Literature for peptidase C14.001: caspase-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Braun,L.M. and Zeiser,R.
Cutting without cleaving: How caspase-1 shapes leukemia beyond enzymatic activity
Cell Chem Biol (2026) 33, 1-3. PubMed Europe PubMed DOI
Uible,E.E., Choi,I., Clough,C.A., Hassan,A., Anandappa,A.J., Fisher,J., Karki,B., Hueneman,K., Choi,K., Vick,E.J., Seibel,W., Greis,K.D., Lee,L., Jones,C., Chlon,T.M., Henao-Mejia,J., Pasare,C., Cunningham,J.T., Volk,A.G. and Starczynowski,D.T.
Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia
Cell Chem Biol (2026) 33, 59-73. PubMed Europe PubMed DOI

2025

Fu,X., Xu,W., Yang,Y., Li,D., Shi,W., Li,X., Chen,N., Lv,Q., Shi,Y., Xu,J., Xu,J., Yan,Y., Shi,F. and Li,X.
Diverse strategies utilized by coronaviruses to evade antiviral responses and suppress pyroptosis
Int J Biol Macromol (2025) 296, 139743-139743. PubMed Europe PubMed DOI
Mei,J., Schafer,N., Wei,P., Kong,Z., Li,S., Pann,P., Ehrnsperger,M., Johnstone,B., Matalova,E. and Grassel,S.
Targeting Caspase-1 in osteoarthritis: multi-omics insights into the effects of VX-765 on human chondrocyte function and phenotype
Front Immunol (2025) 16, 1677801-1677801. PubMed Europe PubMed DOI PMC EPMC
Shi,Y., Hu,Y., Li,J., Chen,H., Zhong,Q., Ma,X., Li,X., Zhang,S., Zhuang,S. and Liu,N.
Inhibition of Caspase-1 Suppresses GSDMD-mediated Peritoneal Mesothelial Cell Pyroptosis and Inflammation in Peritoneal Fibrosis
Small (2025) , e2409362-e2409362. PubMed Europe PubMed DOI K
Su,Y.T., Quagliato,S.M., St Louis,B.M., Abdelaziz,M.H., He,Y., Bondage,D., Lehman,S.S. and Lee,P.C.
Activation of the conserved Hippo kinases by inflammasome-triggered proteolytic cleavage controls programmed cell death in macrophages
Proc Natl Acad Sci U S A (2025) 122, e2418613122-e2418613122. PubMed Europe PubMed DOI PMC EPMC
Wang,X., Xie,X., Ni,J.Y., Li,J.Y., Sun,X.A., Xie,H.Y., Yang,N.H., Guo,H.J., Lu,L., Ning,M., Zhou,L., Liu,J., Xu,C., Zhang,W., Wen,Y., Shen,Q., Xu,H. and Lu,L.M.
USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation
Acta Pharmacol Sin (2025) 46, 159-170. PubMed Europe PubMed DOI
Xu,W., Huang,Y. and Zhou,R.
NLRP3 inflammasome in neuroinflammation and central nervous system diseases
Cell Mol Immunol (2025) PubMed Europe PubMed DOI V

2024

Ai,Y., Meng,Y., Yan,B., Zhou,Q. and Wang,X.
The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death
Mol Cell (2024) 84, 170-179. PubMed Europe PubMed DOI V
Azhar,G., Nagano,K., Patyal,P., Zhang,X., Verma,A. and Wei,J.Y.
Deletion of Interleukin-1beta Converting Enzyme Alters Mouse Cardiac Structure and Function
Biology (Basel) (2024) 13 PubMed Europe PubMed DOI PMC EPMC
Babcock,I.W., Sibley,L.A., Labuzan,S.A., Cowan,M.N., Sethi,I., Alemu,S., Kelly,A.G., Kovacs,M.A., Lukens,J.R. and Harris,T.H.
Caspase-1 in Cx3cr1-expressing cells drives an IL-18-dependent T cell response that promotes parasite control during acute Toxoplasma gondii infection
PLoS Pathog (2024) 20, e1012006-e1012006. PubMed Europe PubMed DOI
Billman,Z.P., Kovacs,S.B., Wei,B., Kang,K., Cisse,O.H. and Miao,E.A.
Caspase-1 activates gasdermin A in non-mammals
elife (2024) 12 PubMed Europe PubMed DOI PMC EPMC
Choudhury,S.M., Sarkar,R., Karki,R. and Kanneganti,T.D.
A comparative study of apoptosis, pyroptosis, necroptosis, and PANoptosis components in mouse and human cells
PLoS ONE (2024) 19, e0299577-e0299577. PubMed Europe PubMed DOI PMC EPMC
Fernandes,J.P., Branton,W.G., Cohen,E.A., Koopman,G., Kondova,I., Gelman,B.B. and Power,C.
Caspase cleavage of gasdermin E causes neuronal pyroptosis in HIV-associated neurocognitive disorder
Brain (2024) 147, 717-734. PubMed Europe PubMed DOI PMC EPMC K
Imre,G.
Pyroptosis in health and disease
Am J Physiol Cell Physiol (2024) 326, C784-C784. PubMed Europe PubMed DOI V
Janin,Y.L.
On the origins of SARS-CoV-2 main protease inhibitors
RSC Med Chem (2024) 15, 81-118. PubMed Europe PubMed DOI PMC EPMC V I
Marques-da-Silva,C., Schmidt-Silva,C., Baptista,R.P. and Kurup,S.P.
Inherently Reduced Expression of ASC Restricts Caspase-1 Processing in Hepatocytes and Promotes Plasmodium Infection
J Immunol (2024) 212, 596-606. PubMed Europe PubMed DOI PMC EPMC
Nadella,V. and Kanneganti,T.D.
Inflammasomes and their role in PANoptosomes
Curr Opin Immunol (2024) 91, 102489-102489. PubMed Europe PubMed DOI V
Thygesen,S.J., Burgener,S.S., Mudai,P., Monteleone,M., Boucher,D., Sagulenko,V., Schroder,K. and Stacey,K.J.
Fluorochrome-labeled inhibitors of caspase-1 require membrane permeabilization to efficiently access caspase-1 in macrophages
Eur J Immunol (2024) , e2350515-e2350515. PubMed Europe PubMed DOI
Zhang,J., Cai,H., Sun,W., Wu,W., Nan,Y., Ni,Y., Wu,X., Chen,M., Xu,H. and Wang,Y.
Endoplasmic reticulum aminopeptidase 2 regulates CD4(+) T cells pyroptosis in rheumatoid arthritis
Arthritis Res Ther (2024) 26, 36-36. PubMed Europe PubMed DOI PMC EPMC K
Zhen,H., Hu,Y., Liu,X., Fan,G. and Zhao,S.
The protease caspase-1: Activation pathways and functions
Biochem Biophys Res Commun (2024) 717, 149978-149978. PubMed Europe PubMed DOI V
Zheng,W., Marini,W., Murakami,K., Sotov,V., Butler,M., Gorrini,C., Ohashi,P.S. and Reedijk,M.
Caspase-1-dependent spatiality in triple-negative breast cancer and response to immunotherapy
Nat Commun (2024) 15, 8514-8514. PubMed Europe PubMed DOI PMC EPMC

2023

Alam,M.A., Caocci,M., Ren,M., Chen,Z., Liu,F., Khatun,M.S., Kolls,J.K., Qin,X. and Burdo,T.H.
Deficiency of Caspase-1 Attenuates HIV-1-Associated Atherogenesis in Mice
Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC
Anderson,M.J., den Hartigh,A.B. and Fink,S.L.
Molecular Mechanisms of Pyroptosis
Methods Mol Biol (2023) 2641, 1-16. PubMed Europe PubMed DOI V
Leal,V.N.C. and Pontillo,A.
Canonical Inflammasomes
Methods Mol Biol (2023) 2696, 1-27. PubMed Europe PubMed DOI V
Li,X., Jiang,Q., Song,G., Barkestani,M.N., Wang,Q., Wang,S., Fan,M., Fang,C., Jiang,B., Johnson,J., Geirsson,A., Tellides,G., Pober,J.S. and Jane-Wit,D.
A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells
Nat Commun (2023) 14, 3002-3002. PubMed Europe PubMed DOI PMC EPMC
Sahoo,G., Samal,D., Khandayataray,P. and Murthy,M.K.
A Review on Caspases: Key Regulators of Biological Activities and Apoptosis
Mol Neurobiol (2023) 60, 5805-5837. PubMed Europe PubMed DOI V
Saller,B.S., Neuwirt,E. and Gross,O.
Methods to Activate the NLRP3 Inflammasome
Methods Mol Biol (2023) 2696, 169-197. PubMed Europe PubMed DOI
Shi,X., Sun,Q., Hou,Y., Zeng,H., Cao,Y., Dong,M., Ding,J. and Shao,F.
Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome
Nature (2023) 624, 442-450. PubMed Europe PubMed DOI
Wang,Y., Fang,D., Yang,Q., You,J., Wang,L., Wu,J., Zeng,M. and Luo,M.
Interactions between PCSK9 and NLRP3 inflammasome signaling in atherosclerosis
Front Immunol (2023) 14, 1126823-1126823. PubMed Europe PubMed DOI PMC EPMC V
Xiao,L., Magupalli,V.G. and Wu,H.
Cryo-EM structures of the active NLRP3 inflammasome disc
Nature (2023) 613, 595-600. PubMed Europe PubMed DOI PMC EPMC

