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Literature for peptidase C01.032: cathepsin L

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(References are filtered for relevance to Inhibitor. To remove the filter click here. See explanation.)

    2024
  1. Ciaglia,T., Vestuto,V., Di Sarno,V., Musella,S., Smaldone,G., Di Matteo,F., Napolitano,V., Miranda,M.R., Pepe,G., Basilicata,M.G., Novi,S., Capolupo,I., Bifulco,G., Campiglia,P., Gomez-Monterrey,I., Snoeck,R., Andrei,G., Manfra,M., Ostacolo,C., Lauro,G. and Bertamino,A.
    Peptidomimetics as potent dual SARS-CoV-2 cathepsin-L and main protease inhibitors: In silico design, synthesis and pharmacological characterization
    Eur J Med Chem266, 116128-116128. PubMed  Europe PubMed DOI  I
  2. Deng,W., Hu,X., Tian,X., Zhang,Y., Shang,W., Zhang,L. and Shang,L.
    Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV-2 by Blocking the Function of Cathepsin L
    J Med Chem67, 17124-17143. PubMed  Europe PubMed DOI  I
  3. Falke,S., Lieske,J., Herrmann,A., Loboda,J., Karnicar,K., Gunther,S., Reinke,P.Y.A., Ewert,W., Usenik,A., Lindic,N., Sekirnik,A., Dretnik,K., Tsuge,H., Turk,V., Chapman,H.N., Hinrichs,W., Ebert,G., Turk,D. and Meents,A.
    Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors
    J Med Chem67, 7048-7067. PubMed  Europe PubMed DOI  I
  4. Jangra,S., Raghav,N., Wadhwa,D., Kumar,A., Bhattacharyya,S., Kumar,V. and Sheokand,J.
    Biological evaluation of trans-2,3-dihydrofuro[3,2-c]coumarins as potential cathepsin inhibitors and anticancer agents
    J Biomater Sci Polym Ed1-19. PubMed  Europe PubMed DOI  I
  5. Mao,L., Shaabani,N., Zhang,X., Jin,C., Xu,W., Argent,C., Kushnareva,Y., Powers,C., Stegman,K., Liu,J., Xie,H., Xu,C., Bao,Y., Xu,L., Zhang,Y., Yang,H., Qian,S., Hu,Y., Shao,J., Zhang,C., Li,T., Li,Y., Liu,N., Lin,Z., Wang,S., Wang,C., Shen,W., Lin,Y., Shu,D., Zhu,Z., Kotoi,O., Kerwin,L., Han,Q., Chumakova,L., Teijaro,J., Royal,M., Brunswick,M., Allen,R., Ji,H., Lu,H. and Xu,X.
    Olgotrelvir, a dual inhibitor of SARS-CoV-2 M(pro) and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19
    Med5, 42-61. PubMed  Europe PubMed DOI  I
  6. Mao,L., Shaabani,N., Zhang,X., Jin,C., Xu,W., Argent,C., Kushnareva,Y., Powers,C., Stegman,K., Liu,J., Xie,H., Xu,C., Bao,Y., Xu,L., Zhang,Y., Yang,H., Qian,S., Hu,Y., Shao,J., Zhang,C., Li,T., Li,Y., Liu,N., Lin,Z., Wang,S., Wang,C., Shen,W., Lin,Y., Shu,D., Zhu,Z., Kotoi,O., Kerwin,L., Han,Q., Chumakova,L., Teijaro,J., Royal,M., Brunswick,M., Allen,R., Ji,H., Lu,H. and Xu,X.
    Olgotrelvir, a dual inhibitor of SARS-CoV-2 M(pro) and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19
    Med5, 169-171. PubMed  Europe PubMed DOI  I
  7. Xie,X., Lan,Q., Zhao,J., Zhang,S., Liu,L., Zhang,Y., Xu,W., Shao,M., Peng,J., Xia,S., Zhu,Y., Zhang,K., Zhang,X., Zhang,R., Li,J., Dai,W., Ge,Z., Hu,S., Yu,C., Wang,J., Ma,D., Zheng,M., Yang,H., Xiao,G., Rao,Z., Lu,L., Zhang,L., Bai,F., Zhao,Y., Jiang,S. and Liu,H.
    Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1
    Signal Transduct Target Ther9, 54-54. PubMed  Europe PubMed DOI  I
  8. Zhou,W., You,B., Zhao,X., Si,S., Li,Y. and Zhang,J.
    Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors
    SLAS Discov29, 100153-100153. PubMed  Europe PubMed DOI  I
    9. 2023
  9. Doijen,J., Temmerman,K., Van den Eynde,C., Diels,A., Van den Broeck,N., Van Gool,M., Heo,I., Jaensch,S., Zwaagstra,M., Diosa Toro,M., Chiu,W., De Jonghe,S., Leyssen,P., Bojkova,D., Ciesek,S., Cinatl,J., Verschueren,L., Buyck,C., van Kuppeveld,F., Neyts,J., Van Loock,M. and Van Damme,E.
    Identification of Z-Tyr-Ala-CHN(2), a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2
    Microorganisms11, PubMed  Europe PubMed DOI  I
  10. Huang,H., Zhang,Y., Xu,X., Liu,Y., Zhao,J., Ma,L., Lei,J., Ge,W., Li,N., Ma,E., Li,Y. and Yuan,L.
    Design and synthesis of dual cathepsin L and S inhibitors and antimetastatic activity evaluation in pancreatic cancer cells
    Bioorg Med Chem Lett80, 129087-129087. PubMed  Europe PubMed DOI  I
  11. Li,Y., Wang,K., Sun,H., Wu,S., Wang,H., Shi,Y., Li,X., Yan,H., Yang,G., Wu,M., Li,Y., Ding,X., Si,S., Jiang,J., Du,Y., Li,Y. and Hong,B.
    Omicsynin B4 potently blocks coronavirus infection by inhibiting host proteases cathepsin L and TMPRSS2
    Antiviral Res214, 105606-105606. PubMed  Europe PubMed DOI  I
  12. Tang,T.T., Li,S.M., Pan,B.W., Xiao,J.W., Pang,Y.X., Xie,S.X., Zhou,Y., Yang,J. and Wei,Y.
    Identification of Flavonoids from Scutellaria barbata D. Don as Inhibitors of HIV-1 and Cathepsin L Proteases and Their Structure-Activity Relationships
    Molecules28, PubMed  Europe PubMed DOI  I
  13. Wang,C., Ye,X., Ding,C., Zhou,M., Li,W., Wang,Y., You,Q., Zong,S., Peng,Q., Duanmu,D., Chen,H., Sun,B. and Qiao,J.
    Two Resveratrol Oligomers Inhibit Cathepsin L Activity to Suppress SARS-CoV-2 Entry
    J Agric Food Chem71, 5535-5546. PubMed  Europe PubMed DOI  I
    14. 2022
  14. Kwon,C.W., Yeo,S. and Chang,P.S.
    Characterization and molecular docking study of cathepsin L inhibitory peptides (SnuCalCpIs) from Calotropis procera R. Br
    Sci Rep12, 5825-5825. PubMed  Europe PubMed DOI  I
  15. Meewan,I., Kattoula,J., Kattoula,J.Y., Skinner,D., Fajtova,P., Giardini,M.A., Woodworth,B., McKerrow,J.H., Lage de Siqueira-Neto,J., O'Donoghue,A.J. and Abagyan,R.
    Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L
    Pharmaceuticals (Basel)15, PubMed  Europe PubMed DOI  I
  16. Mondal,S., Chen,Y., Lockbaum,G.J., Sen,S., Chaudhuri,S., Reyes,A.C., Lee,J.M., Kaur,A.N., Sultana,N., Cameron,M.D., Shaffer,S.A., Schiffer,C.A., Fitzgerald,K.A. and Thompson,P.R.
    Dual Inhibitors of Main Protease (M(Pro)) and Cathepsin L as Potent Antivirals against SARS-CoV2
    J Am Chem Soc144, 21035-21045. PubMed  Europe PubMed DOI  K  I
  17. Yang,W.L., Li,Q., Sun,J., Huat Tan,S., Tang,Y.H., Zhao,M.M., Li,Y.Y., Cao,X., Zhao,J.C. and Yang,J.K.
    Potential drug discovery for COVID-19 treatment targeting Cathepsin L using a deep learning-based strategy
    Comput Struct Biotechnol J20, 2442-2454. PubMed  Europe PubMed DOI  I
  18. Yu,F., Pan,T., Huang,F., Ying,R., Liu,J., Fan,H., Zhang,J., Liu,W., Lin,Y., Yuan,Y., Yang,T., Li,R., Zhang,X., Lv,X., Chen,Q., Liang,A., Zou,F., Liu,B., Hu,F., Tang,X., Li,L., Deng,K., He,X., Zhang,H., Zhang,Y. and Ma,X.
    Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin L
    Front Microbiol13, 884034-884034. PubMed  Europe PubMed DOI  I
    19. 2021
  19. Breidenbach,J., Lemke,C., Pillaiyar,T., Schakel,L., Al Hamwi,G., Diett,M., Gedschold,R., Geiger,N., Lopez,V., Mirza,S., Namasivayam,V., Schiedel,A.C., Sylvester,K., Thimm,D., Vielmuth,C., Phuong Vu,L., Zyulina,M., Bodem,J., Gutschow,M. and Muller,C.E.
    Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors
    Angew Chem Int Ed Engl PubMed  Europe PubMed DOI  I
  20. Hu,Y., Ma,C., Szeto,T., Hurst,B., Tarbet,B. and Wang,J.
    Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses
    ACS Infect Dis7, 586-597. PubMed  Europe PubMed DOI  I
  21. Li,Y., Ai,X., Zou,C., Liu,Y., Ma,L., Men,J., Liu,D., Sheng,L., Ruan,X., Liu,H., Li,W., Ma,E. and Yuan,L.
    Discovery of a novel and selective cathepsin L inhibitor with anti-metastatic ability in vitro and in vivo against breast cancer cells
    Bioorg Chem115, 105256-105256. PubMed  Europe PubMed DOI  I
  22. Mellott,D.M., Tseng,C.T., Drelich,A., Fajtova,P., Chenna,B.C., Kostomiris,D.H., Hsu,J., Zhu,J., Taylor,Z.W., Kocurek,K.I., Tat,V., Katzfuss,A., Li,L., Giardini,M.A., Skinner,D., Hirata,K., Yoon,M.C., Beck,S., Carlin,A.F., Clark,A.E., Beretta,L., Maneval,D., Hook,V., Frueh,F., Hurst,B.L., Wang,H., Raushel,F.M., O'Donoghue,A.J., de Siqueira-Neto,J.L., Meek,T.D. and McKerrow,J.H.
    A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells
    ACS Chem Biol16, 642-650. PubMed  Europe PubMed DOI  I
  23. Munikishore,R., Wang,L.L., Zhang,S., Zhao,Q.S. and Zuo,Z.
    An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94
    Bioorg Chem116, 105317-105317. PubMed  Europe PubMed DOI  I
  24. Phan,H.A.T., Giannakoulias,S.G., Barrett,T.M., Liu,C. and Petersson,E.J.
    Rational design of thioamide peptides as selective inhibitors of cysteine protease cathepsin L
    Chem Sci12, 10825-10835. PubMed  Europe PubMed DOI  I
    25. 2020
  25. Abhinand,C.S., Nair,A.S., Krishnamurthy,A., Oommen,O.V. and Sudhakaran,P.R.
    Potential protease inhibitors and their combinations to block SARS-CoV-2
    J Biomol Struct Dyn1-15. PubMed  Europe PubMed DOI  I
  26. Arafet,K., Gonzalez,F.V. and Moliner,V.
    Quantum mechanics/molecular mechanics studies of the mechanism of cysteine proteases inhibition by dipeptidyl nitroalkenes
    Chemistry26, 2002-2012. PubMed  Europe PubMed DOI  I
  27. Ashhurst,A.S., Tang,A.H., Fajtova,P., Yoon,M., Aggarwal,A., Stoye,A., Larance,M., Beretta,L., Drelich,A., Skinner,D., Li,L., Meek,T.D., McKerrow,J.H., Hook,V., Tseng,C.K., Turville,S., Gerwick,W.H., O'Donoghue,A.J. and Payne,R.J.
    Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L
    bioRxiv PubMed  Europe PubMed DOI  I
  28. Cianni,L., Rocho,F.D.R., Rosini,F., Bonatto,V., Ribeiro,J.F.R., Lameira,J., Leitao,A., Shamim,A. and Montanari,C.A.
    Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases
    Bioorg Chem101, 104039-104039. PubMed  Europe PubMed DOI  I
  29. Dana,D. and Pathak,S.K.
    A review of small molecule inhibitors and functional probes of human cathepsin L
    Molecules25, PubMed  Europe PubMed DOI  V  I
  30. Mellott,D., Tseng,C.T., Drelich,A., Fajtova,P., Chenna,B.C., Kostomiris,D., Hsu,J.C., Zhu,J., Taylor,Z., Tat,V., Katzfuss,A., Li,L., Giardini,M.A., Skinner,D., Hirata,K., Beck,S., Carlin,A.F., Clark,A.E., Berreta,L., Maneval,D., Frueh,F., Hurst,B.L., Wang,H., Kocurek,K.I., Raushel,F.M., O'Donoghue,A., Siqueira-Neto,J.L., Meek,T.D. and McKerrow,J.H.
    A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells
    bioRxiv PubMed  Europe PubMed DOI  I
  31. Ribeiro,J.F.R., Cianni,L., Li,C., Warwick,T.G., De Vita,D., Rosini,F., Dos Reis Rocho,F., Martins,F.C.P., Kenny,P.W., Lameira,J., Leitao,A., Emsley,J. and Montanari,C.A.
    Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor
    Bioorg Med Chem28, 115743-115743. PubMed  Europe PubMed DOI  I
  32. Sacco,M.D., Ma,C., Lagarias,P., Gao,A., Townsend,J.A., Meng,X., Dube,P., Zhang,X., Hu,Y., Kitamura,N., Hurst,B., Tarbet,B., Marty,M.T., Kolocouris,A., Xiang,Y., Chen,Y. and Wang,J.
    Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M(pro) and cathepsin L
    Sci Adv PubMed  Europe PubMed DOI  I
  33. Sacco,M.D., Ma,C., Lagarias,P., Gao,A., Townsend,J.A., Meng,X., Dube,P., Zhang,X., Hu,Y., Kitamura,N., Hurst,B., Tarbet,B., Marty,M.T., Kolocouris,A., Xiang,Y., Chen,Y. and Wang,J.
    Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M(pro) and cathepsin L
    bioRxiv PubMed  Europe PubMed DOI  I
    34. 2019
  34. Boudreau,P.D., Miller,B.W., McCall,L.I., Almaliti,J., Reher,R., Hirata,K., Le,T., Siqueira-Neto,J.L., Hook,V. and Gerwick,W.H.
    Design of gallinamide A analogs as potent inhibitors of the cysteine proteases human cathepsin L and Trypanosoma cruzi cruzain
    J Med Chem62, 9026-9044. PubMed  Europe PubMed DOI  I
  35. Dana,D., Garcia,J., Bhuiyan,A.I., Rathod,P., Joo,L., Novoa,D.A., Paroly,S., Fath,K.R., Chang,E.J. and Pathak,S.K.
    Cell penetrable, clickable and tagless activity-based probe of human cathepsin L
    Bioorg Chem85, 505-514. PubMed  Europe PubMed DOI  L  I
  36. Shockey,W.A., Kieslich,C.A., Wilder,C.L., Watson,V. and Platt,M.O.
    Dynamic model of protease state and inhibitor trafficking to predict protease activity in breast cancer cells
    Cell Mol Bioeng12, 275-288. PubMed  Europe PubMed DOI  I
  37. Weiss-Sadan,T., Itzhak,G., Kaschani,F., Yu,Z., Mahameed,M., Anaki,A., Ben-Nun,Y., Merquiol,E., Tirosh,B., Kessler,B., Kaiser,M. and Blum,G.
    Cathepsin L regulates metabolic networks controlling rapid cell growth and proliferation
    Mol Cell Proteomics18, 1330-1344. PubMed  Europe PubMed DOI  I
  38. Yuan,L., Liu,J., He,W., Bao,Y., Sheng,L., Zou,C., Hu,B., Ge,W., Liu,Y., Wang,J., Lin,B., Li,Y. and Ma,E.
    Discovery of a novel cathepsin inhibitor with dual autophagy-inducing and metastasis-inhibiting effects on breast cancer cells
