$VAR1 = undef;

Summary for peptidase A02.009: Mason-Pfizer leukemia virus retropepsin

Names
MEROPS Name	Mason-Pfizer leukemia virus retropepsin
Other names	squirrel monkey retrovirus protease, retropepsin (Mason-Pfizer leukemia virus), rhesus monkey immunodeficiency virus retropepsin, retropepsin (rhesus monkey immunodeficiency virus)

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A2 >> Subfamily A >> A02.009
Holotype	Mason-Pfizer leukemia virus retropepsin (Mason-Pfizer monkey virus), Uniprot accession P07570 (peptidase unit: 167-269), MERNUM MER0000969
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Aspartic
Peplist	Included in the Peplist with identifier PL00031
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (4 cleavages)
Physiology	Processing of viral polyprotein.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	S/q/Nv/YP/Iva/V/Q (based on 18 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	1	0	0	1	0	0	0
Pro	3	0	0	0	13	0	0	0
Ala	0	1	1	0	2	2	0	1
Val	0	1	4	0	0	4	15	0
Leu	0	1	0	1	0	0	0	0
Ile	0	0	1	0	0	12	0	0
Met	0	0	0	3	0	0	0	0
Phe	0	1	0	2	0	0	0	0
Tyr	0	0	0	12	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	12	0	0	0	0	0	0	1
Thr	0	1	0	0	0	0	1	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	12	0	0	0	0	1
Gln	0	10	0	0	0	0	0	12
Asp	0	1	0	0	0	0	0	0
Glu	0	0	0	0	0	0	0	1
Lys	2	1	0	0	0	0	0	2
Arg	0	0	0	0	0	0	2	0
His	1	0	0	0	0	0	0	0

Mouse genetics
Gene symbol	Position	Megabases	Ensembl	Entrez gene	MGI
	12