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Literature for peptidase S08.076: PCSK5 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2021
  1. Parvaz,N. and Jalali,Z.<br>Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss<br>PLoS ONE (2021) 16, e0259085-e0259085. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Shakya,M. and Lindberg,I.<br>Mouse models of human proprotein convertase insufficiency<br>Endocr Rev (2021) 42, 259-294. PubMed  Europe PubMed DOI  V
  3. Tong,J., Zhang,M., Li,X. and Ren,G.<br>MicroRNA3383p regulates ageassociated osteoporosis via targeting PCSK5<br>Mol Med Rep (2021) 23 PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2018
  4. Li,J.J., Liu,J., Lupino,K., Liu,X., Zhang,L. and Pei,L.<br>Growth Differentiation Factor 15 maturation requires proteolytic cleavage by PCSK3, 5 and 6<br>Mol Cell Biol (2018) 38, e00249-18-e00249-18. PubMed  Europe PubMed DOI
    5. 2017
  5. Hoac,B., Susan-Resiga,D., Essalmani,R., Marcinkiweicz,E., Seidah,N.G. and McKee,M.D.<br>Osteopontin as a novel substrate for the proprotein convertase 5/6 (PCSK5) in bone<br>Bone (2017) 107, 45-55. PubMed  Europe PubMed DOI
    6. 2016
  6. Maluch,I., Walewska,A., Sikorska,E. and Prahl,A.<br>[Proprotein convertases - family of serine proteases with a broad spectrum of physiological functions]<br>Postepy Biochem (2016) 62, 472-481. PubMed  Europe PubMed  V
    7. 2015
  7. Heng,S., Dynon,K., Li,Y., Edgell,T., Walton,K., Rombauts,L.J., Vollenhoven,B. and Nie,G.<br>Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity<br>Anal Biochem (2015) 475, 14-21. PubMed  Europe PubMed DOI  A
  8. Heng,S., Paule,S.G., Li,Y., Rombauts,L.J., Vollenhoven,B., Salamonsen,L.A. and Nie,G.<br>Posttranslational removal of alpha-dystroglycan N terminus by PC5/6 cleavage is important for uterine preparation for embryo implantation in women<br>FASEB J (2015) 29, 4011-4022. PubMed  Europe PubMed DOI
  9. Sathyamurthy,M., Kim,C.L., Bang,Y.L., Kim,Y.S., Jang,J.W. and Lee,G.M.<br>Characterization and expression of proprotein convertases in CHO cells: efficient proteolytic maturation of human bone morphogenetic protein-7<br>Biotechnol Bioeng (2015) 112, 560-568. PubMed  Europe PubMed DOI  I
    10. 2014
  10. Ho,H., Li,Y. and Nie,G.<br>Inhibition of embryo implantation in mice through vaginal administration of a proprotein convertase 6 inhibitor<br>Reprod Biol (2014) 14, 155-159. PubMed  Europe PubMed DOI  I
    11. 2013
  11. Ho,H., Singh,H., Heng,S., Nero,T.L., Paule,S., Parker,M.W., Johnson,A.T., Jiao,G.S. and Nie,G.<br>Small molecule proprotein convertase inhibitors for inhibition of embryo implantation<br>PLoS ONE (2013) 8, e81380-e81380. PubMed  Europe PubMed DOI  PMC  EPMC  I
  12. Seidah,N.G., Sadr,M.S., Chretien,M. and Mbikay,M.<br>The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions<br>J Biol Chem (2013) 288, 21473-21481. PubMed  Europe PubMed DOI  V
  13. Turpeinen,H., Ortutay,Z. and Pesu,M.<br>Genetics of the first seven proprotein convertase enzymes in health and disease<br>Curr Genomics (2013) 14, 453-467. PubMed  Europe PubMed DOI  PMC  EPMC  V
    14. 2012
  14. Aljofan,M., Singh,H., Ho,H., Xie,S., Zhu,Y., Sun,Z., Guo,X., Wang,J. and Nie,G.<br>Inhibition of proprotein convertase 5/6 activity: potential for nonhormonal women-centered contraception<br>Contraception (2012) 85, 602-610. PubMed  Europe PubMed DOI  T  I
