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Literature for peptidase M14.001: carboxypeptidase A1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: A Assay, S Structure, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, R Splicing. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Demcsak,A. and Sahin-Toth,M.
    Misfolding CPA1 mutation accelerates precancerous pancreas lesions in KC mice
    Am J Physiol Gastrointest Liver Physiol (2025) 329, G546-G546. PubMed  Europe PubMed DOI
  2. Goulet,D.L., Bignucolo,M.W. and Siemann,S.
    Accessibility of Carboxypeptidase A-bound Zinc to Chelation Correlates with an Intermediate State in the Protein's Unfolding Pathway
    Biochemistry (2025) 64, 1244-1256. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Amador Balderas,J.A., Beierlein,F., Horn,A.H.C., Volkenandt,S., Volcker,L., Mokhtari,N., Ndongue,J.C.E. and Imhof,P.
    Mode of Metal Ligation Governs Inhibition of Carboxypeptidase A
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Gluszek,S., Adamus-Bialek,W., Chrapek,M., Dziuba,A., Dulebska,J., Koziel,D., Matykiewicz,J. and Wawszczak-Kasza,M.
    Genetic Variability in the CPA1 Gene and Its Impact on Acute Pancreatitis Risk: New Insights from a Large-Scale Study
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2023
  5. Ming,Y., Zhang,H., Zhao,Z., Zhang,Z., Wang,H. and Liang,Z.
    Enhancing the thermostability of carboxypeptidase A by a multiple computer-aided rational design based on amino acids preferences at beta-turns
    Int J Biol Macromol (2023) 245, 125447-125447. PubMed  Europe PubMed DOI
    6. 2020
  6. Li,G., Wei,H., Bi,J., Ding,X., Li,L., Xu,S., Yang,G. and Ren,W.
    Insights into dietary switch in cetaceans: evidence from molecular evolution of proteinases and lipases
    J Mol Evol (2020) PubMed  Europe PubMed DOI
  7. Mohammadi,M., Shareghi,B., Akbar Saboury,A. and Farhadian,S.
    Spermine as a possible endogenous allosteric activator of carboxypeptidase A: multispectroscopic and molecular simulation studies
    J Biomol Struct Dyn (2020) 38, 101-113. PubMed  Europe PubMed DOI
  8. Mohammadi,M., Shareghi,B. and Akbar Saboury,A.
    Comparative studies on the interaction of spermidine with carboxypeptidase A using multispectroscopic and docking methods
    Int J Biol Macromol (2020) 147, 821-831. PubMed  Europe PubMed DOI
  9. Shu,L., Zhong,L., Xiao,Y., Wu,X., Liu,Y., Jiang,X., Tang,T., Hoo,R., Zhou,Z. and Xu,A.
    Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice
    Clin Sci (Lond) (2020) 134, 1679-1696. PubMed  Europe PubMed DOI
    10. 2019
  10. Ahmad,S., Wright,K.N., Sun,X., Groban,L. and Ferrario,C.M.
    Mast cell peptidases (carboxypeptidase A and chymase)-mediated hydrolysis of human angiotensin-(1-12) substrate
    Biochem Biophys Res Commun (2019) 518, 651-656. PubMed  Europe PubMed DOI
  11. Covaleda,G., Gallego,P., Vendrell,J., Georgiadis,D., Lorenzo,J., Dive,V., Aviles,F.X., Reverter,D. and Devel,L.
    Synthesis and structural/functional characterization of selective M14 metallocarboxypeptidase inhibitors based on phosphinic pseudo peptide scaffold: implications on the design of specific optical probes
    J Med Chem (2019) 62, 1917-1931. PubMed  Europe PubMed DOI  S  I
    12. 2017
  12. Testero,S.A., Granados,C., Fernandez,D., Gallego,P., Covaleda,G., Reverter,D., Vendrell,J., Aviles,F.X., Pallares,I. and Mobashery,S.
