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Literature for peptidase M14.001: carboxypeptidase A1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, R Splicing. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Goulet,D.L., Bignucolo,M.W. and Siemann,S.
    Accessibility of Carboxypeptidase A-bound Zinc to Chelation Correlates with an Intermediate State in the Protein's Unfolding Pathway
    Biochemistry64, 1244-1256. PubMed  Europe PubMed DOI
    2. 2024
  2. Amador Balderas,J.A., Beierlein,F., Horn,A.H.C., Volkenandt,S., Volcker,L., Mokhtari,N., Ndongue,J.C.E. and Imhof,P.
    Mode of Metal Ligation Governs Inhibition of Carboxypeptidase A
    Int J Mol Sci25, PubMed  Europe PubMed DOI
  3. Gluszek,S., Adamus-Bialek,W., Chrapek,M., Dziuba,A., Dulebska,J., Koziel,D., Matykiewicz,J. and Wawszczak-Kasza,M.
    Genetic Variability in the CPA1 Gene and Its Impact on Acute Pancreatitis Risk: New Insights from a Large-Scale Study
    Int J Mol Sci25, PubMed  Europe PubMed DOI
    4. 2023
  4. Ming,Y., Zhang,H., Zhao,Z., Zhang,Z., Wang,H. and Liang,Z.
    Enhancing the thermostability of carboxypeptidase A by a multiple computer-aided rational design based on amino acids preferences at beta-turns
    Int J Biol Macromol245, 125447-125447. PubMed  Europe PubMed DOI
    5. 2020
  5. Li,G., Wei,H., Bi,J., Ding,X., Li,L., Xu,S., Yang,G. and Ren,W.
    Insights into dietary switch in cetaceans: evidence from molecular evolution of proteinases and lipases
    J Mol Evol PubMed  Europe PubMed DOI
  6. Mohammadi,M., Shareghi,B. and Akbar Saboury,A.
    Comparative studies on the interaction of spermidine with carboxypeptidase A using multispectroscopic and docking methods
    Int J Biol Macromol147, 821-831. PubMed  Europe PubMed DOI
  7. Mohammadi,M., Shareghi,B., Akbar Saboury,A. and Farhadian,S.
    Spermine as a possible endogenous allosteric activator of carboxypeptidase A: multispectroscopic and molecular simulation studies
    J Biomol Struct Dyn38, 101-113. PubMed  Europe PubMed DOI
  8. Shu,L., Zhong,L., Xiao,Y., Wu,X., Liu,Y., Jiang,X., Tang,T., Hoo,R., Zhou,Z. and Xu,A.
    Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice
    Clin Sci (Lond)134, 1679-1696. PubMed  Europe PubMed DOI
    9. 2019
  9. Ahmad,S., Wright,K.N., Sun,X., Groban,L. and Ferrario,C.M.
    Mast cell peptidases (carboxypeptidase A and chymase)-mediated hydrolysis of human angiotensin-(1-12) substrate
    Biochem Biophys Res Commun518, 651-656. PubMed  Europe PubMed DOI
  10. Covaleda,G., Gallego,P., Vendrell,J., Georgiadis,D., Lorenzo,J., Dive,V., Aviles,F.X., Reverter,D. and Devel,L.
    Synthesis and structural/functional characterization of selective M14 metallocarboxypeptidase inhibitors based on phosphinic pseudo peptide scaffold: implications on the design of specific optical probes
    J Med Chem62, 1917-1931. PubMed  Europe PubMed DOI  S  I
    11. 2017
  11. Testero,S.A., Granados,C., Fernandez,D., Gallego,P., Covaleda,G., Reverter,D., Vendrell,J., Aviles,F.X., Pallares,I. and Mobashery,S.
    Discovery of mechanism-based inactivators for human pancreatic carboxypeptidase A from a focused synthetic library
    ACS Med Chem Lett8, 1122-1127. PubMed  Europe PubMed DOI  I
    12. 2016
  12. Harms,H., Kurita,K.L., Pan,L., Wahome,P.G., He,H., Kinghorn,A.D., Carter,G.T. and Linington,R.G.
    Discovery of anabaenopeptin 679 from freshwater algal bloom material: Insights into the structure-activity relationship of anabaenopeptin protease inhibitors
    Bioorg Med Chem Lett26, 4960-4965. PubMed  Europe PubMed DOI  I
  13. Kukk,K. and Samel,N.
    Enhanced expression of human prostaglandin H synthase-2 in the yeast Pichia pastoris and removal of the C-terminal tag with bovine carboxypeptidase A
    J Biotechnol231, 224-231. PubMed  Europe PubMed DOI
  14. Szabo,A., Pilsak,C., Bence,M., Witt,H. and Sahin-Toth,M.
    Complex formation of human proelastases with procarboxypeptidases A1 and A2
    J Biol Chem291, 17706-17716. PubMed  Europe PubMed DOI
  15. Valdez,C.E., Morgenstern,A., Eberhart,M.E. and Alexandrova,A.N.
    Predictive methods for computational metalloenzyme redesign - a test case with carboxypeptidase A
    Phys Chem Chem Phys18, 31744-31756. PubMed  Europe PubMed DOI  S
    16. 2014
  16. Godahewa,G.I., Wickramaarachchi,W.D., Whang,I., Bathige,S.D., Lim,B.S., Choi,C.Y., De Zoysa,M., Noh,J.K. and Lee,J.
    Two carboxypeptidase counterparts from rock bream (Oplegnathus fasciatus): Molecular characterization, genomic arrangement and immune responses upon pathogenic stresses
    Vet Immunol Immunopathol162, 180-191. PubMed  Europe PubMed DOI
  17. Hirose,J.
    [Coordination chemical studies on the zinc enzymes]
    Yakugaku Zasshi134, 1109-1124. PubMed  Europe PubMed DOI
  18. Masamune,A.
    Genetics of pancreatitis: the 2014 update
    Tohoku J Exp Med232, 69-77. PubMed  Europe PubMed DOI  M
  19. Pathak,N., Austin-Tse,C.A., Liu,Y., Vasilyev,A. and Drummond,I.A.
    Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function
    Mol Biol Cell25, 1836-1844. PubMed  Europe PubMed DOI
    20. 2013
  20. Lyons,P.J., Sapio,M.R. and Fricker,L.D.
    Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development
    J Biol Chem288, 30454-30462. PubMed  Europe PubMed DOI
    21. 2012
  21. Auld,D.S.
    Carboxypeptidase A
    [ISSN:978-0-12-407744-7]3, 1289-1301. DOI
  22. Cheruku,P., Plaza,A., Lauro,G., Keffer,J., Lloyd,J.R., Bifulco,G. and Bewley,C.A.
    Discovery and synthesis of namalide reveals a new anabaenopeptin scaffold and peptidase inhibitor
    J Med Chem55, 735-742. PubMed  Europe PubMed DOI  I
  23. Jitonnom,J. and Sontag,C.
    Comparative study on activation mechanism of carboxypeptidase A1, A2 and B: first insights from steered molecular dynamics simulations
    J Mol Graph Model38, 298-303. PubMed  Europe PubMed DOI
    24. 2011
  24. Chang,Y.C., Chao,P.W. and Tung,C.H.
    Sensitive luciferin derived probes for selective carboxypeptidase activity
    Bioorg Med Chem Lett21, 3931-3934. PubMed  Europe PubMed DOI  A
  25. Fernandez,D., Boix,E., Pallares,I., Aviles,F.X. and Vendrell,J.
    Structural and functional analysis of the complex between citrate and the zinc peptidase carboxypeptidase A
    Enzyme Res2011, 128676-128676. PubMed  Europe PubMed DOI  S
  26. Shushanyan,M., Khoshtariya,D.E., Tretyakova,T., Makharadze,M. and van Eldik,R.
    Diverse role of conformational dynamics in carboxypeptidase A-driven peptide and ester hydrolyses: disclosing the "perfect induced fit" and "protein local unfolding" pathways by altering protein stability
    Biopolymers95, 852-870. PubMed  Europe PubMed DOI
  27. Szmola,R., Bence,M., Carpentieri,A., Szabo,A., Costello,C.E., Samuelson,J. and Sahin-Toth,M.
    Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2
    J Biol Chem286, 1819-1827. PubMed  Europe PubMed DOI
  28. Wu,S., Zhang,C., Cao,R., Xu,D. and Guo,H.
    pH-Dependent reactivity for glycyl-L-tyrosine in carboxypeptidase-A-catalyzed hydrolysis
    J Phys Chem B115, 10360-10367. PubMed  Europe PubMed DOI
    29. 2010
  29. Fernandez,D., Testero,S., Vendrell,J., Aviles,F.X. and Mobashery,S.
    The X-ray structure of carboxypeptidase A inhibited by a thiirane mechanism-based inhibitor
    Chem Biol Drug Des75, 29-34. PubMed  Europe PubMed DOI  S  I
  30. Wang,S.F., Jin,J.-Y., Zeng,Z.H. and Tian,G.R.
    Optical 2-benzyl-5-hydroxy4oxopentanoic acids against carboxypeptidase A: Synthesis, kinetic evaluation and X-ray crystallographic study
    Chin Chem Lett21, 159-162.
