Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M01.008: pyroglutamyl-peptidase II

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2020
  1. Charli,J.L., Rodriguez-Rodriguez,A., Hernandez-Ortega,K., Cote-Velez,A., Uribe,R.M., Jaimes-Hoy,L. and Joseph-Bravo,P.
    The thyrotropin-releasing hormone-degrading ectoenzyme, a therapeutic target?
    Front Pharmacol11, 640-640. PubMed  Europe PubMed DOI  V
  2. Ramirez-Exposito,M.J., Martinez-Martos,J.M., Canton-Habas,V. and Carrera-Gonzalez,M.D.P.
    Moderate Beer Consumption Modifies Tumoral Growth Parameters and Pyrrolidone Carboxypeptidase Type-I and Type-II Specific Activities in the Hypothalamus-Pituitary-Mammary Gland Axis in an Animal Model of Breast Cancer
    Nutr Cancer1-13. PubMed  Europe PubMed DOI
    3. 2012
  3. Sanchez,E., Charli,J.L. and Lechan,R.M.
    Pyroglutamyl-peptidase II
    [ISSN:978-0-12-407744-7]3, 414-419. DOI
    4. 2009
  4. Sanchez,E., Vargas,M.A., Singru,P.S., Pascual,I., Romero,F., Fekete,C., Charli,J.L. and Lechan,R.M.
    Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence
    Endocrinology150, 2283-2291. PubMed  Europe PubMed DOI
    5. 2008
  5. Cruz,R., Vargas,M.A., Uribe,R.M., Pascual,I., Lazcano,I., Yiotakis,A., Matziari,M., Joseph-Bravo,P. and Charli,J.L.
    Anterior pituitary pyroglutamyl peptidase II activity controls TRH-induced prolactin release
    Peptides29, 1953-1964. PubMed  Europe PubMed DOI
  6. Matziari,M., Bauer,K., Dive,V. and Yiotakis,A.
    Synthesis of the phosphinic analogue of thyrotropin releasing hormone
    J Org Chem73, 8591-8593. PubMed  Europe PubMed DOI  I
    7. 2006
  7. [YEAR:12-4-2006]Chavez-Gutierrez,L., Matta-Camacho,E., Osuna,J., Horjales,E., Joseph-Bravo,P., Maigret,B. and Charli,J.L.
    Homology modeling and site-directed mutagenesis of pyroglutamyl peptidase II. Insights into omega-versus aminopeptidase specificity in the M1 family
    J Biol Chem281, 18581-18590. PubMed  Europe PubMed DOI
    8. 2005
  8. Chavez-Gutierrez,L., Bourdais,J., Aranda,G., Vargas,M.A., Matta-Camacho,E., Ducancel,F., Segovia,L., Joseph-Bravo,P. and Charli,J.L.
    A truncated isoform of pyroglutamyl aminopeptidase II produced by exon extension has dominant-negative activity
    J Neurochem92, 807-817. PubMed  Europe PubMed DOI
  9. de Gortari,P., Romero,F., Cisneros,M. and Joseph-Bravo,P.
    Acute administration of alcohol modulates pyroglutamyl amino peptidase II activity and mRNA levels in rat limbic regions
    Neurochem Int46, 347-356. PubMed  Europe PubMed DOI
  10. [YEAR:31-3-2005]Kelly,J.A., Scalabrino,G.A., Slator,G.R., Cullen,A.A., Gilmer,J.F., Lloyd,D.G., Bennett,G.W., Bauer,K., Tipton,K.F. and Williams,C.H.
    Structure-activity studies with high-affinity inhibitors of pyroglutamyl-peptidase II
    Biochem J389, 569-576. PubMed  Europe PubMed DOI  I
    11. 2004
  11. Bauer,K.
    Pyroglutamyl-peptidase II
    [ISSN:0-12-079610-4]2, 303-307.  V
  12. Pascual,I., Gil-Parrado,S., Cisneros,M., Joseph-Bravo,P., Diaz,J., Possani,L.D., Charli,J.L. and Chavez,M.
    Purification of a specific inhibitor of pyroglutamyl aminopeptidase II from the marine annelide Hermodice carunculata. in vivo effects in rodent brain
    Int J Biochem Cell Biol36, 138-152. PubMed  Europe PubMed DOI  I
    13. 2002
  13. Schmitmeier,S., Thole,H., Bader,A. and Bauer,K.
    Purification and characterization of the thyrotropin-releasing hormone (TRH)-degrading serum enzyme and its identification as a product of liver origin
    Eur J Biochem269, 1278-1286. PubMed  Europe PubMed DOI
    14. 2001
  14. [YEAR:7-8-2001]Papadopoulos,T., Kelly,J.A. and Bauer,K.