    Discovery of mechanism-based inactivators for human pancreatic carboxypeptidase A from a focused synthetic library
    ACS Med Chem Lett (2017) 8, 1122-1127. PubMed  Europe PubMed DOI  PMC  EPMC  I
    13. 2016
  13. Harms,H., Kurita,K.L., Pan,L., Wahome,P.G., He,H., Kinghorn,A.D., Carter,G.T. and Linington,R.G.
    Discovery of anabaenopeptin 679 from freshwater algal bloom material: Insights into the structure-activity relationship of anabaenopeptin protease inhibitors
    Bioorg Med Chem Lett (2016) 26, 4960-4965. PubMed  Europe PubMed DOI  I
  14. Kukk,K. and Samel,N.
    Enhanced expression of human prostaglandin H synthase-2 in the yeast Pichia pastoris and removal of the C-terminal tag with bovine carboxypeptidase A
    J Biotechnol (2016) 231, 224-231. PubMed  Europe PubMed DOI
  15. Szabo,A., Pilsak,C., Bence,M., Witt,H. and Sahin-Toth,M.
    Complex formation of human proelastases with procarboxypeptidases A1 and A2
    J Biol Chem (2016) 291, 17706-17716. PubMed  Europe PubMed DOI
  16. Valdez,C.E., Morgenstern,A., Eberhart,M.E. and Alexandrova,A.N.
    Predictive methods for computational metalloenzyme redesign - a test case with carboxypeptidase A
    Phys Chem Chem Phys (2016) 18, 31744-31756. PubMed  Europe PubMed DOI  S
    17. 2014
  17. Godahewa,G.I., Wickramaarachchi,W.D., Whang,I., Bathige,S.D., Lim,B.S., Choi,C.Y., De Zoysa,M., Noh,J.K. and Lee,J.
    Two carboxypeptidase counterparts from rock bream (Oplegnathus fasciatus): Molecular characterization, genomic arrangement and immune responses upon pathogenic stresses
    Vet Immunol Immunopathol (2014) 162, 180-191. PubMed  Europe PubMed DOI
  18. Hirose,J.
    [Coordination chemical studies on the zinc enzymes]
    Yakugaku Zasshi (2014) 134, 1109-1124. PubMed  Europe PubMed DOI
  19. Masamune,A.
    Genetics of pancreatitis: the 2014 update
    Tohoku J Exp Med (2014) 232, 69-77. PubMed  Europe PubMed DOI  M
  20. Pathak,N., Austin-Tse,C.A., Liu,Y., Vasilyev,A. and Drummond,I.A.
    Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function
    Mol Biol Cell (2014) 25, 1836-1844. PubMed  Europe PubMed DOI
    21. 2013
  21. Lyons,P.J., Sapio,M.R. and Fricker,L.D.
    Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development
    J Biol Chem (2013) 288, 30454-30462. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 2012
  22. Auld,D.S.
    Carboxypeptidase A
    [ISSN:978-0-12-407744-7] (2012) 3, 1289-1301. DOI
  23. Cheruku,P., Plaza,A., Lauro,G., Keffer,J., Lloyd,J.R., Bifulco,G. and Bewley,C.A.
    Discovery and synthesis of namalide reveals a new anabaenopeptin scaffold and peptidase inhibitor
    J Med Chem (2012) 55, 735-742. PubMed  Europe PubMed DOI  I
  24. Jitonnom,J. and Sontag,C.
    Comparative study on activation mechanism of carboxypeptidase A1, A2 and B: first insights from steered molecular dynamics simulations