  15. Ho,H., Nero,T.L., Singh,H., Parker,M.W. and Nie,G.<br>PEGylation of a proprotein convertase peptide inhibitor for vaginal route of drug delivery: in vitro bioactivity, stability and in vivo pharmacokinetics<br>Peptides (2012) 38, 266-274. PubMed  Europe PubMed DOI  I
  16. Seidah,N.G. and Prat,A.<br>The biology and therapeutic targeting of the proprotein convertases<br>Nat Rev Drug Discov (2012) 11, 367-383. PubMed  Europe PubMed DOI  V
  17. Seidah,N.G.<br>Proprotein convertase 5<br>[ISSN:978-0-12-407742-3] (2012) 3, 3305-3310. DOI
    18. 2011
  18. Basak,A., Chen,A., Majumdar,S. and Smith,H.P.<br>In vitro assay for protease activity of proprotein convertase subtilisin kexins (PCSKs): an overall review of existing and new methodologies<br>Methods Mol Biol (2011) 768, 127-153. PubMed  Europe PubMed DOI  A
  19. Chitramuthu,B.P. and Bennett,H.P.<br>Use of zebrafish and knockdown technology to define proprotein convertase activity<br>Methods Mol Biol (2011) 768, 273-296. PubMed  Europe PubMed DOI
  20. Heng,S., Cervero,A., Simon,C., Stephens,A.N., Li,Y., Zhang,J., Paule,S., Rainczuk,A., Singh,H., Quinonero,A., Tapia,A., Velasquez,L., Salamonsen,L., Rombauts,L.J. and Nie,G.<br>Proprotein convertase 5/6 is critical for embryo implantation in women: regulating receptivity by cleaving EBP50, modulating ezrin binding, and membrane-cytoskeletal interactions<br>Endocrinology (2011) 152, 5041-5052. PubMed  Europe PubMed DOI
  21. Marchesi,C., Essalmani,R., Lemarie,C.A., Leibovitz,E., Ebrahimian,T., Paradis,P., Seidah,N.G., Schiffrin,E.L. and Prat,A.<br>Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy<br>J Mol Med (Berl) (2011) 89, 1103-1111. PubMed  Europe PubMed DOI  K
  22. Seidah,N.G.<br>What lies ahead for the proprotein convertases?<br>Ann N Y Acad Sci (2011) 1220, 149-161. PubMed  Europe PubMed DOI  V
  23. Seidah,N.G.<br>The proprotein convertases, 20 years later<br>Methods Mol Biol (2011) 768, 23-57. PubMed  Europe PubMed DOI  V
  24. Sun,X., Essalmani,R., Susan-Resiga,D., Prat,A. and Seidah,N.G.<br>Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A<br>J Biol Chem (2011) 286, 29063-29073. PubMed  Europe PubMed DOI
    25. 2010
  25. Chitramuthu,B.P., Baranowski,D.C., Cadieux,B., Rousselet,E., Seidah,N.G. and Bennett,H.P.<br>Molecular cloning and embryonic expression of zebrafish PCSK5 co-orthologues: functional assessment during lateral line development<br>Dev Dyn (2010) 239, 2933-2946. PubMed  Europe PubMed DOI  K
  26. Heng,S., Paule,S., Hardman,B., Li,Y., Singh,H., Rainczuk,A., Stephens,A.N. and Nie,G.<br>Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment<br>Endocrinology (2010) 151, 3909-3917. PubMed  Europe PubMed DOI
  27. Khatib,A.M., Lahlil,R., Scamuffa,N., Akimenko,M.A., Ernest,S., Lomri,A., Lalou,C., Seidah,N.G., Villoutreix,B.O., Calvo,F. and Siegfried,G.<br>Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration<br>PLoS ONE (2010) 5, e11438-e11438. PubMed  Europe PubMed DOI  PMC  EPMC  I
  28. Tian,S. and Jianhua,W.<br>Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors<br>Int J Biol Sci (2010) 6, 89-95. PubMed  Europe PubMed  PMC  EPMC  P  I
    29. 2009
  29. Nelsen,S.M. and Christian,J.L.<br>Site-specific cleavage of BMP4 by furin, PC6, and PC7<br>J Biol Chem (2009) 284, 27157-27166. PubMed  Europe PubMed DOI
  30. Rholam,M. and Fahy,C.<br>Processing of peptide and hormone precursors at the dibasic cleavage sites<br>Cell Mol Life Sci (2009) 66, 2075-2091. PubMed  Europe PubMed DOI
    31. 2008
  31. Creemers,J.W. and Khatib,A.M.<br>Knock-out mouse models of proprotein convertases: unique functions or redundancy?<br>Front Biosci (2008) 13, 4960-4971. PubMed  Europe PubMed DOI  K