  31. Wu,S., Zhang,C., Xu,D. and Guo,H.
    Catalysis of carboxypeptidase A: promoted-water versus nucleophilic pathways
    J Phys Chem B114, 9259-9267. PubMed  Europe PubMed DOI
    32. 2009
  32. Kilshtain,A.V. and Warshel,A.
    On the origin of the catalytic power of carboxypeptidase A and other metalloenzymes
    Proteins77, 536-550. PubMed  Europe PubMed DOI
  33. Wang,S.F., Tian,G.R., Zhang,W.Z. and Jin,J.Y.
    Characterization of alpha-nitromethyl ketone as a new zinc-binding group based on structural analysis of its complex with carboxypeptidase A
    Bioorg Med Chem Lett19, 5009-5011. PubMed  Europe PubMed DOI  I
  34. Xu,D. and Guo,H.
    Quantum mechanical/molecular mechanical and density functional theory studies of a prototypical zinc peptidase (carboxypeptidase A) suggest a general acid-general base mechanism
    J Am Chem Soc131, 9780-9788. PubMed  Europe PubMed DOI
    35. 2008
  35. Fernandez,D., Illa,O., Aviles,F.X., Branchadell,V., Vendrell,J. and Ortuno,R.M.
    Thioxophosphoranyl aryl- and heteroaryloxiranes as the representants of a new class of metallocarboxypeptidase inhibitors
    Bioorg Med Chem16, 4823-4828. PubMed  Europe PubMed DOI  I
  36. Pallares,I., Fernandez,D., Comellas-Bigler,M., Fernandez-Recio,J., Ventura,S., Aviles,F.X., Bode,W. and Vendrell,J.
    Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid)
    Acta Crystallogr D Biol CrystallogrD64, 784-791. PubMed  Europe PubMed DOI  S
  37. Wang,S.H., Wang,S.F., Xuan,W., Zeng,Z.H., Jin,J.Y., Ma,J. and Tian,G.R.
    Nitro as a novel zinc-binding group in the inhibition of carboxypeptidase A
    Bioorg Med Chem16, 3596-3601. PubMed  Europe PubMed DOI  I
    38. 2007
  38. Chong,C.R. and Auld,D.S.
    Catalysis of zinc transfer by d-penicillamine to secondary chelators
    J Med Chem50, 5524-5527. PubMed  Europe PubMed DOI  I
    39. 2006
  39. [YEAR:25-10-2006]Mouradov,D., Craven,A., Forwood,J.K., Flanagan,J.U., Garcia-Castellanos,R., Gomis-Ruth,F.X., Hume,D.A., Martin,J.L., Kobe,B. and Huber,T.
    Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking
    Protein Eng Des Sel19, 9-16. PubMed  Europe PubMed DOI
    40. 2005
  40. Arolas,J.L., Popowicz,G.M., Bronsoms,S., Aviles,F.X., Huber,R., Holak,T.A. and Ventura,S.
    Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond
    J Mol Biol352, 961-975. PubMed  Europe PubMed DOI  S
  41. Arolas,J.L., Popowicz,G.M., Lorenzo,J., Sommerhoff,C.P., Huber,R., Aviles,F.X. and Holak,T.A.
    The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode
    J Mol Biol350, 489-498. PubMed  Europe PubMed DOI  S
  42. [YEAR:17-3-2005]Cross,J.B., Vreven,T., Meroueh,S.O., Mobashery,S. and Schlegel,H.B.
    Computational investigation of irreversible inactivation of the zinc-dependent protease carboxypeptidase A
    J Phys Chem B109, 4761-4769. PubMed  Europe PubMed DOI  I
    43. 2004
  43. Auld,D.S.
    Carboxypeptidase A
    [ISSN:0-12-079610-4]2, 812-821.  V
  44. Kim,D.H.
    Chemistry-based design of inhibitors for carboxypeptidase A
    Curr Top Med Chem4, 1217-1226. PubMed  Europe PubMed DOI  I
    45. 2003
  45. Kilshtain-Vardi,A., Glick,M., Greenblatt,H.M., Goldblum,A. and Shoham,G.
    Refined structure of bovine carboxypeptidase A at 1.25 A resolution
    Acta Crystallogr D Biol Crystallogr59, 323-333. PubMed  Europe PubMed DOI  S
  46. [YEAR:15-5-2003]Reddanna,P., Prabhu,K.S., Whelan,J. and Reddy,C.C.
    Carboxypeptidase A-catalyzed direct conversion of leukotriene C4 to leukotriene F4
    Arch Biochem Biophys413, 158-163. PubMed  Europe PubMed DOI
  47. Seddi,R., Chaix,J.C., Puigserver,A. and Guo,X.J.
    Expression of a soluble and activatable form of bovine procarboxypeptidase A in Escherichia coli
    Protein Expr Purif27, 220-228. PubMed  Europe PubMed DOI
    48. 2002
  48. Cho,J.H., Kim,D.H., Chung,S.J., Ha,N.C., Oh,B.H. and Yong Choi,K.
    Insight into the stereochemistry in the inhibition of carboxypeptidase A with N-(hydroxyaminocarbonyl)phenylalanine: binding modes of an enantiomeric pair of the inhibitor to carboxypeptidase A
    Bioorg Med Chem10, 2015-2022. PubMed  Europe PubMed DOI  S  I
  49. Jensen,F., Bukrinsky,T., Bjerrum,J. and Larsen,S.
    Three high-resolution crystal structures of cadmium-substituted carboxypeptidase A provide insight into the enzymatic function
    J Biol Inorg Chem7, 490-499. PubMed  Europe PubMed DOI  S
  50. [YEAR:14-2-2002]Park,J.D. and Kim,D.H.
    Cysteine derivatives as inhibitors for carboxypeptidase A: synthesis and structure-activity relationships
    J Med Chem45, 911-918. PubMed  Europe PubMed DOI  I
  51. [YEAR:21-11-2002]Park,J.D., Kim,D.H., Kim,S.J., Woo,J.R. and Ryu,S.E.
    Sulfamide-based inhibitors for carboxypeptidase A. Novel type transition state analogue inhibitors for zinc proteases
    J Med Chem45, 5295-5302. PubMed  Europe PubMed DOI  I
    52. 2001
  52. [YEAR:28-8-2001]Cho,J.H., Kim,D.H., Lee,K.J. and Choi,K.Y.
    The role of Tyr248 probed by mutant bovine carboxypeptidase A: Insight into the catalytic mechanism of carboxypeptidase A
    Biochemistry40, 10197-10203. PubMed  Europe PubMed DOI
  53. [YEAR:21-9-2001]Chung,S.J., Chung,S., Lee,H.S., Kim,E.J., Oh,K.S., Choi,H.S., Kim,K.S., Kin,Y.J., Hahn,J.H. and Kim,D.H.
    Mechanistic insight into the inactivation of carboxypeptidase A by alpha-benzyl-2-oxo-1,3-oxazolidine-4-acetic acid, a novel type of irreversible inhibitor for carboxypeptidase A with no stereospecificity
    J Org Chem66, 6462-6471. PubMed  Europe PubMed DOI  I
  54. Chung,S.J. and Kim,D.H.
    N-(Hydroxyaminocarbonyl)phenylalanine: a novel class of inhibitor for carboxypeptidase A
    Bioorg Med Chem9, 185-189. PubMed  Europe PubMed DOI  I
  55. [YEAR:4-6-2001]Han,M.S. and Kim,D.H.
    Effect of zinc ion on the inhibition of carboxypeptidase A by imidazole-bearing substrate analogues
    Bioorg Med Chem Lett11, 1425-1427. PubMed  Europe PubMed DOI
  56. Park,J.D., Lee,K.J. and Kim,D.H.
    A new inhibitor design strategy for carboxypeptidase A as exemplified by N-(2-chloroethyl)-N-methylphenylalanine
    Bioorg Med Chem9, 237-243. PubMed  Europe PubMed DOI  I
  57. Park,J.I. and Kim,D.H.
    2-Benzyl-3,4-iminobutanoic acid as inhibitor of carboxypeptidase A
    Bioorg Med Chem Lett11, 2967-2970. PubMed  Europe PubMed DOI  I
    58. 2000
  58. [YEAR:27-6-2000]Chong,C.R. and Auld,D.S.
    Inhibition of carboxypeptidase A by D-penicillamine: mechanism and implications for drug design
    Biochemistry39, 7580-7588. PubMed  Europe PubMed DOI  I
  59. [YEAR:1-2-2000]Hamstra,D.A., Page,M., Maybaum,J. and Rehemtulla,A.
    Expression of endogenously activated secreted or cell surface carboxypeptidase A sensitizes tumor cells to methotrexate-alpha-peptide prodrugs
    Cancer Res60, 657-665. PubMed  Europe PubMed
  60. Marino-Buslje,C., Venhudova,G., Molina,M.A., Oliva,B., Jorba,X., Canals,F., Aviles,F.X. and Querol,E.
    Contribution of C-tail residues of potato carboxypeptidase inhibitor to the binding to carboxypeptidase A: a mutagenesis analysis
    Eur J Biochem267, 1502-1509. PubMed  Europe PubMed DOI
  61. [YEAR:14-11-2000]Mock,W.L. and Cheng,H.
    Principles of hydroxamate inhibition of metalloproteases: carboxypeptidase A
    Biochemistry39, 13945-13952. PubMed  Europe PubMed DOI  I
  62. Murakami,M., Suzuki,S., Itou,Y., Kodani,S. and Ishida,K.
    New anabaenopeptins, potent carboxypeptidase-A inhibitors from the cyanobacterium Aphanizomenon flos-aquae
    J Nat Prod63, 1280-1282. PubMed  Europe PubMed DOI  I
  63. Rahmo,A. and Fife,T.H.
    Inhibition effects in the hydrolysis reactions of esters and peptides catalyzed by carboxypeptidase A: An example of cooperative binding effects with a monomeric enzyme
    Bioorg Chem28, 226-241. PubMed  Europe PubMed DOI
  64. [YEAR:22-8-2000]van Aalten,D.M., Chong,C.R. and Joshua-Tor,L.
    Crystal structure of carboxypeptidase A complexed with D-cysteine at 1.75 A - inhibitor-induced conformational changes
    Biochemistry39, 10082-10089. PubMed  Europe PubMed DOI  S  I
    65. 1999
  65. Darnis,S., Juge,N., Marino,C., Aviles,F.X., Puigserver,A., Chaix,J.C. and Guo,X.J.
    Cloning, sequencing and functional expression of a cDNA encoding porcine pancreatic preprocarboxypeptidase A1
    Eur J Biochem259, 719-725. PubMed  Europe PubMed DOI
  66. [YEAR:20-1-1999]Hamstra,D.A. and Rehemtulla,A.
    Toward an enzyme/prodrug strategy for cancer gene therapy: endogenous activation of carboxypeptidase A mutants by the PACE/furin family of propeptidases
    Hum Gene Ther10, 235-248. PubMed  Europe PubMed DOI
  67. [YEAR:3-5-1999]Itou,Y., Suzuki,S., Ishida,K. and Murakami,M.
    Anabaenopeptins G and H, potent carboxypeptidase A inhibitors from the cyanobacterium Oscillatoria agardhii (NIES-595)
    Bioorg Med Chem Lett9, 1243-1246. PubMed  Europe PubMed DOI  I
  68. [YEAR:8-3-1999]Kim,D.H. and Jin,Y.