2022

Banerjee,S.K., Chatterjee,A., Gupta,S. and Nagar,A.
Activation and Regulation of NLRP3 by Sterile and Infectious Insults
Front Immunol (2022) 13, 896353-896353. PubMed Europe PubMed DOI PMC EPMC V
Bibo-Verdugo,B., Joglekar,I., Karadi Giridhar,M.N., Ramirez,M.L., Snipas,S.J., Clark,A.C., Poreba,M. and Salvesen,G.S.
Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold
J Biol Chem (2022) 298, 101931-101931. PubMed Europe PubMed DOI PMC EPMC
Chen,C. and Xu,P.
Activation and Pharmacological Regulation of Inflammasomes
Biomolecules (2022) 12 PubMed Europe PubMed DOI PMC EPMC V
Guan,Y., Gu,Y., Li,H., Liang,B., Han,C., Zhang,Y., Liu,Q., Wei,W. and Ma,Y.
NLRP3 inflammasome activation mechanism and its role in autoimmune liver disease
Acta Biochim Biophys Sin (Shanghai) (2022) 54, 1577-1586. PubMed Europe PubMed DOI V
Han,L., Hao,Y., Wu,X. and Hu,D.
PSMB5 Alleviates Ulcerative Colitis by Inhibiting ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis
Dis Markers (2022) 2022, 2329904-2329904. PubMed Europe PubMed DOI PMC EPMC
Hu,Y., Jiang,Y., Li,S., Ma,X., Chen,M., Yang,R., Wen,S., Moynagh,P.N., Wang,B., Hu,G. and Yang,S.
The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1/11
Proc Natl Acad Sci U S A (2022) 119, e2210809119-e2210809119. PubMed Europe PubMed DOI PMC EPMC
Liao,Y., Liu,K. and Zhu,L.
Emerging Roles of Inflammasomes in Cardiovascular Diseases
Front Immunol (2022) 13, 834289-834289. PubMed Europe PubMed DOI PMC EPMC V
Lin,C., Jiang,Z., Cao,L., Zou,H. and Zhu,X.
Role of NLRP3 inflammasome in systemic sclerosis
Arthritis Res Ther (2022) 24, 196-196. PubMed Europe PubMed DOI PMC EPMC V
Lin,Z., Xia,Y., Guo,J., Xu,G., Liu,Y., Yang,Y., Xie,H., Huang,Y. and Fu,Q.
Caspase-1 deficiency impairs neutrophils recruitment and bacterial clearance in Streptococcus equi ssp. zooepidemicus infected mice
Vet Microbiol (2022) 268, 109411-109411. PubMed Europe PubMed DOI
Lv,H., Liu,X. and Zhou,H.
USP25 UPREGULATION BOOSTS GSDMD -MEDIATED PYROPTOSIS OF ACINAR CELLS IN ACUTE PANCREATITIS
Shock (2022) 58, 408-416. PubMed Europe PubMed DOI
Paget,C., Doz-Deblauwe,E., Winter,N. and Briard,B.
Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases
Cells (2022) 11 PubMed Europe PubMed DOI PMC EPMC V
Ross,C., Chan,A.H., von Pein,J.B., Maddugoda,M.P., Boucher,D. and Schroder,K.
Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes
Annu Rev Immunol (2022) PubMed Europe PubMed DOI V
Sullivan,G.P., Davidovich,P., Munoz-Wolf,N., Ward,R.W., Hernandez Santana,Y.E., Clancy,D.M., Gorman,A., Najda,Z., Turk,B., Walsh,P.T., Lavelle,E.C. and Martin,S.J.
Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement
Sci Immunol (2022) 7, eade5728-eade5728. PubMed Europe PubMed DOI
Weir,A. and Vince,J.E.
No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death
Biochem J (2022) 479, 1083-1102. PubMed Europe PubMed DOI PMC EPMC V
Wu,J., Lan,Y., Shi,X., Huang,W., Li,S., Zhang,J., Wang,H., Wang,F. and Meng,X.
Sennoside A is a novel inhibitor targeting caspase-1
Food Funct (2022) 13, 9782-9795. PubMed Europe PubMed DOI K
Ye,X., Song,G., Huang,S., Liang,Q., Fang,Y., Lian,L. and Zhu,S.
Caspase-1: A Promising Target for Preserving Blood-Brain Barrier Integrity in Acute Stroke
Front Mol Neurosci (2022) 15, 856372-856372. PubMed Europe PubMed DOI PMC EPMC V

2021

Bateman,G., Hill,B., Knight,R. and Boucher,D.
Great balls of fire: activation and signalling of inflammatory caspases
Biochem Soc Trans (2021) 49, 1311-1324. PubMed Europe PubMed DOI V
Devant,P., Cao,A. and Kagan,J.C.
Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1beta converting enzyme
Sci Immunol (2021) 6 PubMed Europe PubMed DOI PMC EPMC
Huang,Y., Xu,W. and Zhou,R.
NLRP3 inflammasome activation and cell death
Cell Mol Immunol (2021) PubMed Europe PubMed DOI V
Liao,Y., Liu,C., Wang,J., Song,Y., Sabir,N., Hussain,T., Yao,J., Luo,L., Wang,H., Cui,Y., Yang,L., Zhao,D. and Zhou,X.
Caspase-1 inhibits IFN-beta production via cleavage of cGAS during M. bovis infection
Vet Microbiol (2021) 258, 109126-109126. PubMed Europe PubMed DOI
Lima,C., Falcao,M.A.P., Andrade-Barros,A.I., Seni-Silva,A.C., Grund,L.Z., Balogh,E., Conceicao,K., Queniaux,V.F., Ryffel,B. and Lopes-Ferreira,M.
Natterin an aerolysin-like fish toxin drives IL-1beta-dependent neutrophilic inflammation mediated by caspase-1 and caspase-11 activated by the inflammasome sensor NLRP6
Int Immunopharmacol (2021) 91, 107287-107287. PubMed Europe PubMed DOI
Wang,J., Wang,L., Zhang,X., Xu,Y., Chen,L., Zhang,W., Liu,E., Xiao,C. and Kou,Q.
Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis
Int Immunopharmacol (2021) 94, 107496-107496. PubMed Europe PubMed DOI I
Wu,Z., Tian,Y., Alam,H.B., Li,P., Duan,X., Williams,A.M., Liu,B., Ma,J. and Li,Y.
PAD2 Mediates Caspase-1 Associated Lethality in Pseudomonas Aeruginosa Pneumonia Induced Sepsis
J Infect Dis (2021) 223, 1093-1102. PubMed Europe PubMed DOI
Yoo,N.J., Park,W.S., Kim,S.Y., Reed,J.C., Son,S.G., Lee,J.Y. and Lee,S.H.
Corrigendum to "Nod 1, a CARD protein, enhances pro-interleukin-1 beta processing through the interaction with pro-caspase-1" [Biochem. Biophys. Res. Commun. 299(4) (2002) 652-8]
Biochem Biophys Res Commun (2021) 543, 97-97. PubMed Europe PubMed DOI
Zhu,Y., Zhou,J., Niu,P., Chen,H. and Shi,D.
Cardamonin inhibits cell proliferation by caspase-mediated cleavage of Raptor
Naunyn Schmiedebergs Arch Pharmacol (2021) 394, 809-817. PubMed Europe PubMed DOI I
Zuo,Y., Chen,L., Gu,H., He,X., Ye,Z., Wang,Z., Shao,Q. and Xue,C.
GSDMD-mediated pyroptosis: a critical mechanism of diabetic nephropathy
Expert Rev Mol Med (2021) 23, e23-e23. PubMed Europe PubMed DOI PMC EPMC V

