$VAR1 = undef;

Summary for peptidase S01.458: chymase 1 (Mus musculus-type)

Names
MEROPS Name	chymase 1 (Mus musculus-type)
Other names	chymase beta (Mus-type), mMCP1, mouse mast cell protease-1, mouse chymase 1, Mcpt-1 g.p. (Mus musculus), mouse mast cell protease 1, mast cell protease 1 (Mus musculus), beta-chymase, mMCP-1, intestinal-mucosal mast cell-specific chymase (Mus musculus), chymase 2 (Mus musculus)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.458
Holotype	chymase 1 (Mus musculus-type), Uniprot accession P11034 (peptidase unit: 21-246), MERNUM MER0000124
History	Identifier created: MEROPS 8.0 (8 January 2008)

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Other databases	TREEFAM	http://www.treefam.org/family/TF333630
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/v/-/FYSra/lva/rsg/h (based on 44 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	6	6	4	0	0	0	8	3
Pro	7	0	1	0	1	0	0	1
Ala	2	4	0	0	3	6	5	2
Val	7	11	0	0	0	10	0	8
Leu	2	1	8	0	0	18	1	2
Ile	3	1	1	0	0	1	0	1
Met	2	2	2	0	0	1	2	2
Phe	1	1	7	31	0	0	0	0
Tyr	0	0	1	12	0	0	1	1
Trp	6	0	7	1	0	0	0	1
Ser	1	6	1	0	27	3	9	3
Thr	2	5	3	0	2	2	1	2
Cys	0	0	0	0	0	0	0	0
Asn	0	0	2	0	0	1	0	1
Gln	2	2	1	0	0	0	1	0
Asp	0	0	0	0	0	0	0	0
Glu	0	0	0	0	1	0	1	0
Lys	1	0	1	0	0	0	0	1
Arg	2	5	5	0	10	1	10	2
His	0	0	0	0	0	1	5	14

Mouse genetics
Gene symbol	Position	Megabases	Ensembl	Entrez gene	MGI
Mcpt1	14:C1		ENSMUSG00000022227	17224	MGI:96937