$VAR1 = undef;

Summary for peptidase T01.012: proteasome subunit beta5c

Names
MEROPS Name	proteasome subunit beta5c
Other names	constitutive proteasome catalytic subunit 3, chymotrypsin-like proteasome subunit, DOA3 g.p. (Saccharomyces cerevisiae), proteasome subunit beta5, proteasome subunit beta 5c, PRE2 g.p. (Saccharomyces cerevisiae), proteasome subunit epsilon (Homo sapiens), proteasome subunit MB1 (Homo sapiens), proteasome subunit X (Homo sapiens), PSMB5 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan PB >> Subclan PB(T) >> Family T1 >> Subfamily A >> T01.012
Holotype	proteasome subunit beta5c (Saccharomyces cerevisiae), Uniprot accession P30656 (peptidase unit: 76-280), MERNUM MER0001516
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Threonine
Peplist	Included in the Peplist with identifier PL00420
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.25 (Threonine-type endopeptidases) >> Peptidase 3.4.25.1
Enzymology	BRENDA database
Activity status	human: active (Seemuller et al., 2004) mouse: active (by similarity to other mammals)
Physiology	One of the peptidase units of the 20 S proteasome, and thus contributing to the major role of the proteasome in intracellular protein degradation.
Pharmaceutical relevance	Proteasome inhibitors exhibit anti-inflammatory and antiproliferative effects, and it is threrefore considered that inhibitors have the potential to be drugs for conditions such as cancer, rheumatoid arthritis and psoriasis that are characterised by these processes (Delcros et al., 2003; Elliott et al., 2003).
Pathways	KEGG	Proteasome
Other databases	TREEFAM	http://www.treefam.org/family/TF106223
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/--/-/-/- (based on 221 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	12	7	7	7	16	18	18	16
Pro	19	7	7	3	14	12	13	14
Ala	13	14	18	21	14	16	12	11
Val	20	17	18	22	15	10	15	20
Leu	22	19	27	43	24	27	25	18
Ile	12	8	4	5	3	14	7	9
Met	3	3	8	9	8	9	2	7
Phe	9	7	3	17	7	9	10	7
Tyr	4	6	2	13	1	3	3	3
Trp	5	2	2	6	2	1	2	4
Ser	30	26	33	31	31	26	32	22
Thr	10	19	11	13	14	10	10	15
Cys	4	7	4	5	4	3	3	7
Asn	7	12	15	8	13	5	8	6
Gln	5	6	12	11	11	7	9	5
Asp	3	13	7	2	6	7	8	6
Glu	9	20	15	0	14	14	16	14
Lys	6	3	4	0	5	5	6	9
Arg	16	19	13	0	12	13	13	18
His	6	4	9	5	1	4	1	2