$VAR1 = undef;
Summary for peptidase S08.020: C5a peptidase
| Names | |
|---|---|
| MEROPS Name | C5a peptidase |
| Other names | scpA g.p. (Streptococcus pyogenes), scpB g.p. (Streptococcus agalaciae) |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.020 |
| Holotype | C5a peptidase (Streptococcus pyogenes), Uniprot accession P15926 (peptidase unit: 50-570), MERNUM MER0000349 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Serine | ||
| Peplist | Included in the Peplist with identifier PL00347 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.110 | ||
| Enzymology | BRENDA database | ||
| Proteolytic events | CutDB database (2 cleavages) | ||
| Physiology | Destroys complement component C5a, apparently aiding organism to evade host immune response. | ||
| Pharmaceutical relevance | Proposed target for vaccine against group B streptococcal infection (Cheng et al., 2002). | ||
