$VAR1 = undef;

Summary for peptidase M10.056: aeruginolysin

Names
MEROPS Name	aeruginolysin
Other names	alkaline protease (Pseudomonas aeruginosa), apr g.p. (Pseudomonas aeruginosa)

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily B >> M10.056
Holotype	aeruginolysin (Pseudomonas aeruginosa), Uniprot accession Q03023 (peptidase unit: 75-236), MERNUM MER0001097
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00171
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.40
Enzymology	BRENDA database
Physiology	Enhances attachment of organism to corneal epithelium, playing a major role in pathogenesis.
Pharmaceutical relevance	Target for vaccine development, and chemotherapy of bacterial infection.
Other databases	PANTHER	http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR36921:SF3
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/g-/-/-/- (based on 13 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	2	3	1	4	4	1	1	1
Pro	0	0	0	0	0	1	1	0
Ala	0	1	1	0	1	0	2	1
Val	0	1	2	0	0	1	0	1
Leu	1	2	2	1	2	3	2	2
Ile	0	0	0	0	0	0	0	0
Met	0	0	0	0	0	0	0	0
Phe	0	2	3	1	1	2	1	1
Tyr	0	0	0	2	1	0	2	1
Trp	0	0	0	0	0	0	0	0
Ser	0	0	0	0	1	1	0	0
Thr	0	0	0	0	1	1	0	1
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	1	0	0	0	0
Gln	1	0	0	0	1	0	0	0
Asp	0	0	0	0	0	0	0	0
Glu	1	1	1	1	1	0	0	0
Lys	0	0	0	0	0	0	1	1
Arg	1	0	1	2	0	1	0	0
His	2	1	0	0	0	2	1	0