$VAR1 = undef;

Summary for peptidase S01.155: pancreatic elastase II

Names
MEROPS Name	pancreatic elastase II
Other names	elastase 2A, elastase C (Gadus morhua), CELA2A g.p. (Homo sapiens), CELA2B g.p. (Homo sapiens), chymotrypsin-like elastase family, member 2A, ELA2A g.p. (Homo sapiens), pancreatic elastase 2, pancreatic elastase IIA (Homo sapiens), rat mesenteric arterial bed elastase-2

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.155
Holotype	pancreatic elastase II (Sus scrofa), Uniprot accession P08419 (peptidase unit: 29-269), MERNUM MER0000144
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00285
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.71
Enzymology	BRENDA database
Activity status	human: active (Bieth, 2004) mouse: active (by similarity)
Pharmaceutical relevance	Evaluated as drug target for acute pancreatitis.
Pathways	KEGG	Pancreatic secretion
	KEGG	Protein digestion and absorption
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Pancreatic_elastase
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	ai/ah/P/fly-/l/-/- (based on 19 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	1	0	0	3	0	1	0
Pro	0	0	7	0	0	0	1	0
Ala	5	4	1	0	3	0	0	1
Val	1	0	1	0	1	1	1	1
Leu	0	1	0	6	1	4	1	0
Ile	4	0	0	0	1	0	0	0
Met	0	0	0	1	0	0	0	0
Phe	1	1	0	6	0	1	0	0
Tyr	0	0	1	3	1	1	0	0
Trp	0	0	1	0	0	0	0	0
Ser	0	0	1	0	0	0	0	1
Thr	0	0	0	0	1	0	1	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	0
Gln	0	0	0	1	0	0	0	0
Asp	0	1	0	0	0	0	0	0
Glu	0	1	0	0	0	0	1	1
Lys	0	0	0	1	0	0	0	0
Arg	0	0	0	0	0	0	0	0
His	0	3	0	1	3	0	0	0