Literature for peptidase S01.153: elastase-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Jamwal,D., Kumar,P., Meena,K., Yadav,V., Kumar,R., Adlakha,N. and Das,S. Human CELA1 has pancreatic elastase-like activity Biochimie (2026) 243, 18-20. PubMed Europe PubMed DOI

2024

Abdollahi-Najafabadi,M., Farhadian,S., Shareghi,B. and Asgharzadeh,S. The investigation of the interaction determination between carbendazim and elastase, using both in vitro and in silico methods Spectrochim Acta A Mol Biomol Spectrosc (2024) 319, 124586-124586. PubMed Europe PubMed DOI
Ge,J., Weng,C., Zhang,X., Zhao,J., Zhang,H., Yuan,D. and Wang,T. A Mouse Abdominal Aortic Aneurysm Model by Periadventitial Calcium Chloride and Elastase Infiltration J Vis Exp (2024) PubMed Europe PubMed DOI

2022

Ahmed,A., Saeed,A., Ejaz,S.A., Aziz,M., Hashmi,M.Z., Channar,P.A., Abbas,Q., Raza,H., Shafiq,Z. and El-Seedi,H.R. Novel adamantyl clubbed iminothiazolidinones as promising elastase inhibitors: design, synthesis, molecular docking, ADMET and DFT studies RSC Adv (2022) 12, 11974-11991. PubMed Europe PubMed DOI PMC EPMC I
Li,H., Gao,Z. and Zhang,S. Localization of trypsin, chymotrypsin and elastase in the digestive tract of amphioxus Branchiostoma japonicum with implications to the origin of vertebrate pancreas Tissue Cell (2022) 79, 101943-101943. PubMed Europe PubMed DOI
Xiong,Y., Peng,P., Chen,S.J., Chang,M., Wang,Q., Yin,S.N. and Ren,D.F. Preparation, identification, and molecular docking of novel elastase inhibitory peptide from walnut (Juglans regia L.) meal Food Chem (Oxf) (2022) 5, 100139-100139. PubMed Europe PubMed DOI PMC EPMC I

2021

Fu,Z., Akula,S., Thorpe,M. and Hellman,L. Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins Biol Chem (2021) 402, 861-867. PubMed Europe PubMed DOI
Ghosh,D., Bansode,S., Joshi,R., Kolte,B. and Gacche,R. Molecular elucidation of pancreatic elastase inhibition by baicalein J Biomol Struct Dyn (2021) , 1-10. PubMed Europe PubMed DOI I
Mota,F.A.R., Pereira,S.A.P., Araujo,A.R.T.S. and Saraiva,M.L.M.F. Evaluation of Ionic Liquids and Ionic Liquids Active Pharmaceutical Ingredients Inhibition in Elastase Enzyme Activity Molecules (2021) 26 PubMed Europe PubMed DOI PMC EPMC
Zheng,D., Wang,J., Li,G., An,L., Qu,Y., Zhang,Q., Ye,W., Zhao,X. and Zhao,Z. S-Allylmercapto-N-acetylcysteine ameliorates elastase-induced chronic obstructive pulmonary disease in mice via regulating autophagy Biochem Biophys Res Commun (2021) 562, 83-88. PubMed Europe PubMed DOI

2020

Becerra,D., Jeffs,S., Wojtkiewicz,G. and Ott,H. Characterization of an elastase-induced emphysema model in immune-deficient rats Eur J Cardiothorac Surg (2020) PubMed Europe PubMed DOI
Dige,N.C., Mahajan,P.G., Raza,H., Hassan,M., Vanjare,B.D., Hong,H., Lee,K.H., Latip,J. and Seo,S.Y. Synthesis and characterization of new 4H-chromene-3-carboxylates ensuring potent elastase inhibition activity along with their molecular docking and chemoinformatics properties Bioorg Chem (2020) 100, 103906-103906. PubMed Europe PubMed DOI I
Kodama,R.T., Kuniyoshi,A.K., da Silva,C.C.F., Cajado-Carvalho,D., Duzzi,B., Mariano,D.C., Pimenta,D.C., Borges,R., da Silva,W.D. and Portaro,F.C.V. A Kunitz-type peptide from Dendroaspis polylepis venom as a simultaneous inhibitor of serine and cysteine proteases J Venom Anim Toxins Incl Trop Dis (2020) 26, e20200037-e20200037. PubMed Europe PubMed DOI PMC EPMC
Lee,J.H., Moon,S.H., Hong,Y., Ahn,D.U. and Paik,H.D. Anti-elastase and anti-hyaluronidase activity of phosvitin isolated from hen egg yolk Br Poult Sci (2020) 61, 17-21. PubMed Europe PubMed DOI
Li,G., Wei,H., Bi,J., Ding,X., Li,L., Xu,S., Yang,G. and Ren,W. Insights into dietary switch in cetaceans: evidence from molecular evolution of proteinases and lipases J Mol Evol (2020) PubMed Europe PubMed DOI
Sadeghi-Kaji,S., Shareghi,B., Saboury,A.A. and Farhadian,S. Spermine as a porcine pancreatic elastase activator: spectroscopic and molecular simulation studies J Biomol Struct Dyn (2020) 38, 78-88. PubMed Europe PubMed DOI
Sadeghi-Kaji,S., Shareghi,B., Saboury,A.A. and Farhadian,S. Investigating the interaction of porcine pancreatic elastase and propanol: a spectroscopy and molecular simulation study Int J Biol Macromol (2020) 146, 687-691. PubMed Europe PubMed DOI
Toumpanakis,D., Mizi,E., Vassilakopoulou,V., Dettoraki,M., Chatzianastasiou,A., Perlikos,F., Giatra,G., Moscholaki,M., Theocharis,S. and Vassilakopoulos,T. Spontaneous Breathing Through Increased Airway Resistance Augments Elastase-Induced Pulmonary Emphysema Int J Chron Obstruct Pulmon Dis (2020) 15, 1679-1688. PubMed Europe PubMed DOI PMC EPMC