    Bioorg Chem84, 239-253. PubMed  Europe PubMed DOI  I
  39. Yuan,L., Zou,C., Ge,W., Liu,Y., Hu,B., Wang,J., Lin,B., Li,Y. and Ma,E.
    A novel cathepsin L inhibitor prevents the progression of idiopathic pulmonary fibrosis
    Bioorg Chem103417-103417. PubMed  Europe PubMed DOI  I
    40. 2018
  40. Huisman,M., Kodanko,J.P., Arora,K., Herroon,M., Alnaed,M., Endicott,J., Podgorski,I. and Kodanko,J.J.
    Affinity-enhanced luminescent Re(I)- and Ru(II)-based inhibitors of the cysteine protease cathepsin L
    Inorg Chem57, 7881-7891. PubMed  Europe PubMed DOI  I
    41. 2017
  41. Dos Santos,D.A., Deobald,A.M., Cornelio,V.E., Avila,R.M.D., Cornea,R.C., Bernasconi,G.C.R., Paixao,M.W., Vieira,P.C. and Correa,A.G.
    Asymmetric synthesis and evaluation of epoxy-alpha-acyloxycarboxamides as selective inhibitors of cathepsin L
    Bioorg Med Chem25, 4620-4627. PubMed  Europe PubMed DOI  I
  42. Giroud,M., Ivkovic,J., Martignoni,M., Fleuti,M., Trapp,N., Haap,W., Kuglstatter,A., Benz,J., Kuhn,B., Schirmeister,T. and Diederich,F.
    Inhibition of the cysteine protease human cathepsin L by triazine nitriles: amide???heteroarene pi-stacking interactions and chalcogen bonding in the S3 pocket
    ChemMedChem12, 257-270. PubMed  Europe PubMed DOI  I
  43. Hashimoto,Y.
    Gelatin zymography using leupeptin for the detection of various cathepsin L forms
    Methods Mol Biol1594, 243-254. PubMed  Europe PubMed DOI  L  I
  44. Kikuta,S., Murai,Y. and Tanaka,E.
    Activation of cathepsin L contributes to the irreversible depolarization induced by oxygen and glucose deprivation in rat hippocampal CA1 neurons
    Neurosci Lett636, 120-126. PubMed  Europe PubMed DOI  I
  45. Kuhn,B., Tichy,M., Wang,L., Robinson,S., Martin,R.E., Kuglstatter,A., Benz,J., Giroud,M., Schirmeister,T., Abel,R., Diederich,F. and Hert,J.
    Prospective evaluation of free energy calculations for the prioritization of cathepsin L inhibitors
    J Med Chem60, 2485-2497. PubMed  Europe PubMed DOI  I
  46. Li,Y.Y., Fang,J. and Ao,G.Z.
    Cathepsin B and L inhibitors: a patent review (2010 - present)
    Expert Opin Ther Pat27, 643-656. PubMed  Europe PubMed DOI  V  I
  47. Parker,E.N., Odutola,S.O., Wang,Y., Strecker,T.E., Mukherjee,R., Shi,Z., Chaplin,D.J., Trawick,M.L. and Pinney,K.G.
    Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L
    Bioorg Med Chem Lett27, 1304-1310. PubMed  Europe PubMed DOI  I
    48. 2016
  48. Burton,L.J., Dougan,J., Jones,J., Smith,B.N., Randle,D., Henderson,V. and Odero-Marah,V.A.
    Targeting the nuclear cathepsin L- CCAAT-displacement protein/cut homeobox transcription factor-epithelial mesenchymal transition pathway in prostate and breast cancer cells with Z-FY-CHO inhibitor
    Mol Cell Biol37, e00297-16.-e00297-16. PubMed  Europe PubMed DOI  I
  49. Giroud,M., Harder,M., Kuhn,B., Haap,W., Trapp,N., Schweizer,W.B., Schirmeister,T. and Diederich,F.
    Fluorine scan of inhibitors of the cysteine protease human cathepsin L: dipolar and quadrupolar effects in the pi-stacking of fluorinated phenyl rings on peptide amide bonds
    ChemMedChem11, 1042-1047. PubMed  Europe PubMed DOI  I
  50. Raghav,N., Jangra,S., Kumar,A., Bhattacharyya,S., Wadhwa,D. and Sindhu,J.
    Cathepsin B, H and L inhibitors as cell proliferating agents: design, synthesis, computational and pharmacological studies of some novel 2-(2-naphthoyl)-6,6-dimethyl-3-aryl-2,3,6,7-tetrahydrobenzofuran-4(5H)-ones