    J Mol Graph Model (2012) 38, 298-303. PubMed  Europe PubMed DOI
    25. 2011
  25. Chang,Y.C., Chao,P.W. and Tung,C.H.
    Sensitive luciferin derived probes for selective carboxypeptidase activity
    Bioorg Med Chem Lett (2011) 21, 3931-3934. PubMed  Europe PubMed DOI  A
  26. Fernandez,D., Boix,E., Pallares,I., Aviles,F.X. and Vendrell,J.
    Structural and functional analysis of the complex between citrate and the zinc peptidase carboxypeptidase A
    Enzyme Res (2011) 2011, 128676-128676. PubMed  Europe PubMed DOI  PMC  EPMC  S
  27. Shushanyan,M., Khoshtariya,D.E., Tretyakova,T., Makharadze,M. and van Eldik,R.
    Diverse role of conformational dynamics in carboxypeptidase A-driven peptide and ester hydrolyses: disclosing the "perfect induced fit" and "protein local unfolding" pathways by altering protein stability
    Biopolymers (2011) 95, 852-870. PubMed  Europe PubMed DOI
  28. Szmola,R., Bence,M., Carpentieri,A., Szabo,A., Costello,C.E., Samuelson,J. and Sahin-Toth,M.
    Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2
    J Biol Chem (2011) 286, 1819-1827. PubMed  Europe PubMed DOI
  29. Wu,S., Zhang,C., Cao,R., Xu,D. and Guo,H.
    pH-Dependent reactivity for glycyl-L-tyrosine in carboxypeptidase-A-catalyzed hydrolysis
    J Phys Chem B (2011) 115, 10360-10367. PubMed  Europe PubMed DOI
    30. 2010
  30. Fernandez,D., Testero,S., Vendrell,J., Aviles,F.X. and Mobashery,S.
    The X-ray structure of carboxypeptidase A inhibited by a thiirane mechanism-based inhibitor
    Chem Biol Drug Des (2010) 75, 29-34. PubMed  Europe PubMed DOI  S  I
  31. Wang,S.F., Jin,J.-Y., Zeng,Z.H. and Tian,G.R.
    Optical 2-benzyl-5-hydroxy4oxopentanoic acids against carboxypeptidase A: Synthesis, kinetic evaluation and X-ray crystallographic study
    Chin Chem Lett (2010) 21, 159-162.
  32. Wu,S., Zhang,C., Xu,D. and Guo,H.
    Catalysis of carboxypeptidase A: promoted-water versus nucleophilic pathways
    J Phys Chem B (2010) 114, 9259-9267. PubMed  Europe PubMed DOI
    33. 2009
  33. Kilshtain,A.V. and Warshel,A.
    On the origin of the catalytic power of carboxypeptidase A and other metalloenzymes
    Proteins (2009) 77, 536-550. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Wang,S.F., Tian,G.R., Zhang,W.Z. and Jin,J.Y.
    Characterization of alpha-nitromethyl ketone as a new zinc-binding group based on structural analysis of its complex with carboxypeptidase A
    Bioorg Med Chem Lett (2009) 19, 5009-5011. PubMed  Europe PubMed DOI  I
  35. Xu,D. and Guo,H.
    Quantum mechanical/molecular mechanical and density functional theory studies of a prototypical zinc peptidase (carboxypeptidase A) suggest a general acid-general base mechanism
    J Am Chem Soc (2009) 131, 9780-9788. PubMed  Europe PubMed DOI  PMC  EPMC
    36. 2008
  36. Fernandez,D., Illa,O., Aviles,F.X., Branchadell,V., Vendrell,J. and Ortuno,R.M.
    Thioxophosphoranyl aryl- and heteroaryloxiranes as the representants of a new class of metallocarboxypeptidase inhibitors
    Bioorg Med Chem (2008) 16, 4823-4828. PubMed  Europe PubMed DOI  I
  37. Pallares,I., Fernandez,D., Comellas-Bigler,M., Fernandez-Recio,J., Ventura,S., Aviles,F.X., Bode,W. and Vendrell,J.
    Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid)
    Acta Crystallogr D Biol Crystallogr (2008) D64, 784-791. PubMed  Europe PubMed DOI  S