2019

Butt,A.R.S., Abbasi,M.A., Aziz-Ur-Rehman, Siddiqui,S.Z., Hassan,M., Raza,H., Shah,S.A.A. and Seo,S.Y. Synthesis and structure-activity relationship of elastase inhibiting novel ethylated thiazole-triazole acetamide hybrids: mechanistic insights through kinetics and computational contemplations Bioorg Chem (2019) 86, 197-209. PubMed Europe PubMed DOI I
Gloyn,A.L. Exocrine or endocrine? A circulating pancreatic elastase that regulates glucose homeostasis Nat Metab (2019) 1, 853-855. PubMed Europe PubMed DOI
Hamdani,S.S., Khan,B.A., Saeed,A., Larik,F.A., Hameed,S., Channar,P.A., Ahmad,K., Mughal,E.U., Abbas,Q., Amin,N.U., Ghumro,S.A., Maitlo,H., Hassan,M., Raza,H. and Seo,S.Y. Densely substituted piperidines as a new class of elastase inhibitors: synthesis and molecular modeling studies Arch Pharm (Weinheim) (2019) 352, e1900061-e1900061. PubMed Europe PubMed DOI I

2018

Socan,J., Kazemi,M., Isaksen,G.V., Brandsdal,B.O. and Aqvist,J. Catalytic adaptation of psychrophilic elastase Biochemistry (2018) 57, 2984-2993. PubMed Europe PubMed DOI

2017

Boros,E., Szabo,A., Zboray,K., Heja,D., Pal,G. and Sahin-Toth,M. Overlapping specificity of duplicated human pancreatic elastase 3 isoforms and archetypal porcine elastase 1 provides clues to evolution of digestive enzymes J Biol Chem (2017) 292, 2690-2702. PubMed Europe PubMed DOI P
Hasdemir,B., Sacan,O., Yasa,H., Kucuk,H.B., Yusufoglu,A.S. and Yanardag,R. Synthesis and elastase inhibition activities of novel aryl, substituted aryl, and heteroaryl oxime ester derivatives Arch Pharm (Weinheim) (2017) 351 PubMed Europe PubMed DOI I

2016

Stergiou,P.Y., Foukis,A., Gkini,O.A., Bieth,J.G. and Papamichael,E.M. Kinetic and computational analysis of the reversible inhibition of porcine pancreatic elastase: a structural and mechanistic approach J Enzyme Inhib Med Chem (2016) 31, 131-139. PubMed Europe PubMed DOI I
Wong,M.D., Bingham,K., Moss,E., Warn,J.D., Smirnov,I., Bland,K.S., Starcher,B., Franano,F.N. and Burke,S.K. Recombinant human elastase treatment of cephalic veins Cardiovasc Pharm Open Access (2016) 5 PubMed Europe PubMed DOI PMC EPMC U

2015

Hernandez Gonzalez,J.E., Garcia-Fernandez,R. and Valiente,P.A. Polar desolvation and position 226 of pancreatic and neutrophil elastases are crucial to their affinity for the Kunitz-type inhibitors ShPI-1 and ShPI-1/K13L PLoS ONE (2015) 10, e0137787-e0137787. PubMed Europe PubMed DOI PMC EPMC

2014

Burke,S.K., Macdonald,K., Moss,E., Bunton,D., Starcher,B., Wong,M.D., Bland,K.S. and Franano,F.N. Effects of recombinant human type I pancreatic elastase on human atherosclerotic arteries J Cardiovasc Pharmacol (2014) 64, 530-535. PubMed Europe PubMed DOI
Han,M., Wang,X., Yan,G., Wang,W., Tao,Y., Liu,X., Cao,H. and Yu,X. Modification of recombinant elastase expressed in Pichia pastoris by introduction of N-glycosylation sites J Biotechnol (2014) 171, 3-7. PubMed Europe PubMed DOI E
Liu,S., Young,S.M. and Varisco,B.M. Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development Am J Physiol Lung Cell Mol Physiol (2014) 306, L1104-L1116. PubMed Europe PubMed DOI

2013

Bunger,J.C., Melton-Celsa,A.R. and O'Brien,A.D. Shiga toxin type 2dact displays increased binding to globotriaosylceramide in vitro and increased lethality in mice after activation by elastase Toxins (Basel) (2013) 5, 2074-2092. PubMed Europe PubMed DOI
Qasim,M.A., Wang,L., Qasim,S., Lu,S., Lu,W., Wynn,R., Yi,Z.P. and Laskowski,M., Jr. Additivity-based design of the strongest possible turkey ovomucoid third domain inhibitors for porcine pancreatic elastase (PPE) and Streptomyces griseus protease B (SGPB) FEBS Lett (2013) 587, 3021-3026. PubMed Europe PubMed DOI

2012

Monleon,L.M., Diez-Garcia,F., Zamora,H., Anaya,J., Grande,M., De Diego,J.G. and David Rodriguez,F. In vitro evaluation of the antielastase activity of polycyclic beta-lactams Bioorg Chem (2012) 45, 29-35. PubMed Europe PubMed DOI I
Oliveira,E.B. and Salgado,M.C.O. Pancreatic elastases [ISSN:978-0-12-407742-3] (2012) 3, 2639-2645. DOI
Qamar,A.A., Burke,S.K., Lafleur,J.D., Ding,B.C., Bland,K.S., Wong,M.D., Gustafson,P.N., Blair,A.T. and Franano,F.N. The ability of serum from alpha 1-antitrypsin-deficient patients to inhibit PRT-201, a recombinant human type I pancreatic elastase Biotechnol Appl Biochem (2012) 59, 22-28. PubMed Europe PubMed DOI
Santana,A.B., Lucas,S.D., Goncalves,L.M., Correia,H.F., Cardote,T.A., Guedes,R.C., Iley,J. and Moreira,R. N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases Bioorg Med Chem Lett (2012) 22, 3993-3997. PubMed Europe PubMed DOI I

