$VAR1 = undef;

Summary for peptidase S26.010: signalase (animal) 21 kDa component

Names
MEROPS Name	signalase (animal) 21 kDa component
Other names	leader peptidase, signal peptidase complex 21 kDa component, SPC21

Domain architecture

MEROPS Classification
Classification	Clan SF >> Subclan (none) >> Family S26 >> Subfamily B >> S26.010
Holotype	signalase (animal) 21 kDa component (Saccharomyces cerevisiae), Uniprot accession P15367 (peptidase unit: 32-167), MERNUM MER0000602
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00394
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.89
Enzymology	BRENDA database
Activity status	human: active (Liang et al., 2003) mouse: active (by similarity to dog) (Liang et al., 2003)
Physiology	Cleaves signal peptides from secreted proteins cotranslationally.
Pharmaceutical relevance	'The revelation of signal peptidase involved in HCV polyprotein processing presents a novel drug target to suppress HCV viral replication for the much needed HCV therapy' (Wu, 2001).
Other databases	TREEFAM	http://www.treefam.org/family/TF313648
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/avs/-/Aa/-/-/- (based on 363 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	34	10	9	46	25	37	22	23
Pro	18	3	4	6	0	30	39	39
Ala	44	117	31	200	91	29	25	24
Val	23	90	15	2	20	26	25	21
Leu	43	6	35	4	14	12	16	29
Ile	13	5	10	1	16	21	21	18
Met	12	1	6	0	2	0	1	2
Phe	8	3	22	3	11	7	13	15
Tyr	9	0	13	1	10	11	15	17
Trp	0	0	4	1	1	2	6	6
Ser	54	41	43	48	31	36	39	22
Thr	35	32	20	3	25	35	35	30
Cys	8	25	4	6	4	5	36	23
Asn	8	4	23	9	6	20	15	17
Gln	16	1	23	5	36	15	6	11
Asp	5	7	18	1	26	27	19	16
Glu	9	8	34	4	24	22	16	21
Lys	10	7	9	5	10	17	4	18
Arg	8	2	17	18	6	7	6	8
His	6	1	23	0	5	4	4	3