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Literature for peptidase C02.001: calpain-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

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    2024
  1. Xie,X., Lan,Q., Zhao,J., Zhang,S., Liu,L., Zhang,Y., Xu,W., Shao,M., Peng,J., Xia,S., Zhu,Y., Zhang,K., Zhang,X., Zhang,R., Li,J., Dai,W., Ge,Z., Hu,S., Yu,C., Wang,J., Ma,D., Zheng,M., Yang,H., Xiao,G., Rao,Z., Lu,L., Zhang,L., Bai,F., Zhao,Y., Jiang,S. and Liu,H.
    Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1
    Signal Transduct Target Ther9, 54-54. PubMed  Europe PubMed DOI  I
    2. 2020
  2. Asano,T., Nagayo,Y., Tsuda,S., Ito,A., Kobayashi,W., Fujita,K., Sato,K., Nishiguchi,K.M., Kunikata,H., Fujioka,H., Kamiya,M., Urano,Y. and Nakazawa,T.
    Companion Diagnosis for Retinal Neuroprotective Treatment by Real-Time Imaging of Calpain Activation Using a Novel Fluorescent Probe
    Bioconjug Chem31, 2241-2251. PubMed  Europe PubMed DOI  I
  3. Donkor,I.O., Xu,J., Liu,J. and Cameron,K.
    Synthesis and antiproliferative activity of sulfonamide-based peptidomimetic calpain inhibitors
    Bioorg Med Chem115433-115433. PubMed  Europe PubMed DOI  I
  4. Jastaniah,A., Gaisina,I.N., Knopp,R.C. and Thatcher,G.R.J.
    Synthesis of alpha-Ketoamide-Based Stereoselective Calpain-1 Inhibitors as Neuroprotective Agents
    ChemMedChem PubMed  Europe PubMed DOI  I
  5. Ko,Y.U., Song,H.Y., Kim,W.K., Yune,T.Y., Yun,N. and Oh,Y.J.
    Calpain-mediated cleavage of Fbxw7 during excitotoxicity
    Neurosci Lett736, 135265-135265. PubMed  Europe PubMed DOI  I
    6. 2019
  6. Jantos,K., Kling,A., Mack,H., Hornberger,W., Moeller,A., Nimmrich,V., Lao,Y. and Nijsen,M.
    Discovery of ABT-957: 1-benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability
    Bioorg Med Chem Lett29, 1968-1973. PubMed  Europe PubMed DOI  I
  7. Jiang,S., Shao,C., Tang,F., Wang,W. and Zhu,X.
    Dynamin-like protein 1 cleavage by calpain in Alzheimer's disease
    Aging Celle12912-e12912. PubMed  Europe PubMed DOI  I
  8. Kitagawa,S.
    Experimental manipulation of calpain activity in vitro
    Methods Mol Biol1915, 209-218. PubMed  Europe PubMed DOI  I
  9. Ong,S.B., Lee,W.H., Shao,N.Y., Ismail,N.I., Katwadi,K., Lim,M.M., Kwek,X.Y., Michel,N.A., Li,J., Newson,J., Tahmasebi,S., Rehman,J., Kodo,K., Jang,H.R. and Ong,S.G.
    Calpain inhibition restores autophagy and prevents mitochondrial fragmentation in a human iPSC model of diabetic endotheliopathy
    Stem Cell Reports12, 597-610. PubMed  Europe PubMed DOI  I
    10. 2018
  10. Gutierrez,S., Moron,M., Griera,M., Sucunza,D., Calleros,L., Garcia-Jerez,A., Coderch,C., Hermoso,F.J., Burgos,C., Rodriguez-Puyol,M., de Pascual-Teresa,B., Diez-Marques,M.L., Jimenez,A., Toro-Londono,M., Rodriguez-Puyol,D. and Vaquero,J.J.
