Literature for peptidase S08.076: PCSK5 peptidase

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2021
1. Parvaz,N. and Jalali,Z.
   Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss
   PLoS ONE16, e0259085-e0259085. PubMed  Europe PubMed DOI
2. Shakya,M. and Lindberg,I.
   Mouse models of human proprotein convertase insufficiency
   Endocr Rev42, 259-294. PubMed  Europe PubMed DOI  V
3. Tong,J., Zhang,M., Li,X. and Ren,G.
   MicroRNA3383p regulates ageassociated osteoporosis via targeting PCSK5
   Mol Med Rep23, PubMed  Europe PubMed DOI
2018
4. Li,J.J., Liu,J., Lupino,K., Liu,X., Zhang,L. and Pei,L.
   Growth Differentiation Factor 15 maturation requires proteolytic cleavage by PCSK3, 5 and 6
   Mol Cell Biol38, e00249-18-e00249-18. PubMed  Europe PubMed DOI
2017
5. Hoac,B., Susan-Resiga,D., Essalmani,R., Marcinkiweicz,E., Seidah,N.G. and McKee,M.D.
   Osteopontin as a novel substrate for the proprotein convertase 5/6 (PCSK5) in bone
   Bone107, 45-55. PubMed  Europe PubMed DOI
2016
6. Maluch,I., Walewska,A., Sikorska,E. and Prahl,A.
   [Proprotein convertases - family of serine proteases with a broad spectrum of physiological functions]
   Postepy Biochem62, 472-481. PubMed  Europe PubMed  V
2015
7. Heng,S., Dynon,K., Li,Y., Edgell,T., Walton,K., Rombauts,L.J., Vollenhoven,B. and Nie,G.
   Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity
   Anal Biochem475, 14-21. PubMed  Europe PubMed DOI  A
8. Heng,S., Paule,S.G., Li,Y., Rombauts,L.J., Vollenhoven,B., Salamonsen,L.A. and Nie,G.
   Posttranslational removal of alpha-dystroglycan N terminus by PC5/6 cleavage is important for uterine preparation for embryo implantation in women
   FASEB J29, 4011-4022. PubMed  Europe PubMed DOI
9. Sathyamurthy,M., Kim,C.L., Bang,Y.L., Kim,Y.S., Jang,J.W. and Lee,G.M.
   Characterization and expression of proprotein convertases in CHO cells: efficient proteolytic maturation of human bone morphogenetic protein-7
   Biotechnol Bioeng112, 560-568. PubMed  Europe PubMed DOI  I
2014
10. Ho,H., Li,Y. and Nie,G.
    Inhibition of embryo implantation in mice through vaginal administration of a proprotein convertase 6 inhibitor
    Reprod Biol14, 155-159. PubMed  Europe PubMed DOI  I
2013
11. Ho,H., Singh,H., Heng,S., Nero,T.L., Paule,S., Parker,M.W., Johnson,A.T., Jiao,G.S. and Nie,G.
    Small molecule proprotein convertase inhibitors for inhibition of embryo implantation
    PLoS ONE8, e81380-e81380. PubMed  Europe PubMed DOI  I
12. Seidah,N.G., Sadr,M.S., Chretien,M. and Mbikay,M.
    The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions
    J Biol Chem288, 21473-21481. PubMed  Europe PubMed DOI  V
13. Turpeinen,H., Ortutay,Z. and Pesu,M.
    Genetics of the first seven proprotein convertase enzymes in health and disease
    Curr Genomics14, 453-467. PubMed  Europe PubMed DOI  V
2012
14. Aljofan,M., Singh,H., Ho,H., Xie,S., Zhu,Y., Sun,Z., Guo,X., Wang,J. and Nie,G.
    Inhibition of proprotein convertase 5/6 activity: potential for nonhormonal women-centered contraception