2010

Bras,N.F., Goncalves,R., Mateus,N., Fernandes,P.A., Ramos,M.J. and De Freitas,V. Inhibition of pancreatic elastase by polyphenolic compounds J Agric Food Chem (2010) 58, 10668-10676. PubMed Europe PubMed DOI I
Sun,T., Zhang,S. and Ji,G. Identification and expression of an elastase homologue in Branchiostoma belcheri with implications to the origin of vertebrate pancreas Mol Biol Rep (2010) 37, 3303-3309. PubMed Europe PubMed DOI

2009

Rietschel,B., Arrey,T.N., Meyer,B., Bornemann,S., Schuerken,M., Karas,M. and Poetsch,A. Elastase digests: new ammunition for shotgun membrane proteomics Mol Cell Proteomics (2009) 8, 1029-1043. PubMed Europe PubMed DOI PMC EPMC
Tamada,T., Kinoshita,T., Kurihara,K., Adachi,M., Ohhara,T., Imai,K., Kuroki,R. and Tada,T. Combined high-resolution neutron and X-ray analysis of inhibited elastase confirms the active-site oxyanion hole but rules against a low-barrier hydrogen bond J Am Chem Soc (2009) 131, 11033-11040. PubMed Europe PubMed DOI S

2008

Mulchande,J., Guedes,R.C., Tsang,W.Y., Page,M.I., Moreira,R. and Iley,J. Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors J Med Chem (2008) 51, 1783-1790. PubMed Europe PubMed DOI I
Nadarajah,D., Atkinson,M.A., Huebner,P. and Starcher,B. Enzyme kinetics and characterization of mouse pancreatic elastase Connect Tissue Res (2008) 49, 409-415. PubMed Europe PubMed DOI
Wang,B., Malik,R., Nigg,E.A. and Korner,R. Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis Anal Chem (2008) 80, 9526-9533. PubMed Europe PubMed DOI P

2007

Buzas,G.M. Pancreatic elastase: a forgotten Hungarian discovery Pancreatology (2007) 7, 546-546. PubMed Europe PubMed DOI V
Korkmaz,B., Hajjar,E., Kalupov,T., Reuter,N., Brillard-Bourdet,M., Moreau,T., Juliano,L. and Gauthier,F. Influence of charge distribution at the active site surface on the substrate specificity of human neutrophil protease 3 and elastase. A kinetic and molecular modeling analysis J Biol Chem (2007) 282, 1989-1997. PubMed Europe PubMed DOI P
Oliveira,T.F., Mulchande,J., Moreira,R., Iley,J. and Archer,M. Crystallization and preliminary diffraction studies of porcine pancreatic elastase in complex with a novel inhibitor Protein Pept Lett (2007) 14, 93-95. PubMed Europe PubMed I
Tsang,W.Y., Ahmed,N., Hemming,K. and Page,M.I. Reactivity and selectivity in the inhibition of elastase by 3-oxo-beta-sultams and in their hydrolysis Org Biomol Chem (2007) 5, 3993-4000. PubMed Europe PubMed DOI I

2006

Dementiev,A., Dobo,J. and Gettins,P.G. Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastase J Biol Chem (2006) 281, 3452-3457. PubMed Europe PubMed DOI S
Ding,X., Rasmussen,B.F., Petsko,G.A. and Ringe,D. Direct crystallographic observation of an acyl-enzyme intermediate in the elastase-catalyzed hydrolysis of a peptidyl ester substrate: exploiting the "glass transition" in protein dynamics Bioorg Chem (2006) 34, 410-423. PubMed Europe PubMed DOI PMC EPMC S
[YEAR:1-7-2006]Kinoshita,T., Yamaguchi,A. and Tada,T. Tris(hydroxymethyl)aminomethane induces conformational change and crystal-packing contraction of porcine pancreatic elastase Acta Crystallograph Sect F Struct Biol Cryst Commun (1-7-2006) 62, 623-626. PubMed Europe PubMed DOI PMC EPMC S
Papaleo,E., Riccardi,L., Villa,C., Fantucci,P. and De Gioia,L. Flexibility and enzymatic cold-adaptation: a comparative molecular dynamics investigation of the elastase family Biochim Biophys Acta (2006) 1764, 1397-1406. PubMed Europe PubMed DOI
[YEAR:1-12-2006]Szepessy,E. and Sahin-Toth,M. Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans Pancreatology (1-12-2006) 6, 117-122. PubMed Europe PubMed DOI PMC EPMC

2005

[YEAR:29-6-2005]Tsang,W.Y., Ahmed,N., Harding,L.P., Hemming,K., Laws,A.P. and Page,M.I. Acylation versus sulfonylation in the inhibition of elastase by 3-oxo-beta-sultams J Am Chem Soc (29-6-2005) 127, 8946-8947. PubMed Europe PubMed DOI I

2004

Bieth,J.G. Pancreatic elastase [ISSN:0-12-079610-4] (2004) 2, 1504-1508. V
[YEAR:8-10-2004]Hietaranta,A., Mustonen,H., Puolakkainen,P., Haapiainen,R. and Kemppainen,E. Proinflammatory effects of pancreatic elastase are mediated through TLR4 and NF-kappaB Biochem Biophys Res Commun (8-10-2004) 323, 192-196. PubMed Europe PubMed DOI
[YEAR:1-1-2004]Koizumi,M., Muratani,E., Fujii,K. and Takimoto-Kamimura,M. Crystal structure of the complex of porcine pancreatic elastase with TEI-8362 J Synchrotron Radiat (1-1-2004) 11, 101-104. PubMed Europe PubMed DOI S I