2020

Abu Khweek,A. and Amer,A.O.
Pyroptotic and non-pyroptotic effector functions of caspase-11
Immunol Rev (2020) , e12910-e12910. PubMed Europe PubMed DOI
Barber,G., Anand,A., Katarzyna,O., Phelan,J.J., Heeran,A.B., Flis,E., Clarke,N.E., Watson,J.A., Strangmann,J., Flood,B., O'Neill,H., O'Toole,D., MacCarthy,F., Ravi,N., Reynolds,J.V., Kay,E.W., Quante,M., O'Sullivan,J. and Creagh,E.M.
Characterizing caspase-1 involvement during esophageal disease progression
Cancer Immunol Immunother (2020) PubMed Europe PubMed DOI
Cao,R., Zhang,Y., Du,J., Chen,S., Wang,N., Ying,H. and Shen,B.
Increased FURIN expression in rheumatoid arthritis patients and its anti-inflammatory effect
J Clin Lab Anal (2020) , e23530-e23530. PubMed Europe PubMed DOI
Chao,L., Li,Z., Zhou,J., Chen,W., Li,Y., Lv,W., Guo,A., Qu,Q. and Guo,S.
Shen-Ling-Bai-Zhu-San Improves Dextran Sodium Sulfate-Induced Colitis by Inhibiting Caspase-1/Caspase-11-Mediated Pyroptosis
Front Pharmacol (2020) 11, 814-814. PubMed Europe PubMed DOI PMC EPMC
Chen,H., Peng,Y., Wang,L. and Wang,X.
Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus via upregulation of SIRT1 in a sepsis model
Arch Physiol Biochem (2020) , 1-8. PubMed Europe PubMed DOI
Chuang,J.P., Kao,C.Y., Lee,J.C., Ling,P., Maa,M.C. and Leu,T.H.
EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages
Biochem Biophys Res Commun (2020) PubMed Europe PubMed DOI
de Vasconcelos,N.M., Van Opdenbosch,N., Van Gorp,H., Martin-Perez,R., Zecchin,A., Vandenabeele,P. and Lamkanfi,M.
An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
Cell Rep (2020) 32, 107959-107959. PubMed Europe PubMed DOI
Ding,P.H., Yang,M.X., Wang,N.N., Jin,L.J., Dong,Y., Cai,X. and Chen,L.L.
Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1beta Release Depend on Caspase-4
Front Microbiol (2020) 11, 1881-1881. PubMed Europe PubMed DOI PMC EPMC K
El-Sharkawy,L.Y., Brough,D. and Freeman,S.
Inhibiting the NLRP3 Inflammasome
Molecules (2020) 25 PubMed Europe PubMed DOI PMC EPMC V
Fagenson,A.M., Xu,K., Saaoud,F., Nanayakkara,G., Jhala,N.C., Liu,L., Drummer,C., Sun,Y., Lau,K.N., Di Carlo,A., Jiang,X., Wang,H., Karhadkar,S.S. and Yang,X.
Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice
Pathogens (2020) 9 PubMed Europe PubMed DOI
Fisch,D., Clough,B., Domart,M.C., Encheva,V., Bando,H., Snijders,A.P., Collinson,L.M., Yamamoto,M., Shenoy,A.R. and Frickel,E.M.
Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death
Cell Rep (2020) 32, 108008-108008. PubMed Europe PubMed DOI PMC EPMC
Frank,M.G., Baratta,M.V., Zhang,K., Fallon,I.P., Pearson,M.A., Liu,G., Hutchinson,M.R., Watkins,L.R., Goldys,E.M. and Maier,S.F.
Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1beta protein in dorsal hippocampus
Brain Behav Immun (2020) PubMed Europe PubMed DOI
Gao,M.R., Wang,M., Jia,Y.Y., Tian,D.D., Liu,A., Wang,W.J., Yang,L., Chen,J.Y., Yang,Q., Liu,R. and Wu,Y.M.
Echinacoside protects dopaminergic neurons by inhibiting NLRP3/Caspase-1/IL-1beta signaling pathway in MPTP-induced Parkinson's disease model
Brain Res Bull (2020) 164, 55-64. PubMed Europe PubMed DOI
Goh,G., Ahn,M., Zhu,F., Lee,L.B., Luo,D., Irving,A.T. and Wang,L.F.
Complementary regulation of caspase-1 and IL-1beta reveals additional mechanisms of dampened inflammation in bats
Proc Natl Acad Sci U S A (2020) PubMed Europe PubMed DOI
Heilig,R., Dilucca,M., Boucher,D., Chen,K.W., Hancz,D., Demarco,B., Shkarina,K. and Broz,P.
Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD
Life Sci Alliance (2020) 3 PubMed Europe PubMed DOI PMC EPMC
Hong,W., Gu,Y., Guan,R., Xie,D., Zhou,H. and Yu,M.
Pan-cancer analysis of the CASP gene family in relation to survival, tumor-infiltrating immune cells and therapeutic targets
Genomics (2020) PubMed Europe PubMed DOI
Huang,H., Wang,J., Liu,Z. and Gao,F.
The angiotensin-converting enzyme 2/angiotensin (1-7)/mas axis protects against pyroptosis in LPS-induced lung injury by inhibiting NLRP3 activation
Arch Biochem Biophys (2020) 693, 108562-108562. PubMed Europe PubMed DOI I
Israelov,H., Ravid,O., Atrakchi,D., Rand,D., Elhaik,S., Bresler,Y., Twitto-Greenberg,R., Omesi,L., Liraz-Zaltsman,S., Gosselet,F., Schnaider Beeri,M. and Cooper,I.
Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair
J Neuroinflammation (2020) 17, 267-267. PubMed Europe PubMed DOI PMC EPMC I
Jiao,Y., Wang,L., Lu,L., Liu,J., Li,X., Zhao,H., Hou,Z. and Zheng,B.
The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors
Stem Cells Int (2020) 2020, 8867115-8867115. PubMed Europe PubMed DOI PMC EPMC K
Kovacs,S.B., Oh,C., Maltez,V.I., McGlaughon,B.D., Verma,A., Miao,E.A. and Aachoui,Y.
Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium
Cell Rep (2020) 32, 107967-107967. PubMed Europe PubMed DOI
Kumari,P., Russo,A.J., Shivcharan,S. and Rathinam,V.A.
AIM2 in health and disease: Inflammasome and beyond
Immunol Rev (2020) PubMed Europe PubMed DOI V
Leng,Y., Chen,R., Chen,R., He,S., Shi,X., Zhou,X., Zhang,Z. and Chen,A.F.
HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway
Biochem Biophys Res Commun (2020) 532, 640-646. PubMed Europe PubMed DOI
Li,J., Zhang,Y., Ruan,R., He,W. and Qian,Y.
The novel interplay between CD44 standard isoform and the caspase-1/IL1B pathway to induce hepatocellular carcinoma progression
Cell Death Dis (2020) 11, 961-961. PubMed Europe PubMed DOI PMC EPMC
Li,Y., Ouyang,Y., Jiao,J., Xu,Z. and Zhang,L.
Exposure to environmental black carbon exacerbates nasal epithelial inflammation via the reactive oxygen species (ROS)-nucleotide-binding, oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3)-caspase-1-interleukin 1beta (IL-1beta) pathway
Int Forum Allergy Rhinol (2020) PubMed Europe PubMed DOI I
Liang,H., Li,F., Li,H., Wang,R. and Du,M.
Overexpression of lncRNA HULC Attenuates Myocardial Ischemia/reperfusion Injury in Rat Models and Apoptosis of Hypoxia/reoxygenation Cardiomyocytes via Targeting miR-377-5p through NLRP3/Caspase1/IL1beta Signaling Pathway Inhibition
Immunol Invest (2020) , 1-14. PubMed Europe PubMed DOI I
Liu,L., Chen,M., Lin,K., Xiang,X., Zheng,Y. and Zhu,S.
Inhibiting Caspase-12 Mediated Inflammasome Activation protects against Oxygen-Glucose Deprivation Injury in Primary Astrocytes