    First hydroxamate inhibitors for carboxypeptidase A. N-acyl-N-hydroxy-beta-phenylalanines
    Bioorg Med Chem Lett9, 691-696. PubMed  Europe PubMed DOI  I
  69. Mkwetshana,N.T., Naude,R.J., Oelofsen,W., Naganuma,T. and Muramoto,K.
    The isolation and partial characterization of precursor forms of ostrich carboxypeptidase
    Int J Biochem Cell Biol31, 331-343. PubMed  Europe PubMed DOI
  70. [YEAR:2-4-1999]Mock,W.L. and Wang,L.
    Synergistic inhibition of carboxypeptidase A by zinc ion and imidazole
    Biochem Biophys Res Commun257, 239-243. PubMed  Europe PubMed DOI
  71. Wolfe,L.A., Mullin,R.J., Laethem,R., Blumenkopf,T.A., Cory,M., Miller,J.F., Keith,B.R., Humphreys,J. and Smith,G.K.
    Antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1: in vitro and in vivo studies with prodrugs of methotrexate and the thymidylate synthase inhibitors GW1031 and GW1843
    Bioconjug Chem10, 38-48. PubMed  Europe PubMed DOI
    72. 1998
  72. Aloy,P., Catasus,L., Villegas,V., Reverter,D., Vendrell,J. and Aviles,F.X.
    Comparative analysis of the sequences and three-dimensional models of human procarboxypeptidases A1, A2 and B
    Biol Chem379, 149-155. PubMed  Europe PubMed
  73. Alvarez-Santos,S., Gonzalez-Lafont,A., Lluch,J.M., Oliva,B. and Aviles,F.X.
    Theoretical study of the role of arginine 127 in the water-promoted mechanism of peptide cleavage by carboxypeptidase A
    New J Chem22, 319-325.
  74. [YEAR:24-11-1998]Bukrinsky,J.T., Bjerrum,M.J. and Kadziola,A.
    Native carboxypeptidase A in a new crystal environment reveals a different conformation of the important tyrosine 248
    Biochemistry37, 16555-16564. PubMed  Europe PubMed DOI  S
  75. [YEAR:1-5-1998]Greenblatt,H.M., Feinberg,H., Tucker,P.A. and Shoham,G.
    Carboxypeptidase A: native, zinc-removed and mercury-replaced forms
    Acta Crystallogr D Biol Crystallogr54, 289-305. PubMed  Europe PubMed DOI  S
  76. [YEAR:7-4-1998]Kim,D.H., Chung,S.J., Kim,E.J. and Tian,G.R.
    Irreversible inhibition of zinc-containing protease by oxazolidinone derivatives. Novel inactivation chemistry
    Bioorg Med Chem Lett8, 859-864. PubMed  Europe PubMed DOI  I
  77. [YEAR:1-12-1998]Lee,H.C., Ko,Y.H., Baek,S.B. and Kim,D.H.
    Detection of an anhydride intermediate in the carboxypeptidase a catalyzed hydrolysis of a peptide substrate by solid state NMR spectroscopy and its mechanistic implication
    Bioorg Med Chem Lett8, 3379-3384. PubMed  Europe PubMed
  78. Lee,K.J. and Kim,D.H.
    Design of mechanism-based carboxypeptidase A inactivators on the basis of the X-ray crystal structure and catalytic reaction pathway
    Bioorg Med Chem6, 1613-1622. PubMed  Europe PubMed DOI  I
  79. Tatsuta,T., Tomoyasu,T., Bukau,B., Kitagawa,M., Mori,H., Karata,K. and Ogura,T.
    Heat shock regulation in the FtsH null mutant of Escherichia coli: dissection of stability and activity control mechanisms of sigma32 in vivo
    Mol Microbiol30, 583-593. PubMed  Europe PubMed DOI
  80. [YEAR:18-11-1998]Vertesi,A. and Simon,L.M.
    Carboxypeptidase A-catalyzed dipeptide synthesis in organic media
    J Biotechnol66, 75-82. PubMed  Europe PubMed DOI
    81. 1997
  81. Asante-Appiah,E., Seetharaman,J., Sicheri,F., Yang,D.S. and Chan,W.W.
    gem-Dialkyl succinic acids: a novel class of inhibitors for carboxypeptidases
    Biochemistry36, 8710-8715. PubMed  Europe PubMed DOI  I
  82. Gomis-Ruth,F.X., Gomez-Ortiz,M., Vendrell,J., Ventura,S., Bode,W., Huber,R. and Aviles,F.X.
    Crystal structure of an oligomer of proteolytic zymogens: detailed conformational analysis of the bovine ternary complex and implications for their activation
    J Mol Biol269, 861-880. PubMed  Europe PubMed DOI  S
    83. 1996
  83. Laethem,R.M., Blumenkopf,T.A., Cory,M., Elwell,L., Moxham,C.P., Ray,P.H., Walton,L.M. and Smith,G.K.
    Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2
    Arch Biochem Biophys332, 8-18. PubMed  Europe PubMed DOI  E
  84. Mock,W.L., Liu,Y. and Stanford,D.J.
    Arazoformyl peptide surrogates as spectrophotometric kinetic assay substrates for carboxypeptidase A
    Anal Biochem239, 218-222. PubMed  Europe PubMed DOI  A
    85. 1995
  85. Gomis-Ruth,F.X., Gomez,M., Bode,W., Huber,R. and Aviles,F.X.
    The three-dimensional structure of the native ternary complex of bovine pancreatic procarboxypeptidase A with proproteinase E and chymotrypsinogen C
    EMBO J14, 4387-4394. PubMed  Europe PubMed  S
  86. Kim,D.H. and Chung,S.J.
    Inactivation of carboxypeptidase A by 2-benzyl-3,4-epithiobutanoic acid
    Bioorg Med Chem Lett5, 1667-1672.  I
  87. Lee,S.S., Li,Z.H., Lee,D.H. and Kim,D.H.
    (2R,3S)- and (2S, 3R)-2-Benzyl-3,4-epoxybutanoic acid as highly efficient and fast acting pseudomechanism-based inactivators for carboxypeptidase A: design, asymmetric synthesis and inhibitory kinetics
    J Chem Soc Perkin Trans1, 2877-2882.  I
  88. Normant,E., Martres,M.P., Schwartz,J.C. and Gros,C.
    Purification, cDNA cloning, functional expression, and characterization of a 26-kDa endogenous mammalian carboxypeptidase inhibitor
    Proc Natl Acad Sci U S A92, 12225-12229. PubMed  Europe PubMed DOI
  89. Normant,E., Gros,C. and Schwartz,J.C.
    Carboxypeptidase A isoforms produced by distinct genes or alternative splicing in brain and other extrapancreatic tissues
    J Biol Chem270, 20543-20549. PubMed  Europe PubMed DOI  R
    90. 1994
  90. [YEAR:11-2-1994]Mustafi,D. and Makinen,M.W.
    Catalytic conformation of carboxypeptidase A. Structure of a true enzyme reaction intermediate determined by electron nuclear double resonance
    J Biol Chem269, 4587-4595. PubMed  Europe PubMed
  91. Tanaka,Y., Grapsas,I., Dakoji,S., Cho,J.Y. and Mobashery,S.
    Conscripting the active-site zinc ion in carboxypeptidase A in inactivation chemistry by a new type of irreversible enzyme inactivator
    J Am Chem Soc116, 7475-7480.  I
    92. 1993
  92. Aviles,F.X., Vendrell,J., Guasch,A., Coll,M. and Huber,R.
    Advances in metallo-procarboxypeptidases. Emerging details on the inhibition mechanism and on the activation process
    Eur J Biochem211, 381-389. PubMed  Europe PubMed DOI
  93. [YEAR:1-1-1993]Mock,W.L., Freeman,D.J. and Aksamawati,M.
    Fluxionate Lewis acidity of the Zn2+ ion in carboxypeptidase A
    Biochem J289, 185-193. PubMed  Europe PubMed
  94. Teplyakov,A., Wilson,K.S., Orioli,P. and Mangani,S.
    High-resolution structure of the complex between carboxypeptidase A and L-phenyl lactate
    Acta Crystallogr D Biol Crystallogr49, 534-540. PubMed  Europe PubMed DOI  S
    95. 1992
  95. Artymiuk,P.J., Grindley,H.M., Park,J.E., Rice,D.W. and Willett,P.
    Three-dimensional structural resemblance between leucine aminopeptidase and carboxypeptidase A revealed by graph- theoretical techniques
    FEBS Lett303, 48-52. PubMed  Europe PubMed DOI
  96. Cappalonga,A.M., Alexander,R.S. and Christianson,D.W.
    Structural comparison of sulfodiimine and sulfonamide inhibitors in their complexes with zinc enzymes
    J Biol Chem267, 19192-19197. PubMed  Europe PubMed  S  I
  97. Catasus,L., Villegas,V., Pascual,R., Aviles,F.X., Wicker-Planquart,C. and Puigserver,A.
    cDNA cloning and sequence analysis of human pancreatic procarboxypeptidase A1
    Biochem J287, 299-303. PubMed  Europe PubMed
  98. Guasch,A., Coll,M., Aviles,F.X. and Huber,R.
    Three-dimensional structure of porcine pancreatic procarboxypeptidase A. A comparison of the A and B zymogens and their determinants for inhibition and activation
    J Mol Biol224, 141-157. PubMed  Europe PubMed DOI  S
  99. [YEAR:20-1-1992]Mangani,S., Carloni,P. and Orioli,P.
