$VAR1 = undef;

Summary for peptidase M10.024: membrane-type matrix metallopeptidase-6

Names
MEROPS Name	membrane-type matrix metallopeptidase-6
Other names	leukolysin, membrane-type matrix metalloproteinase 6, MT-6 MMP, matrix metalloproteinase 25, MMP-25, MTMMP-6

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.024
Holotype	membrane-type matrix metallopeptidase-6 (Homo sapiens), Uniprot accession Q9NPA2 (peptidase unit: 104-306), MERNUM MER0012071
History	Identifier created: MEROPS 5.2 (31 August 2000)

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (32 cleavages)
Other databases	TREEFAM	http://www.treefam.org/family/TF315428
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/--/-/-/g (based on 178 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	18	33	10	14	30	13	20	42
Pro	13	28	26	21	4	17	17	16
Ala	14	18	15	17	19	13	23	24
Val	12	15	5	3	17	11	12	3
Leu	17	13	19	15	32	13	10	16
Ile	4	5	4	0	7	7	7	10
Met	5	3	5	1	4	4	0	1
Phe	3	6	8	15	13	9	3	6
Tyr	6	2	3	8	6	5	4	3
Trp	0	0	0	0	0	2	2	0
Ser	11	13	14	12	18	15	16	10
Thr	9	9	5	5	6	4	13	6
Cys	0	1	2	1	0	0	1	1
Asn	3	5	5	8	3	6	6	1
Gln	14	5	8	5	5	13	9	7
Asp	7	3	12	8	3	8	6	7
Glu	10	3	6	11	2	13	8	7
Lys	10	7	15	15	2	9	6	4
Arg	15	6	12	12	1	7	5	6
His	2	1	3	6	2	3	5	2