    Contraception85, 602-610. PubMed  Europe PubMed DOI  T  I
15. Ho,H., Nero,T.L., Singh,H., Parker,M.W. and Nie,G.
    PEGylation of a proprotein convertase peptide inhibitor for vaginal route of drug delivery: in vitro bioactivity, stability and in vivo pharmacokinetics
    Peptides38, 266-274. PubMed  Europe PubMed DOI  I
16. Seidah,N.G.
    Proprotein convertase 5
    [ISSN:978-0-12-407742-3]3, 3305-3310. DOI
17. Seidah,N.G. and Prat,A.
    The biology and therapeutic targeting of the proprotein convertases
    Nat Rev Drug Discov11, 367-383. PubMed  Europe PubMed DOI  V
2011
18. Basak,A., Chen,A., Majumdar,S. and Smith,H.P.
    In vitro assay for protease activity of proprotein convertase subtilisin kexins (PCSKs): an overall review of existing and new methodologies
    Methods Mol Biol768, 127-153. PubMed  Europe PubMed DOI  A
19. Chitramuthu,B.P. and Bennett,H.P.
    Use of zebrafish and knockdown technology to define proprotein convertase activity
    Methods Mol Biol768, 273-296. PubMed  Europe PubMed DOI
20. Heng,S., Cervero,A., Simon,C., Stephens,A.N., Li,Y., Zhang,J., Paule,S., Rainczuk,A., Singh,H., Quinonero,A., Tapia,A., Velasquez,L., Salamonsen,L., Rombauts,L.J. and Nie,G.
    Proprotein convertase 5/6 is critical for embryo implantation in women: regulating receptivity by cleaving EBP50, modulating ezrin binding, and membrane-cytoskeletal interactions
    Endocrinology152, 5041-5052. PubMed  Europe PubMed DOI
21. Marchesi,C., Essalmani,R., Lemarie,C.A., Leibovitz,E., Ebrahimian,T., Paradis,P., Seidah,N.G., Schiffrin,E.L. and Prat,A.
    Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy
    J Mol Med (Berl)89, 1103-1111. PubMed  Europe PubMed DOI  K
22. Seidah,N.G.
    The proprotein convertases, 20 years later
    Methods Mol Biol768, 23-57. PubMed  Europe PubMed DOI  V
23. Seidah,N.G.
    What lies ahead for the proprotein convertases?
    Ann N Y Acad Sci1220, 149-161. PubMed  Europe PubMed DOI  V
24. Sun,X., Essalmani,R., Susan-Resiga,D., Prat,A. and Seidah,N.G.
    Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A
    J Biol Chem286, 29063-29073. PubMed  Europe PubMed DOI
2010
25. Chitramuthu,B.P., Baranowski,D.C., Cadieux,B., Rousselet,E., Seidah,N.G. and Bennett,H.P.
    Molecular cloning and embryonic expression of zebrafish PCSK5 co-orthologues: functional assessment during lateral line development
    Dev Dyn239, 2933-2946. PubMed  Europe PubMed DOI  K
26. Heng,S., Paule,S., Hardman,B., Li,Y., Singh,H., Rainczuk,A., Stephens,A.N. and Nie,G.
    Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment
    Endocrinology151, 3909-3917. PubMed  Europe PubMed DOI
27. Khatib,A.M., Lahlil,R., Scamuffa,N., Akimenko,M.A., Ernest,S., Lomri,A., Lalou,C., Seidah,N.G., Villoutreix,B.O., Calvo,F. and Siegfried,G.
    Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration
    PLoS ONE5, e11438-e11438. PubMed  Europe PubMed DOI  I
28. Tian,S. and Jianhua,W.
    Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors
    Int J Biol Sci6, 89-95. PubMed  Europe PubMed  P  I
2009
29. Nelsen,S.M. and Christian,J.L.
    Site-specific cleavage of BMP4 by furin, PC6, and PC7
    J Biol Chem284, 27157-27166. PubMed  Europe PubMed DOI
30. Rholam,M. and Fahy,C.
    Processing of peptide and hormone precursors at the dibasic cleavage sites
    Cell Mol Life Sci66, 2075-2091. PubMed  Europe PubMed DOI
2008
31. Creemers,J.W. and Khatib,A.M.
    Knock-out mouse models of proprotein convertases: unique functions or redundancy?