  38. Wang,S.H., Wang,S.F., Xuan,W., Zeng,Z.H., Jin,J.Y., Ma,J. and Tian,G.R.
    Nitro as a novel zinc-binding group in the inhibition of carboxypeptidase A
    Bioorg Med Chem (2008) 16, 3596-3601. PubMed  Europe PubMed DOI  I
    39. 2007
  39. Chong,C.R. and Auld,D.S.
    Catalysis of zinc transfer by d-penicillamine to secondary chelators
    J Med Chem (2007) 50, 5524-5527. PubMed  Europe PubMed DOI  I
    40. 2006
  40. [YEAR:25-10-2006]Mouradov,D., Craven,A., Forwood,J.K., Flanagan,J.U., Garcia-Castellanos,R., Gomis-Ruth,F.X., Hume,D.A., Martin,J.L., Kobe,B. and Huber,T.
    Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking
    Protein Eng Des Sel (25-10-2006) 19, 9-16. PubMed  Europe PubMed DOI
    41. 2005
  41. Arolas,J.L., Popowicz,G.M., Lorenzo,J., Sommerhoff,C.P., Huber,R., Aviles,F.X. and Holak,T.A.
    The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode
    J Mol Biol (2005) 350, 489-498. PubMed  Europe PubMed DOI  S
  42. Arolas,J.L., Popowicz,G.M., Bronsoms,S., Aviles,F.X., Huber,R., Holak,T.A. and Ventura,S.
    Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond
    J Mol Biol (2005) 352, 961-975. PubMed  Europe PubMed DOI  S
  43. [YEAR:17-3-2005]Cross,J.B., Vreven,T., Meroueh,S.O., Mobashery,S. and Schlegel,H.B.
    Computational investigation of irreversible inactivation of the zinc-dependent protease carboxypeptidase A
    J Phys Chem B (17-3-2005) 109, 4761-4769. PubMed  Europe PubMed DOI  I
    44. 2004
  44. Auld,D.S.
    Carboxypeptidase A
    [ISSN:0-12-079610-4] (2004) 2, 812-821.  V
  45. Kim,D.H.
    Chemistry-based design of inhibitors for carboxypeptidase A
    Curr Top Med Chem (2004) 4, 1217-1226. PubMed  Europe PubMed DOI  I
    46. 2003
  46. Kilshtain-Vardi,A., Glick,M., Greenblatt,H.M., Goldblum,A. and Shoham,G.
    Refined structure of bovine carboxypeptidase A at 1.25 A resolution
    Acta Crystallogr D Biol Crystallogr (2003) 59, 323-333. PubMed  Europe PubMed DOI  S
  47. [YEAR:15-5-2003]Reddanna,P., Prabhu,K.S., Whelan,J. and Reddy,C.C.
    Carboxypeptidase A-catalyzed direct conversion of leukotriene C4 to leukotriene F4
    Arch Biochem Biophys (15-5-2003) 413, 158-163. PubMed  Europe PubMed DOI
  48. Seddi,R., Chaix,J.C., Puigserver,A. and Guo,X.J.
    Expression of a soluble and activatable form of bovine procarboxypeptidase A in Escherichia coli
    Protein Expr Purif (2003) 27, 220-228. PubMed  Europe PubMed DOI
    49. 2002
  49. Cho,J.H., Kim,D.H., Chung,S.J., Ha,N.C., Oh,B.H. and Yong Choi,K.
    Insight into the stereochemistry in the inhibition of carboxypeptidase A with N-(hydroxyaminocarbonyl)phenylalanine: binding modes of an enantiomeric pair of the inhibitor to carboxypeptidase A
    Bioorg Med Chem (2002) 10, 2015-2022. PubMed  Europe PubMed DOI  S  I
  50. Jensen,F., Bukrinsky,T., Bjerrum,J. and Larsen,S.
    Three high-resolution crystal structures of cadmium-substituted carboxypeptidase A provide insight into the enzymatic function
    J Biol Inorg Chem (2002) 7, 490-499. PubMed  Europe PubMed DOI  S
  51. [YEAR:21-11-2002]Park,J.D., Kim,D.H., Kim,S.J., Woo,J.R. and Ryu,S.E.