    Mutational analysis of the thyrotropin-releasing hormone-degrading ectoenzyme. Similarities and differences with other members of the M1 family of aminopeptidases and thermolysin
    Biochemistry40, 9347-9355. PubMed  Europe PubMed DOI
  15. Schmitmeier,S., Thole,H., Bader,A. and Bauer,K.
    Purification and characterization of the thyrotropin-releasing hormone (TRH)-degrading serum enzyme and its identification as a product of liver origin
    Eur J Biochem269, 1278-1286.
    16. 2000
  16. [YEAR:2-6-2000]Kelly,J.A., Slator,G.R., Tipton,K.F., Williams,C.H. and Bauer,K.
    Kinetic investigation of the specificity of porcine brain thyrotropin-releasing hormone-degrading ectoenzyme for thyrotropin-releasing hormone-like peptides
    J Biol Chem275, 16746-16751. PubMed  Europe PubMed DOI
  17. [YEAR:3-11-2000]Mayas,M.D., Ramirez-Exposito,M.J., Garcia,M.J., Tsuboyama,G., Ramirez,M. and Martinez-Martos,J.M.
    Calcium-dependent modulation by ethanol of mouse synaptosomal pyroglutamyl aminopeptidase activity under basal and K(+)-stimulated conditions
    Neurosci Lett293, 199-202. PubMed  Europe PubMed DOI
  18. Vargas,M.A., Cisneros,M., Joseph-Bravo,P. and Charli,J.L.
    Regulation of adenohypophyseal pyroglutamyl aminopeptidase II activity by thyrotropin-releasing hormone and phorbol esters
    Endocrine13, 267-272. PubMed  Europe PubMed DOI
    19. 1999
  19. Schomburg,L., Turwitt,S., Prescher,G., Lohmann,D., Horsthemke,B. and Bauer,K.
    Human TRH-degrading ectoenzyme cDNA cloning, functional expression, genomic structure and chromosomal assignment
    Eur J Biochem265, 415-422. PubMed  Europe PubMed DOI
    20. 1998
  20. Charli,J.L., Vargas,M.A., Cisneros,M., de Gortari,P., Baeza,M.A., Jasso,P., Bourdais,J., Perez,L., Uribe,R.M. and Joseph-Bravo,P.
    TRH inactivation in the extracellular compartment: role of pyroglutamyl peptidase II
    Neurobiology (Bp)6, 45-57. PubMed  Europe PubMed  V
  21. [YEAR:8-12-1998]Cummins,P.M. and O'Connor,B.
    Pyroglutamyl peptidase: an overview of the three known enzymatic forms
    Biochim Biophys Acta1429, 1-17. PubMed  Europe PubMed DOI
  22. Gallagher,S.P. and O'Connor,B.
    A study of a highly specific pyroglutamyl aminopeptidase type-II from the membrane fraction of bovine brain
    Int J Biochem Cell Biol30, 115-133. PubMed  Europe PubMed DOI
  23. Heuer,H., Ehrchen,J., Bauer,K. and Schafer,M.K.
    Region-specific expression of thyrotrophin-releasing hormone-degrading ectoenzyme in the rat central nervous system and pituitary gland
    Eur J Neurosci10, 1465-1478. PubMed  Europe PubMed DOI
  24. Heuer,H., Schafer,M.K. and Bauer,K.
    The thyrotropin-releasing hormone-degrading ectoenzyme: the third element of the thyrotropin-releasing hormone-signaling system
    Thyroid8, 915-920. PubMed  Europe PubMed
  25. Lin,J. and Wilk,S.
    Quantitation and regulation of pyroglutamyl peptidase II messenger RNA levels in rat tissues and GH3 cells
    Neuroendocrinology67, 197-208. PubMed  Europe PubMed DOI
  26. Vargas,M.A., Bourdais,J., Sanchez,S., Uriostegui,B., Moreno,E., Joseph-Bravo,P. and Charli,J.L.
    Multiple hypothalamic factors regulate pyroglutamyl peptidase II in cultures of adenohypophyseal cells: Role of the cAMP pathway
    J Neuroendocrinol10, 199-206. PubMed  Europe PubMed DOI
    27. 1997
  27. Gallagher,S.P., O'Leary,R.M. and O'Connor,B.
    The development of two fluorimetric assays for the determination of pyroglutamyl aminopeptidase type-II activity
    Anal Biochem250, 1-9. PubMed  Europe PubMed DOI  A
    28. 1995
  28. Bauer,K.
    Inactivation of thyrotropin-releasing hormone (TRH) by the hormonally regulated TRH-degrading ectoenzyme: a potential regulator of TRH signals?