2003

Ay,J., Hilpert,K., Krauss,N., Schneider-Mergener,J. and Hohne,W. Structure of a hybrid squash inhibitor in complex with porcine pancreatic elastase at 1.8 A resolution Acta Crystallogr D Biol Crystallogr (2003) 59, 247-254. PubMed Europe PubMed DOI S
[YEAR:15-2-2003]Bousquet,J.A., Duranton,J., Mely,Y. and Bieth,J.G. Conformational change in elastase following complexation with alpha1-proteinase inhibitor: a CD investigation Biochem J (15-2-2003) 370, 345-349. PubMed Europe PubMed DOI PMC EPMC
[YEAR:6-1-2003]Kinoshita,T., Nakanishi,I., Sato,A. and Tada,T. True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor Bioorg Med Chem Lett (6-1-2003) 13, 21-24. PubMed Europe PubMed DOI S I
Matern,U., Schleberger,C., Jelakovic,S., Weckesser,J. and Schulz,G.E. Binding structure of elastase inhibitor scyptolin A Chem Biol (2003) 10, 997-1001. PubMed Europe PubMed DOI S I

2002

[YEAR:14-6-2002]Katona,G., Wilmouth,R.C., Wright,P.A., Berglund,G.I., Hajdu,J., Neutze,R. and Schofield,C.J. X-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolution J Biol Chem (14-6-2002) 277, 21962-21970. PubMed Europe PubMed DOI S
Weiss,M.S., Panjikar,S., Nowak,E. and Tucker,P.A. Metal binding to porcine pancreatic elastase: calcium or not calcium Acta Crystallogr D Biol Crystallogr (2002) 58, 1407-1412. PubMed Europe PubMed DOI S

2001

Wright,P.A., Wilmouth,R.C., Clifton,I.J. and Schofield,C.J. Kinetic and crystallographic analysis of complexes formed between elastase and peptides from beta-casein Eur J Biochem (2001) 268, 2969-2974. PubMed Europe PubMed S

2000

Achilles,K., Schneider,M., Schirmeister,T. and Otto,H.H. beta-Lactam derivatives as enzyme inhibitors: N-substituted derivatives of (S)-4-oxoazetidine-2-carboxylate as inhibitors of elastase and papain Pharmazie (2000) 55, 798-802. PubMed Europe PubMed I
[YEAR:15-4-2000]Nakanishi,I., Kinoshita,T., Sato,A. and Tada,T. Structure of porcine pancreatic elastase complexed with FR901277, a novel macrocyclic inhibitor of elastases, at 1.6 A resolution Biopolymers (15-4-2000) 53, 434-445. PubMed Europe PubMed DOI S I
Talas,U., Dunlop,J., Khalaf,S., Leigh,I.M. and Kelsell,D.P. Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism J Invest Dermatol (2000) 114, 165-170. PubMed Europe PubMed DOI M
Wurtele,M., Hahn,M., Hilpert,K. and Hohne,W. Atomic resolution structure of native porcine pancreatic elastase at 1.1 A Acta Crystallogr D Biol Crystallogr (2000) 56, 520-523. PubMed Europe PubMed DOI S

1999

[YEAR:6-8-1999]Guyonnet,V., Tluscik,F., Long,P.L., Polanowski,A. and Travis,J. Purification and partial characterization of the pancreatic proteolytic enzymes trypsin, chymotrypsin, and elastase from the chicken J Chromatogr A (6-8-1999) 852, 217-225. PubMed Europe PubMed DOI
[YEAR:27-8-1999]Taylor,P., Anderson,V., Dowden,J., Flitsch,S.L., Turner,N.J., Loughran,K. and Walkinshaw,M.D. Novel mechanism of inhibition of elastase by beta-lactams is defined by two inhibitor crystal complexes J Biol Chem (27-8-1999) 274, 24901-24905. PubMed Europe PubMed DOI S I

1998

Berglund,G.I., Smalas,A.O., Outzen,H. and Willassen,N.P. Purification and characterization of pancreatic elastase from North Atlantic salmon (Salmo salar) Mol Mar Biol Biotechnol (1998) 7, 105-114. PubMed Europe PubMed
Cregge,R.J., Durham,S.L., Farr,R.A., Gallion,S.L., Hare,C.M., Hoffman,R.V., Janusz,M.J., Kim,H.O., Koehl,J.R., Mehdi,S., Metz,W.A., Peet,N.P., Pelton,J.T., Schreuder,H.A., Sunder,S. and Tardif,C. Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones J Med Chem (1998) 41, 2461-2480. PubMed Europe PubMed DOI I
[YEAR:5-3-1998]Packard,B.Z., Komoriya,A., Nanda,V. and Brand,L. Intramolecular excitonic dimers in protease substrates: modification of the backbone moiety to probe the H-dimer structure J Phys.Chem B (5-3-1998) 102, 1820-1827. A
[YEAR:15-12-1998]Wilmouth,R.C., Westwood,N.J., Anderson,K., Brownlee,W., Claridge,T.D., Clifton,I.J., Pritchard,G.J., Aplin,R.T. and Schofield,C.J. Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex Biochemistry (15-12-1998) 37, 17506-17513. PubMed Europe PubMed DOI I