    Crystal structure of the complex between carboxypeptidase A and the biproduct analog inhibitor L-benzylsuccinate at 2.0 A resolution
    J Mol Biol223, 573-578. PubMed  Europe PubMed  S  I
  100. Phillips,M.A., Hedstrom,L. and Rutter,W.J.
    Guanidine derivatives restore activity to carboxypeptidase lacking arginine-127
    Protein Sci1, 517-521. PubMed  Europe PubMed DOI
  101. Yun,M., Park,C., Kim,S., Nam,D., Kim,S.C. and Kim,D.H.
    The x-ray crystallographic study of covalently modified carboxypeptidase A by 2-benzyl-3,4-epoxybutanoic acid, a pseudomechanism-based inactivator
    J Am Chem Soc114, 2281-2282.  I
    102. 1991
  102. Faming,Z., Kobe,B., Stewart,C.B., Rutter,W.J. and Goldsmith,E.J.
    Structural evolution of an enzyme specificity. The structure of rat carboxypeptidase A2 at 1.9-A resolution
    J Biol Chem266, 24606-24612. PubMed  Europe PubMed  S
  103. Kim,D.H. and Kim,K.B.
    Design of a novel type of zinc-containing protease inhibitor
    J Am Chem Soc113, 3200-3202.  I
  104. Kim,H. and Lipscomb,W.N.
    Comparison of the structures of three carboxypeptidase A-phosphonate complexes determined by X-ray crystallography
    Biochemistry30, 8171-8180. PubMed  Europe PubMed  S  I
  105. Larsen,K.S. and Auld,D.S.
    Characterization of an inhibitory metal binding site in carboxypeptidase A
    Biochemistry30, 2613-2618. PubMed  Europe PubMed
    106. 1990
  106. Kim,H. and Lipscomb,W.N.
    Crystal structure of the complex of carboxypeptidase A with a strongly bound phosphonate in a new crystalline form: comparison with structures of other complexes
    Biochemistry29, 5546-5555. PubMed  Europe PubMed DOI  S  I
  107. [YEAR:25-11-1990]Phillips,M.A., Fletterick,R. and Rutter,W.J.
    Arginine 127 stabilizes the transition state in carboxypeptidase
    J Biol Chem265, 20692-20698. PubMed  Europe PubMed  I
    108. 1989
  108. Christianson,D.W., Mangani,S., Shoham,G. and Lipscomb,W.N.
    Binding of D-phenylalanine and D-tyrosine to carboxypeptidase A
    J Biol Chem264, 12849-12853. PubMed  Europe PubMed
  109. Homandberg,G.A., Litwiller,R.D. and Peanasky,R.J.
    Carboxypeptidase inhibitors from Ascaris suum: the primary structure
    Arch Biochem Biophys270, 153-161. PubMed  Europe PubMed
  110. Mock,W.L. and Tsay,J.T.
    Sulfoximine and sulfodiimine transition-state analogue inhibitors for carboxypeptidase A
    J Am Chem Soc111, 4467-4472.  I
  111. [YEAR:3-7-1989]Moulard,M., Kerfelec,B., Mallet,B. and Chapus,C.
    Identification of a procarboxypeptidase A-truncated protease E binary complex in human pancreatic juice
    FEBS Lett250, 166-170. PubMed  Europe PubMed
  112. Pascual,R., Burgos,F.J., Salva,M., Soriano,F., Mendez,E. and Aviles,F.X.
    Purification and properties of five different forms of human procarboxypeptidases
    Eur J Biochem179, 609-616. PubMed  Europe PubMed
    113. 1988
  113. [YEAR:9-2-1988]Bicknell,R., Schaffer,A., Bertini,I., Luchinat,C., Vallee,B.L. and Auld,D.S.
    Interaction of anions with the active site of carboxypeptidase A
    Biochemistry27, 1050-1057. PubMed  Europe PubMed
  114. Foglizzo,E., Bonicel,J., Kerfelec,B., Granon,S. and Chapus,C.
    Primary structure of the activation peptide from bovine pancreatic procarboxypeptidase A
    Biochim Biophys Acta954, 183-188. PubMed  Europe PubMed
  115. Mock,W.L. and Tsay,J.T.
    pK values for active site residues of carboxypeptidase A
    J Biol Chem263, 8635-8641. PubMed  Europe PubMed
  116. Shoham,G., Christianson,D.W. and Oren,D.A.
    Complex between carboxypeptidase A and a hydrated ketomethylene substrate analogue
    Proc Natl Acad Sci U S A85, 684-688. PubMed  Europe PubMed  I
    117. 1987
  117. Akama,K. and Tobita,T.
    Simultaneous purification of carboxypeptidase A, carboxypeptidase B and chymotrypsin C from autolyzed porcine pancreas glands
    Anal Sci3, 167-170. DOI
  118. Auld,D.S. and Vallee,B.L.
    Carboxypeptidase A
    201-255.
  119. Christianson,D.W. and Lipscomb,W.N.
    Carboxypeptidase A: novel enzyme-substrate-product complex
    J Am Chem Soc109, 5536-5538.
  120. [YEAR:15-1-1987]Gardell,S.J., Hilvert,D., Barnett,J., Kaiser,E.T. and Rutter,W.J.
    Use of directed mutagenesis to probe the role of tyrosine 198 in the catalytic mechanism of carboxypeptidase A
    J Biol Chem262, 576-582. PubMed  Europe PubMed
    121. 1986
  121. [YEAR:11-2-1986]Galdes,A., Auld,D.S. and Vallee,B.L.
    Elucidation of the chemical nature of the steady-state intermediates in the mechanism of carboxypeptidase A
    Biochemistry25, 646-651. PubMed  Europe PubMed
  122. Hilvert,D., Gardell,S.J., Rutter,W.J. and Kaiser,E.T.
    Evidence against a crucial role for the phenolic hydroxyl of Tyr-248 in peptide and ester hydrolyses catalyzed by carboxypeptidase A: comparative studies of the pH dependencies of the native and Phe-248-mutant forms
    J Am Chem Soc108, 5298-5304.
    123. 1985
  123. [YEAR:17-12-1985]Bicknell,R., Schaeffer,A., Auld,D.S., Riordan,J.F., Monnanni,R. and Bertini,I.
    Protease susceptibility of zinc- and apo-carboxypeptidase A
    Biochem Biophys Res Commun133, 787-793. PubMed  Europe PubMed
  124. [YEAR:17-12-1985]Galardy,R.E. and Kortylewicz,Z.P.
    alpha-Bromo ketone substrate analogues are powerful reversible inhibitors of carboxypeptidase A
    Biochemistry24, 7607-7612. PubMed  Europe PubMed  I
  125. [YEAR:10-10-1985]Gardell,S.J., Craik,C.S., Hilvert,D., Urdea,M.S. and Rutter,W.J.
    Site-directed mutagenesis shows that tyrosine 248 of carboxypeptidase A does not play a crucial role in catalysis
    Nature317, 551-555. PubMed  Europe PubMed
    126. 1984
  126. Auld,D.S., Galdes,A., Geoghegan,K.F., Holmquist,B., Martinelli,R.A. and Vallee,B.L.
    Cryospectrokinetic characterization of intermediates in biochemical reactions: carboxypeptidase A
    Proc Natl Acad Sci U S A81, 5041-5045. PubMed  Europe PubMed
  127. [YEAR:24-4-1984]Galardy,R.E. and Kortylewicz,Z.P.
    Inhibition of carboxypeptidase A by aldehyde and ketone substrate analogues
    Biochemistry23, 2083-2087. PubMed  Europe PubMed  I
    128. 1983
  128. [YEAR:12-4-1983]Galdes,A., Auld,D.S. and Vallee,B.L.
    Cryokinetic studies of the intermediates in the mechanism of carboxypeptidase A
    Biochemistry22, 1888-1893. PubMed  Europe PubMed
  129. [YEAR:12-4-1983]Geoghegan,K.F., Holmquist,B., Spilburg,C.A. and Vallee,B.L.
    Spectral properties of cobalt carboxypeptidase A. Interaction of the metal atom with anions
    Biochemistry22, 1847-1852. PubMed  Europe PubMed
  130. [YEAR:26-4-1983]Geoghegan,K.F., Galdes,A., Martinelli,R.A., Holmquist,B., Auld,D.S. and Vallee,B.L.
    Cryospectroscopy of intermediates in the mechanism of carboxypeptidase A
    Biochemistry22, 2255-2262. PubMed  Europe PubMed
  131. [YEAR:19-7-1983]King,S.W. and Fife,T.H.
    Effects of metal ion substitution on carboxypeptidase A catalyzed hydrolysis of O-trans-cinnamoyl-L-beta-phenyllactate
    Biochemistry22, 3603-3610. PubMed  Europe PubMed
  132. [YEAR:1-4-1983]Pearce,G. and Ryan,C.A.
    A rapid, large-scale method for purification of the metallo-carboxypeptidase inhibitor from potato tubers
    Anal Biochem130, 223-225. PubMed  Europe PubMed
  133. [YEAR:21-6-1983]Peterson,L.M. and Holmquist,B.
    Human serum procarboxypeptidase A
    Biochemistry22, 3077-3082. PubMed  Europe PubMed
  134. Rees,D.C., Lewis,M. and Lipscomb,W.N.
    Refined crystal structure of carboxypeptidase A at 1.54 A resolution
    J Mol Biol168, 367-387. PubMed  Europe PubMed  S
  135. Rees,D.C. and Lipscomb,W.N.
    Crystallographic studies on apocarboxypeptidase A and the complex with glycyl-L-tyrosine
    Proc Natl Acad Sci U S A80, 7151-7154. PubMed  Europe PubMed  S
    136. 1982
  136. [YEAR:29-11-1982]Aviles,F.X., Segundo,B.S., Vilanova,M., Cuchillo,C.M. and Turner,C.
    The activation segment of procarboxypeptidase A from porcine pancreas constitutes a folded structural domain
    FEBS Lett149, 257-260. PubMed  Europe PubMed
  137. [YEAR:8-6-1982]Bachovchin,W.W., Kanamori,K., Vallee,B.L. and Roberts,J.D.
    Nitrogen-15 nuclear magnetic resonance of arsanilazotyrosine-248 carboxypeptidase A and its complex with beta-phenylpropionate. Structure and dynamics in solution
    Biochemistry21, 2885-2892. PubMed  Europe PubMed
  138. [YEAR:30-3-1982]Bartlett,P.A., Spear,K.L. and Jacobsen,N.E.
    A thioamide substrate of carboxypeptidase A
    Biochemistry21, 1608-1611. PubMed  Europe PubMed
  139. [YEAR:10-1-1982]Kuo,L.C. and Makinen,M.W.
    Hydrolysis of esters by carboxypeptidase A requires a penta-coordinate metal ion
    J Biol Chem257, 24-27. PubMed  Europe PubMed
  140. [YEAR:28-9-1982]Palmer,A.R., Ellis,P.D. and Wolfenden,R.