    Discovery of potent calpain inhibitors based on the azolo-imidazolidenone scaffold
    Eur J Med Chem157, 946-959. PubMed  Europe PubMed DOI  I
  11. Kalash,L., Cresser-Brown,J., Habchi,J., Morgan,C., Miller,D.J., Glen,R.C., Allemann,R.K. and Bender,A.
    Structure-based design of allosteric calpain-1 inhibitors populating a novel bioactivity space
    Eur J Med Chem157, 1264-1275. PubMed  Europe PubMed DOI  I
  12. Kling,A., Jantos,K., Mack,H., Hornberger,W., Backfisch,G., Lao,Y., Nijsen,M., Rendenbach-Mueller,B. and Moeller,A.
    Mitigating the metabolic liability of carbonyl reduction: novel calpain inhibitors with P1' extension
    ACS Med Chem Lett9, 221-226. PubMed  Europe PubMed DOI  I
  13. MacLeod,J.A., Gao,Y., Hall,C., Muller,W.J., Gujral,T.S. and Greer,P.A.
    Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib
    Oncotarget9, 33382-33395. PubMed  Europe PubMed DOI  K  I
  14. Pahima,H., Reina,S., Tadmor,N., Dadon-Klein,D., Shteinfer-Kuzmine,A., Mazure,N.M., Pinto,V. and Shoshan-Barmatz,V.
    Hypoxic-induced truncation of voltage-dependent anion channel 1 is mediated by both asparagine endopeptidase and calpain 1 activities
    Oncotarget9, 12825-12841. PubMed  Europe PubMed DOI  I
  15. Salimi,R., Bandaru,S., Devarakonda,S., Gokalp,S., Ala,C., Alvandian,A., Yener,N. and Akyurek,L.M.
    Blocking the cleavage of filamin A by calpain inhibitor decreases tumor cell growth
    Anticancer Res38, 2079-2085. PubMed  Europe PubMed DOI  I
  16. Wang,Y., Chen,B., Huang,C.K., Guo,A., Wu,J., Zhang,X., Chen,R., Chen,C., Kutschke,W., Weiss,R.M., Boudreau,R.L., Margulies,K.B., Hong,J. and Song,L.S.
    Targeting calpain for heart failure therapy: implications from multiple murine models
    JACC Basic Transl Sci3, 503-517. PubMed  Europe PubMed DOI  I
  17. Wang,Y., Liu,Y., Lopez,D., Lee,M., Dayal,S., Hurtado,A., Bi,X. and Baudry,M.
    Protection against TBI-induced neuronal death with post-treatment with a selective calpain-2 inhibitor in mice
    J Neurotrauma35, 105-117. PubMed  Europe PubMed DOI  I
    18. 2017
  18. Ferreras,S., Fernandez,G., Danelon,V., Pisano,M.V., Masseroni,L., Chapleau,C.A., Krapacher,F.A., Mlewski,E.C., Masco,D.H., Arias,C., Pozzo-Miller,L. and Paglini,M.G.
    Cdk5 is essential for amphetamine to increase dendritic spine density in hippocampal pyramidal neurons
    Front Cell Neurosci11, 372-372. PubMed  Europe PubMed DOI  I
  19. Kling,A., Jantos,K., Mack,H., Hornberger,W., Drescher,K., Nimmrich,V., Relo,A., Wicke,K., Hutchins,C.W., Lao,Y., Marsh,K. and Moeller,A.
    Discovery of novel and highly selective inhibitors of calpain for the treatment of Alzheimer's disease: 2-(3-phenyl-1H-pyrazol-1-yl)-nicotinamides
    J Med Chem60, 7123-7138. PubMed  Europe PubMed DOI  I
  20. Li,J., Yang,S. and Zhu,G.
    Postnatal calpain inhibition elicits cerebellar cell death and motor dysfunction
    Oncotarget8, 87997-88007. PubMed  Europe PubMed DOI  I
  21. Li,Z., Li,X., Gao,X., Du,M. and Zhang,D.
    Effect of inhibition of mu-calpain on the myofibril structure and myofibrillar protein degradation in postmortem ovine muscle
    J Sci Food Agric97, 2122-2131. PubMed  Europe PubMed DOI  I
  22. Lin,X.Y. and Chen,S.Z.
    Calpain inhibitors ameliorate muscle wasting in a cachectic mouse model bearing CT26 colorectal adenocarcinoma
    Oncol Rep37, 1601-1610. PubMed  Europe PubMed DOI  I
  23. Nagayoshi,T., Isoda,K., Mamiya,N. and Kida,S.
    Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory
    Mol Brain10, 61-61. PubMed  Europe PubMed DOI  I
  24. Tan,W.J., Tan,Q.Y., Wang,T., Lian,M., Zhang,L. and Cheng,Z.S.
    Calpain 1 regulates TGF-beta1-induced epithelial-mesenchymal transition in human lung epithelial cells via PI3K/Akt signaling pathway
    Am J Transl Res9, 1402-1409. PubMed  Europe PubMed  I
  25. Yuan,X.C., Wu,C.H., Gao,F., Li,H.P., Xiang,H.C., Zhu,H., Pan,X.L., Lin,L.X., Liu,Y.S., Yu,W., Tian,B., Meng,X.F. and Li,M.