    Front Biosci13, 4960-4971. PubMed  Europe PubMed DOI  K
32. Mayer,G., Hamelin,J., Asselin,M.C., Pasquato,A., Marcinkiewicz,E., Tang,M., Tabibzadeh,S. and Seidah,N.G.
    The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates
    J Biol Chem283, 2373-2384. PubMed  Europe PubMed DOI
33. Remacle,A.G., Shiryaev,S.A., Oh,E.S., Cieplak,P., Srinivasan,A., Wei,G., Liddington,R.C., Ratnikov,B.I., Parent,A., Desjardins,R., Day,R., Smith,J.W., Lebl,M. and Strongin,A.Y.
    Substrate cleavage analysis of furin and related proprotein convertases. A comparative study
    J Biol Chem283, 20897-20906. PubMed  Europe PubMed DOI  P
34. Szumska,D., Pieles,G., Essalmani,R., Bilski,M., Mesnard,D., Kaur,K., Franklyn,A., El Omari,K., Jefferis,J., Bentham,J., Taylor,J.M., Schneider,J.E., Arnold,S.J., Johnson,P., Tymowska-Lalanne,Z., Stammers,D., Clarke,K., Neubauer,S., Morris,A., Brown,S.D., Shaw-Smith,C., Cama,A., Capra,V., Ragoussis,J., Constam,D., Seidah,N.G., Prat,A. and Bhattacharya,S.
    VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5
    Genes Dev22, 1465-1477. PubMed  Europe PubMed DOI  M
2007
35. Dikeakos,J.D., Mercure,C., Lacombe,M.J., Seidah,N.G. and Reudelhuber,T.L.
    PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism
    FEBS J274, 4094-4102. PubMed  Europe PubMed DOI
36. Fugere,M., Appel,J., Houghten,R.A., Lindberg,I. and Day,R.
    Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences
    Mol Pharmacol71, 323-332. PubMed  Europe PubMed DOI  I
37. Tsuji,A., Kanie,H., Makise,H., Yuasa,K., Nagahama,M. and Matsuda,Y.
    Engineering of alpha1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: importance of the P2' residue in stable complex formation of the serpin with proprotein convertase
    Protein Eng Des Sel20, 163-170. PubMed  Europe PubMed DOI
2006
38. Essalmani,R., Hamelin,J., Marcinkiewicz,J., Chamberland,A., Mbikay,M., Chretien,M., Seidah,N.G. and Prat,A.
    Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse
    Mol Cell Biol26, 354-361. PubMed  Europe PubMed DOI  K
39. Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.
    Proprotein convertases: lessons from knockouts
    FASEB J20, 1954-1963. PubMed  Europe PubMed DOI  K  V
40. [YEAR:27-6-2006]Stein,J., Shah,R., Steiner,D.F. and Dey,A.
    RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor
    Biochem J400, 209-215. PubMed  Europe PubMed DOI  K
2005
41. [YEAR:14-1-2005]Henrich,S., Lindberg,I., Bode,W. and Than,M.E.
    Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity
    J Mol Biol345, 211-227. PubMed  Europe PubMed DOI  S
42. [YEAR:20-4-2005]Nelsen,S., Berg,L., Wong,C. and Christian,J.L.
    Proprotein convertase genes in Xenopus development
    Dev Dyn233, 1038-1044. PubMed  Europe PubMed DOI
43. [YEAR:15-12-2005]Nie,G., Li,Y., Wang,M., Liu,Y.X., Findlay,J.K. and Salamonsen,L.A.
    Inhibiting uterine PC6 blocks embryo implantation: an obligatory role for a proprotein convertase in fertility
    Biol Reprod72, 1029-1036. PubMed  Europe PubMed DOI  K
44. Nour,N., Mayer,G., Mort,J.S., Salvas,A., Mbikay,M., Morrison,C.J., Overall,C.M. and Seidah,N.G.
    The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases
    Mol Biol Cell16, 5215-5226. PubMed  Europe PubMed DOI
45. [YEAR:2-11-2005]Okada,H., Nie,G. and Salamonsen,L.A.