Int J Med Sci (2020) 17, 1936-1945. PubMed Europe PubMed DOI PMC EPMC
Liu,Z., Wang,C., Yang,J., Chen,Y., Zhou,B., Abbott,D.W. and Xiao,T.S.
Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage
Immunity (2020) 53, 106-114. PubMed Europe PubMed DOI PMC EPMC
Lu,J. and Sun,P.D.
High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity
J Biol Chem (2020) PubMed Europe PubMed DOI
Ma,S., Wang,Y., Zhou,X., Li,Z., Zhang,Z., Wang,Y., Huang,T., Zhang,Y., Shi,J. and Guan,F.
MG53 Protects hUC-MSCs against Inflammatory Damage and Synergistically Enhances Their Efficacy in Neuroinflammation Injured Brain through Inhibiting NLRP3/Caspase-1/IL-1beta Axis
ACS Chem Neurosci (2020) 11, 2590-2601. PubMed Europe PubMed DOI
McKenzie,B.A., Fernandes,J.P., Doan,M.A.L., Schmitt,L.M., Branton,W.G. and Power,C.
Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis
J Neuroinflammation (2020) 17, 253-253. PubMed Europe PubMed DOI PMC EPMC K
Molla,M.D., Ayelign,B., Dessie,G., Geto,Z. and Admasu,T.D.
Caspase-1 as a regulatory molecule of lipid metabolism
Lipids Health Dis (2020) 19, 34-34. PubMed Europe PubMed DOI PMC EPMC
Pang,Y., Zhang,P.C., Lu,R.R., Li,H.L., Li,J.C., Fu,H.X., Cao,Y.W., Fang,G.X., Liu,B.H., Wu,J.B., Zhou,J.Y. and Zhou,Y.
Andrade-Oliveira Salvianolic Acid B Modulates Caspase-1-Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via Nrf2 Pathway
Front Pharmacol (2020) 11, 541426-541426. PubMed Europe PubMed DOI PMC EPMC
Pinar,A.A., Yuferov,A., Gaspari,T.A. and Samuel,C.S.
Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1
Front Pharmacol (2020) 11, 1201-1201. PubMed Europe PubMed DOI PMC EPMC K
Roman-Melendez,G.D., Venkataraman,T., Monaco,D.R. and Larman,H.B.
Protease Activity Profiling via Programmable Phage Display of Comprehensive Proteome-Scale Peptide Libraries
Cell Syst (2020) 11, 375-381. PubMed Europe PubMed DOI
Sabino,F., Madzharova,E. and auf dem Keller,U.
Cell density-dependent proteolysis by HtrA1 induces translocation of zyxin to the nucleus and increased cell survival
Cell Death Dis (2020) 11, 674-674. PubMed Europe PubMed DOI PMC EPMC
Sachdev,U., Ferrari,R., Cui,X., Pius,A., Sahu,A., Reynolds,M., Liao,H., Sun,P., Shinde,S., Ambrosio,F., Shiva,S., Loughran,P. and Scott,M.
Caspase1/11 signaling affects muscle regeneration and recovery following ischemia, and can be modulated by chloroquine
Mol Med (2020) 26, 69-69. PubMed Europe PubMed DOI PMC EPMC K
Saito,L.B., Fernandes,J.P., Smith,M.J., Doan,M.A.L., Branton,W.G., Schmitt,L.M., Wuest,M., Monaco,M.C., Major,E.O., Wuest,F. and Power,C.
Intranasal anti-caspase-1 therapy preserves myelin and glucose metabolism in a model of progressive multiple sclerosis
Glia (2020) PubMed Europe PubMed DOI I
Sukhanov,S., Higashi,Y., Yoshida,T., Mummidi,S., Aroor,A.R., Jeffrey Russell,J., Bender,S.B., Demarco,V.G. and Chandrasekar,B.
The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1beta and IL-18 secretion
Cell Signal (2020) 77, 109825-109825. PubMed Europe PubMed DOI
Sun,X., Zhou,R., Lei,Y., Hu,J. and Li,X.
The ligand-gated ion channel P2X7 receptor mediates NLRP3/caspase-1-mediated pyroptosis in cerebral cortical neurons of juvenile rats with sepsis
Brain Res (2020) 1748, 147109-147109. PubMed Europe PubMed DOI
Sunderhauf,A., Raschdorf,A., Hicken,M., Schlichting,H., Fetzer,F., Brethack,A.K., Perner,S., Kemper,C., Ghebrehiwet,B., Sina,C. and Derer,S.
GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells
Front Oncol (2020) 10, 575854-575854. PubMed Europe PubMed DOI PMC EPMC
Tang,J., Chen,R., Wang,L., Yu,L., Zuo,D., Cui,G. and Gong,X.
Melatonin Attenuates Thrombin-induced Inflammation in BV2 Cells and Then Protects HT22 Cells from Apoptosis
Inflammation (2020) 43, 1959-1970. PubMed Europe PubMed DOI
Thorstenberg,M.L., Martins,M.D.A., Figliuolo,V., Silva,C.L.M., Savio,L.E.B. and Coutinho-Silva,R.
P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1beta Secretion
Mediators Inflamm (2020) 2020, 2545682-2545682. PubMed Europe PubMed DOI PMC EPMC
Vande Walle,L. and Lamkanfi,M.
Snapshot of a Deadly Embrace: The Caspase-1-GSDMD Interface
Immunity (2020) 53, 6-8. PubMed Europe PubMed DOI
Wang,X., Li,X., Liu,S., Brickell,A.N., Zhang,J., Wu,Z., Zhou,S. and Ding,Z.
PCSK9 regulates pyroptosis via mtDNA damage in chronic myocardial ischemia
Basic Res Cardiol (2020) 115, 66-66. PubMed Europe PubMed DOI
Wang,Y., Zhang,M., Sun,Y., Wang,X., Song,Z., Li,H., Liu,K. and Li,Z.
Role of short-wavelength blue light in the formation of cataracts and the expression of caspase-1, caspase-11, Gasdermin D in rat lens epithelial cells: insights into a novel pathogenic mmechanism of cataracts
BMC Ophthalmol (2020) 20, 289-289. PubMed Europe PubMed DOI PMC EPMC I
Xiao,Q., Yu,J.S., Wang,Y., Ma,D., Zhou,J. and Lou,X.
3-Difluoroalkyl Quaternary Oxindoles Inhibit Macrophage Pyroptosis by Blocking Inflammasome Recruitment of Caspase-1
ACS Med Chem Lett (2020) 11, 1392-1401. PubMed Europe PubMed DOI PMC EPMC
Yan,C.Y., Ouyang,S.H., Wang,X., Wu,Y.P., Sun,W.Y., Duan,W.J., Liang,L., Luo,X., Kurihara,H., Li,Y.F. and He,R.R.
Celastrol ameliorates Propionibacterium acnes/LPS-induced liver damage and MSU-induced gouty arthritis via inhibiting K63 deubiquitination of NLRP3
Phytomedicine (2020) 80, 153398-153398. PubMed Europe PubMed DOI I
Zaslona,Z., Flis,E., Nulty,C., Kearney,J., FitzGerald,R., Douglas,A.R., McNamara,D., Smith,S., O'Neill,L.A.J. and Creagh,E.M.
Caspase-4: A Therapeutic Target for Peptic Ulcer Disease
Immunohorizons (2020) 4, 627-633. PubMed Europe PubMed DOI
Zhuo,L., Chen,X., Sun,Y., Wang,Y., Shi,Y., Bu,L., Xia,W., Han,J., Chen,D. and Li,X.
Rapamycin Inhibited Pyroptosis and Reduced the Release of IL-1beta and IL-18 in the Septic Response
Biomed Res Int (2020) 2020, 5960375-5960375. PubMed Europe PubMed DOI PMC EPMC
Zu,S.Q., Feng,Y.B., Zhu,C.J., Wu,X.S., Zhou,R.P., Li,G., Dai,B.B., Wang,Z.S., Xie,Y.Y., Li,Y., Ge,J.F. and Chen,F.H.
Acid-sensing ion channel 1a mediates acid-induced pyroptosis through calpain-2/calcineurin pathway in rat articular chondrocytes
Cell Biol Int (2020) 44, 2140-2152. PubMed Europe PubMed DOI