  32. Mayer,G., Hamelin,J., Asselin,M.C., Pasquato,A., Marcinkiewicz,E., Tang,M., Tabibzadeh,S. and Seidah,N.G.<br>The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates<br>J Biol Chem (2008) 283, 2373-2384. PubMed  Europe PubMed DOI
  33. Remacle,A.G., Shiryaev,S.A., Oh,E.S., Cieplak,P., Srinivasan,A., Wei,G., Liddington,R.C., Ratnikov,B.I., Parent,A., Desjardins,R., Day,R., Smith,J.W., Lebl,M. and Strongin,A.Y.<br>Substrate cleavage analysis of furin and related proprotein convertases. A comparative study<br>J Biol Chem (2008) 283, 20897-20906. PubMed  Europe PubMed DOI  PMC  EPMC  P
  34. Szumska,D., Pieles,G., Essalmani,R., Bilski,M., Mesnard,D., Kaur,K., Franklyn,A., El Omari,K., Jefferis,J., Bentham,J., Taylor,J.M., Schneider,J.E., Arnold,S.J., Johnson,P., Tymowska-Lalanne,Z., Stammers,D., Clarke,K., Neubauer,S., Morris,A., Brown,S.D., Shaw-Smith,C., Cama,A., Capra,V., Ragoussis,J., Constam,D., Seidah,N.G., Prat,A. and Bhattacharya,S.<br>VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5<br>Genes Dev (2008) 22, 1465-1477. PubMed  Europe PubMed DOI  PMC  EPMC  M
    35. 2007
  35. Dikeakos,J.D., Mercure,C., Lacombe,M.J., Seidah,N.G. and Reudelhuber,T.L.<br>PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism<br>FEBS J (2007) 274, 4094-4102. PubMed  Europe PubMed DOI
  36. Fugere,M., Appel,J., Houghten,R.A., Lindberg,I. and Day,R.<br>Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences<br>Mol Pharmacol (2007) 71, 323-332. PubMed  Europe PubMed DOI  I
  37. Tsuji,A., Kanie,H., Makise,H., Yuasa,K., Nagahama,M. and Matsuda,Y.<br>Engineering of alpha1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: importance of the P2' residue in stable complex formation of the serpin with proprotein convertase<br>Protein Eng Des Sel (2007) 20, 163-170. PubMed  Europe PubMed DOI
    38. 2006
  38. Essalmani,R., Hamelin,J., Marcinkiewicz,J., Chamberland,A., Mbikay,M., Chretien,M., Seidah,N.G. and Prat,A.<br>Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse<br>Mol Cell Biol (2006) 26, 354-361. PubMed  Europe PubMed DOI  PMC  EPMC  K
  39. Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.<br>Proprotein convertases: lessons from knockouts<br>FASEB J (2006) 20, 1954-1963. PubMed  Europe PubMed DOI  K  V
  40. [YEAR:27-6-2006]Stein,J., Shah,R., Steiner,D.F. and Dey,A.<br>RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor<br>Biochem J (27-6-2006) 400, 209-215. PubMed  Europe PubMed DOI  PMC  EPMC  K
    41. 2005
  41. [YEAR:14-1-2005]Henrich,S., Lindberg,I., Bode,W. and Than,M.E.<br>Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity<br>J Mol Biol (14-1-2005) 345, 211-227. PubMed  Europe PubMed DOI  S
  42. [YEAR:20-4-2005]Nelsen,S., Berg,L., Wong,C. and Christian,J.L.<br>Proprotein convertase genes in Xenopus development<br>Dev Dyn (20-4-2005) 233, 1038-1044. PubMed  Europe PubMed DOI
  43. [YEAR:15-12-2005]Nie,G., Li,Y., Wang,M., Liu,Y.X., Findlay,J.K. and Salamonsen,L.A.<br>Inhibiting uterine PC6 blocks embryo implantation: an obligatory role for a proprotein convertase in fertility<br>Biol Reprod (15-12-2005) 72, 1029-1036. PubMed  Europe PubMed DOI  K
  44. Nour,N., Mayer,G., Mort,J.S., Salvas,A., Mbikay,M., Morrison,C.J., Overall,C.M. and Seidah,N.G.<br>The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases<br>Mol Biol Cell (2005) 16, 5215-5226. PubMed  Europe PubMed DOI  PMC  EPMC
