Summary for peptidase M04.009: aureolysin

Names
MEROPS Name	aureolysin
Other names	elastase (Staphylococcus), neutral proteinase (Staphylococcus aureus), SepP1 g.p. (Staphylococcus aureus), sepA g.p. (Staphylococcus epidermidis)

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(E) >> Family M4 >> Subfamily (none) >> M04.009
Holotype	aureolysin (Staphylococcus aureus), Uniprot accession P81177 (peptidase unit: 210-509), MERNUM MER0004711
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00147
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.29
Enzymology	BRENDA database
Proteolytic events	CutDB database (5 cleavages)
Physiology	Activates precursor of glutamyl endopeptidase of organism.
Pharmaceutical relevance	Several possible roles in pathology of S. aureus infection.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/-lfiv/-/-/- (based on 24 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	2	2	0	5	0	2	3	2
Pro	1	1	0	0	0	1	1	1
Ala	2	3	1	2	0	2	2	1
Val	1	2	0	0	3	6	0	1
Leu	4	2	2	1	10	1	2	1
Ile	1	0	0	0	4	1	0	2
Met	0	0	1	0	0	0	1	0
Phe	1	2	2	2	5	1	0	1
Tyr	0	0	0	2	1	2	2	0
Trp	0	0	0	0	0	0	0	0
Ser	1	0	3	2	0	1	0	3
Thr	2	0	1	0	0	1	0	3
Cys	1	0	0	0	0	0	0	0
Asn	0	2	1	1	0	0	2	0
Gln	0	0	2	0	0	0	1	2
Asp	0	0	0	0	0	1	1	1
Glu	2	3	2	0	0	1	3	0
Lys	0	0	4	5	1	1	0	1
Arg	1	3	1	2	0	0	1	1
His	0	0	0	2	0	0	0	0