    Trends Endocrinol Metab6, 101-105. PubMed  Europe PubMed
  29. de Gortari,P., Fernandez-Guardiola,A., Martinez,A., Cisneros,M. and Joseph-Bravo,P.
    Changes in TRH and its degrading enzyme pyroglutamyl peptidase II, during the development of amygdaloid kindling
    Brain Res679, 144-150. PubMed  Europe PubMed DOI
  30. Kim,J. and Kim,K.
    The use of FAB mass spectrometry and pyroglutamate aminopeptidase digestion for the structure determination of pyroglutamate in modified peptides
    Biochem Mol Biol Int35, 803-811. PubMed  Europe PubMed
  31. O'Leary,R.M. and O'Connor,B.
    A study of a synaptosomal thyrotropin releasing hormone-inactivating pyroglutamate aminopeptidase from bovine brain
    Int J Biochem Cell Biol27, 881-890. PubMed  Europe PubMed DOI
  32. Schomburg,L. and Bauer,K.
    Thyroid hormones rapidly and stringently regulate the messenger RNA levels of the thyrotropin-releasing hormone (TRH) receptor and the TRH-degrading ectoenzyme
    Endocrinology136, 3480-3485. PubMed  Europe PubMed DOI
    33. 1994
  33. Awade,A.C., Cleuziat,P., Gonzales,T. and Robert-Baudouy,J.
    Pyrrolidone carboxyl peptidase (Pcp): an enzyme that removes pyroglutamic acid (pGlu) from pGlu-peptides and pGlu-proteins
    Proteins20, 34-51. PubMed  Europe PubMed DOI
  34. Bauer,K.
    Purification and characterization of the thyrotropin-releasing- hormone-degrading ectoenzyme
    Eur J Biochem224, 387-396. PubMed  Europe PubMed
  35. Schauder,B., Schomburg,L., Kohrle,J. and Bauer,K.
    Cloning of a cDNA encoding an ectoenzyme that degrades thyrotropin-releasing hormone
    Proc Natl Acad Sci U S A91, 9534-9538. PubMed  Europe PubMed
    36. 1993
  36. Czekay,G. and Bauer,K.
    Identification of the thyrotropin-releasing-hormone-degrading ectoenzyme as a metallopeptidase
    Biochem J290, 921-926. PubMed  Europe PubMed
    37. 1991
  37. [YEAR:1-2-1991]Scharfmann,R. and Aratan-Spire,S.
    Ontogeny of two topologically distinct TRH-degrading pyroglutamate aminopeptidase activities in the rat liver
    Regul Pept32, 75-83. PubMed  Europe PubMed DOI
    38. 1989
  38. Charli,J.L., Mendez,M., Vargas,M.A., Cisneros,M., Assai,M., Joseph-Bravo,P. and Wilk,S.
    Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices
    Neuropeptides14, 191-196. PubMed  Europe PubMed
  39. Wilk,S. and Wilk,E.K.
    Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme
    Neurochem Int15, 81-89. PubMed  Europe PubMed
    40. 1988
  40. Charli,J.L., Cruz,C., Vargas,M.A. and Joseph-Bravo,P.
    The narrow specificity pyroglutamate amino peptidase degrading TRH in rat brain is an ectoenzyme
    Neurochem Int13, 237-242. PubMed  Europe PubMed
    41. 1986
  41. Friedman,T.C. and Wilk,S.
    Delineation of a particulate thyrotropin-releasing hormone-degrading enzyme in rat brain by the use of specific inhibitors of prolyl endopeptidase and pyroglutamyl peptide hydrolase
    J Neurochem46, 1231-1239. PubMed  Europe PubMed  I
    42. 1985
  42. O'Connor,B. and O'Cuinn,G.
    Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain
    Eur J Biochem150, 47-52. PubMed  Europe PubMed
    43. 1984
  43. [YEAR:15-10-1984]O'Connor,B. and O'Cuinn,G.
    Localization of a narrow-specificity thyroliberin hydrolyzing pyroglutamate aminopeptidase in synaptosomal membranes of guinea-pig brain
    Eur J Biochem144, 271-278. PubMed  Europe PubMed
    44. 1979
  44. Bauer,K. and Nowak,P.
    Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond
    Eur J Biochem99, 239-246. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use