    RSC Adv6, 34588-34599. DOI  I
  51. Sudhan,D.R., Pampo,C., Rice,L. and Siemann,D.W.
    Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model
    Int J Cancer138, 2665-2677. PubMed  Europe PubMed DOI  I
  52. Sudhan,D.R., Rabaglino,M.B., Wood,C.E. and Siemann,D.W.
    Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94
    Clin Exp Metastasis33, 461-473. PubMed  Europe PubMed DOI  I
  53. Ueki,N., Wang,W., Swenson,C., McNaughton,C., Sampson,N.S. and Hayman,M.J.
    Synthesis and preclinical evaluation of a highly improved anticancer prodrug activated by histone deacetylases and cathepsin L
    Theranostics6, 808-816. PubMed  Europe PubMed DOI  I
  54. Zhou,N., Pan,T., Zhang,J., Li,Q., Zhang,X., Bai,C., Huang,F., Peng,T., Zhang,J., Liu,C., Tao,L. and Zhang,H.
    Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of Ebola virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)
    J Biol Chem291, 9218-9232. PubMed  Europe PubMed DOI  I
    55. 2015
  55. Celis-Barros,C., Saavedra-Rivas,L., Salgado,J.C., Cassels,B.K. and Zapata-Torres,G.
    Molecular dynamics simulation of halogen bonding mimics experimental data for cathepsin L inhibition
    J Comput Aided Mol Des29, 37-46. PubMed  Europe PubMed DOI  I
  56. Parker,E.N., Song,J., Kishore Kumar,G.D., Odutola,S.O., Chavarria,G.E., Charlton-Sevcik,A.K., Strecker,T.E., Barnes,A.L., Sudhan,D.R., Wittenborn,T.R., Siemann,D.W., Horsman,M.R., Chaplin,D.J., Trawick,M.L. and Pinney,K.G.
    Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L
    Bioorg Med Chem23, 6974-6992. PubMed  Europe PubMed DOI  I
  57. Wang,H., Sang,N., Zhang,C., Raghupathi,R., Tanzi,R.E. and Saunders,A.
    Cathepsin L mediates the degradation of novel APP C-terminal fragments
    Biochemistry54, 2806-2816. PubMed  Europe PubMed DOI  I
  58. Yang,N., Wang,P., Wang,W.J., Song,Y.Z. and Liang,Z.Q.
    Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-kappaB signaling pathway
    Acta Pharmacol Sin36, 400-410. PubMed  Europe PubMed DOI  I
    59. 2014
  59. Chua,K.C., Pietsch,M., Zhang,X., Hautmann,S., Chan,H.Y., Bruning,J.B., Gutschow,M. and Abell,A.D.
    Macrocyclic protease inhibitors with reduced peptide character
    Angew Chem Int Ed Engl53, 7828-7831. PubMed  Europe PubMed DOI  I
  60. Dana,D., De,S., Rathod,P., Davalos,A.R., Novoa,D.A., Paroly,S., Torres,V.M., Afzal,N., Lankalapalli,R.S., Rotenberg,S.A., Chang,E.J., Subramaniam,G. and Kumar,S.
    Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L - a hybrid design approach
    Chem Commun (Camb)50, 10875-10878. PubMed  Europe PubMed DOI  I
  61. Elshabrawy,H.A., Fan,J., Haddad,C.S., Ratia,K., Broder,C.C., Caffrey,M. and Prabhakar,B.S.
    Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay
    J Virol88, 4353-4365. PubMed  Europe PubMed DOI  I
  62. Miller,B., Friedman,A.J., Choi,H., Hogan,J., McCammon,J.A., Hook,V. and Gerwick,W.H.
    The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L
    J Nat Prod77, 92-99. PubMed  Europe PubMed DOI  I
  63. Ramalho,S.D., De Sousa,L.R., Nebo,L., Maganhi,S.H., Caracelli,I., Zukerman-Schpector,J., Lima,M.I., Alves,M.F., da Silva,M.F., Fernandes,J.B. and Vieira,P.C.
    Triterpenoids as novel natural inhibitors of human cathepsin L
    Chem Biodivers11, 1354-1363. PubMed  Europe PubMed DOI  I
    64. 2013
  64. Baek,K.H., Karki,R., Lee,E.S., Na,Y. and Kwon,Y.
    Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors
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  65. Ehmke,V., Winkler,E., Banner,D.W., Haap,W., Schweizer,W.B., Rottmann,M., Kaiser,M., Freymond,C., Schirmeister,T. and Diederich,F.
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