1997

Gestin,M., Le Huerou-Luron,I., Wicker-Planquart,C., Le Drean,G., Chaix,J.C., Puigserver,A. and Guilloteau,P. Bovine pancreatic preproelastases I and II: Comparison of nucleotide and amino acid sequences and tissue specific expression Comp Biochem Physiol B Biochem Mol Biol (1997) 118, 181-187. PubMed Europe PubMed DOI
[YEAR:1-9-1997]Packard,B.Z., Toptygin,D.D., Komoriya,A. and Brand,L. Characterization of fluorescence quenching in bifluorophoric protease substrates Biophys Chem (1-9-1997) 67, 167-176. PubMed Europe PubMed A
Rao,S.K., Mathrubutham,M., Karteron,A., Sorensen,K. and Cohen,J.R. A versatile microassay for elastase using succinylated elastin Anal Biochem (1997) 250, 222-227. PubMed Europe PubMed DOI A
Rose,S.D. and Macdonald,R.J. Evolutionary silencing of the human elastase I gene (ELA1) Hum Mol Genet (1997) 6, 897-903. PubMed Europe PubMed DOI

1996

[YEAR:10-9-1996]Tsunemi,M., Matsuura,Y., Sakakibara,S. and Katsube,Y. Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution Biochemistry (10-9-1996) 35, 11570-11576. PubMed Europe PubMed DOI S

1995

Berglund,G.I., Willassen,N.P., Hordvik,A. and Smalas,A.O. Structure of native pancreatic elastase from North Atlantic salmon at 1.61 A resolution Acta Crystallogr D Biol Crystallogr (1995) 51, 925-937. PubMed Europe PubMed DOI S
Berglund,G.I., Smalas,A.O., Hansen,L.K. and Willassen,N.P. Crystallization and preliminary X-ray crystallographic studies of native elastase from North Atlantic salmon (Salmo salar) Acta Crystallogr D Biol Crystallogr (1995) 51, 393-394. PubMed Europe PubMed DOI S
Peisach,E., Casebier,D., Gallion,S.L., Furth,P., Petsko,G.A., Hogan,J.C., Jr. and Ringe,D. Interaction of a peptidomimetic aminimide inhibitor with elastase Science (1995) 269, 66-69. PubMed Europe PubMed S I

1994

Mattos,C., Rasmussen,B., Ding,X., Petsko,G.A. and Ringe,D. Analogous inhibitors of elastase do not always bind analogously Nat Struct Biol (1994) 1, 55-58. PubMed Europe PubMed S I

1993

[YEAR:1-2-1993]Plaskon,R.R., Kam,C.M., Kerrigan,J.E., Burgess,E.M., Powers,J.C. and Suddath,F.L. Inhibition of porcine pancreatic elastase by 7-substituted 4-chloro-3-ethoxyisocoumarins: structural characteristics of modeled noncovalent complexes relate to the measured inhibition kinetics Arch Biochem Biophys (1-2-1993) 300, 588-597. PubMed Europe PubMed DOI I
[YEAR:5-7-1993]Tsunemi,M., Matsuura,Y., Sakakibara,S. and Katsube,Y. Crystallization of a complex between an elastase-specific inhibitor elafin and porcine pancreatic elastase J Mol Biol (5-7-1993) 232, 310-311. PubMed Europe PubMed DOI

1992

Edwards,P.D., Meyer,E.F., Jr., Vijayalakshmi,J., Tuthill,P.A., Andisik,D.A., Gomes,B. and Strimpler,A. Design, synthesis, and kinetic evaluation of a unique class of elastase inhibitors, the peptidyl alpha-ketobenzoxazoles, and the X-ray crystal structure of the covalent complex between porcine pancreatic elastase and Ac-Ala-Pro-Val-2-benzoxazole J Am Chem Soc (1992) 114, 1854-1863. S I
Hernandez,M.A., Powers,J.C., Glinski,J., Oleksyszyn,J., Vijayalakshmi,J. and Meyer,E.F., Jr. Effect of the 7-amino substituent on the inhibitory potency of mechanism-based isocoumarin inhibitors for porcine pancreatic and human neutrophil elastases: A 1.85-A X-ray structure of the complex between porcine pancreatic elastase and 7-[(N- tosylphenylalanyl)amino]-4-chloro-3-methoxyisocoumarin J Med Chem (1992) 35, 1121-1129. PubMed Europe PubMed S I
Kawashima,I., Tani,T., Mita-Honjo,K., Shimoda-Takano,K., Ohmine,T., Furukawa,H. and Takiguchi,Y. Genomic organization of the human homologue of the rat pancreatic elastase I gene DNA Seq (1992) 2, 303-312. PubMed Europe PubMed
Nassar,M.N., Agha,B.J. and Digenis,G.A. Effects of structural variations on the rates of enzymatic and nonenzymatic hydrolysis of carbonate and carbamate esters J Pharm Sci (1992) 81, 295-298. PubMed Europe PubMed I

1991

Geller,M., laczkowski,A., Swanson,S.M. and Meyer,E.F., Jr. Dynamical analysis of the conformation of the active site of porcine pancreatic elastase in native and Michaelis complex states. Molecular dynamics simulations Comput Chem (1991) 15, 261-272.
Hakansson,H.O., Borgstrom,A. and Ohlsson,K. Porcine pancreatic cationic pro-elastase. Studies on the activation, turnover and interaction with plasma proteinase inhibitors Biol Chem Hoppe Seyler (1991) 372, 465-472. PubMed Europe PubMed
[YEAR:26-2-1991]Vijayalakshmi,J., Meyer,E.F., Jr., Kam,C.M. and Powers,J.C. Structural study of porcine pancreatic elastase complexed with 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin as a nonreactivatable doubly covalent enzyme-inhibitor complex Biochemistry (26-2-1991) 30, 2175-2183. PubMed Europe PubMed I

