$VAR1 = undef;
Summary for peptidase C01.050: histolysain
| Names | |
|---|---|
| MEROPS Name | histolysain |
| Other names | amebapain, amoebapain, ACP2 Entamoeba histolytica, CPNP (Entamoeba histolytica), CPP (Entamoeba histolytica), CPP1 (Entamoeba histolytica), EhCP-A5 (Entamoeba histolytica), EhCP1 g.p. (Entamoeba histolytica), EhCP2 g.p. (Entamoeba histolytica), EhCP3 g.p. (Entamoeba histolytica), EhCP5 g.p. (Entamoeba histolytica), EhCP6 g.p. (Entamoeba histolytica), EhCP8 g.p. (Entamoeba histolytica), EhCP9 g.p. (Entamoeba histolytica), EhCP10 g.p. (Entamoeba histolytica), EhCP17 g.p. (Entamoeba histolytica), EhCP19 g.p. (Entamoeba histolytica), EhCP-A peptidase (Entamoeba histolytica), EhlCP1, histolysin |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan CA >> Subclan (none) >> Family C1 >> Subfamily A >> C01.050 |
| Holotype | histolysain (Entamoeba histolytica), Uniprot accession Q01958 (peptidase unit: 98-312), MERNUM MER0000680 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Cysteine | ||
| Peplist | Included in the Peplist with identifier PL00066 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.35 | ||
| Enzymology | BRENDA database | ||
| Physiology | Assists in the invasion of host tissues by the parasitic amoeba. Disrupts colonic mucin, decreasing its protective function (Moncada et al., 2003). | ||
| Pharmaceutical relevance | Histolysain is a potential drug target for amoebic dysentery as there is evidence that it is necessary for the survival of trophozoites in vivo (Olivos-Garcia et al., 2004). It can also be used to diagnose infection (Luaces et al., 1992; Luaces et al., 1993). | ||
| Pathways | KEGG | Amoebiasis | |
| Other databases | PANTHER | http://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR12411:SF426 | |
| Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
| Cleavage pattern | -/-/Raf/R -/-/-/- (based on 11 cleavages) | ||
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| Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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