    Sulfamide-based inhibitors for carboxypeptidase A. Novel type transition state analogue inhibitors for zinc proteases
    J Med Chem (21-11-2002) 45, 5295-5302. PubMed  Europe PubMed DOI  I
  52. [YEAR:14-2-2002]Park,J.D. and Kim,D.H.
    Cysteine derivatives as inhibitors for carboxypeptidase A: synthesis and structure-activity relationships
    J Med Chem (14-2-2002) 45, 911-918. PubMed  Europe PubMed DOI  I
    53. 2001
  53. [YEAR:28-8-2001]Cho,J.H., Kim,D.H., Lee,K.J. and Choi,K.Y.
    The role of Tyr248 probed by mutant bovine carboxypeptidase A: Insight into the catalytic mechanism of carboxypeptidase A
    Biochemistry (28-8-2001) 40, 10197-10203. PubMed  Europe PubMed DOI
  54. [YEAR:21-9-2001]Chung,S.J., Chung,S., Lee,H.S., Kim,E.J., Oh,K.S., Choi,H.S., Kim,K.S., Kin,Y.J., Hahn,J.H. and Kim,D.H.
    Mechanistic insight into the inactivation of carboxypeptidase A by alpha-benzyl-2-oxo-1,3-oxazolidine-4-acetic acid, a novel type of irreversible inhibitor for carboxypeptidase A with no stereospecificity
    J Org Chem (21-9-2001) 66, 6462-6471. PubMed  Europe PubMed DOI  I
  55. Chung,S.J. and Kim,D.H.
    N-(Hydroxyaminocarbonyl)phenylalanine: a novel class of inhibitor for carboxypeptidase A
    Bioorg Med Chem (2001) 9, 185-189. PubMed  Europe PubMed DOI  I
  56. [YEAR:4-6-2001]Han,M.S. and Kim,D.H.
    Effect of zinc ion on the inhibition of carboxypeptidase A by imidazole-bearing substrate analogues
    Bioorg Med Chem Lett (4-6-2001) 11, 1425-1427. PubMed  Europe PubMed DOI
  57. Park,J.D., Lee,K.J. and Kim,D.H.
    A new inhibitor design strategy for carboxypeptidase A as exemplified by N-(2-chloroethyl)-N-methylphenylalanine
    Bioorg Med Chem (2001) 9, 237-243. PubMed  Europe PubMed DOI  I
  58. Park,J.I. and Kim,D.H.
    2-Benzyl-3,4-iminobutanoic acid as inhibitor of carboxypeptidase A
    Bioorg Med Chem Lett (2001) 11, 2967-2970. PubMed  Europe PubMed DOI  I
    59. 2000
  59. [YEAR:27-6-2000]Chong,C.R. and Auld,D.S.
    Inhibition of carboxypeptidase A by D-penicillamine: mechanism and implications for drug design
    Biochemistry (27-6-2000) 39, 7580-7588. PubMed  Europe PubMed DOI  I
  60. [YEAR:1-2-2000]Hamstra,D.A., Page,M., Maybaum,J. and Rehemtulla,A.
    Expression of endogenously activated secreted or cell surface carboxypeptidase A sensitizes tumor cells to methotrexate-alpha-peptide prodrugs
    Cancer Res (1-2-2000) 60, 657-665. PubMed  Europe PubMed
  61. Marino-Buslje,C., Venhudova,G., Molina,M.A., Oliva,B., Jorba,X., Canals,F., Aviles,F.X. and Querol,E.
    Contribution of C-tail residues of potato carboxypeptidase inhibitor to the binding to carboxypeptidase A: a mutagenesis analysis
    Eur J Biochem (2000) 267, 1502-1509. PubMed  Europe PubMed DOI
  62. [YEAR:14-11-2000]Mock,W.L. and Cheng,H.