2019

Martin,D.D.O., Schmidt,M.E., Nguyen,Y.T., Lazic,N. and Hayden,M.R.
Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance
FASEB J (2019) 33, 3190-3197. PubMed Europe PubMed DOI
Ramos-Guzman,C.A., Zinovjev,K. and Tunon,I.
Modeling caspase-1 inhibition: implications for catalytic mechanism and drug design
Eur J Med Chem (2019) 169, 159-167. PubMed Europe PubMed DOI I
Sandstrom,A., Mitchell,P.S., Goers,L., Mu,E.W., Lesser,C.F. and Vance,R.E.
Functional degradation: a mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes
Science (2019) 364, eaau1330-eaau1330. PubMed Europe PubMed DOI
Yang,G., Wang,J., Luo,T. and Zhang,X.
White spot syndrome virus infection activates caspase 1-mediated cell death in crustacean
Virology (2019) 528, 37-47. PubMed Europe PubMed DOI

2018

Adams,A., Weinman,S.A. and Wozniak,A.L.
Caspase-1 regulates cellular trafficking via cleavage of the Rab7 adaptor protein RILP
Biochem Biophys Res Commun (2018) 503, 2619-2624. PubMed Europe PubMed DOI P
Akazawa,K., Sugihara,F., Minoshima,M., Mizukami,S. and Kikuchi,K.
Sensing caspase-1 activity using activatable (19)F MRI nanoprobes with improved turn-on kinetics
Chem Commun (Camb) (2018) 54, 11785-11788. PubMed Europe PubMed DOI L
Baker,P.J. and Masters,S.L.
Caspase substrates won't be defined by a four-letter code
J Biol Chem (2018) 293, 7068-7069. PubMed Europe PubMed DOI PMC EPMC P
Boucher,D., Monteleone,M., Coll,R.C., Chen,K.W., Ross,C.M., Teo,J.L., Gomez,G.A., Holley,C.L., Bierschenk,D., Stacey,K.J., Yap,A.S., Bezbradica,J.S. and Schroder,K.
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
J Exp Med (2018) 215, 827-840. PubMed Europe PubMed DOI
Fournier,J.F., Clary,L., Chambon,S., Dumais,L., Harris,C.S., Millois,C., Pierre,R., Talano,S., Thoreau,E., Aubert,J., Aurelly,M., Bouix-Peter,C., Brethon,A., Chantalat,L., Christin,O., Comino,C., El-Bazbouz,G., Ghilini,A.L., Isabet,T., Lardy,C., Luzy,A.P., Mathieu,C., Mebrouk,K., Orfila,D., Pascau,J., Reverse,K., Roche,D., Rodeschini,V. and Hennequin,L.F.
Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne
J Med Chem (2018) 61, 4030-4051. PubMed Europe PubMed DOI I
Lin,H., Yang,H., Huang,S., Wang,F., Wang,D.M., Liu,B., Tang,Y.D. and Zhang,C.J.
Caspase-1 specific light-up probe with aggregation-induced emission characteristics for inhibitor screening of coumarin-originated natural products
ACS Appl Mater Interfaces (2018) 10, 12173-12180. PubMed Europe PubMed DOI A
Patel,S., Modi,P., Ranjan,V. and Chhabria,M.
Structure-based design, synthesis and evaluation of 2,4-diaminopyrimidine derivatives as novel caspase-1 inhibitors
Bioorg Chem (2018) 78, 258-268. PubMed Europe PubMed DOI I
Ramirez,M.L.G., Poreba,M., Snipas,S.J., Groborz,K., Drag,M. and Salvesen,G.S.
Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1
J Biol Chem (2018) 293, 7058-7067. PubMed Europe PubMed DOI P
Yang,J., Liu,Z., Wang,C., Yang,R., Rathkey,J.K., Pinkard,O.W., Shi,W., Chen,Y., Dubyak,G.R., Abbott,D.W. and Xiao,T.S.
Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
Proc Natl Acad Sci U S A (2018) 115, 6792-6797. PubMed Europe PubMed DOI I
Zheng,Y., Liu,Q., Wu,Y., Ma,L., Zhang,Z., Liu,T., Jin,S., She,Y., Li,Y.P. and Cui,J.
Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis
EMBO J (2018) 37, e99347-e99347. PubMed Europe PubMed DOI

2017

Adriaenssens,Y., Jimenez Fernandez,D., Vande Walle,L., Elvas,F., Joossens,J., Lambeir,A., Augustyns,K., Lamkanfi,M. and Van der Veken,P.
Carboxylate isosteres for caspase inhibitors: the acylsulfonamide case revisited
Org Biomol Chem (2017) 15, 7456-7473. PubMed Europe PubMed DOI I
Brethon,A., Chantalat,L., Christin,O., Clary,L., Fournier,J.F., Gastreich,M., Harris,C.S., Isabet,T., Pascau,J., Thoreau,E., Roche,D. and Rodeschini,V.
New caspase-1 inhibitor by scaffold hopping into bio-inspired 3D-fragment space
Bioorg Med Chem Lett (2017) 27, 5373-5377. PubMed Europe PubMed DOI S I
O'Brien,M., Moehring,D., Munoz-Planillo,R., Nunez,G., Callaway,J., Ting,J., Scurria,M., Ugo,T., Bernad,L., Cali,J. and Lazar,D.
A bioluminescent caspase-1 activity assay rapidly monitors inflammasome activation in cells
J Immunol Methods (2017) 447, 1-13. PubMed Europe PubMed DOI A
Qian,L., Zhang,C.J., Wu,J. and Yao,S.Q.
Fused bicyclic caspase-1 inhibitors assembled by copper-free strain-promoted alkyne-azide cycloaddition (SPAAC)
Chemistry (2017) 23, 360-369. PubMed Europe PubMed DOI I

2016

Guey,B. and Petrilli,V.
Assessing caspase-1 activation
Methods Mol Biol (2016) 1417, 197-206. PubMed Europe PubMed DOI A
Julien,O., Zhuang,M., Wiita,A.P., O'Donoghue,A.J., Knudsen,G.M., Craik,C.S. and Wells,J.A.
Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
Proc Natl Acad Sci U S A (2016) 113, E2001-E2010. PubMed Europe PubMed DOI P
Kent,C.R., Bryja,M., Gustafson,H.A., Kawarski,M.Y., Lenti,G., Pierce,E.N., Knopp,R.C., Ceja,V., Pati,B., Walters,D.E. and Karver,C.E.
Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases
Bioorg Med Chem Lett (2016) 26, 5476-5480. PubMed Europe PubMed DOI I
Lu,A., Li,Y., Schmidt,F.I., Yin,Q., Chen,S., Fu,T.M., Tong,A.B., Ploegh,H.L., Mao,Y. and Wu,H.
Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism
Nat Struct Mol Biol (2016) 23, 416-425. PubMed Europe PubMed DOI S

2015

Caution,K., Gavrilin,M.A., Tazi,M., Kanneganti,A., Layman,D., Hoque,S., Krause,K. and Amer,A.O.
Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance
Sci Rep (2015) 5, 18479-18479. PubMed Europe PubMed DOI PMC EPMC
Cerqueira,D.M., Pereira,M.S., Silva,A.L., Cunha,L.D. and Zamboni,D.S.
Caspase-1 but not caspase-11 is required for NLRC4-mediated pyroptosis and restriction of infection by flagellated Legionella species in mouse macrophages and in vivo
J Immunol (2015) 195, 2303-2311. PubMed Europe PubMed DOI
Hendrikx,T., Jeurissen,M.L., van Gorp,P.J., Gijbels,M.J., Walenbergh,S.M., Houben,T., van Gorp,R., Pottgens,C.C., Stienstra,R., Netea,M.G., Hofker,M.H., Donners,M.M. and Shiri-Sverdlov,R.
Bone marrow-specific caspase-1/11 deficiency inhibits atherosclerosis development in Ldlr(-/-) mice
FEBS J (2015) 282, 2327-2338. PubMed Europe PubMed DOI K
Kawarski,M., Hagerman,T.K. and Karver,C.E.
Lazaroids U83836E and U74389G are potent, time-dependent inhibitors of caspase-1
Chem Biol Drug Des (2015) 86, 1049-1054. PubMed Europe PubMed DOI I
Moriwaki,K., Bertin,J., Gough,P.J. and Chan,F.K.
A RIPK3-caspase 8 complex mediates atypical pro-IL-1beta processing
J Immunol (2015) 194, 1938-1944. PubMed Europe PubMed DOI
Rahman,M.A., Mitra,S., Sarkar,A. and Wewers,M.D.
Alpha 1-antitrypsin does not inhibit human monocyte caspase-1
PLoS ONE (2015) 10, e0117330-e0117330. PubMed Europe PubMed DOI PMC EPMC
Shi,J., Zhao,Y., Wang,K., Shi,X., Wang,Y., Huang,H., Zhuang,Y., Cai,T., Wang,F. and Shao,F.
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Nature (2015) 526, 660-665. PubMed Europe PubMed DOI
Shim,Y.R. and Lee,H.K.
Caspase-1 independent viral clearance and adaptive immunity against mucosal respiratory syncytial virus infection
Immune Netw (2015) 15, 73-82. PubMed Europe PubMed DOI PMC EPMC
Sollberger,G., Strittmatter,G.E., Grossi,S., Garstkiewicz,M., auf dem Keller,U., French,L.E. and Beer,H.D.
Caspase-1 activity is required for UVB-induced apoptosis of human keratinocytes
J Invest Dermatol (2015) 135, 1395-1404. PubMed Europe PubMed DOI
Wu,Y. and Nie,F.
Caspase-1 assay based on peptide and luminol labeled gold nanoparticle as chemiluminescence probe coupling magnetic separation technology
Sens Actuators, B Chem (2015) 220, 481-484. DOI A