1990

Baici,A., Pelloso,R. and Horler,D. The kinetic mechanism of inhibition of human leukocyte elastase by MR889, a new cyclic thiolic compound Biochem Pharmacol (1990) 39, 919-924. PubMed Europe PubMed DOI I
de la Sierra,I.L., Papamichael,E., Sakarellos,C., Dimicoli,J.L. and Prange,T. Interaction of the peptide CF3-Leu-Ala-NH-C6H4-CF3 (TFLA) with porcine pancreatic elastase. X-ray studies at 1.8 A J Mol Recognit (1990) 3, 36-44. PubMed Europe PubMed DOI S I
Geller,M., Swanson,S.M. and Meyer,E.F., Jr. Dynamic properties of the first steps of the enzymatic reaction of porcine pancreatic elastase (PPE). 2. Molecular dynamics simulation of a Michaelis complex: PPE and the hexapeptide Thr- Pro-nVal-Leu-Tyr-Thr J Am Chem Soc (1990) 112, 8925-8931. DOI
Geller,M., Carlson-Golab,G., Lesyng,B., Swanson,S.M. and Meyer,E.F., Jr. Dynamic properties of the first enzymatic reaction steps of porcine pancreatic elastase. How rigid is the active site of the native enzyme? Molecular dynamics simulation Biopolymers (1990) 30, 781-796. PubMed Europe PubMed DOI
Geller,M., Swanson,S.M. and Meyer,E.F., Jr. Simulations of dynamical properties of a Michaelis complex: porcine pancreatic elastase and the hexapeptide, Thr-Pro-nVal-Leu-Tyr-Thr J Biomol Struct Dyn (1990) 7, 1043-1052. PubMed Europe PubMed DOI
Powers,J.C., Oleksyszyn,J., Narasimhan,S.L. and Kam,C.M. Reaction of porcine pancreatic elastase with 7-substituted 3- alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3- ethoxy-7-guanidinoisocoumarin Biochemistry (1990) 29, 3108-3118. PubMed Europe PubMed S I
[YEAR:5-9-1990]Wiedow,O., Schroder,J.M., Gregory,H., Young,J.A. and Christophers,E. Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence J Biol Chem (5-9-1990) 265, 14791-14795. PubMed Europe PubMed

1989

Bode,W., Meyer,E., Jr. and Powers,J.C. Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors Biochemistry (1989) 28, 1951-1963. PubMed Europe PubMed S I
Takahashi,L.H., Radhakrishnan,R., Rosenfield,R.E., Jr., Meyer,E.F. and Trainor,D.A. Crystal structure of the covalent complex formed by a peptidyl alpha, alpha-difluoro-beta-keto amide with porcine pancreatic elastase at 1.78- _ resolution J Am Chem Soc (1989) 111, 3368-3374. S
Takahashi,L.H., Radhakrishnan,R., Rosenfield,R.E., Jr. and Meyer,E.F., Jr. Crystallographic analysis of the inhibition of porcine pancreatic elastase by a peptidyl boronic acid: structure of a reaction intermediate Biochemistry (1989) 28, 7610-7617. PubMed Europe PubMed S I
Wendorf,P., Geyer,R., Sziegoleit,A. and Linder,D. Localization and characterization of the glycosylation site of human pancreatic elastase 1 FEBS Lett (1989) 249, 275-278. PubMed Europe PubMed

1988

Hakansson,H.O. and Ohlsson,K. Interactions in vitro and in vivo between human and porcine cationic pancreatic elastase and plasma protease inhibitors Biol Chem Hoppe Seyler (1988) 369, 309-315. PubMed Europe PubMed DOI
Meyer,E., Cole,G., Radhakrishnan,R. and Epp,O. Structure of native porcine pancreatic elastase at 1.65 A resolutions Acta Crystallogr B (1988) 44, 26-38. PubMed Europe PubMed DOI S
Meyer,E.F., Jr., Clore,G.M., Gronenborn,A.M. and Hansen,H.A. Analysis of an enzyme-substrate complex by X-ray crystallography and transferred nuclear Overhauser enhancement measurements: porcine pancreatic elastase and a hexapeptide Biochemistry (1988) 27, 725-730. PubMed Europe PubMed S

1987

[YEAR:7-5-1987]Navia,M.A., Springer,J.P., Lin,T.Y., Williams,H.R., Firestone,R.A., Pisano,J.M., Doherty,J.B., Finke,P.E. and Hoogsteen,K. Crystallographic study of a beta-lactam inhibitor complex with elastase at 1.84 A resolution Nature (7-5-1987) 327, 79-82. PubMed Europe PubMed DOI S I
Radhakrishnan,R., Presta,L.G., Meyer,E.F., Jr. and Wildonger,R. Crystal structures of the complex of porcine pancreatic elastase with two valine-derived benzoxazinone inhibitors J Mol Biol (1987) 198, 417-424. PubMed Europe PubMed S I
Stein,R.L. and Strimpler,A.M. P1 residue determines the operation of the catalytic triad of serine proteases during hydrolyses of acyl-enzymes J Am Chem Soc (1987) 109, 4387-4390.
Williams,H.R., Lin,T.Y., Navia,M.A., Springer,J.P. and Hoogsteen,K. Pig pancreatic anhydro-elastase. Role of the serine-195 hydroxy group in the binding of inhibitors and substrate Biochem J (1987) 242, 267-273. PubMed Europe PubMed PMC EPMC

1986

Clore,G.M., Gronenborn,A.M., Carlson,G. and Meyer,E.F. Stereochemistry of binding of the tetrapeptide acetyl-Pro-Ala-Pro-Tyr-NH2 to porcine pancreatic elastase. Combined use of two-dimensional transferred nuclear Overhauser enhancement measurements, restrained molecular dynamics, X-ray crystallography and molecular modelling J Mol Biol (1986) 190, 259-267. PubMed Europe PubMed S I
Digenis,G.A., Agha,B.J., Tsuji,K., Kato,M. and Shinogi,M. Peptidyl carbamates incorporating amino acid isosteres as novel elastase inhibitors J Med Chem (1986) 29, 1468-1476. PubMed Europe PubMed I
Meyer,E.F., Jr., Radhakrishnan,R., Cole,G.M. and Presta,L.G. Structure of the product complex of acetyl-Ala-Pro-Ala with porcine pancreatic elastase at 1.65 A resolution J Mol Biol (1986) 189, 533-539. PubMed Europe PubMed S
Shirasu,Y., Yoshida,H., Mikayama,T., Matsuki,S., Tanaka,J. and Ikenaga,H. Isolation and expression in Escherichia coli of a cDNA clone encoding porcine pancreatic elastase J Biochem (1986) 99, 1707-1712. PubMed Europe PubMed