    Principles of hydroxamate inhibition of metalloproteases: carboxypeptidase A
    Biochemistry (14-11-2000) 39, 13945-13952. PubMed  Europe PubMed DOI  I
  63. Murakami,M., Suzuki,S., Itou,Y., Kodani,S. and Ishida,K.
    New anabaenopeptins, potent carboxypeptidase-A inhibitors from the cyanobacterium Aphanizomenon flos-aquae
    J Nat Prod (2000) 63, 1280-1282. PubMed  Europe PubMed DOI  I
  64. Rahmo,A. and Fife,T.H.
    Inhibition effects in the hydrolysis reactions of esters and peptides catalyzed by carboxypeptidase A: An example of cooperative binding effects with a monomeric enzyme
    Bioorg Chem (2000) 28, 226-241. PubMed  Europe PubMed DOI
  65. [YEAR:22-8-2000]van Aalten,D.M., Chong,C.R. and Joshua-Tor,L.
    Crystal structure of carboxypeptidase A complexed with D-cysteine at 1.75 A - inhibitor-induced conformational changes
    Biochemistry (22-8-2000) 39, 10082-10089. PubMed  Europe PubMed DOI  S  I
    66. 1999
  66. Darnis,S., Juge,N., Marino,C., Aviles,F.X., Puigserver,A., Chaix,J.C. and Guo,X.J.
    Cloning, sequencing and functional expression of a cDNA encoding porcine pancreatic preprocarboxypeptidase A1
    Eur J Biochem (1999) 259, 719-725. PubMed  Europe PubMed DOI
  67. [YEAR:20-1-1999]Hamstra,D.A. and Rehemtulla,A.
    Toward an enzyme/prodrug strategy for cancer gene therapy: endogenous activation of carboxypeptidase A mutants by the PACE/furin family of propeptidases
    Hum Gene Ther (20-1-1999) 10, 235-248. PubMed  Europe PubMed DOI
  68. [YEAR:3-5-1999]Itou,Y., Suzuki,S., Ishida,K. and Murakami,M.
    Anabaenopeptins G and H, potent carboxypeptidase A inhibitors from the cyanobacterium Oscillatoria agardhii (NIES-595)
    Bioorg Med Chem Lett (3-5-1999) 9, 1243-1246. PubMed  Europe PubMed DOI  I
  69. [YEAR:8-3-1999]Kim,D.H. and Jin,Y.
    First hydroxamate inhibitors for carboxypeptidase A. N-acyl-N-hydroxy-beta-phenylalanines
    Bioorg Med Chem Lett (8-3-1999) 9, 691-696. PubMed  Europe PubMed DOI  I
  70. Mkwetshana,N.T., Naude,R.J., Oelofsen,W., Naganuma,T. and Muramoto,K.
    The isolation and partial characterization of precursor forms of ostrich carboxypeptidase
    Int J Biochem Cell Biol (1999) 31, 331-343. PubMed  Europe PubMed DOI
  71. [YEAR:2-4-1999]Mock,W.L. and Wang,L.
    Synergistic inhibition of carboxypeptidase A by zinc ion and imidazole
    Biochem Biophys Res Commun (2-4-1999) 257, 239-243. PubMed  Europe PubMed DOI
  72. Wolfe,L.A., Mullin,R.J., Laethem,R., Blumenkopf,T.A., Cory,M., Miller,J.F., Keith,B.R., Humphreys,J. and Smith,G.K.
    Antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1: in vitro and in vivo studies with prodrugs of methotrexate and the thymidylate synthase inhibitors GW1031 and GW1843
    Bioconjug Chem (1999) 10, 38-48. PubMed  Europe PubMed DOI
    73. 1998
  73. Aloy,P., Catasus,L., Villegas,V., Reverter,D., Vendrell,J. and Aviles,F.X.
    Comparative analysis of the sequences and three-dimensional models of human procarboxypeptidases A1, A2 and B
    Biol Chem (1998) 379, 149-155. PubMed  Europe PubMed
  74. Alvarez-Santos,S., Gonzalez-Lafont,A., Lluch,J.M., Oliva,B. and Aviles,F.X.
    Theoretical study of the role of arginine 127 in the water-promoted mechanism of peptide cleavage by carboxypeptidase A
    New J Chem (1998) 22, 319-325.