    Extreme state of ionization of benzylsuccinate bound by carboxypeptidase A
    Biochemistry21, 5056-5059. PubMed  Europe PubMed  I
  141. Quinto,C., Quiroga,M., Swain,W.F., Nikovits,W.C., Jr., Standring,D.N., Pictet,R.L., Valenzuela,P. and Rutter,W.J.
    Rat preprocarboxypeptidase A: cDNA sequence and preliminary characterization of the gene
    Proc Natl Acad Sci U S A79, 31-35. PubMed  Europe PubMed
  142. [YEAR:25-9-1982]Rees,D.C. and Lipscomb,W.N.
    Refined crystal structure of the potato inhibitor complex of carboxypeptidase A at 2.5 A resolution
    J Mol Biol160, 475-498. PubMed  Europe PubMed  S
  143. [YEAR:22-9-1982]Segundo,B.S., Martinez,M.C., Vilanova,M., Cuchillo,C.M. and Aviles,F.X.
    The severed activation segment of porcine pancreatic procarboxypeptidase A is a powerful inhibitor of the active enzyme. Isolation and characterisation of the activation peptide
    Biochim Biophys Acta707, 74-80. PubMed  Europe PubMed
  144. [YEAR:1-8-1982]Vendrell,J., Aviles,F.X., San Segundo,B. and Cuchillo,C.M.
    Isolation and re-association of the subunits from the pro-(carboxypeptidase A)-pro-(proteinase E) binary complex from pig pancreas
    Biochem J205, 449-452. PubMed  Europe PubMed
    145. 1981
  145. Bodwell,J.E. and Meyer,W.L.
    Purification and characterization of carboxypeptidase A from rat skeletal muscle
    Biochemistry20, 2767-2777. PubMed  Europe PubMed
  146. [YEAR:10-3-1981]Kobayashi,Y., Kobayashi,R. and Hirs,C.H.
    Identification of zymogen E in a complex with bovine procarboxypeptidase A
    J Biol Chem256, 2466-2470. PubMed  Europe PubMed
  147. [YEAR:16-6-1981]Koide,A. and Yoshizawa,M.
    Crystallization and identification of a binary complex of a elastase-I and a carboxypeptidase A gamma from porcine pancreas
    Biochem Biophys Res Commun100, 1091-1098. PubMed  Europe PubMed
  148. [YEAR:16-9-1981]Mock,W.L., Chen,J.T. and Tsang,J.W.
    Hydrolysis of a thiopeptide by cadmium carboxypeptidase A
    Biochem Biophys Res Commun102, 389-396. PubMed  Europe PubMed
  149. Rees,D.C. and Lipscomb,W.N.
    Binding of ligands to the active site of carboxypeptidase A
    Proc Natl Acad Sci U S A78, 5455-5459. PubMed  Europe PubMed  I
  150. Rees,D.C., Lewis,M., Honzatko,R.B., Lipscomb,W.N. and Hardman,K.D.
    Zinc environment and cis peptide bonds in carboxypeptidase A at 1.75-A resolution
    Proc Natl Acad Sci U S A78, 3408-3412. PubMed  Europe PubMed  S
  151. [YEAR:31-3-1981]Scheule,R.K., Han,S.L., Van Wart,H.E., Vallee,B.L. and Scheraga,H.A.
    Resonance Raman spectroscopy of arsanilazocarboxypeptidase A: mode of inhibitor binding and active-site topography
    Biochemistry20, 1778-1784. PubMed  Europe PubMed
    152. 1980
  152. [YEAR:15-9-1980]Cueni,L.B., Bazzone,T.J., Riordan,J.F. and Vallee,B.L.
    Affinity chromatographic sorting of carboxypeptidase A and its chemically modified derivatives
    Anal Biochem107, 341-349. PubMed  Europe PubMed  I
  153. [YEAR:31-12-1980]Hass,G.M. and Ryan,C.A.
    Cleavage of the carboxypeptidase inhibitor from potatoes by carboxypeptidase A
    Biochem Biophys Res Commun97, 1481-1486. PubMed  Europe PubMed
  154. [YEAR:11-4-1980]Homandberg,G.A., Minor,S.T. and Peanasky,R.J.
    Modification of the carboxypeptidase A active site residue Glu-270 prevents interaction with a protein protease inhibitor from Ascaris
    Biochim Biophys Acta612, 384-394. PubMed  Europe PubMed
  155. Lipscomb,W.N.
    Carboxypeptidase A mechanisms
    Proc Natl Acad Sci U S A77, 3875-3878. PubMed  Europe PubMed
  156. Rees,D.C. and Lipscomb,W.N.
    Structure of potato inhibitor complex of carboxypeptidase A at 5.5-A resolution
    Proc Natl Acad Sci U S A77, 277-280. PubMed  Europe PubMed  S
  157. Rees,D.C., Honzatko,R.B. and Lipscomb,W.N.
    Structure of an actively exchanging complex between carboxypeptidase A and a substrate analogue
    Proc Natl Acad Sci U S A77, 3288-3291. PubMed  Europe PubMed  S
  158. Rees,D.C. and Lipscomb,W.N.
    Structure of the potato inhibitor complex of carboxypeptidase A at 2.5-A resolution
    Proc Natl Acad Sci U S A77, 4633-4637. PubMed  Europe PubMed  S
  159. Rogers,R.J. and Billo,E.J.
    Inhibition of cobalt(II) carboxypeptidase A by ligands. Kinetic evidence for the formation of a ternary enzyme-metal-ligand complex
    J Inorg Biochem12, 335-341. PubMed  Europe PubMed  I
  160. [YEAR:19-2-1980]Scheule,R.K., Van Wart,H.E., Vallee,B.L. and Scheraga,H.A.
    Resonance Raman spectroscopy of arsanilazocarboxypeptidase A: conformational equilibria in solution and crystal phases
    Biochemistry19, 759-766. PubMed  Europe PubMed
  161. Thompson,J.S., Gehring,H. and Vallee,B.L.
    Structure and function of carboxypeptidase A alpha in supercooled water
    Proc Natl Acad Sci U S A77, 132-136. PubMed  Europe PubMed
    162. 1979
  162. [YEAR:27-9-1979]Bauer,R., Christensen,C., Johansen,J.T., Bethune,J.L. and Vallee,B.L.
    Perturbed angular correlation gamma ray (PAC) spectroscopy of 111Cd carboxypeptidase A alpha
    Biochem Biophys Res Commun90, 679-685. PubMed  Europe PubMed
  163. [YEAR:2-10-1979]Bazzone,T.J., Sokolovsky,M., Cueni,L.B. and Vallee,B.L.
    Single-step isolation and resolution of pancreatic carboxypeptidases A and B
    Biochemistry18, 4362-4366. PubMed  Europe PubMed  I
  164. Billo,E.J.
    Kinetics of interaction of ligands with carboxypeptidase A
    J Inorg Biochem10, 331-339. PubMed  Europe PubMed DOI
  165. Holmquist,B. and Vallee,B.L.
    Metal-coordinating substrate analogs as inhibitors of metalloenzymes
    Proc Natl Acad Sci U S A76, 6216-6220. PubMed  Europe PubMed  I
  166. [YEAR:27-3-1979]Liu Wu,L.N. and Horton,R.
    Structure of 2-hydroxy-5-nitrobenzylated carboxypeptidase A
    Biochim Biophys Acta577, 22-33. PubMed  Europe PubMed
  167. [YEAR:25-1-1979]Makinen,M.W., Kuo,L.C., Dymowski,J.J. and Jaffer,S.
    Catalytic role of the metal ion of carboxypeptidase A in ester hydrolysis
    J Biol Chem254, 356-366. PubMed  Europe PubMed
  168. Marinkovic,D.V.
    N-terminal amino acid sequences of human carboxypeptidases A, B1, and B2
    Biochem Med22, 11-26. PubMed  Europe PubMed
  169. Nakano,A., Tasumi,M., Fujiwara,K., Fuwa,K. and Miyazawa,T.
    Nuclear magnetic relaxation study on the interaction of glycyl-L-tyrosine with manganese-carboxypeptidase A in solution
    J Biochem86, 1001-1011. PubMed  Europe PubMed
  170. Poorman,R., Kuo,M., Johnson,D.I., Lin,S. and Sebastian,J.F.
    Inhibition of carboxypeptidase A catalyzed peptide hydrolysis by 3-phenylpropanoate at activating and nonactivating substrate concentrations
    Can J Biochem57, 357-365. PubMed  Europe PubMed  I
  171. [YEAR:10-12-1979]Urdea,M.S. and Legg,J.I.
    A peptidase-inactive derivative of carboxypeptidase A modified specifically at tyrosine 248. Cobalt(III) (ethylenediamine-N,N'-diacetato) (arsanilazotyrosinato 248 carboxypeptidase A)
    J Biol Chem254, 11868-11874. PubMed  Europe PubMed
    172. 1978
  172. [YEAR:10-11-1978]Bunting,J.W. and Kabir,S.H.
    The pH-dependence of the non-specific esterase activity of carboxypeptidase A
    Biochim Biophys Acta527, 98-107. PubMed  Europe PubMed
  173. [YEAR:8-8-1978]Van Wart,H.E. and Vallee,B.L.
    Enzymatically inactive, exchange-inert Co(III)-carboxypeptidase A: role of inner sphere coordination in peptide and ester catalysis
    Biochemistry17, 3385-3394. PubMed  Europe PubMed
    174. 1977
  174. Ager,S.P. and Hass,G.M.
    Affinity chromatography of pancreatic carboxypeptidases using a carboxypeptidase inhibitor from potatoes as ligand
    Anal Biochem83, 285-295. PubMed  Europe PubMed
  175. [YEAR:10-11-1977]Kester,W.R. and Matthews,B.W.
    Comparison of the structures of carboxypeptidase A and thermolysin
    J Biol Chem252, 7704-7710. PubMed  Europe PubMed  S
    176. 1976
  176. [YEAR:15-6-1976]Ako,H., Hass,G.M., Grahn,D.T. and Neurath,H.
    Carboxypeptidase inhibitor from potatoes. Interaction with derivatives of carboxypeptidase A
    Biochemistry15, 2573-2578. PubMed  Europe PubMed
  177. [YEAR:24-2-1976]Bazzone,T.J. and Vallee,B.L.
