on isatin sulfonamide analogues as caspase-3 inhibitors
    J Chem Inf Model49, 1963-1973. PubMed  Europe PubMed DOI  I
    55. 2008
  55. Akdemir,O., Berksoy,I., Karaoclan,A., Barut,S., Bilguvar,K., Cirakoclu,B., Sahan,E. and Colak,A.
    Therapeutic efficacy of Ac-DMQD-CHO, a caspase 3 inhibitor, for rat spinal cord injury
    J Clin Neurosci15, 672-678. PubMed  Europe PubMed DOI  I
  56. Colantonio,P., Leboffe,L., Bolli,A., Marino,M., Ascenzi,P. and Luisi,G.
    Human caspase-3 inhibition by Z-tLeu-Asp-H: tLeu(P2) counterbalances Asp(P4) and Glu(P3) specific inhibitor truncation
    Biochem Biophys Res Commun377, 757-762. PubMed  Europe PubMed DOI  I
  57. Du,J.Q., Wu,J., Zhang,H.J., Zhang,Y.H., Qiu,B.Y., Wu,F., Chen,Y.H., Li,J.Y., Nan,F.J., Ding,J.P. and Li,J.
    Isoquinoline-1,3,4-trione derivatives inactivate caspase-3 by generation of reactive oxygen species
    J Biol Chem283, 30205-30215. PubMed  Europe PubMed DOI  I
  58. Kim,K.W., Moretti,L. and Lu,B.
    M867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated lung cancer models
    PLoS ONE3, e2275-e2275. PubMed  Europe PubMed DOI  I
  59. Pereira,N.A. and Song,Z.
    Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity
    Biochem Biophys Res Commun377, 873-877. PubMed  Europe PubMed DOI  P  I
  60. Sakai,J., Yoshimori,A., Nose,Y., Mizoroki,A., Okita,N., Takasawa,R. and Tanuma,S.
    Structure-based discovery of a novel non-peptidic small molecular inhibitor of caspase-3
    Bioorg Med Chem16, 4854-4859. PubMed  Europe PubMed DOI  I
  61. Sharma,S., Sahu,K., Jain,P., Mourya,V.K. and Agrawal,R.K.
    QSAR study of 1,3-dioxo-4-methyl-2,3-dihydro-1h-pyrrolo[3,4-c]quinolines as caspase-3 inhibitors
    Med Chem Res17, 399-411. DOI  I
  62. Vazquez,J., Garcia-Jareno,A., Mondragon,L., Rubio-Martinez,J., Perez-Paya,E. and Albericio,F.
    Conformationally restricted hydantoin-based peptidomimetics as inhibitors of caspase-3 with basic groups allowed at the S3 enzyme subsite
    ChemMedChem3, 979-985. PubMed  Europe PubMed DOI  I
    63. 2007
  63. Aulabaugh,A., Kapoor,B., Huang,X., Dollings,P., Hum,W.T., Banker,A., Wood,A. and Ellestad,G.
    Biochemical and biophysical characterization of inhibitor binding to caspase-3 reveals induced asymmetry
    Biochemistry46, 9462-9471. PubMed  Europe PubMed DOI  T  I
  64. Chu,W., Rothfuss,J., d'Avignon,A., Zeng,C., Zhou,D., Hotchkiss,R.S. and Mach,R.H.
    Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors
    J Med Chem50, 3751-3755. PubMed  Europe PubMed DOI  I
  65. Kuzelova,K., Grebenova,D. and Hrkal,Z.
    Labeling of apoptotic JURL-MK1 cells by fluorescent caspase-3 inhibitor FAM-DEVD-fmk occurs mainly at site(s) different from caspase-3 active site
    Cytometry A71, 605-611. PubMed  Europe PubMed DOI  L  I
  66. Yoshimori,A., Sakai,J., Sunaga,S., Kobayashi,T., Takahashi,S., Okita,N., Takasawa,R. and Tanuma,S.
    Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO
    BMC Pharmacol7, 8-8. PubMed  Europe PubMed DOI  I
    67. 2006
  67. [YEAR:9-3-2006]Chen,Y.H., Zhang,Y.H., Zhang,H.J., Liu,D.Z., Gu,M., Li,J.Y., Wu,F., Zhu,X.Z., Li,J. and Nan,F.J.
    Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors
    J Med Chem49, 1613-1623. PubMed  Europe PubMed DOI  I
  68. [YEAR:21-9-2006]Ekici,O.D., Li,Z.Z., Campbell,A.J., James,K.E., Asgian,J.L., Mikolajczyk,J., Salvesen,G.S., Ganesan,R., Jelakovic,S., Grutter,M.G. and Powers,J.C.
    Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10
    J Med Chem49, 5728-5749. PubMed  Europe PubMed DOI  I
  69. [YEAR:1-8-2006]Ganesan,R., Jelakovic,S., Campbell,A.J., Li,Z.Z., Asgian,J.L., Powers,J.C. and Grutter,M.G.
    Exploring the S4 and S1 prime subsite specificities in caspase-3 with aza-peptide epoxide inhibitors
    Biochemistry45, 9059-9067. PubMed  Europe PubMed DOI  S  I
  70. [YEAR:15-11-2006]Kanthasamy,A.G., Anantharam,V., Zhang,D., Latchoumycandane,C., Jin,H., Kaul,S. and Kanthasamy,A.
    A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models
    Free Radic Biol Med41, 1578-1589. PubMed  Europe PubMed DOI  P  I
  71. [YEAR:16-11-2006]Kopka,K., Faust,A., Keul,P., Wagner,S., Breyholz,H.J., Holtke,C., Schober,O., Schafers,M. and Levkau,B.
    5-Pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis
    J Med Chem49, 6704-6715. PubMed  Europe PubMed DOI  I
  72. Kravchenko,D.V., Kuzovkova,J.A., Kysil,V.M., Tkachenko,S.E., Malarchuk,S., Okun,I.M. and Ivachtchenko,A.V.
    Pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors: synthesis and SAR of 8-sulfamoyl-1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4c]quinolines
    Lett Drug Des Discov3, 61-70.  I
  73. [YEAR:21-11-2006]Mitchell,D.A., Morton,S.U. and Marletta,M.A.
    Design and characterization of an active site selective caspase-3 transnitrosating agent
    ACS Chem Biol1, 659-665. PubMed  Europe PubMed DOI  I
  74. [YEAR:8-5-2006]Wu,X., Simone,J., Hewgill,D., Siegel,R., Lipsky,P.E. and He,L.
    Measurement of two caspase activities simultaneously in living cells by a novel dual FRET fluorescent indicator probe
    Cytometry A69, 477-486. PubMed  Europe PubMed DOI  I
  75. [YEAR:4-8-2006]Zhou,D., Chu,W., Rothfuss,J., Zeng,C., Xu,J., Jones,L., Welch,M.J. and Mach,R.H.
    Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis
    Bioorg Med Chem Lett16, 5041-5046. PubMed  Europe PubMed DOI  I
    76. 2005
  76. Balsam,L.B., Kofidis,T. and Robbins,R.C.
    Caspase-3 inhibition preserves myocardial geometry and long-term function after infarction
    J Surg Res124, 194-200. PubMed  Europe PubMed DOI  I
  77. [YEAR:1-12-2005]Chu,W., Zhang,J., Zeng,C., Rothfuss,J., Tu,Z., Chu,Y., Reichert,D.E., Welch,M.J. and Mach,R.H.
    N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies
    J Med Chem48, 7637-7647. PubMed  Europe PubMed DOI  I
  78. [YEAR:4-8-2005]Goode,D.R., Sharma,A.K. and Hergenrother,P.J.
    Using peptidic inhibitors to systematically probe the S1' site of caspase-3 and caspase-7
    Org Lett7, 3529-3532. PubMed  Europe PubMed DOI  I
  79. [YEAR:15-2-2005]Han,Y., Giroux,A., Colucci,J., Bayly,C.I., McKay,D.J., Roy,S., Xanthoudakis,S., Vaillancourt,J., Rasper,D.M., Tam,J., Tawa,P., Nicholson,D.W. and Zamboni,R.J.
    Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors
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