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Literature for peptidase C01.063: falcipain-3

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

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    2024
  1. Madhav,H., Reddy,G.S., Rizvi,Z., Jameel,E., Patel,T.S., Rahman,A., Yadav,V., Fatima,S., Heyat,F., Pal,K., Minju-Op,A., Subbarao,N., Bhattacharjee,S., Dixit,B.C., Sijwali,P.S. and Hoda,N.
    Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of Plasmodial cysteine protease inhibitors for the treatment of malaria
    RSC Med Chem (2024) 15, 1022-1037. PubMed  Europe PubMed DOI  PMC  EPMC  I
    2. 2019
  2. Rana,D., Kalamuddin,M., Sundriyal,S., Jaiswal,V., Sharma,G., Das Sarma,K., Sijwali,P.S., Mohmmed,A., Malhotra,P. and Mahindroo,N.
    Identification of antimalarial leads with dual falcipain-2 and falcipain-3 inhibitory activity
    Bioorg Med Chem (2019) , 115155-115155. PubMed  Europe PubMed DOI  I
  3. Stoye,A., Juillard,A., Tang,A.H., Legac,J., Gut,J., White,K.L., Charman,S.A., Rosenthal,P.J., Grau,G.E.R., Hunt,N.H. and Payne,R.J.
    Falcipain inhibitors based on the natural product gallinamide A are potent in vitro and in vivo antimalarials
    J Med Chem (2019) 62, 5562-5578. PubMed  Europe PubMed DOI  I
    4. 2018
  4. Bekono,B.D., Ntie-Kang,F., Owono Owono,L.C. and Megnassan,E.
    Targeting cysteine proteases from Plasmodium falciparum: a general overview, rational drug design and computational approaches for drug discovery
    Curr Drug Targets (2018) 19, 501-526. PubMed  Europe PubMed DOI  I
  5. Saddala,M.S. and Adi,P.J.
    Discovery of small molecules through pharmacophore modeling, docking and molecular dynamics simulation against Plasmodium vivax vivapain-3 (VP-3)
    Heliyon (2018) 4, e00612-e00612. PubMed  Europe PubMed DOI  PMC  EPMC  I
    6. 2016
  6. Musyoka,T.M., Kanzi,A.M., Lobb,K.A. and Tastan Bishop,O.
    Structure based docking and molecular dynamic studies of plasmodial cysteine proteases against a South African natural compound and its analogs
    Sci Rep (2016) 6, 23690-23690. PubMed  Europe PubMed DOI  PMC  EPMC  I
  7. Musyoka,T.M., Kanzi,A.M., Lobb,K.A. and Tastan Bishop,O.
    Analysis of non-peptidic compounds as potential malarial inhibitors against plasmodial cysteine proteases via integrated virtual screening workflow
    J Biomol Struct Dyn (2016) 34, 2084-2101. PubMed  Europe PubMed DOI  I
  8. Poongavanam,V. and Kongsted,J.
    Binding affinity models for falcipain inhibition based on the linear interaction energy method
    J Mol Graph Model (2016) 70, 236-245. PubMed  Europe PubMed DOI  I
    9. 2014
  9. Conroy,T., Guo,J.T., Elias,N., Cergol,K.M., Gut,J., Legac,J., Khatoon,L., Liu,Y., McGowan,S., Rosenthal,P.J., Hunt,N.H. and Payne,R.J.
    Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials
    J Med Chem (2014) 57, 10557-10563. PubMed  Europe PubMed DOI  I
  10. Weldon,D.J., Shah,F., Chittiboyina,A.G., Sheri,A., Chada,R.R., Gut,J., Rosenthal,P.J., Shivakumar,D., Sherman,W., Desai,P., Jung,J.C. and Avery,M.A.
    Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of alpha-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum
    Bioorg Med Chem Lett (2014) 24, 1274-1279. PubMed  Europe PubMed DOI  I
    11. 2013
  11. Kesharwani,R.K., Singh,D.V. and Misra,K.
    Computation-based virtual screening for designing novel antimalarial drugs by targeting falcipain-III: A structure-based drug designing approach
    J Vector Borne Dis (2013) 50, 93-102. PubMed  Europe PubMed  I
  12. Mane,U.R., Gupta,R.C., Nadkarni,S.S., Giridhar,R.R., Naik,P.P. and Yadav,M.R.
    Falcipain inhibitors as potential therapeutics for resistant strains of malaria: a patent review
    Expert Opin Ther Pat (2013) 23, 165-187. PubMed  Europe PubMed DOI  V  I
  13. Rathi,B., Singh,A.K., Kishan,R., Singh,N., Latha,N., Srinivasan,S., Pandey,K.C., Tiwari,H.K. and Singh,B.K.
    Functionalized hydroxyethylamine based peptide nanostructures as potential inhibitors of falcipain-3, an essential proteases of Plasmodium falciparum
    Bioorg Med Chem (2013) 21, 5503-5509. PubMed  Europe PubMed DOI  I
  14. Wang,J., Li,F., Li,Y., Yang,Y., Zhang,S. and Yang,L.
    Structural features of falcipain-3 inhibitors: an in silico study
    Mol Biosyst (2013) 9, 2296-2310. PubMed  Europe PubMed DOI  I
    15. 2012
  15. Chintakrindi,A.S., Shaikh,M.S. and Coutinho,E.C.
    De novo design of 7-aminocoumarin derivatives as novel falcipain-3 inhibitors
    J Mol Model (2012) 18, 1481-1493. PubMed  Europe PubMed DOI  I
  16. Marco,M. and Coteron,J.M.
    Falcipain inhibition as a promising antimalarial target
    Curr Top Med Chem (2012) 12, 408-444. PubMed  Europe PubMed DOI  I
  17. Pandey,K.C. and Dixit,R.
    Structure-function of falcipains: malarial cysteine proteases
    J Trop Med (2012) 2012, 345195-345195. PubMed  Europe PubMed DOI  I
  18. Shah,F., Gut,J., Legac,J., Shivakumar,D., Sherman,W., Rosenthal,P.J. and Avery,M.A.
    Computer-aided drug design of falcipain inhibitors: virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis
    J Chem Inf Model (2012) 52, 696-710. PubMed  Europe PubMed DOI  I
    19. 2011
  19. Potshangbam,A.M., Tanneeru,K., Reddy,B.M. and Guruprasad,L.
    3D-QSAR and molecular docking studies of 2-pyrimidinecarbonitrile derivatives as inhibitors against falcipain-3
    Bioorg Med Chem Lett (2011) 21, 7219-7223. PubMed  Europe PubMed DOI  I
  20. Shah,F., Mukherjee,P., Gut,J., Legac,J., Rosenthal,P.J., Tekwani,B.L. and Avery,M.A.
    Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library
    J Chem Inf Model (2011) 51, 852-864. PubMed  Europe PubMed DOI  I
    21. 2010
  21. Breuning,A., Degel,B., Schulz,F., Buchold,C., Stempka,M., Machon,U., Heppner,S., Gelhaus,C., Leippe,M., Leyh,M., Kisker,C., Rath,J., Stich,A., Gut,J., Rosenthal,P.J., Schmuck,C. and Schirmeister,T.
    Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids
    J Med Chem (2010) 53, 1951-1963. PubMed  Europe PubMed DOI  I
  22. Coteron,J.M., Catterick,D., Castro,J., Chaparro,M.J., Diaz,B., Fernandez,E., Ferrer,S., Gamo,F.J., Gordo,M., Gut,J., de Las Heras,L., Legac,J., Marco,M., Miguel,J., Munoz,V., Porras,E., de la Rosa,J.C., Ruiz,J.R., Sandoval,E., Ventosa,P., Rosenthal,P.J. and Fiandor,J.M.
    Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series
    J Med Chem (2010) 53, 6129-6152. PubMed  Europe PubMed DOI  I
  23. Gibbons,P., Verissimo,E., Araujo,N.C., Barton,V., Nixon,G.L., Amewu,R.K., Chadwick,J., Stocks,P.A., Biagini,G.A., Srivastava,A., Rosenthal,P.J., Gut,J., Guedes,R.C., Moreira,R., Sharma,R., Berry,N., Cristiano,M.L., Shone,A.E., Ward,S.A. and O'Neill,P.M.
    Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity
    J Med Chem (2010) 53, 8202-8206. PubMed  Europe PubMed DOI  I
  24. Loser,R., Gut,J., Rosenthal,P.J., Frizler,M., Gutschow,M. and Andrews,K.T.
    Antimalarial activity of azadipeptide nitriles
    Bioorg Med Chem Lett (2010) 20, 252-255. PubMed  Europe PubMed DOI  I
    25. 2009
  25. Dude,M.A., Kaeppler,U., Herb,M., Schiller,M., Schulz,F., Vedder,B., Heppner,S., Pradel,G., Gut,J., Rosenthal,P.J., Schirmeister,T., Leippe,M. and Gelhaus,C.
    Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid
    Molecules (2009) 14, 19-35. PubMed  Europe PubMed DOI  I
  26. Kerr,I.D., Lee,J.H., Farady,C.J., Marion,R., Rickert,M., Sajid,M., Pandey,K.C., Caffrey,C.R., Legac,J., Hansell,E., McKerrow,J.H., Craik,C.S., Rosenthal,P.J. and Brinen,L.S.
    Vinyl sulfones as antiparasitic agents and a structural basis for drug design
    J Biol Chem (2009) 284, 25697-25703. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  27. Kerr,I.D., Lee,J.H., Pandey,K.C., Harrison,A., Sajid,M., Rosenthal,P.J. and Brinen,L.S.
    Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity
    J Med Chem (2009) 52, 852-857. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
    28. 2008
  28. Verissimo,E., Berry,N., Gibbons,P., Cristiano,M.L., Rosenthal,P.J., Gut,J., Ward,S.A. and O'Neill,P.M.
    Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors
    Bioorg Med Chem Lett (2008) 18, 4210-4214. PubMed  Europe PubMed DOI  I
    29. 2007
  29. Schulz,F., Gelhaus,C., Degel,B., Vicik,R., Heppner,S., Breuning,A., Leippe,M., Gut,J., Rosenthal,P.J. and Schirmeister,T.
    Screening of protease inhibitors as antiplasmodial agents. Part I: aziridines and epoxides
    ChemMedChem (2007) 2, 1214-1224. PubMed  Europe PubMed DOI  I
    30. 2004
  30. Desai,P.V., Patny,A., Sabnis,Y., Tekwani,B., Gut,J., Rosenthal,P., Srivastava,A. and Avery,M.
    Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database
    J Med Chem (2004) 47, 6609-6615. PubMed  Europe PubMed DOI  I
  31. [YEAR:15-9-2004]Na,B.K., Kim,T.S., Rosenthal,P.J., Lee,J.K. and Kong,Y.
    Evaluation of cysteine proteases of Plasmodium vivax as antimalarial drug targets: sequence analysis and sensitivity to cysteine protease inhibitors
    Parasitol Res (15-9-2004) 94, 312-317. PubMed  Europe PubMed DOI  I
    32. 2003
  32. Lee,B.J., Singh,A., Chiang,P., Kemp,S.J., Goldman,E.A., Weinhouse,M.I., Vlasuk,G.P. and Rosenthal,P.J.
    Antimalarial activities of novel synthetic cysteine protease inhibitors
    Antimicrobial Agents Chemother (2003) 47, 3810-3814. PubMed  Europe PubMed DOI  PMC  EPMC  I
  33. Shenai,B.R., Lee,B.J., Alvarez-Hernandez,A., Chong,P.Y., Emal,C.D., Neitz,R.J., Roush,W.R. and Rosenthal,P.J.
    Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones
    Antimicrobial Agents Chemother (2003) 47, 154-160. PubMed  Europe PubMed DOI  PMC  EPMC  I

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