    Bovine procarboxypeptidase A: kinetics of peptide and ester hydrolysis
    Biochemistry15, 868-875. PubMed  Europe PubMed
  178. [YEAR:13-1-1976]Hass,G.M., Ako,H., Grahn,D.T. and Neurath,H.
    Carboxypeptidase inhibitor from potatoes. The effects of chemical modifications on inhibitory activity
    Biochemistry15, 93-100. PubMed  Europe PubMed
  179. [YEAR:25-4-1976]Homandberg,G.A. and Peanasky,R.J.
    Characterization of proteins from Ascaris lumbricoides which bind specifically to carboxypeptidase
    J Biol Chem251, 2226-2233. PubMed  Europe PubMed
  180. Makinen,M.W., Yammura,K. and Kaiser,E.T.
    Mechanism of action of carboxypeptidase A in ester hydrolysis
    Proc Natl Acad Sci U S A73, 3882-3886. PubMed  Europe PubMed
    181. 1975
  181. Harrison,L.W., Auld,D.S. and Vallee,B.L.
    Intramolecular arsanilazotyrosine-248-Zn complex of carboxypeptidase A: a monitor of catalytic events
    Proc Natl Acad Sci U S A72, 3930-3933. PubMed  Europe PubMed
  182. [YEAR:25-2-1975]Johansen,J.T. and Vallee,B.L.
    Environment and conformation dependent sensitivity of the arsanilazotyrosine-248 carboxypeptidase A chromophore
    Biochemistry14, 649-660. PubMed  Europe PubMed
  183. [YEAR:2-12-1975]Nau,H. and Riordan,J.F.
    Gas chromatography-mass spectrometry for probing the structure and mechanism of action of enzyme active sites. The role of Glu-270 in carboxypeptidase A
    Biochemistry14, 5285-5294. PubMed  Europe PubMed
    184. 1974
  184. [YEAR:8-10-1974]Auld,D.S. and Holmquist,B.
    Carboxypeptidase A. Differences in the mechanisms of ester and peptide hydrolysis
    Biochemistry13, 4355-4361. PubMed  Europe PubMed
  185. [YEAR:10-9-1974]Ryan,C.A., Hass,G.M. and Kuhn,R.W.
    Purification and properties of a carboxypeptidase inhibitor from potatoes
    J Biol Chem249, 5495-5499. PubMed  Europe PubMed
  186. [YEAR:13-8-1974]Uren,J.R. and Neurath,H.
    Intrinsic enzymatic activity of bovine procarboxypeptidase A S5
    Biochemistry13, 3512-3520. PubMed  Europe PubMed
    187. 1973
  187. [YEAR:22-5-1973]Byers,L.D. and Wolfenden,R.
    Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A
    Biochemistry12, 2070-2078. PubMed  Europe PubMed  I
  188. Johansen,J.T. and Vallee,B.L.
    Conformations of arsanilazotyrosine-248 carboxypeptidase A alpha, beta, gamma, comparison of crystals and solution
    Proc Natl Acad Sci U S A70, 2006-2010. PubMed  Europe PubMed
  189. [YEAR:10-10-1973]Naik,V.R. and Horton,H.R.
    Kinetics and spectral properties of carboxypeptidase A labeled with the 2-hydroxy-5-nitrobenzyl reporter group
    J Biol Chem248, 6709-6717. PubMed  Europe PubMed
  190. Rosenberg,R.C., Root,C.A., Wang,R.H., Cerdonio,M. and Gray,H.B.
    The nature of the ground states of cobalt(II) and nickel(II) carboxypeptidase A
    Proc Natl Acad Sci U S A70, 161-163. PubMed  Europe PubMed
    191. 1972
  191. [YEAR:19-12-1972]Auld,D.S., Latt,S.A. and Vallee,B.L.
    An approach to inhibition kinetics. Measurement of enzyme-substrate complexes by electronic energy transfer
    Biochemistry11, 4994-4999. PubMed  Europe PubMed
  192. [YEAR:5-9-1972]Bunting,J.W. and Murphy,J.
    The mechanism of substrate inhibition of the esterase activity of carboxypeptidase A
    Biochem Biophys Res Commun48, 1316-1322. PubMed  Europe PubMed
  193. [YEAR:25-1-1972]Byers,L.D. and Wolfenden,R.
    A potent reversible inhibitor of carboxypeptidase A
    J Biol Chem247, 606-608. PubMed  Europe PubMed  I
  194. [YEAR:14-4-1972]Glovsky,J., Hall,P.L. and Kaiser,E.T.
    On the action of carboxypeptidase A on ester substrates in alkaline solution
    Biochem Biophys Res Commun47, 244-247. PubMed  Europe PubMed  P
  195. Jones,S.R. and Hofmann,T.
    Penicillocarboxypeptidase-S, a nonspecific SH-dependent exopeptidase
    Can J Biochem50, 1297-1310. PubMed  Europe PubMed
  196. Latt,S.A., Auld,D.S. and Vallee,B.L.
    Fluorescende determination of carboxypeptidase A activity based on electronic energy transfer
    Anal Biochem50, 56-62. PubMed  Europe PubMed
  197. [YEAR:1-8-1972]Latt,S.A., Auld,D.S. and Vallee,B.L.
    Distance measurements at the active site of carboxypeptidase A during catalysis
    Biochemistry11, 3015-3022. PubMed  Europe PubMed
  198. Quiocho,F.A., McMurray,C.H. and Lipscomb,W.N.
    Similarities between the conformation of arsanilazotyrosine 248 of carboxypeptidase A in the crystalline state and in solution
    Proc Natl Acad Sci U S A69, 2850-2854. PubMed  Europe PubMed
    199. 1971
  199. Auld,D.S. and Vallee,B.L.
    Kinetics of carboxypeptidase A. pH and temperature dependence of tripeptide hydrolysis
    Biochemistry10, 2892-2897. PubMed  Europe PubMed
  200. [YEAR:16-6-1971]Fretto,L. and Strickland,E.H.
    Effect of temperature upon the conformations of carboxypeptidase A (Anson), A gamma Leu, A gamma Val, AND A alpha + beta
    Biochim Biophys Acta235, 473-488. PubMed  Europe PubMed
  201. Latt,S.A. and Vallee,B.L.
    Spectral properties of cobalt carboxypeptidase. The effects of substrates and inhibitors
    Biochemistry10, 4263-4270. PubMed  Europe PubMed
  202. [YEAR:17-8-1971]Petra,P.H.
    Modification of carboxyl groups in bovine carboxypeptidase A. I. Inactivation of the enzyme by N-ethyl-5-phenylisoxazolium-3'-sulfonate (Woodward's reagent K)
    Biochemistry10, 3163-3170. PubMed  Europe PubMed
  203. Petra,P.H., Hermodson,M.A., Walsh,K.A. and Neurath,H.
    Characterization of bovine carboxypeptidase A (Allan)
    Biochemistry10, 4023-4025. PubMed  Europe PubMed
  204. Quiocho,F.A. and Lipscomb,W.N.
    Carboxypeptidase A: a protein and an enzyme
    Adv Protein Chem25, 1-78. PubMed  Europe PubMed DOI
  205. [YEAR:7-12-1971]Reeck,G.R., Walsh,K.A. and Neurath,H.
    Isolation and characterization of carboxypeptidases A and B from activated pancreatic juice
    Biochemistry10, 4690-4698. PubMed  Europe PubMed
  206. Ryan,C.A.
    Inhibition of carboxypeptidase A by a naturally occurring polypeptide from potatoes
    Biochem Biophys Res Commun44, 1265-1270. PubMed  Europe PubMed
  207. Schechter,I. and Zazepizki,E.
    On the mechanism of acceleration of carboxypeptidase A activity
    Eur J Biochem18, 469-473. PubMed  Europe PubMed
  208. [YEAR:27-4-1971]Uren,J.R.
    Affinity chromatography of proteolytic enzymes
    Biochim Biophys Acta236, 67-73. PubMed  Europe PubMed
    209. 1970
  209. Auld,D.S. and Vallee,B.L.
    Kinetics of carboxypeptidase A. II. Inhibitors of the hydrolysis of oligopeptides
    Biochemistry9, 602-609. PubMed  Europe PubMed
  210. Auld,D.S. and Vallee,B.L.
    Kinetics of carboxypeptidase A. The pH dependence of tripeptide hydrolysis catalyzed by zinc, cobalt, and manganese enzymes
    Biochemistry9, 4352-4359. PubMed  Europe PubMed
  211. [YEAR:14-7-1970]Navon,G., Shulman,R.G., Wyluda,B.J. and Yamane,T.
    Nuclear magnetic resonance study of the binding of fluoride ions to carboxypeptidase A
    J Mol Biol51, 15-30. PubMed  Europe PubMed
  212. Neurath,H., Bradshaw,R.A., Petra,P.H. and Walsh,K.A.
    3. Carboxypeptidase. Bovine carboxypeptidase A - activation, chemical structure and molecular heterogeneity
    Philos Trans R Soc Lond B Biol Sci257, 159-176. PubMed  Europe PubMed
  213. Petra,P.H.
    Bovine procarboxypeptidase and carboxypeptidase A
    Methods Enzymol19, 460-503. DOI  V
  214. [YEAR:9-10-1970]Riordan,J.F. and Hayashida,H.