2014

Guey,B., Bodnar,M., Manie,S.N., Tardivel,A. and Petrilli,V.
Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function
Proc Natl Acad Sci U S A (2014) 111, 17254-17259. PubMed Europe PubMed DOI
Heymann,M.C., Winkler,S., Luksch,H., Flecks,S., Franke,M., Ru,S., Ozen,S., Yilmaz,E., Klein,C., Kallinich,T., Lindemann,D., Brenner,S., Ganser,G., Roesler,J., Rosen-Wolff,A. and Hofmann,S.R.
Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-kappaB signaling
J Immunol (2014) 192, 4379-4385. PubMed Europe PubMed DOI M
Sollberger,G., Strittmatter,G.E., Garstkiewicz,M., Sand,J. and Beer,H.D.
Caspase-1: The inflammasome and beyond
Innate Immun (2014) 20, 115-125. PubMed Europe PubMed DOI V
Wang,H., Capell,W., Yoon,J.H., Faubel,S. and Eckel,R.H.
Obesity development in caspase-1-deficient mice
Int J Obes (Lond) (2014) 38, 152-155. PubMed Europe PubMed DOI K

2013

Bartok,E., Bauernfeind,F., Khaminets,M.G., Jakobs,C., Monks,B., Fitzgerald,K.A., Latz,E. and Hornung,V.
iGLuc: a luciferase-based inflammasome and protease activity reporter
Nat Methods (2013) 10, 147-154. PubMed Europe PubMed DOI L
Case,C.L. and Roy,C.R.
Analyzing caspase-1 activation during Legionella pneumophila infection in macrophages
Methods Mol Biol (2013) 954, 479-491. PubMed Europe PubMed DOI A
Datta,D., McClendon,C.L., Jacobson,M.P. and Wells,J.A.
Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3
J Biol Chem (2013) 288, 9971-9981. PubMed Europe PubMed DOI I
Jakobs,C., Bartok,E., Kubarenko,A., Bauernfeind,F. and Hornung,V.
Immunoblotting for active caspase-1
Methods Mol Biol (2013) 1040, 103-115. PubMed Europe PubMed DOI A
Jin,T., Curry,J., Smith,P., Jiang,J. and Xiao,T.S.
Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1
Proteins (2013) 81, 1266-1270. PubMed Europe PubMed DOI
Juruj,C., Lelogeais,V., Pierini,R., Perret,M., Py,B.F., Jamilloux,Y., Broz,P., Ader,F., Faure,M. and Henry,T.
Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop
Front Cell Infect Microbiol (2013) 3, 14-14. PubMed Europe PubMed DOI PMC EPMC
Luksch,H., Romanowski,M.J., Chara,O., Tungler,V., Caffarena,E.R., Heymann,M.C., Lohse,P., Aksentijevich,I., Remmers,E.F., Flecks,S., Quoos,N., Gramatte,J., Petzold,C., Hofmann,S.R., Winkler,S., Pessler,F., Kallinich,T., Ganser,G., Nimtz-Talaska,A., Baumann,U., Runde,V., Grimbacher,B., Birmelin,J., Gahr,M., Roesler,J. and Rosen-Wolff,A.
Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1beta
Hum Mutat (2013) 34, 122-131. PubMed Europe PubMed DOI M
Xiao,J., Broz,P., Puri,A.W., Deu,E., Morell,M., Monack,D.M. and Bogyo,M.
A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases
J Am Chem Soc (2013) 135, 9130-9138. PubMed Europe PubMed DOI L

2012

Denes,A., Lopez-Castejon,G. and Brough,D.
Caspase-1: is IL-1 just the tip of the ICEberg?
Cell Death Dis (2012) 3, e338-e338. PubMed Europe PubMed DOI
Jorgensen,I. and Miao,E.A.
YopM puts caspase-1 on ice
Cell Host Microbe (2012) 12, 737-738. PubMed Europe PubMed DOI
Puri,A.W., Broz,P., Shen,A., Monack,D.M. and Bogyo,M.
Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection
Nat Chem Biol (2012) 8, 745-747. PubMed Europe PubMed DOI L
Roschitzki-Voser,H., Schroeder,T., Lenherr,E.D., Frolich,F., Schweizer,A., Donepudi,M., Ganesan,R., Mittl,P.R., Baici,A. and Grutter,M.G.
Human caspases in vitro: expression, purification and kinetic characterization
Protein Expr Purif (2012) 84, 236-246. PubMed Europe PubMed DOI E
Scheer,J.M.
Caspase-1
[ISSN:978-0-12-407743-0] (2012) 3, 2237-2243. DOI
Sun,L., Wu,Z., Hayashi,Y., Peters,C., Tsuda,M., Inoue,K. and Nakanishi,H.
Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain
J Neurosci (2012) 32, 11330-11342. PubMed Europe PubMed DOI

2011

Bergheanu,S.C., Pons,D., Van Der Hoeven,B.L., Liem,S.S., Siegerink,B., Schalij,M.J., Van Der Bom,J.G. and Jukema,J.W.
The 5352 a allele of the pro-inflammatory caspase-1 gene predicts late-acquired stent malapposition in STEMI patients treated with sirolimus stents
Heart Vessels (2011) 26, 235-241. PubMed Europe PubMed DOI M
Lee,G., Wang,Z., Sehgal,R., Chen,C.H., Kikuno,K., Hay,B. and Park,J.H.
Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis
J Comp Neurol (2011) 519, 34-48. PubMed Europe PubMed DOI
Pei-Yu,S., Geng-Liang,Y., Hua,Z., Xin-Hua,L. and Shao-Jing,L.
High-throughput screening for interleukin-1beta converting enzyme inhibitors
Chin J Antibiot (2011) 36, 346-350. I
Vande Walle,L. and Lamkanfi,M.
Inflammasomes: caspase-1-activating platforms with critical roles in host defense
Front Microbiol (2011) 2, 3-3. PubMed Europe PubMed DOI PMC EPMC
Walsh,J.G., Logue,S.E., Luthi,A.U. and Martin,S.J.
Caspase-1 promiscuity is counterbalanced by rapid inactivation of processed enzyme
J Biol Chem (2011) 286, 32513-32524. PubMed Europe PubMed DOI P

2010

Agard,N.J., Maltby,D. and Wells,J.A.
Inflammatory stimuli regulate caspase substrate profiles
Mol Cell Proteomics (2010) 9, 880-893. PubMed Europe PubMed DOI P
Boxer,M.B., Quinn,A.M., Shen,M., Jadhav,A., Leister,W., Simeonov,A., Auld,D.S. and Thomas,C.J.
A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety
ChemMedChem (2010) 5, 730-738. PubMed Europe PubMed DOI I
Boxer,M.B., Shen,M., Auld,D.S., Wells,J.A. and Thomas,C.J.
A small molecule inhibitor of caspase 1
(2010) PubMed Europe PubMed I
Galatsis,P., Caprathe,B., Downing,D., Gilmore,J., Harter,W., Hays,S., Kostlan,C., Linn,K., Lunney,E., Para,K., Thomas,A., Warmus,J., Allen,H., Brady,K., Talanian,R. and Walker,N.
Inhibition of interleukin-1beta converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones
Bioorg Med Chem Lett (2010) 20, 5089-5094. PubMed Europe PubMed DOI I
Galatsis,P., Caprathe,B., Gilmore,J., Thomas,A., Linn,K., Sheehan,S., Harter,W., Kostlan,C., Lunney,E., Stankovic,C., Rubin,J., Brady,K., Allen,H. and Talanian,R.
Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1)
Bioorg Med Chem Lett (2010) 20, 5184-5190. PubMed Europe PubMed DOI I
Kindermann,M., Roschitzki-Voser,H., Caglic,D., Repnik,U., Miniejew,C., Mittl,P.R., Kosec,G., Grutter,M.G., Turk,B. and Wendt,K.U.
Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe
Chem Biol (2010) 17, 999-1007. PubMed Europe PubMed DOI A
Loser,R., Abbenante,G., Madala,P.K., Halili,M., Le,G.T. and Fairlie,D.P.
Noncovalent tripeptidyl benzyl- and cyclohexyl-amine inhibitors of the cysteine protease caspase-1
J Med Chem (2010) 53, 2651-2655. PubMed Europe PubMed DOI I
Muller,A.J., Hoffmann,C. and Hardt,W.D.
Caspase-1 activation via Rho GTPases: a common theme in mucosal infections?
PLoS Pathog (2010) 6, e1000795-e1000795. PubMed Europe PubMed DOI PMC EPMC
Ulrichts,P., Bovijn,C., Lievens,S., Beyaert,R., Tavernier,J. and Peelman,F.
Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site
J Cell Sci (2010) 123, 256-265. PubMed Europe PubMed DOI P
Vezzani,A., Balosso,S., Maroso,M., Zardoni,D., Noe,F. and Ravizza,T.
ICE/caspase 1 inhibitors and IL-1beta receptor antagonists as potential therapeutics in epilepsy
Curr Opin Investig Drugs (2010) 11, 43-50. PubMed Europe PubMed T
Weigert,A., Cremer,S., Schmidt,M.V., von Knethen,A., Angioni,C., Geisslinger,G. and Brune,B.
Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells
Blood (2010) 115, 3531-3540. PubMed Europe PubMed DOI
Wu,B., Ma,Q., Khatibi,N., Chen,W., Sozen,T., Cheng,O. and Tang,J.
Ac-YVAD-CMK decreases blood-brain barrier degradation by inhibiting caspase-1 activation of interleukin-1beta in intracerebral hemorrhage mouse model
Transl Stroke Res (2010) 1, 57-64. PubMed Europe PubMed DOI PMC EPMC I
Yazdi,A.S., Guarda,G., D'Ombrain,M.C. and Drexler,S.K.
Inflammatory caspases in innate immunity and inflammation
J Innate Immun (2010) 2, 228-237. PubMed Europe PubMed DOI

