$VAR1 = undef;

Summary for peptidase A01.040: nepenthesin

Names
MEROPS Name	nepenthesin
Other names	Nepenthes aspartic endopeptidase, nepenthesin-1 (Nepenthes sp.), nepenthesin-2 (Nepenthes sp.)

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A1 >> Subfamily B >> A01.040
Holotype	nepenthesin (Nepenthes gracilis), Uniprot accession Q766C3 (peptidase unit: 75-437), MERNUM MER0031323
History	Identifier created: MEROPS 4.0 (27 January 2000)

Activity
Catalytic type	Aspartic
Peplist	Included in the Peplist with identifier PL00022
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.12
Enzymology	BRENDA database
Physiology	Believed to be responsible for digestion of insect prey by insectivorous plants in the genus Nepenthes.
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Nepenthesin
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/--/-/-/- (based on 733 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	37	40	26	16	18	35	30	39
Pro	27	23	0	3	22	17	23	36
Ala	33	33	38	45	46	63	43	29
Val	43	36	68	23	56	69	46	41
Leu	80	84	78	135	79	67	73	68
Ile	52	40	62	11	61	24	42	38
Met	27	29	25	36	28	17	19	27
Phe	40	34	21	37	48	35	22	29
Tyr	35	37	12	46	41	28	28	22
Trp	8	9	5	5	9	10	7	7
Ser	34	41	48	14	42	57	47	42
Thr	48	27	38	26	37	44	36	33
Cys	10	18	17	17	17	20	17	9
Asn	31	25	29	28	40	20	29	39
Gln	27	33	37	24	19	25	33	33
Asp	43	39	40	54	54	25	53	40
Glu	52	58	78	61	46	68	61	66
Lys	44	64	65	103	33	67	59	67
Arg	43	41	37	39	27	29	41	43
His	14	20	7	10	9	13	21	22