    Chemical evidence for a functional carboxyl group in carboxypeptidase A
    Biochem Biophys Res Commun41, 122-127. PubMed  Europe PubMed
    215. 1969
  215. Bradshaw,R.A., Ericsson,L.H., Walsh,K.A. and Neurath,H.
    The amino acid sequence of bovine carboxypeptidase A
    Proc Natl Acad Sci U S A63, 1389-1394. PubMed  Europe PubMed
  216. Bradshaw,R.A., Babin,D.R., Nomoto,M., Srinivasin,N.G., Ericsson,L.H., Walsh,K.A. and Neurath,H.
    The amino acid sequence of bovine carboxypeptidase A. II. Tryptic and chymotryptic peptides of the cyanogen bromide fragment F-III
    Biochemistry8, 3859-3871. PubMed  Europe PubMed
  217. Bradshaw,R.A.
    The amino acid sequence of bovine carboxypeptidase A. 3
    Biochemistry8, 3871-3877. PubMed  Europe PubMed
  218. [YEAR:15-1-1969]Hall,P.L., Kaiser,B.L. and Kaiser,E.T.
    pH dependence and competitive product inhibition of the carboxypeptidase A catalyzed hydrolysis of O-(trans-cinnamoyl)-L-beta-phenyllactate
    J Am Chem Soc91, 485-491. PubMed  Europe PubMed
  219. Kagan,H.M. and Vallee,B.L.
    Environmental sensitivity of azo chromophores in arsanilazocarboxypeptidase
    Biochemistry8, 4223-4231. PubMed  Europe PubMed
  220. Kaiser,B.L. and Kaiser,E.T.
    Effect of D2O on the carboxypeptidase-catalyzed hydrolysis of O-(trans-cinnamoyl)-L-beta-phenyllactate and N-(N-benzoylglycyl)-L-phenylalanine
    Proc Natl Acad Sci U S A64, 36-41. PubMed  Europe PubMed
  221. Lin,Y., Means,G.E. and Feeney,R.E.
    An assay for carboxypeptidases A and B on polypeptides from protein
    Anal Biochem32, 436-445. PubMed  Europe PubMed
  222. Lipscomb,W.N., Hartsuck,J.A., Quiocho,F.A. and Reeke,G.N., Jr.
    The structure of carboxypeptidase A. IX. The x-ray diffraction results in the light of the chemical sequence
    Proc Natl Acad Sci U S A64, 28-35. PubMed  Europe PubMed
  223. Nomoto,M., Srinivasan,N.G., Bradshaw,R.A., Wade,R.D. and Neurath,H.
    The amino acid sequence of bovine carboxypeptidase A. I. Preparation and properties of the fragments obtained by cyanogen bromide cleavage
    Biochemistry8, 2755-2762. PubMed  Europe PubMed
  224. Petra,P.H. and Neurath,H.
    The heterogeneity of bovine carboxypeptidase A. I. The chromatographic purification of carboxypeptidase A (Anson)
    Biochemistry8, 2466-2475. PubMed  Europe PubMed
  225. Petra,P.H. and Neurath,H.
    Heterogeneity of bovine carboxypeptidase A. II. Chromatographic purification of carboxypeptidase A (Cox)
    Biochemistry8, 5029-5036. PubMed  Europe PubMed
  226. Petra,P.H., Bradshaw,R.A., Walsh,K.A. and Neurath,H.
    Identification of the amino acid replacements characterizing the allotypic forms of bovine carboxypeptidase A
    Biochemistry8, 2762-2768. PubMed  Europe PubMed
  227. Pitout,M.J.
    A rapid spectrophotometric method for the assay of carboxypeptidase A
    Biochem Pharmacol18, 1829-1836. PubMed  Europe PubMed  A
    228. 1968
  228. [YEAR:23-5-1968]Davies,R.C., Auld,D.S. and Vallee,B.L.
    The effect of modifiers on the hydrolysis of esters and peptides by carboxypeptidase A
    Biochem Biophys Res Commun31, 628-633. PubMed  Europe PubMed
  229. Davies,R.C., Riordan,J.F., Auld,D.S. and Vallee,B.L.
    Kinetics of carboxypeptidase A. I. Hydrolysis of carbobenzoxyglycyl-l-phenylalanine, benzoylglycyl-l-phenylalanine, and hippuryl-dl-beta-phenyllactic acid by metal-substituted and acetylated carboxypeptidases
    Biochemistry7, 1090-1099. PubMed  Europe PubMed  P
  230. Lipscomb,W.N., Hartsuck,J.A., Reeke,G.N., Jr., Quiocho,F.A., Bethge,P.H., Ludwig,M.L., Steitz,T.A., Muirhead,H. and Coppola,J.C.
    The structure of carboxypeptidase A. VII. The 2.0-angstrom resolution studies of the enzyme and of its complex with glycyltyrosine, and mechanistic deductions
    Brookhaven Symp Biol21, 24-90. PubMed  Europe PubMed  S
  231. Navon,G., Shulman,R.G., Wyluda,B.J. and Yamane,T.
    Nuclear magnetic resonance studies of the active site of carboxypeptidase A
    Proc Natl Acad Sci U S A60, 86-91. PubMed  Europe PubMed
  232. Neurath,H., Bradshaw,R.A., Ericsson,L.H., Babin,D.R., Petra,P.H. and Walsh,K.A.
    Current status of the chemical structure of bovine pancreatic carboxypeptidase A
    Brookhaven Symp Biol21, 1-23. PubMed  Europe PubMed
  233. Vallee,B.L. and Riordan,J.F.
    Chemical approaches to the mode of action of carboxypeptidase A
    Brookhaven Symp Biol21, 91-119. PubMed  Europe PubMed
  234. Vallee,B.L., Riordan,J.F., Bethune,J.L., Coombs,T.L., Auld,D.S. and Sokolovsky,M.
    A model for substrate binding and kinetics of carboxypeptidase A
    Biochemistry7, 3547-3556. PubMed  Europe PubMed
    235. 1967
  235. Freisheim,J.H., Walsh,K.A. and Neurath,H.
    The activation of bovine procarboxypeptidase A. II. Mechanism of activation of the succinylated enzyme precursor
    Biochemistry6, 3020-3028. PubMed  Europe PubMed
  236. Freisheim,J.H., Walsh,K.A. and Neurath,H.
    The activation of bovine procarboxypeptidase A. I. Isolation and properties of the succinylated enzyme precursor
    Biochemistry6, 3010-3019. PubMed  Europe PubMed
  237. [YEAR:26-10-1967]Hall,P.L. and Kaiser,E.T.
    On the question of transesterification in carboxypeptidase-A catalyzed hydrolyses
    Biochem Biophys Res Commun29, 205-210. PubMed  Europe PubMed
  238. Piras,R. and Vallee,B.L.
    Procarboxypeptidase A-carboxypeptidase A interrelationships. Metal and substrate binding
    Biochemistry6, 348-357. PubMed  Europe PubMed
  239. Riordan,J.F., Sokolovsky,M. and Vallee,B.L.
    The functional tyrosyl residues of carboxypeptidase A. Nitration with tetranitromethane
    Biochemistry6, 3609-3617. PubMed  Europe PubMed
  240. Roholt,O.A. and Pressman,D.
    The sequence around the active-center tyrosyl residue of bovine pancreatic carboxypeptidase A
    Proc Natl Acad Sci U S A58, 280-285. PubMed  Europe PubMed
  241. Sokolovsky,M. and Vallee,B.L.
    Azocarboxypeptidase: functional consequences of tyrosyl and histidyl modification
    Biochemistry6, 700-708. PubMed  Europe PubMed
  242. [YEAR:25-10-1967]Steitz,T.A., Ludwig,M.L., Quiocho,F.A. and Lipscomb,W.N.
    The structure of carboxypepidase A. V. Studies of enzyme-substrate and enzyme-inhibitor complexes at 6 A resolution
    J Biol Chem242, 4662-4668. PubMed  Europe PubMed  S
    243. 1966
  243. [YEAR:20-3-1966]Carson,F.W. and Kaiser,E.T.
    pH dependence of the hydrolysis of O-acetyl-L-mandelate catalyzed by carboxypeptidase A. A critical examination
    J Am Chem Soc88, 1212-1223. PubMed  Europe PubMed
  244. Coleman,J.E., Pulido,P. and Vallee,B.L.
    Organic modifications of metallocarboxypeptidases
    Biochemistry5, 2019-2026. PubMed  Europe PubMed
  245. Coombs,T.L. and Vallee,B.L.
    The interaction of polypeptides and proteins with apocarboxypeptidase A
    Biochemistry5, 3272-3280. PubMed  Europe PubMed
  246. McClure,W.O. and Neurath,H.
    The reaction of carboxypeptidase A with chromophoric substrates
    Biochemistry5, 1425-1438. PubMed  Europe PubMed
  247. Schechter,I. and Berger,A.
    The hydrolysis of diastereoisomers of alanine peptides by carboxypeptidase A and leucine aminopeptidase
    Biochemistry5, 3371-3375. PubMed  Europe PubMed
  248. Shulman,R.G., Navon,G., Wyluda,B.J., Douglass,D.C. and Yamane,T.
    Nuclear magnetic resonance studies of the active site of carboxypeptidase A
    Proc Natl Acad Sci U S A56, 39-44. PubMed  Europe PubMed
  249. Simpson,R.T. and Vallee,B.L.
    Iodocarboxypeptidase
    Biochemistry5, 1760-1767. PubMed  Europe PubMed
  250. Walsh,K.A., Ericsson,L.H. and Neurath,H.
    Bovine carboxypeptidase A variants resulting from allelomorphism
    Proc Natl Acad Sci U S A56, 1339-1344. PubMed  Europe PubMed
    251. 1965
  251. Bethune,J.L.
    The polymerization of carboxypeptidase A in solutions containing sodium chloride
    Biochemistry4, 2691-2698. PubMed  Europe PubMed
  252. Bethune,J.L.
    Induction of polymer formation in solutions of bovine pancreas carboxypeptidase A by aromatic compounds
    Biochemistry4, 2698-2704. PubMed  Europe PubMed
  253. [YEAR:17-2-1965]Kaiser,E.T. and Carson,F.W.
    Inhibition of the esterase action of carboxypeptidase A
    Biochem Biophys Res Commun18, 457-461. PubMed  Europe PubMed
  254. [YEAR:9-12-1965]Kaiser,E.T., Awazu,S. and Carson,F.W.