2009

Benkova,B., Lozanov,V., Ivanov,I.P. and Mitev,V.
Evaluation of recombinant caspase specificity by competitive substrates
Anal Biochem (2009) 394, 68-74. PubMed Europe PubMed DOI A P
Cayrol,C. and Girard,J.P.
The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
Proc Natl Acad Sci U S A (2009) 106, 9021-9026. PubMed Europe PubMed DOI PMC EPMC
Elliott,J.M., Rouge,L., Wiesmann,C. and Scheer,J.M.
Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation
J Biol Chem (2009) 284, 6546-6553. PubMed Europe PubMed DOI PMC EPMC S
Guma,M., Ronacher,L., Liu-Bryan,R., Takai,S., Karin,M. and Corr,M.
Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation
Arthritis Rheum (2009) 60, 3642-3650. PubMed Europe PubMed DOI
Lan,Q., Morton,L.M., Armstrong,B., Hartge,P., Menashe,I., Zheng,T., Purdue,M.P., Cerhan,J.R., Zhang,Y., Grulich,A., Cozen,W., Yeager,M., Holford,T.R., Vajdic,C.M., Davis,S., Leaderer,B., Kricker,A., Schenk,M., Zahm,S.H., Chatterjee,N., Chanock,S.J., Rothman,N. and Wang,S.S.
Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies
Blood (2009) 114, 264-267. PubMed Europe PubMed DOI PMC EPMC M

2008

Chae,J.J., Wood,G., Richard,K., Jaffe,H., Colburn,N.T., Masters,S.L., Gumucio,D.L., Shoham,N.G. and Kastner,D.L.
The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment
Blood (2008) 112, 1794-1803. PubMed Europe PubMed DOI PMC EPMC
Datta,D., Scheer,J.M., Romanowski,M.J. and Wells,J.A.
An allosteric circuit in caspase-1
J Mol Biol (2008) 381, 1157-1167. PubMed Europe PubMed DOI PMC EPMC
Lamkanfi,M., Kanneganti,T.D., Van Damme,P., Vanden Berghe,T., Vanoverberghe,I., Vandekerckhove,J., Vandenabeele,P., Gevaert,K. and Nunez,G.
Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes
Mol Cell Proteomics (2008) 7, 2350-2363. PubMed Europe PubMed DOI PMC EPMC P
Pereira,N.A. and Song,Z.
Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity
Biochem Biophys Res Commun (2008) 377, 873-877. PubMed Europe PubMed DOI P I
Soung,Y.H., Jeong,E.G., Ahn,C.H., Kim,S.S., Song,S.Y., Yoo,N.J. and Lee,S.H.
Mutational analysis of caspase 1, 4, and 5 genes in common human cancers
Hum Pathol (2008) 39, 895-900. PubMed Europe PubMed DOI M
Wickliffe,K.E., Leppla,S.H. and Moayeri,M.
Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome
Cell Microbiol (2008) 10, 332-343. PubMed Europe PubMed DOI PMC EPMC

2007

Boost,K.A., Hoegl,S., Hofstetter,C., Flondor,M., Stegewerth,K., Platacis,I., Pfeilschifter,J., Muhl,H. and Zwissler,B.
Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia
Intensive Care Med (2007) 33, 863-871. PubMed Europe PubMed DOI I
Brodsky,M., Yosef,S., Galit,R., Albeck,M., Longo,D.L., Albeck,A. and Sredni,B.
The synthetic tellurium compound, AS101, is a novel inhibitor of IL-1beta converting enzyme
J Interferon Cytokine Res (2007) 27, 453-462. PubMed Europe PubMed DOI I
Edelstein,C.L., Hoke,T.S., Somerset,H., Fang,W., Klein,C.L., Dinarello,C.A. and Faubel,S.
Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury
Nephrol Dial Transplant (2007) 22, 1052-1061. PubMed Europe PubMed DOI K I
Hsu,S., Qin,H., Dickinson,D., Xie,D., Bollag,W.B., Stoppler,H., Pearl,H., Vu,A., Watkins,M., Koehler,M. and Schuster,G.
Expression of caspase-14 reduces tumorigenicity of skin cancer cells
In Vivo (2007) 21, 279-283. PubMed Europe PubMed U
Kersse,K., Vanden Berghe,T., Lamkanfi,M. and Vandenabeele,P.
A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins
Biochem Soc Trans (2007) 35, 1508-1511. PubMed Europe PubMed DOI
Ma,X.Q., Zhang,H.J., Zhang,Y.H., Chen,Y.H., Wu,F., Du,J.Q., Yu,H.P., Zhou,Z.L., Li,J.Y., Nan,F.J. and Li,J.
Novel irreversible caspase-1 inhibitor attenuates the maturation of intracellular interleukin-1beta
Biochem Cell Biol (2007) 85, 56-65. PubMed Europe PubMed DOI I
Martinon,F. and Tschopp,J.
Inflammatory caspases and inflammasomes: master switches of inflammation
Cell Death Differ (2007) 14, 10-22. PubMed Europe PubMed DOI
Mastronardi,C., Whelan,F., Yildiz,O.A., Hannestad,J., Elashoff,D., McCann,S.M., Licinio,J. and Wong,M.L.
Caspase 1 deficiency reduces inflammation-induced brain transcription
Proc Natl Acad Sci U S A (2007) 104, 7205-7210. PubMed Europe PubMed DOI PMC EPMC K
Ross,J., Brough,D., Gibson,R.M., Loddick,S.A. and Rothwell,N.J.
A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat
Neuropharmacology (2007) 53, 638-642. PubMed Europe PubMed DOI I
Scott,A.M. and Saleh,M.
The inflammatory caspases: guardians against infections and sepsis
Cell Death Differ (2007) 14, 23-31. PubMed Europe PubMed DOI
Shao,W., Yeretssian,G., Doiron,K., Hussain,S.N. and Saleh,M.
The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock
J Biol Chem (2007) 282, 36321-36329. PubMed Europe PubMed DOI
Wang,Y., O'Neil,S.V., Wos,J.A., Oppong,K.A., Laufersweiler,M.C., Soper,D.L., Ellis,C.D., Baize,M.W., Fancher,A.N., Lu,W., Suchanek,M.K., Wang,R.L., Schwecke,W.P., Cruze,C.A., Buchalova,M., Belkin,M., De,B. and Demuth,T.P., Jr.
Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors
Bioorg Med Chem (2007) 15, 1311-1322. PubMed Europe PubMed DOI I
Wannamaker,W., Davies,R., Namchuk,M., Pollard,J., Ford,P., Ku,G., Decker,C., Charifson,P., Weber,P., Germann,U.A., Kuida,K. and Randle,J.C.
(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl- butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18
J Pharmacol Exp Ther (2007) 321, 509-516. PubMed Europe PubMed DOI I