  45. [YEAR:2-11-2005]Okada,H., Nie,G. and Salamonsen,L.A.<br>Requirement for proprotein convertase 5/6 during decidualization of human endometrial stromal cells in vitro<br>J Clin Endocrinol Metab (2-11-2005) 90, 1028-1034. PubMed  Europe PubMed DOI  K
    46. 2004
  46. Seidah,N.G. and Chretien,M.<br>Proprotein convertase 5<br>[ISSN:0-12-079610-4] (2004) 2, 1874-1877.  V
  47. Veinot,J.P., Prichett-Pejic,W., Picard,P., Parks,W., Schwartz,R., Seidah,N.G. and Chretien,M.<br>Implications of proprotein convertase 5 (PC5) in the arterial restenotic process in a porcine model<br>Cardiovasc Pathol (2004) 13, 241-250. PubMed  Europe PubMed DOI
    48. 2003
  48. [YEAR:27-1-2003]Gangnon,F., Jegou,S., Vallarino,M., Vieau,D. and Vaudry,H.<br>Molecular characterization of the cDNA and localization of the mRNA encoding the prohormone convertase PC5-A in the European green frog<br>J Comp Neurol (27-1-2003) 456, 60-72. PubMed  Europe PubMed DOI
  49. [YEAR:21-3-2003]Kalus,I., Schnegelsberg,B., Seidah,N.G., Kleene,R. and Schachner,M.<br>The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1<br>J Biol Chem (21-3-2003) 278, 10381-10388. PubMed  Europe PubMed DOI
  50. [YEAR:31-1-2003]Nour,N., Basak,A., Chretien,M. and Seidah,N.G.<br>Structure-function analysis of the prosegment of the proprotein convertase PC5A<br>J Biol Chem (31-1-2003) 278, 2886-2895. PubMed  Europe PubMed DOI
  51. Siegfried,G., Basak,A., Cromlish,J.A., Benjannet,S., Marcinkiewicz,J., Chretien,M., Seidah,N.G. and Khatib,A.M.<br>The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis<br>J Clin Invest (2003) 111, 1723-1732. PubMed  Europe PubMed DOI  PMC  EPMC
  52. Stawowy,P., Graf,K., Goetze,S., Roser,M., Chretien,M., Seidah,N.G., Fleck,E. and Marcinkiewicz,M.<br>Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo<br>Histochem Cell Biol (2003) 119, 239-245. PubMed  Europe PubMed DOI
  53. Taylor,N.A., Van de Ven,W.J. and Creemers,J.W.<br>Curbing activation: proprotein convertases in homeostasis and pathology<br>FASEB J (2003) 17, 1215-1227. PubMed  Europe PubMed DOI  K
  54. [YEAR:31-1-2003]Tsuji,A., Sakurai,K., Kiyokage,E., Yamazaki,T., Koide,S., Toida,K., Ishimura,K. and Matsuda,Y.<br>Secretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrix<br>Biochim Biophys Acta (31-1-2003) 1645, 95-104. PubMed  Europe PubMed DOI
    55. 2002
  55. Cain,B.M., Vishnuvardhan,D., Wang,W., Foulon,T., Cadel,S., Cohen,P. and Beinfeld,M.C.<br>Production, purification, and characterization of recombinant prohormone convertase 5 from baculovirus-infected insect cells<br>Protein Expr Purif (2002) 24, 227-233. PubMed  Europe PubMed DOI  E
  56. Fugere,M. and Day,R.<br>Inhibitors of the subtilase-like pro-protein convertases (SPCs)<br>Curr Pharm Des (2002) 8, 549-562. PubMed  Europe PubMed DOI  V  I
  57. Seidah,N.G. and Prat,A.<br>Precursor convertases in the secretory pathway, cytosol and extracellular milieu<br>Essays Biochem (2002) 38, 79-94. PubMed  Europe PubMed
    58. 2001
  58. Cain,B.M., Vishnuvardhan,D. and Beinfeld,M.C.<br>Neuronal cell lines expressing PC5, but not PC1 or PC2, process pro-CCK into glycine-extended CCK 12 and 22<br>Peptides (2001) 22, 1271-1277. PubMed  Europe PubMed DOI
  59. [YEAR:15-6-2001]Ulloa,L., Creemers,J.W., Roy,S., Liu,S., Mason,J. and Tabibzadeh,S.<br>Lefty proteins exhibit unique processing and activate the MAPK pathway<br>J Biol Chem (15-6-2001) 276, 21387-21396. PubMed  Europe PubMed DOI
    60. 2000