1985

[YEAR:9-4-1985]Hemmi,K., Harper,J.W. and Powers,J.C. Inhibition of human leukocyte elastase, cathepsin G, chymotrypsin A alpha, and porcine pancreatic elastase with substituted isobenzofuranones and benzopyrandiones Biochemistry (9-4-1985) 24, 1841-1848. PubMed Europe PubMed I
Kasafirek,E., Fric,P. and Slaby,J. Anionic inhibitors of pancreatic and leukocyte elastase. Alkylamides of 3-carboxypropionyl- and 4-carboxybutyrylalanine peptides Biol Chem Hoppe Seyler (1985) 366, 333-343. PubMed Europe PubMed I
[YEAR:16-1-1985]Laurent,P. and Bieth,J.G. Cigarette smoke decreases the rate constant for the association of elastase with alpha 1-proteinase inhibitor by a non-oxidative mechanism Biochem Biophys Res Commun (16-1-1985) 126, 275-281. PubMed Europe PubMed
Meyer,E.F., Jr., Presta,L.G. and Radhakrishnan,R. Stereospecific reaction of 3-methoxy-4-chloro-7-aminoisocoumarin with crystalline porcine pancreatic elastase J Am Chem Soc (1985) 107, 4091-4093. I

1984

Harper,J.W., Cook,R.R., Roberts,C.J., McLaughlin,B.J. and Powers,J.C. Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin Aalpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates Biochemistry (1984) 23, 2995-3002. PubMed Europe PubMed
Honey,N.K., Sakaguchi,A.Y., Lalley,P.A., Quinto,C., Macdonald,R.J., Craik,C., Bell,G.I., Rutter,W.J. and Naylor,S.L. Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse Somat Cell Mol Genet (1984) 10, 377-383. PubMed Europe PubMed
[YEAR:31-7-1984]Tsuji,K., Agha,B.J., Shinogi,M. and Digenis,G.A. Peptidyl carbamate esters: a new class of specific elastase inhibitors Biochem Biophys Res Commun (31-7-1984) 122, 571-576. PubMed Europe PubMed I

1983

Harper,J.W., Hemmi,K. and Powers,J.C. New mechanism-based serine protease inhibitors: inhibition of human leukocyte elastase, porcine pancreatic elastase, human leukocyte cathepsin G, and chymotrypsin by 3-chloroisocoumarin and 3,3-dichlorophthatide J Am Chem Soc (1983) 105, 6518-6520. I

1982

[YEAR:10-5-1982]Yoshimura,T., Barker,L.N. and Powers,J.C. Specificity and reactivity of human leukocyte elastase, porcine pancreatic elastase, human granulocyte cathepsin G, and bovine pancreatic chymotrypsin with arylsulfonyl fluorides. Discovery of a new series of potent and specific irreversible elastase inhibitors J Biol Chem (10-5-1982) 257, 5077-5084. PubMed Europe PubMed I

1981

[YEAR:16-6-1981]Koide,A. and Yoshizawa,M. Crystallization and identification of a binary complex of a elastase-I and a carboxypeptidase A gamma from porcine pancreas Biochem Biophys Res Commun (16-6-1981) 100, 1091-1098. PubMed Europe PubMed

1980

[YEAR:19-8-1980]McRae,B., Nakajima,K., Travis,J. and Powers,J.C. Studies on reactivity of human leukocyte elastase, cathepsin G, and porcine pancreatic elastase toward peptides including sequences related to the reactive site of alpha 1-protease inhibitor (alpha 1-antitrypsin) Biochemistry (19-8-1980) 19, 3973-3978. PubMed Europe PubMed P
[YEAR:24-1-1980]Reilly,C.F. and Travis,J. The degradation of human lung elastin by neutrophil proteinases Biochim Biophys Acta (24-1-1980) 621, 147-157. PubMed Europe PubMed

1978

Lively,M.O. and Powers,J.C. Specificity and reactivity of human granulocyte elastase and cathepsin G, porcine pancreatic elastase, bovine chymotrypsin and trypsin toward inhibition with sulfonyl fluorides Biochim Biophys Acta (1978) 525, 171-179. PubMed Europe PubMed I
Sawyer,L., Shotton,D.M., Campbell,J.W., Wendell,P.L., Muirhead,H. and Watson,H.C. The atomic structure of crystalline porcine pancreatic elastase at 2.5 A resolution: comparisons with the structure of alpha-chymotrypsin J Mol Biol (1978) 118, 137-208. PubMed Europe PubMed S

1977

Powers,J.C., Gupton,B.F., Harley,A.D., Nishino,N. and Whitley,R.J. Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G. Inhibition with peptide chloromethyl ketones Biochim Biophys Acta (1977) 485, 156-166. PubMed Europe PubMed I
Powers,J.C. and Gupton,B.F. Reaction of serine proteases with aza-amino acid and aza-peptide derivatives Methods Enzymol (1977) 46, 208-216. PubMed Europe PubMed DOI V I

1976

Ardelt,W., Koj,A., Chudzik,J. and Dubin,A. Inactivation of some pancreatic and leucocyte elastases by peptide chloromethyl ketones and alkyl isocyanates FEBS Lett (1976) 67, 156-160. PubMed Europe PubMed DOI I

