$VAR1 = undef;

Summary for peptidase M23.001: beta-lytic metallopeptidase

Names
MEROPS Name	beta-lytic metallopeptidase
Other names	achromopeptidase component

Domain architecture

MEROPS Classification
Classification	Clan MO >> Subclan (none) >> Family M23 >> Subfamily A >> M23.001
Holotype	beta-lytic metallopeptidase (Achromobacter lyticus), Uniprot accession P27458 (peptidase unit: 196-374), MERNUM MER0001281
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00233
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.32
Enzymology	BRENDA database
Physiology	Lysis of other organisms for bacterial nutrition.
Pharmaceutical relevance	Use as antimicrobial agent has been considered.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/ayf/-/Ghl/fm/m/- (based on 15 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	0	2	13	1	1	0	0
Pro	0	0	0	0	0	0	0	0
Ala	0	5	1	0	0	1	2	0
Val	0	0	3	1	0	0	0	0
Leu	1	0	1	0	4	1	0	0
Ile	0	0	2	0	0	0	0	0
Met	0	0	2	0	0	4	4	0
Phe	0	2	0	0	2	4	0	1
Tyr	0	3	0	0	0	0	1	0
Trp	2	1	0	0	2	1	0	0
Ser	0	0	0	0	0	0	1	1
Thr	0	0	1	0	0	0	0	2
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	1	1	1	0	0
Gln	0	0	0	0	0	0	0	0
Asp	1	0	0	0	0	0	2	0
Glu	0	1	0	0	0	0	1	0
Lys	1	0	0	0	0	0	0	0
Arg	0	0	1	0	0	0	0	1
His	0	0	0	0	4	0	0	0