  60. [YEAR:15-2-2000]Lissitzky,J.C., Luis,J., Munzer,J.S., Benjannet,S., Parat,F., Chretien,M., Marvaldi,J. and Seidah,N.G.<br>Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7<br>Biochem J (15-2-2000) 346, 133-138. PubMed  Europe PubMed DOI  PMC  EPMC  R
  61. [YEAR:7-3-2000]Oliva,A.A., Jr., Chan,S.J. and Steiner,D.F.<br>Evolution of the prohormone convertases: identification of a homologue of PC6 in the protochordate amphioxus<br>Biochim Biophys Acta (7-3-2000) 1477, 338-348. PubMed  Europe PubMed DOI
  62. [YEAR:28-8-2000]Villeneuve,P., Lafortune,L., Seidah,N.G., Kitabgi,P. and Beaudet,A.<br>Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing of pro-neurotensin in rat brain<br>J Comp Neurol (28-8-2000) 424, 461-475. PubMed  Europe PubMed DOI
  63. Xiang,Y., Molloy,S.S., Thomas,L. and Thomas,G.<br>The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments<br>Mol Biol Cell (2000) 11, 1257-1273. PubMed  Europe PubMed  PMC  EPMC
    64. 1999
  64. [YEAR:27-11-1999]Seidah,N.G. and Chretien,M.<br>Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides<br>Brain Res (27-11-1999) 848, 45-62. PubMed  Europe PubMed DOI  K
    65. 1996
  65. Campan,M., Yoshizumi,M., Seidah,N.G., Lee,M.E., Bianchi,C. and Haber,E.<br>Increased proteolytic processing of protein tyrosine phosphatase mu in confluent vascular endothelial cells: the role of PC5, a member of the subtilisin family<br>Biochemistry (1996) 35, 3797-3802. PubMed  Europe PubMed DOI
  66. Constam,D.B., Calfon,M. and Robertson,E.J.<br>SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis<br>J Cell Biol (1996) 134, 181-191. PubMed  Europe PubMed DOI  PMC  EPMC
  67. De Bie,I., Marcinkiewicz,M., Malide,D., Lazure,C., Nakayama,K., Bendayan,M. and Seidah,N.G.<br>The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments<br>J Cell Biol (1996) 135, 1261-1275. PubMed  Europe PubMed DOI  PMC  EPMC  R
  68. Mercure,C., Jutras,I., Day,R., Seidah,N.G. and Reudelhuber,T.L.<br>Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex<br>Hypertension (1996) 28, 840-846. PubMed  Europe PubMed
  69. Miranda,L., Wolf,J., Pichuantes,S., Duke,R. and Franzusoff,A.<br>Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes<br>Proc Natl Acad Sci U S A (1996) 93, 7695-7700. PubMed  Europe PubMed DOI  PMC  EPMC  R
  70. van de Loo,J.W., Creemers,J.W., Kas,K., Roebroek,A.J. and Van de Ven,W.J.<br>Assignment of the human proprotein convertase gene PCSK5 to chromosome 9q21.3<br>Cytogenet Cell Genet (1996) 75, 227-229. PubMed  Europe PubMed
    71. 1995
  71. Brakch,N., Galanopoulou,A.S., Patel,Y.C., Boileau,G. and Seidah,N.G.<br>Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways<br>FEBS Lett (1995) 362, 143-146. PubMed  Europe PubMed DOI
  72. Dong,W., Marcinkiewicz,M., Vieau,D., Chretien,M., Seidah,N.G. and Day,R.<br>Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary<br>J Neurosci (1995) 15, 1778-1796. PubMed  Europe PubMed
  73. Mbikay,M., Seidah,N.G., Chretien,M. and Simpson,E.M.<br>Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human<br>Genomics (1995) 26, 123-129. PubMed  Europe PubMed DOI
    74. 1993
  74. [YEAR:15-7-1993]Lusson,J., Vieau,D., Hamelin,J., Day,R., Chretien,M. and Seidah,N.G.<br>cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells<br>Proc Natl Acad Sci U S A (15-7-1993) 90, 6691-6695. PubMed  Europe PubMed  PMC  EPMC
  75. [YEAR:26-7-1993]Nakagawa,T., Murakami,K. and Nakayama,K.<br>Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease<br>FEBS Lett (26-7-1993) 327, 165-171. PubMed  Europe PubMed DOI

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