1975

Okura,A., Morishima,H., Takita,T., Aoyagi,T., Takeuchi,T. and Umezawa,H. The structure of elastatinal, an elastase inhibitor of microbial origin J Antibiot (Tokyo) (1975) 28, 337-339. PubMed Europe PubMed I

1973

Sawyer,L., Shotton,D.M.W. and Watson,H.C. Atomic coordinates for tosyl-elastase Biochem Biophys Res Commun (1973) 53, 944-951. PubMed Europe PubMed S
Shotton,D.M. and Hartley,B.S. Evidence for the amino acid sequence of porcine pancreatic elastase Biochem J (1973) 131, 643-675. PubMed Europe PubMed PMC EPMC
Thompson,R.C. and Blout,E.R. Dependence of the kinetic parameters for elastase-catalyzed amide hydrolysis on the length of peptide substrates Biochemistry (1973) 12, 57-65. PubMed Europe PubMed P
Thompson,R.C. and Blout,E.R. Restrictions on the binding of proline-containing peptides to elastase Biochemistry (1973) 12, 51-57. PubMed Europe PubMed
Umezawa,H., Aoyagi,T., Okura,A., Morishima,H., Takeuchi,T. and Okami,Y. Elastatinal, a new elastase inhibitor produced by actinomycetes J Antibiot (Tokyo) (1973) 26, 787-789. PubMed Europe PubMed I

1971

Gertler,A. and Feinstein,G. Inhibition of porcine elastase by turkey ovomucoid and chicken ovoinhibitor Eur J Biochem (1971) 20, 547-552. PubMed Europe PubMed
Hartley,B.S. and Shotton,D.M. Pancreatic elastase (1971) 1, 323-373.
Hartley,B.S. and Shotton,D.M. 10. Pancreatic elastase Enzymes (1971) 3, 323-373. DOI

1970

Shotton,D.M. and Watson,H.C. The three-dimensional structure of crystalline porcine pancreatic elastase Philos Trans R Soc Lond B Biol Sci (1970) 257, 111-118. PubMed Europe PubMed S
[YEAR:28-2-1970]Watson,H.C., Shotton,D.M., Cox,J.M. and Muirhead,H. Three-dimensional Fourier synthesis of tosyl-elastase at 3.5A resolution Nature (28-2-1970) 225, 806-811. PubMed Europe PubMed DOI S I

1969

Narayanan,A.S. and Anwar,R.A. The specificity of purified porcine pancreatic elastase Biochem J (1969) 114, 11-17. PubMed Europe PubMed PMC EPMC P

1967

Brown,J.R., Kauffman,D.L. and Hartley,B.S. The primary structure of porcine pancreatic elastase. The N-terminus and disulphide bridges Biochem J (1967) 103, 497-507. PubMed Europe PubMed PMC EPMC
Geokas,M.C., Rinderknecht,H., Lillard,Y. and Haverback,B.J. Elastase in human pancreas Clin Biochem (1967) 1, 331-334.

1965

Hartley,B.S., Brown,J.R., Kauffman,D.L. and Smillie,L.B. Evolutionary similarities between pancreatic proteolytic enzymes Nature (1965) 207, 1157-1159. PubMed Europe PubMed DOI

1961

Hall,D.A. and Czerkawski,J.W. The reaction between elastase and elastic tissue. 6. The mechanism of elastolysis Biochem J (1961) 80, 134-136. PubMed Europe PubMed PMC EPMC
Naughton,M.A. and Sanger,F. Purification and specificity of pancreatic elastase Biochem J (1961) 78, 156-163. PubMed Europe PubMed PMC EPMC

1960

Moon,H.D. and McIvor,B.C. Elastase in the exocrine pancreas: localization with fluorescent antibody J Immunol (1960) 85, 78-80. PubMed Europe PubMed
Thomas,J. and Partridge,S.M. The chemistry of connective tissues. 5. The elastase activity of proteolytic enzymes Biochem J (1960) 74, 600-607. PubMed Europe PubMed

1959

Hartley,B.S., Naughton,M.A. and Sanger,F. The amino acid sequence around the reactive serine of elastase Biochim Biophys Acta (1959) 34, 243-244. PubMed Europe PubMed

1957

Bagdy,D. and Banga,I.B. Extraction and purification of elastase from dried pancreas Acta Physiol Hung (1957) 11, 371-376. PubMed Europe PubMed
Grant,N.H. and Robbins,K.C. Studies on porcine elastase and proelastase Arch Biochem Biophys (1957) 66, 396-403. PubMed Europe PubMed

1956

Grant,N.H. and Robbins,K.C. Partial purification and characterization of pankrin, a new pancreatic proteinase J Am Chem Soc (1956) 78, 5888-5890. DOI

1955

Grant,N.H. and Robbins,K.C. Occurrence and activation of an elastase precursor in pancreas Proc Soc Exp Biol Med (1955) 90, 264-265. PubMed Europe PubMed
Grant,N.H. and Robbins,K.C. A new pancreatic proteinase J Am Chem Soc (1955) 77, 2027-2028. DOI

1953

Banga,I. and Balo,J. Elastin and elastase Nature (1953) 171, 44-44. PubMed Europe PubMed DOI

1952

Banga,I. Isolation and crystallisation of elastase from the pancreas of cattle Acta Physiol Hung (1952) 3, 317-324. PubMed Europe PubMed

1950

Balo,J. and Banga,I. The elastolytic activity of pancreatic extracts Biochem J (1950) 46, 384-387. PubMed Europe PubMed PMC EPMC

1949

Balo,J. and Banga,I. Die Zerst"rung der elastischen Fasern der Gef"sswand Schweiz Z Pathol Bakt (1949) 12, 350-352.
Balo,J. and Banga,I. Elastase and elastase-inhibitor [9] Nature (1949) 164, 491-496. PubMed Europe PubMed