$VAR1 = undef;

Summary for peptidase A02.004: equine infectious anaemia virus retropepsin

Names
MEROPS Name	equine infectious anaemia virus retropepsin
Other names	retropepsin (equine infectious anaemia virus)

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A2 >> Subfamily D >> A02.004
Holotype	equine infectious anaemia virus retropepsin (equine infectious anemia virus), Uniprot accession P32542 (peptidase unit: 84-184), MERNUM MER0001447
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Aspartic
Peplist	Included in the Peplist with identifier PL00028
NC-IUBMB	Not yet included in IUBMB recommendations.
Physiology	Processing of viral polyprotein.
Pharmaceutical relevance	Drug target for equine swamp fever.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	S/q/N/YP/I/V/Q (based on 13 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	1	0	0	0	0	0	0
Pro	0	0	0	0	13	0	0	0
Ala	0	1	0	0	0	0	0	0
Val	0	1	0	0	0	0	13	0
Leu	0	1	0	1	0	0	0	0
Ile	0	0	0	0	0	13	0	0
Met	0	0	0	1	0	0	0	0
Phe	0	1	0	1	0	0	0	0
Tyr	0	0	0	10	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	13	0	0	0	0	0	0	0
Thr	0	0	0	0	0	0	0	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	13	0	0	0	0	0
Gln	0	7	0	0	0	0	0	12
Asp	0	0	0	0	0	0	0	0
Glu	0	0	0	0	0	0	0	0
Lys	0	1	0	0	0	0	0	0
Arg	0	0	0	0	0	0	0	0
His	0	0	0	0	0	0	0	0