    Activation and expression of mu-calpain in dorsal root contributes to RTX-induced mechanical allodynia
    Mol Pain13, 1744806917719169-1744806917719169. PubMed  Europe PubMed DOI  I
    26. 2016
  26. Bi,W., Jang,G.F., Zhang,L., Crabb,J.W., Laird,J., Linetsky,M. and Salomon,R.G.
    Molecular structures of isolevuglandin-protein cross-links
    Chem Res Toxicol29, 1628-1640. PubMed  Europe PubMed DOI  I
  27. Fa,M., Zhang,H., Staniszewski,A., Saeed,F., Shen,L.W., Schiefer,I.T., Siklos,M.I., Tapadar,S., Litosh,V.A., Libien,J., Petukhov,P.A., Teich,A.F., Thatcher,G.R. and Arancio,O.
    Novel selective calpain 1 inhibitors as potential therapeutics in Alzheimer's disease
    J Alzheimers Dis49, 707-721. PubMed  Europe PubMed DOI  I
  28. Hudson,I.L., Leemaqz,S.Y., Neffe,A.T. and Abell,A.D.
    Classifying calpain inhibitors for the treatment of cataracts: A self organising map (SOM) ANN/KM approach in drug discovery
    Stud Comput Intell628, 161-212. DOI  I
  29. Kumar,P., Choonara,Y.E. and Pillay,V.
    In silico affinity profiling of neuroactive polyphenols for post-traumatic calpain inactivation: a molecular docking and atomistic simulation sensitivity analysis
    Molecules20, 135-168. PubMed  Europe PubMed DOI  I
  30. Thompson,J., Hu,Y., Lesnefsky,E.J. and Chen,Q.
    Activation of mitochondrial calpain and increased cardiac injury: beyond AIF release
    Am J Physiol Heart Circ Physiol310, H376-H384. PubMed  Europe PubMed DOI  I
  31. Wan,F., Letavernier,E., Abid,S., Houssaini,A., Czibik,G., Marcos,E., Rideau,D., Parpaleix,A., Lipskaia,L., Amsellem,V., Gellen,B., Sawaki,D., Derumeaux,G., Dubois-Rande,J.L., Delcroix,M., Quarck,R., Baud,L. and Adnot,S.
    Extracellular calpain/calpastatin balance is involved in the progression of pulmonary hypertension
    Am J Respir Cell Mol Biol55, 337-351. PubMed  Europe PubMed DOI  I
  32. Wang,Y., Lopez,D., Davey,P.G., Cameron,D.J., Nguyen,K., Tran,J., Marquez,E., Liu,Y., Bi,X. and Baudry,M.
    Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury
    Neurobiol Dis93, 121-128. PubMed  Europe PubMed DOI  I
  33. Zhang,J.N., Michel,U., Lenz,C., Friedel,C.C., Koster,S., d'Hedouville,Z., Tonges,L., Urlaub,H., Bahr,M., Lingor,P. and Koch,J.C.
    Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration
    Sci Rep6, 37050-37050. PubMed  Europe PubMed DOI  I
    34. 2015
  34. Adams,S.E., Robinson,E.J., Miller,D.J., Rizkallah,P.J., Hallett,M.B. and Allemann,R.K.
    Conformationally restricted calpain inhibitors
    Chem Sci6, 6865-6871. PubMed  Europe PubMed DOI  I
  35. Cagmat,E.B., Guingab-Cagmat,J.D., Vakulenko,V., Hayes,R.L. and Anagli,J.
    Potential use of calpain inhibitors as brain injury therapy
     PubMed  Europe PubMed  I
  36. Chimura,T., Launey,T. and Yoshida,N.
    Calpain-mediated degradation of drebrin by excitotoxicity in vitro and in vivo
    PLoS ONE10, e0125119- PubMed  Europe PubMed DOI  I
  37. Donkor,I.O.
    An updated patent review of calpain inhibitors (2012 - 2014)
    Expert Opin Ther Pat25, 17-31. PubMed  Europe PubMed DOI  I
  38. Elgheznawy,A., Shi,L., Hu,J., Wittig,I., Laban,H., Pircher,J., Mann,A., Provost,P., Randriamboavonjy,V. and Fleming,I.
    Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes
    Circ Res117, 157-165. PubMed  Europe PubMed DOI  I
  39. Lu,L., Meehan,M.J., Gu,S., Chen,Z., Zhang,W., Zhang,G., Liu,L., Huang,X., Dorrestein,P.C., Xu,Y., Moore,B.S. and Qian,P.Y.
    Mechanism of action of thalassospiramides, a new class of calpain inhibitors
    Sci Rep5, 8783-8783. PubMed  Europe PubMed DOI  I
  40. Luo,T., Yue,R., Hu,H., Zhou,Z., Yiu,K.H., Zhang,S., Xu,L., Li,K. and Yu,Z.
    PD150606 protects against ischemia/reperfusion injury by preventing mu-calpain-induced mitochondrial apoptosis
    Arch Biochem Biophys586, 1-9. PubMed  Europe PubMed DOI  I
  41. Muralidharan,A.R., Selvaraj,C., Singh,S.K., Sheu,J.R., Thomas,P.A. and Geraldine,P.
    Structure-based virtual screening and biological evaluation of a calpain inhibitor for prevention of selenite-induced cataractogenesis in an in vitro system
    J Chem Inf Model55, 1686-1697. PubMed  Europe PubMed DOI  I
    42. 2014
  42. Adams,S.E., Rizkallah,P.J., Miller,D.J., Robinson,E.J., Hallett,M.B. and Allemann,R.K.
    The structural basis of differential inhibition of human calpain by indole and phenyl alpha-mercaptoacrylic acids
    J Struct Biol187, 236-241. PubMed  Europe PubMed DOI  S  I
  43. Li,X., Luo,R., Chen,R., Song,L., Zhang,S., Hua,W. and Chen,H.
    Cleavage of IkappaBalpha by calpain induces myocardial NF-kappaB activation, TNF-alpha expression, and cardiac dysfunction in septic mice
    Am J Physiol Heart Circ Physiol306, H833-H843. PubMed  Europe PubMed DOI  I
  44. Low,K.E., Karunan Partha,S., Davies,P.L. and Campbell,R.L.
    Allosteric inhibitors of calpains: reevaluating inhibition by PD150606 and LSEAL
    Biochim Biophys Acta1840, 3367-3373. PubMed  Europe PubMed DOI  I
  45. Nabeshima,Y., Washida,M., Tamura,M., Maeno,A., Ohnishi,M., Shiroishi,T., Imura,A., Razzaque,M.S. and Nabeshima,Y.
    Calpain 1 inhibitor BDA-410 ameliorates alpha-klotho-deficiency phenotypes resembling human aging-related syndromes
    Sci Rep4, 5847-5847. PubMed  Europe PubMed DOI  I
    46. 2013
  46. Baek,K.H., Karki,R., Lee,E.S., Na,Y. and Kwon,Y.
    Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors
    Bioorg Chem51, 24-30. PubMed  Europe PubMed DOI  I
  47. De Franceschi,L., Franco,R.S., Bertoldi,M., Brugnara,C., Matte,A., Siciliano,A., Wieschhaus,A.J., Chishti,A.H. and Joiner,C.H.
    Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease
    FASEB J27, 750-759. PubMed  Europe PubMed DOI  I
  48. Escalante,A.M., McGrath,R.T., Karolak,M.R., Dorr,R.T., Lynch,R.M. and Landowski,T.H.
    Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo
    Cancer Chemother Pharmacol71, 1567-1576. PubMed  Europe PubMed DOI  I
  49. Miller,D.J., Adams,S.E., Hallett,M.B. and Allemann,R.K.
    Calpain-1 inhibitors for selective treatment of rheumatoid arthritis: what is the future?
    Future Med Chem5, 2057-2074. PubMed  Europe PubMed DOI  I
  50. Ozaki,T., Ishiguro,S., Hirano,S., Baba,A., Yamashita,T., Tomita,H. and Nakazawa,M.
    Inhibitory peptide of mitochondrial mu-calpain protects against photoreceptor degeneration in rhodopsin transgenic S334ter and P23H rats
    PLoS ONE8, e71650-e71650. PubMed  Europe PubMed DOI  I
  51. Schiefer,I.T., Tapadar,S., Litosh,V., Siklos,M., Scism,R., Wijewickrama,G.T., Chandrasena,E.P., Sinha,V., Tavassoli,E., Brunsteiner,M., Fa',M., Arancio,O., Petukhov,P. and Thatcher,G.R.
    Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors
    J Med Chem56, 6054-6068. PubMed  Europe PubMed DOI  I
  52. Subramanian,V., Moorleghen,J.J., Balakrishnan,A., Howatt,D.A., Chishti,A.H. and Uchida,H.A.
    Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice
    PLoS ONE8, e72214-e72214. PubMed  Europe PubMed DOI  I
    53. 2012
  53. Adams,S.E., Parr,C., Miller,D.J., Allemann,R.K. and Hallett,M.B.
    Potent inhibition of Ca2+-dependent activation of calpain-1 by novel mercaptoacrylates
    MedChemComm3, 566-570. DOI  I
  54. Liang,J.L., Cha,H.C., Lee,S.H., Son,J.K., Chang,H.W., Eom,J.E., Kwon,Y. and Jahng,Y.
    A facile synthesis of emodin derivatives, emodin carbaldehyde, citreorosein, and their 10-deoxygenated derivatives and their inhibitory activities on mu-calpain
    Arch Pharm Res35, 447-454. PubMed  Europe PubMed DOI  I
  55. Ozaki,T., Nakazawa,M., Yamashita,T., Sorimachi,H., Hata,S., Tomita,H., Isago,H., Baba,A. and Ishiguro,S.
    Intravitreal injection or topical eye-drop application of a mu-calpain C2L domain peptide protects against photoreceptor cell death in Royal College of Surgeons' rats, a model of retinitis pigmentosa
    Biochim Biophys Acta1822, 1783-1795. PubMed  Europe PubMed DOI  I
    56. 2011
  56. Chen,Q., Paillard,M., Gomez,L., Ross,T., Hu,Y., Xu,A. and Lesnefsky,E.J.
    Activation of mitochondrial mu-calpain increases AIF cleavage in cardiac mitochondria during ischemia-reperfusion
    Biochem Biophys Res Commun415, 533-538. PubMed  Europe PubMed DOI  I
  57. Donkor,I.O.
    Calpain inhibitors: a survey of compounds reported in the patent and scientific literature
    Expert Opin Ther Pat21, 601-636. PubMed  Europe PubMed DOI  I
  58. Lee,E., Jang,I., Shin,M.J., Cho,H.J., Kim,J., Eom,J.E., Kwon,Y. and Na,Y.
    Chalcones as novel non-peptidic mu-calpain inhibitors
    Bull Korean Chem Soc32, 3459-3464. DOI  I
  59. Liu,M.C., Kobeissy,F., Zheng,W., Zhang,Z., Hayes,R.L. and Wang,K.K.
    Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions
    ASN Neuro3, e00051-e00051. PubMed  Europe PubMed DOI  P  I
  60. Stuart,B.G., Coxon,J.M., Morton,J.D., Abell,A.D., McDonald,D.Q., Aitken,S.G., Jones,M.A. and Bickerstaffe,R.
    Molecular modeling: a search for a calpain inhibitor as a new treatment for cataractogenesis
    J Med Chem54, 7503-7522. PubMed  Europe PubMed DOI  I
  61. Yoo,Y.J., Nam,D.H., Jung,S.Y., Jang,J.W., Kim,H.J., Jin,C., Pae,A.N. and Lee,Y.S.
    Synthesis of cinnamoyl ketoamides as hybrid structures of antioxidants and calpain inhibitors
    Bioorg Med Chem Lett21, 2850-2854. PubMed  Europe PubMed DOI  I
    62. 2010
  62. Kim,K.A., Lee,Y.A. and Shin,M.H.
    Calpain-dependent cleavage of SHP-1 and SHP-2 is involved in the dephosphorylation of Jurkat T cells induced by Entamoeba histolytica