    Requirement for proprotein convertase 5/6 during decidualization of human endometrial stromal cells in vitro
    J Clin Endocrinol Metab90, 1028-1034. PubMed  Europe PubMed DOI  K
2004
46. Seidah,N.G. and Chretien,M.
    Proprotein convertase 5
    [ISSN:0-12-079610-4]2, 1874-1877.  V
47. Veinot,J.P., Prichett-Pejic,W., Picard,P., Parks,W., Schwartz,R., Seidah,N.G. and Chretien,M.
    Implications of proprotein convertase 5 (PC5) in the arterial restenotic process in a porcine model
    Cardiovasc Pathol13, 241-250. PubMed  Europe PubMed DOI
2003
48. [YEAR:27-1-2003]Gangnon,F., Jegou,S., Vallarino,M., Vieau,D. and Vaudry,H.
    Molecular characterization of the cDNA and localization of the mRNA encoding the prohormone convertase PC5-A in the European green frog
    J Comp Neurol456, 60-72. PubMed  Europe PubMed DOI
49. [YEAR:21-3-2003]Kalus,I., Schnegelsberg,B., Seidah,N.G., Kleene,R. and Schachner,M.
    The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1
    J Biol Chem278, 10381-10388. PubMed  Europe PubMed DOI
50. [YEAR:31-1-2003]Nour,N., Basak,A., Chretien,M. and Seidah,N.G.
    Structure-function analysis of the prosegment of the proprotein convertase PC5A
    J Biol Chem278, 2886-2895. PubMed  Europe PubMed DOI
51. Siegfried,G., Basak,A., Cromlish,J.A., Benjannet,S., Marcinkiewicz,J., Chretien,M., Seidah,N.G. and Khatib,A.M.
    The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis
    J Clin Invest111, 1723-1732. PubMed  Europe PubMed DOI
52. Stawowy,P., Graf,K., Goetze,S., Roser,M., Chretien,M., Seidah,N.G., Fleck,E. and Marcinkiewicz,M.
    Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo
    Histochem Cell Biol119, 239-245. PubMed  Europe PubMed DOI
53. Taylor,N.A., Van de Ven,W.J. and Creemers,J.W.
    Curbing activation: proprotein convertases in homeostasis and pathology
    FASEB J17, 1215-1227. PubMed  Europe PubMed DOI  K
54. [YEAR:31-1-2003]Tsuji,A., Sakurai,K., Kiyokage,E., Yamazaki,T., Koide,S., Toida,K., Ishimura,K. and Matsuda,Y.
    Secretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrix
    Biochim Biophys Acta1645, 95-104. PubMed  Europe PubMed DOI
2002
55. Cain,B.M., Vishnuvardhan,D., Wang,W., Foulon,T., Cadel,S., Cohen,P. and Beinfeld,M.C.
    Production, purification, and characterization of recombinant prohormone convertase 5 from baculovirus-infected insect cells
    Protein Expr Purif24, 227-233. PubMed  Europe PubMed DOI  E
56. Fugere,M. and Day,R.
    Inhibitors of the subtilase-like pro-protein convertases (SPCs)
    Curr Pharm Des8, 549-562. PubMed  Europe PubMed DOI  V  I
57. Seidah,N.G. and Prat,A.
    Precursor convertases in the secretory pathway, cytosol and extracellular milieu
    Essays Biochem38, 79-94. PubMed  Europe PubMed
2001
58. Cain,B.M., Vishnuvardhan,D. and Beinfeld,M.C.
    Neuronal cell lines expressing PC5, but not PC1 or PC2, process pro-CCK into glycine-extended CCK 12 and 22
    Peptides22, 1271-1277. PubMed  Europe PubMed DOI
59. [YEAR:15-6-2001]Ulloa,L., Creemers,J.W., Roy,S., Liu,S., Mason,J. and Tabibzadeh,S.
