$VAR1 = undef;

Summary for peptidase S01.405: kallikrein 1 (Rattus sp.)

Names
MEROPS Name	kallikrein 1 (Rattus sp.)
Other names	kallikrein rK1 (Rattus sp.), Klk1 g.p. (Rattus norvegicus), rKLK-1

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.405
Holotype	kallikrein 1 (Rattus sp.) (Rattus norvegicus), Uniprot accession P00758 (peptidase unit: 25-260), MERNUM MER0000106
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (2 cleavages)
Physiology	Liberates bradykinin from kinogens.
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/KLK1
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/pv/Fli/R-/-/-/- (based on 10 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	0	0	0	1
Pro	0	3	0	0	0	2	1	0
Ala	0	0	0	0	1	0	0	0
Val	0	2	0	0	0	0	0	1
Leu	0	0	3	0	0	0	0	0
Ile	0	0	1	0	0	0	0	0
Met	0	0	0	0	0	0	0	0
Phe	0	0	5	0	0	0	0	0
Tyr	0	0	0	0	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	2	0	0	0	1	0	0	0
Thr	0	0	0	0	0	0	0	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	0
Gln	0	0	0	0	0	0	0	0
Asp	0	0	0	0	0	0	0	0
Glu	0	0	0	0	0	0	0	0
Lys	0	0	0	0	0	0	0	0
Arg	0	0	0	10	1	1	1	0
His	0	0	0	0	0	0	0	0