    Parasite Immunol32, 176-183. PubMed  Europe PubMed DOI  I
  63. Ovat,A., Li,Z.Z., Hampton,C.Y., Asress,S.A., Fernandez,F.M., Glass,J.D. and Powers,J.C.
    Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors
    J Med Chem53, 6326-6336. PubMed  Europe PubMed DOI  I
    64. 2009
  64. Guyton,M.K., Brahmachari,S., Das,A., Samantaray,S., Inoue,J., Azuma,M., Ray,S.K. and Banik,N.L.
    Inhibition of calpain attenuates encephalitogenicity of MBP-specific T cells
    J Neurochem110, 1895-1907. PubMed  Europe PubMed DOI  I
  65. Kang,D.H., Jun,K.Y., Lee,J.P., Pak,C.S., Na,Y. and Kwon,Y.
    Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity
    J Med Chem52, 3093-3097. PubMed  Europe PubMed DOI  I
  66. Lee,K.Y., Lee,K.S., Jin,C. and Lee,Y.S.
    Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives
    Eur J Med Chem44, 1331-1334. PubMed  Europe PubMed DOI  I
  67. Passiatore,G., Rom,S., Eletto,D. and Peruzzi,F.
    HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity
    Biochim Biophys Acta1793, 378-387. PubMed  Europe PubMed DOI  I
  68. Zhang,Y., Jung,S.Y., Jin,C., Kim,N.D., Gong,P. and Lee,Y.S.
    Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors
    Bioorg Med Chem Lett19, 502-507. PubMed  Europe PubMed DOI  I
    69. 2008
  69. Azuma,M. and Shearer,T.R.
    The role of calcium-activated protease calpain in experimental retinal pathology
    Surv Ophthalmol53, 150-163. PubMed  Europe PubMed DOI  I
  70. Donkor,I.O., Assefa,H. and Liu,J.
    Structural basis for the potent calpain inhibitory activity of peptidyl alpha-ketoacids
    J Med Chem51, 4346-4350. PubMed  Europe PubMed DOI  I
  71. Donkor,I.O. and Korukonda,R.
    Synthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position
    Bioorg Med Chem Lett18, 4806-4808. PubMed  Europe PubMed DOI  I
  72. Jones,M.A., Morton,J.D., Coxon,J.M., McNabb,S.B., Lee,H.Y., Aitken,S.G., Mehrtens,J.M., Robertson,L.J., Neffe,A.T., Miyamoto,S., Bickerstaffe,R., Gately,K., Wood,J.M. and Abell,A.D.
    Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors
    Bioorg Med Chem16, 6911-6923. PubMed  Europe PubMed DOI  I
  73. Koumura,A., Nonaka,Y., Hyakkoku,K., Oka,T., Shimazawa,M., Hozumi,I., Inuzuka,T. and Hara,H.
    A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl )-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice
    Neuroscience157, 309-318. PubMed  Europe PubMed DOI  I
  74. Qian,J., Cuerrier,D., Davies,P.L., Li,Z., Powers,J.C. and Campbell,R.L.
    Cocrystal structures of primed side-extending alpha-ketoamide inhibitors reveal novel calpain-inhibitor aromatic interactions
    J Med Chem51, 5264-5270. PubMed  Europe PubMed DOI  S  I
    75. 2007
  75. Cuerrier,D., Moldoveanu,T., Campbell,R.L., Kelly,J., Yoruk,B., Verhelst,S.H., Greenbaum,D., Bogyo,M. and Davies,P.L.
    Development of calpain-specific inactivators by screening of positional scanning epoxide libraries
    J Biol Chem282, 9600-9611. PubMed  Europe PubMed DOI  I
  76. Yu,C.G. and Geddes,J.W.
    Sustained calpain inhibition improves locomotor function and tissue sparing following contusive spinal cord injury
    Neurochem Res32, 2046-2053. PubMed  Europe PubMed DOI  I
    77. 2006
  77. Chicharro,R., Alonso,M., Mazo,M.T., Aran,V.J. and Herradon,B.
    Derivatives of 3-sec-butyl-1-oxo-2,3-dihydroisoquinoline as inhibitors of mu-calpain
    ChemMedChem1, 710-714. PubMed  Europe PubMed DOI  I
  78. [YEAR:20-6-2006]Cuerrier,D., Moldoveanu,T., Inoue,J., Davies,P.L. and Campbell,R.L.
    Calpain inhibition by alpha-ketoamide and cyclic hemiacetal inhibitors revealed by X-ray crystallography
    Biochemistry45, 7446-7452. PubMed  Europe PubMed DOI  S  I
  79. Guan,N., Korukonda,R., Hurh,E., Schmittgen,T.D., Donkor,I.O. and Dalton,J.T.
    Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines
    Int J Oncol29, 655-663. PubMed  Europe PubMed  I
  80. [YEAR:24-8-2006]Korukonda,R., Guan,N., Dalton,J.T., Liu,J. and Donkor,I.O.
    Synthesis, calpain inhibitory activity, and cytotoxicity of P2-substituted proline and thiaproline peptidyl aldehydes and peptidyl alpha-ketoamides
    J Med Chem49, 5282-5290. PubMed  Europe PubMed DOI  I
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