    Lefty proteins exhibit unique processing and activate the MAPK pathway
    J Biol Chem276, 21387-21396. PubMed  Europe PubMed DOI
2000
60. [YEAR:15-2-2000]Lissitzky,J.C., Luis,J., Munzer,J.S., Benjannet,S., Parat,F., Chretien,M., Marvaldi,J. and Seidah,N.G.
    Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7
    Biochem J346, 133-138. PubMed  Europe PubMed DOI  R
61. [YEAR:7-3-2000]Oliva,A.A., Jr., Chan,S.J. and Steiner,D.F.
    Evolution of the prohormone convertases: identification of a homologue of PC6 in the protochordate amphioxus
    Biochim Biophys Acta1477, 338-348. PubMed  Europe PubMed DOI
62. [YEAR:28-8-2000]Villeneuve,P., Lafortune,L., Seidah,N.G., Kitabgi,P. and Beaudet,A.
    Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing of pro-neurotensin in rat brain
    J Comp Neurol424, 461-475. PubMed  Europe PubMed DOI
63. Xiang,Y., Molloy,S.S., Thomas,L. and Thomas,G.
    The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments
    Mol Biol Cell11, 1257-1273. PubMed  Europe PubMed
1999
64. [YEAR:27-11-1999]Seidah,N.G. and Chretien,M.
    Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides
    Brain Res848, 45-62. PubMed  Europe PubMed DOI  K
1996
65. Campan,M., Yoshizumi,M., Seidah,N.G., Lee,M.E., Bianchi,C. and Haber,E.
    Increased proteolytic processing of protein tyrosine phosphatase mu in confluent vascular endothelial cells: the role of PC5, a member of the subtilisin family
    Biochemistry35, 3797-3802. PubMed  Europe PubMed DOI
66. Constam,D.B., Calfon,M. and Robertson,E.J.
    SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis
    J Cell Biol134, 181-191. PubMed  Europe PubMed DOI
67. De Bie,I., Marcinkiewicz,M., Malide,D., Lazure,C., Nakayama,K., Bendayan,M. and Seidah,N.G.
    The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments
    J Cell Biol135, 1261-1275. PubMed  Europe PubMed DOI  R
68. Mercure,C., Jutras,I., Day,R., Seidah,N.G. and Reudelhuber,T.L.
    Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex
    Hypertension28, 840-846. PubMed  Europe PubMed
69. Miranda,L., Wolf,J., Pichuantes,S., Duke,R. and Franzusoff,A.
    Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes
    Proc Natl Acad Sci U S A93, 7695-7700. PubMed  Europe PubMed DOI  R
70. van de Loo,J.W., Creemers,J.W., Kas,K., Roebroek,A.J. and Van de Ven,W.J.
    Assignment of the human proprotein convertase gene PCSK5 to chromosome 9q21.3
    Cytogenet Cell Genet75, 227-229. PubMed  Europe PubMed
1995
71. Brakch,N., Galanopoulou,A.S., Patel,Y.C., Boileau,G. and Seidah,N.G.
    Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways
    FEBS Lett362, 143-146. PubMed  Europe PubMed DOI
72. Dong,W., Marcinkiewicz,M., Vieau,D., Chretien,M., Seidah,N.G. and Day,R.
    Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary
    J Neurosci15, 1778-1796. PubMed  Europe PubMed
73. Mbikay,M., Seidah,N.G., Chretien,M. and Simpson,E.M.
    Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human
    Genomics26, 123-129. PubMed  Europe PubMed DOI
1993
74. [YEAR:15-7-1993]Lusson,J., Vieau,D., Hamelin,J., Day,R., Chretien,M. and Seidah,N.G.
    cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells
    Proc Natl Acad Sci U S A90, 6691-6695. PubMed  Europe PubMed
75. [YEAR:26-7-1993]Nakagawa,T., Murakami,K. and Nakayama,K.
    Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease
    FEBS Lett327, 165-171. PubMed  Europe PubMed DOI