  75. [YEAR:24-11-1998]Bukrinsky,J.T., Bjerrum,M.J. and Kadziola,A.
    Native carboxypeptidase A in a new crystal environment reveals a different conformation of the important tyrosine 248
    Biochemistry (24-11-1998) 37, 16555-16564. PubMed  Europe PubMed DOI  S
  76. [YEAR:1-5-1998]Greenblatt,H.M., Feinberg,H., Tucker,P.A. and Shoham,G.
    Carboxypeptidase A: native, zinc-removed and mercury-replaced forms
    Acta Crystallogr D Biol Crystallogr (1-5-1998) 54, 289-305. PubMed  Europe PubMed DOI  S
  77. [YEAR:7-4-1998]Kim,D.H., Chung,S.J., Kim,E.J. and Tian,G.R.
    Irreversible inhibition of zinc-containing protease by oxazolidinone derivatives. Novel inactivation chemistry
    Bioorg Med Chem Lett (7-4-1998) 8, 859-864. PubMed  Europe PubMed DOI  I
  78. [YEAR:1-12-1998]Lee,H.C., Ko,Y.H., Baek,S.B. and Kim,D.H.
    Detection of an anhydride intermediate in the carboxypeptidase a catalyzed hydrolysis of a peptide substrate by solid state NMR spectroscopy and its mechanistic implication
    Bioorg Med Chem Lett (1-12-1998) 8, 3379-3384. PubMed  Europe PubMed
  79. Lee,K.J. and Kim,D.H.
    Design of mechanism-based carboxypeptidase A inactivators on the basis of the X-ray crystal structure and catalytic reaction pathway
    Bioorg Med Chem (1998) 6, 1613-1622. PubMed  Europe PubMed DOI  I
  80. Tatsuta,T., Tomoyasu,T., Bukau,B., Kitagawa,M., Mori,H., Karata,K. and Ogura,T.
    Heat shock regulation in the FtsH null mutant of Escherichia coli: dissection of stability and activity control mechanisms of sigma32 in vivo
    Mol Microbiol (1998) 30, 583-593. PubMed  Europe PubMed DOI
  81. [YEAR:18-11-1998]Vertesi,A. and Simon,L.M.
    Carboxypeptidase A-catalyzed dipeptide synthesis in organic media
    J Biotechnol (18-11-1998) 66, 75-82. PubMed  Europe PubMed DOI
    82. 1997
  82. Asante-Appiah,E., Seetharaman,J., Sicheri,F., Yang,D.S. and Chan,W.W.
    gem-Dialkyl succinic acids: a novel class of inhibitors for carboxypeptidases
    Biochemistry (1997) 36, 8710-8715. PubMed  Europe PubMed DOI  I
  83. Gomis-Ruth,F.X., Gomez-Ortiz,M., Vendrell,J., Ventura,S., Bode,W., Huber,R. and Aviles,F.X.
    Crystal structure of an oligomer of proteolytic zymogens: detailed conformational analysis of the bovine ternary complex and implications for their activation
    J Mol Biol (1997) 269, 861-880. PubMed  Europe PubMed DOI  S
    84. 1996
  84. Laethem,R.M., Blumenkopf,T.A., Cory,M., Elwell,L., Moxham,C.P., Ray,P.H., Walton,L.M. and Smith,G.K.
    Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2
    Arch Biochem Biophys (1996) 332, 8-18. PubMed  Europe PubMed DOI  E
  85. Mock,W.L., Liu,Y. and Stanford,D.J.
    Arazoformyl peptide surrogates as spectrophotometric kinetic assay substrates for carboxypeptidase A
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    86. 1995
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