    The hydrolysis of O-hippuryglycolate catalyzed by carboxypeptidase A. Evidence for possible allosteric effects
    Biochem Biophys Res Commun21, 444-447. PubMed  Europe PubMed
    255. 1964
  255. Allan,B.J., Keller,P.J. and Neurath,H.
    Procedures for the isolation of crystalline bovine pancreatic carboxypeptidase A. I. Isolation from acetone powders of pancreas glands
    Biochemistry3, 40-43. PubMed  Europe PubMed
  256. Bargetzi,J.P., Thompson,E.O., Sampath Kumar,K.S., Walsh,K.A. and Neurath,H.
    The amino- and carboxyl-terminal residues and the self-digestion of bovine pancreatic carboxypeptidase A
    J Biol Chem239, 3767-3774. PubMed  Europe PubMed
  257. Cox,D.J., Bovard,F.C., Bargetzi,J.P., Walsh,K.A. and Neurath,H.
    PROCEDURES FOR THE ISOLATION OF CRYSTALLINE BOVINE PANCREATIC CARBOXYPEPTIDASE A. II. ISOLATION OF CARBOXYPEPTIDASE A-ALPHA FROM PROCARBOXYPEPTIDASE A
    Biochemistry3, 44-47. PubMed  Europe PubMed
  258. Kumar,K.S., Clegg,J.B. and Walsh,K.A.
    The N-terminal sequence of bovine carboxypeptidase A and its relation of zymogen activation
    Biochemistry3, 1728-1732. PubMed  Europe PubMed
  259. McClure,W.O., Neurath,H. and Walsh,K.A.
    The reaction of carboxypeptidase A with hippuryl-DL-beta-phenyllactate
    Biochemistry3, 1897-1901. PubMed  Europe PubMed
    260. 1963
  260. Folk,J.E.
    THE PORCINE PANCREATIC CARBOXYPEPTIDASE A SYSTEM. II. MECHANISM OF THE CONVERSION OF CARBOXYPEPTIDASE A1 TO CARBOXYPEPTIDASE A2
    J Biol Chem238, 3895-3898. PubMed  Europe PubMed
  261. Folk,J.E. and Schirmer,E.W.
    THE PORCINE PANCREATIC CARBOXYPEPTIDASE A SYSTEM. I. THREE FORMS OF THE ACTIVE ENZYME
    J Biol Chem238, 3884-3894. PubMed  Europe PubMed
  262. [YEAR:15-1-1963]Vallee,B.L., Riordan,J.F. and Coleman,J.E.
    Carboxypeptidase A: approaches to the chemical nature of the active center and the mechanisms of action
    Proc Natl Acad Sci U S A49, 109-116. PubMed  Europe PubMed
    263. 1962
  263. Coleman,J.E. and Vallee,B.L.
    Apocarboxypeptidase-substrate complexes
    J Biol Chem237, 3430-3436. PubMed  Europe PubMed
  264. Coleman,J.E. and Vallee,B.L.
    Metallocarboxypeptidasesubstrate complexes
    Biochemistry1, 1083-1092. PubMed  Europe PubMed
  265. Coombs,T.L., Felber,J.P. and Vallee,B.L.
    Metallocarboxpeptidases: mechanism of inhibition by chelating agents, mercaptans, and metal ions
    Biochemistry1, 899-905. PubMed  Europe PubMed  I
  266. Felber,J.P., Coombs,T.L. and Vallee,B.L.
    The mechanism of inhibition of carboxypeptidase A by 1,10-phenanthroline
    Biochemistry1, 231-238. PubMed  Europe PubMed  I
  267. Walsh,K.A., Sampath Kumar,K.S., Bargetzi,J.P. and Neurath,H.
    Approaches to the selective chemical labeling of the active site of carboxypeptidase A
    Proc Natl Acad Sci U S A48, 1443-1449. PubMed  Europe PubMed
  268. [YEAR:15-10-1961]Brown,J.R., Cox,D.J., Greenshields,R.N., Walsh,K.A., Yamasaki,M. and Neurath,H.
    The chemical structure and enzymatic functions of bovine procarboxypeptidase A
    Proc Natl Acad Sci U S A47, 1554-1560. PubMed  Europe PubMed
    269. 1961
  269. Coleman,J.E. and Vallee,B.L.
    Metallocarboxypeptidases: stability constants and enzymatic characteristics
    J Biol Chem236, 2244-2249. PubMed  Europe PubMed
    270. 1960
  270. Coleman,J.E. and Vallee,B.L.
    Metallocarboxypeptidases
    J Biol Chem235, 390-395. PubMed  Europe PubMed
  271. Rupley,J.A. and Neurath,H.
    The physical properties of metal-free carboxypeptidase
    J Biol Chem235, 609-615. PubMed  Europe PubMed
  272. Vallee,B.L., Coombs,T.L. and Hoch,F.L.
    The "active site" of bovine pancreatic carboxypeptidase A
    J Biol Chem235, C45-C47. PubMed  Europe PubMed
  273. Vallee,B.L., Rupley,J.A., Coombs,T.L. and Neurath,H.
    The role of zinc in carboxypeptidase
    J Biol Chem235, 64-69.
    274. 1959
  274. Davie,E.W., Newman,C.R. and Wilcox,P.E.
    Action of carboxypeptidase on beta-lactoglobulin
    J Biol Chem234, 2635-2641. PubMed  Europe PubMed
    275. 1958
  275. Keller,P.J., Cohen,E. and Neurath,H.
    Procarboxypeptidase. II. Chromatographic isolation, further characterization, and activation
    J Biol Chem230, 905-915. PubMed  Europe PubMed
    276. 1956
  276. Cohen,E., Keller,P.J. and Neurath,H.
    Purification and properties of procarboxypeptidase
    J Biol Chem223, 457-467. PubMed  Europe PubMed
  277. Davis,N.C.
    Action of proteolytic enzymes on some peptides and derivatives containing histidine
    J Biol Chem223, 935-947. PubMed  Europe PubMed  P
    278. 1955
  278. Vallee,B.L. and Neurath,H.
    Carboxypeptidase, a zinc metalloenzyme
    J Biol Chem217, 253-261. PubMed  Europe PubMed
    279. 1954
  279. Smith,E.L. and Stockell,A.
    Amino acid composition of crystalline carboxypeptidase
    J Biol Chem207, 501-514. PubMed  Europe PubMed
    280. 1953
  280. Thompson,E.O.
    The N-terminal sequence of carboxypeptidase
    Biochim Biophys Acta10, 633-634. PubMed  Europe PubMed
    281. 1951
  281. Ravin,H.A. and Seligman,A.M.
    The colorimetric estimation of carboxypeptidase activity
    J Biol Chem190, 391-402. PubMed  Europe PubMed  A
    282. 1950
  282. Neurath,H. and de Maria,G.
    The effect of anions on the activity of carboxypeptidase
    J Biol Chem186, 653-665. PubMed  Europe PubMed
    283. 1949
  283. Dekker,C.A., Taylor,S.P., Jr. and Fruton,J.S.
    Synthesis of peptides of methionine and their cleavage by proteolytic enzymes
    J Biol Chem180, 155-173. PubMed  Europe PubMed
  284. Elkins-Kaufman,E. and Neurath,H.
    Structural requirements for specific inhibitors of carboxypeptidase
    J Biol Chem178, 645-654. PubMed  Europe PubMed  I
  285. Hanson,H.T. and Smith,E.L.
    Papain resolution of DL-tryptophan; optical specificity of carboxypeptidase
    J Biol Chem179, 815-818. PubMed  Europe PubMed
  286. Smith,E.L., Brown,D.M. and Hanson,H.T.
    The sedimentation behavior and molecular weight of pancreatic carboxypeptidase
    J Biol Chem180, 33-36. PubMed  Europe PubMed
  287. Smith,E.L. and Hanson,H.T.
    The chemical nature and mode of action of pancreatic carboxypeptidase
    J Biol Chem179, 803-813. PubMed  Europe PubMed
  288. Snoke,J.E. and Neurath,H.
    Structural requirements of specific substrates for carboxypeptidase
    J Biol Chem181, 789-802. PubMed  Europe PubMed
    289. 1948
  289. Elkins-Kaufman,E. and Neurath,H.
    Kinetics and inhibition of carboxypeptidase activity
    J Biol Chem175, 893-911. PubMed  Europe PubMed
  290. Hanson,H.T. and Smith,E.L.
    The application of peptides containing beta-alanine to the study of the specificity of various peptidases
    J Biol Chem175, 833-848. PubMed  Europe PubMed
  291. Smith,E.L.
    Action of carboxypeptidase on peptide derivatives of L-tryptophan
    J Biol Chem175, 39-47. PubMed  Europe PubMed
  292. Smith,E.L. and Hanson,H.T.
    Pancreatic carboxypeptidase, a metal protein
    J Biol Chem176, 997-997. PubMed  Europe PubMed
  293. Snoke,J.E., Schwert,G.W. and Neurath,H.
    The specific esterase activity of carboxypeptidase
    J Biol Chem175, 7-13. PubMed  Europe PubMed
    294. 1947
  294. Neurath,H., Elkins,E. and Kaufman,S.
    The antipodal specificity and inhibition of crystalline carboxypeptidase
    J Biol Chem170, 221-226.
    295. 1946
  295. Putnam,F.W. and Neurath,H.
    Chemical and enzymatic properties of crystalline carboxypeptidase
    J Biol Chem166, 603-619. PubMed  Europe PubMed
  296. Stahmann,M.A., Fruton,J.S. and Bergmann,M.
    The specificity of carboxypeptidase
    J Biol Chem164, 753-760. PubMed  Europe PubMed
    297. 1942
  297. Bergmann,M. and Fruton,J.S.
    The influence of substrate structure on the kinetics of carboxypeptidase action
    J Biol Chem145, 247-252.
  298. Johnson,M.J. and Berger,J.
    The enzymatic properties of peptidases
    Adv Enzymol Relat Subj Biochem2, 69-92.
    299. 1940
  299. Hofmann,K. and Bergmann,M.
    The specificity of carboxypeptidase
    J Biol Chem134, 225-235.
    300. 1937
  300. Anson,M.L.
    Carboxypeptidase. III. The estimation of carboxypeptidase and pro-carboxypeptidase
    J Gen Physiol20, 781-786. PubMed  Europe PubMed DOI  A
  301. Anson,M.L.
    Carboxypeptidase. II. The partial purification of pro-carboxypeptidase
    J Gen Physiol20, 777-780. PubMed  Europe PubMed DOI
  302. Anson,M.L.
    Carboxypeptidase. I. The preparation of crystalline carboxypeptidase
    J Gen Physiol20, 663-669. PubMed  Europe PubMed DOI
  303. Bergmann,M. and Fruton,J.S.
    On proteolytic enzymes. XII. Regarding the specificity of aminopeptidase and carboxypeptidase. A new type of enzyme in the intestinal tract
    J Biol Chem117, 189-202.
    304. 1935
  304. Anson,M.L.
    Crystalline carboxypolypeptidase
    Science81, 467-468. PubMed  Europe PubMed DOI
    305. 1931
  305. Waldschmidt-Leitz,E.
    The mode of action and differentiation of proteolytic enzymes
    Physiol Rev11, 358-370.  V

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