$VAR1 = undef;
Summary for peptidase C46.001: hedgehog protein
| Names | |
|---|---|
| MEROPS Name | hedgehog protein |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PD >> Subclan PD(C) >> Family C46 >> Subfamily (none) >> C46.001 |
| Holotype | hedgehog protein (Drosophila melanogaster), Uniprot accession Q02936 (peptidase unit: 208-421), MERNUM MER0002023 |
| History | Identifier created: MEROPS 3.1 (22 December 1998) |
| Activity | |||
|---|---|---|---|
| Catalytic type | Cysteine | ||
| NC-IUBMB | Not yet included in IUBMB recommendations. | ||
| Proteolytic events | CutDB database (2 cleavages) | ||
| Physiology | C-terminal domain of Drosophila hedgehog protein possesses a cysteine-dependent autoprocessing activity that results in an intramolecular cleavage of the full-length hedgehog protein and covalent attachment of a cholesterol moiety to the newly generated amino-terminal fragment. It is only this auto-processing activity that qualifies hedgehog as a peptidase. | ||
| Pathways | KEGG | Hedgehog signaling pathway | |
| Other databases | PANTHER | http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR11889:SF31 | |