2006

[YEAR:15-6-2006]Blankenberg,S., Godefroy,T., Poirier,O., Rupprecht,H.J., Barbaux,S., Bickel,C., Nicaud,V., Schnabel,R., Kee,F., Morrison,C., Evans,A., Lackner,K.J., Cambien,F., Munzel,T. and Tiret,L.
Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk
Circ Res (15-6-2006) 99, 102-108. PubMed Europe PubMed DOI M
[YEAR:29-8-2006]Clark,A.K., D'Aquisto,F., Gentry,C., Marchand,F., McMahon,S.B. and Malcangio,M.
Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation
J Neurochem (29-8-2006) 99, 868-880. PubMed Europe PubMed DOI
[YEAR:24-7-2006]Ellis,C.D., Oppong,K.A., Laufersweiler,M.C., O'Neil,S.V., Soper,D.L., Wang,Y., Wos,J.A., Fancher,A.N., Lu,W., Suchanek,M.K., Wang,R.L., De,B. and Demuth,T.P., Jr.
Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors
Bioorg Med Chem Lett (24-7-2006) 16, 4728-4732. PubMed Europe PubMed DOI I
[YEAR:22-9-2006]Gurcel,L., Abrami,L., Girardin,S., Tschopp,J. and van der Goot,F.G.
Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
Cell (22-9-2006) 126, 1135-1145. PubMed Europe PubMed DOI
[YEAR:22-6-2006]Kleinke,A.S., Li,C., Rabasso,N. and Porco,J.A., Jr.
Total synthesis of the interleukin-1beta converting enzyme inhibitor EI-1941-2 using tandem oxa-electrocyclization/oxidation
Org Lett (22-6-2006) 8, 2847-2850. PubMed Europe PubMed DOI I
[YEAR:1-10-2006]Nadiri,A., Wolinski,M.K. and Saleh,M.
The inflammatory caspases: key players in the host response to pathogenic invasion and sepsis
J Immunol (1-10-2006) 177, 4239-4245. PubMed Europe PubMed V
Ravizza,T., Lucas,S.M., Balosso,S., Bernardino,L., Ku,G., Noe,F., Malva,J., Randle,J.C., Allan,S. and Vezzani,A.
Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy
Epilepsia (2006) 47, 1160-1168. PubMed Europe PubMed DOI I
[YEAR:22-9-2006]Saleh,M.
Caspase-1 builds a new barrier to infection
Cell (22-9-2006) 126, 1028-1030. PubMed Europe PubMed DOI
[YEAR:14-8-2006]Sarkar,A., Hall,M.W., Exline,M., Hart,J., Knatz,N., Gatson,N.T. and Wewers,M.D.
Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18
Am J Respir Crit Care Med (14-8-2006) 174, 1003-1010. PubMed Europe PubMed DOI PMC EPMC I
[YEAR:16-5-2006]Scheer,J.M., Romanowski,M.J. and Wells,J.A.
A common allosteric site and mechanism in caspases
Proc Natl Acad Sci U S A (16-5-2006) 103, 7595-7600. PubMed Europe PubMed DOI PMC EPMC I
[YEAR:15-6-2006]Soper,D.L., Sheville,J., O'Neil,S.V., Wang,Y., Laufersweiler,M.C., Oppong,K.A., Wos,J.A., Ellis,C.D., Fancher,A.N., Lu,W., Suchanek,M.K., Wang,R.L., De,B. and Demuth,T.P., Jr.
Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors
Bioorg Med Chem Lett (15-6-2006) 16, 4233-4236. PubMed Europe PubMed DOI I
[YEAR:12-8-2006]Soper,D.L., Sheville,J.X., O'Neil,S.V., Wang,Y., Laufersweiler,M.C., Oppong,K.A., Wos,J.A., Ellis,C.D., Baize,M.W., Chen,J.J., Fancher,A.N., Lu,W., Suchanek,M.K., Wang,R.L., Schwecke,W.P., Cruze,C.A., Buchalova,M., Belkin,M., Wireko,F., Ritter,A., De,B., Wang,D. and Demuth,T.P., Jr.
Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme (ICE) inhibitors
Bioorg Med Chem (12-8-2006) 14, 7880-7892. PubMed Europe PubMed DOI I

2005

[YEAR:22-4-2005]Corasaniti,M.T., Russo,R., Amantea,D., Gliozzi,M., Siviglia,E., Stringaro,A.R., Malorni,W., Melino,G. and Bagetta,G.
Neuroprotection by the caspase-1 inhibitor Ac-YVAD-(acyloxy)mk in experimental neuroAIDS is independent from IL-1beta generation
Cell Death Differ (22-4-2005) 12 Suppl 1, 999-1001. PubMed Europe PubMed DOI I
Dinarello,C.A.
An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor
Immunity (2005) 23, 461-462. PubMed Europe PubMed DOI
Gemma,C., Fister,M., Hudson,C. and Bickford,P.C.
Improvement of memory for context by inhibition of caspase-1 in aged rats
Eur J Neurosci (2005) 22, 1751-1756. PubMed Europe PubMed DOI I
[YEAR:1-5-2005]O'Brien,T., Fahr,B.T., Sopko,M.M., Lam,J.W., Waal,N.D., Raimundo,B.C., Purkey,H.E., Pham,P. and Romanowski,M.J.
Structural analysis of caspase-1 inhibitors derived from tethering
Acta Crystallograph Sect F Struct Biol Cryst Commun (1-5-2005) 61, 451-458. PubMed Europe PubMed DOI PMC EPMC S
[YEAR:7-10-2005]O'Neil,S.V., Wang,Y., Laufersweiler,M.C., Oppong,K.A., Soper,D.L., Wos,J.A., Ellis,C.D., Baize,M.W., Bosch,G.K., Fancher,A.N., Lu,W., Suchanek,M.K., Wang,R.L., De,B. and Demuth,T.P., Jr.
Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme inhibitors
Bioorg Med Chem Lett (7-10-2005) 15, 5434-5438. PubMed Europe PubMed DOI I
Scheer,J.M., Wells,J.A. and Romanowski,M.J.
Malonate-assisted purification of human caspases
Protein Expr Purif (2005) 41, 148-153. PubMed Europe PubMed DOI E
[YEAR:15-8-2005]Stack,J.H., Beaumont,K., Larsen,P.D., Straley,K.S., Henkel,G.W., Randle,J.C. and Hoffman,H.M.
IL-Converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients
J Immunol (15-8-2005) 175, 2630-2634. PubMed Europe PubMed I
[YEAR:1-12-2005]Verhoef,P.A., Kertesy,S.B., Lundberg,K., Kahlenberg,J.M. and Dubyak,G.R.
Inhibitory effects of chloride on the activation of caspase-1, Il-1beta secretion, and cytolysis by the p2x7 receptor
J Immunol (1-12-2005) 175, 7623-7634. PubMed Europe PubMed

2004

Faubel,S., Ljubanovic,D., Reznikov,L., Somerset,H., Dinarello,C.A. and Edelstein,C.L.
Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis
Kidney Int (2004) 66, 2202-2213. PubMed Europe PubMed DOI K
Feng,Q., Li,P., Leung,P.C. and Auersperg,N.
Caspase-1zeta, a new splice variant of the caspase-1 gene
Genomics (2004) 84, 587-591. PubMed Europe PubMed DOI R
[YEAR:23-3-2004]Lamkanfi,M., Kalai,M., Saelens,X., Declercq,W. and Vandenabeele,P.
Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity
J Biol Chem (23-3-2004) 279, 24785-24793. PubMed Europe PubMed DOI
Loher,F., Bauer,C., Landauer,N., Schmall,K., Siegmund,B., Lehr,H.A., Dauer,M., Schoenharting,M., Endres,S. and Eigler,A.
The interleukin-1 beta-converting enzyme inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and T helper 1 T-cell activation
J Pharmacol Exp Ther (2004) 308, 583-590. PubMed Europe PubMed DOI I
[YEAR:8-7-2004]Mariathasan,S., Newton,K., Monack,D.M., Vucic,D., French,D.M., Lee,W.P., Roose-Girma,M., Erickson,S. and Dixit,V.M.
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Nature (8-7-2004) 430, 213-218. PubMed Europe PubMed DOI
Romanowski,M.J., Scheer,J.M., O'Brien,T. and McDowell,R.S.
Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding
Structure (2004) 12, 1361-1371. PubMed Europe PubMed DOI S
Thakur,A., Barrett,R.P., Hobden,J.A. and Hazlett,L.D.
Caspase-1 inhibitor reduces severity of Pseudomonas aeruginosa keratitis in mice
Invest Ophthalmol Vis Sci (2004) 45, 3177-3184. PubMed Europe PubMed DOI I
Thornberry,N.A.
Caspase-1
[ISSN:0-12-079610-4] (2004) 2, 1287-1292. V

2003

Frantz,S., Ducharme,A., Sawyer,D., Rohde,L.E., Kobzik,L., Fukazawa,R., Tracey,D., Allen,H., Lee,R.T. and Kelly,R.A.
Targeted deletion of caspase-1 reduces early mortality and left ventricular dilatation following myocardial infarction
J Mol Cell Cardiol (2003) 35, 685-694. PubMed Europe PubMed DOI K
Hentze,H., Lin,X.Y., Choi,M.S. and Porter,A.G.
Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin
Cell Death Differ (2003) 10, 956-968. PubMed Europe PubMed DOI
Rudolphi,K., Gerwin,N., Verzijl,N., Van der Kraan,P. and Van den Berg,W.
Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis
Osteoarthritis Cartilage (2003) 11, 738-746. PubMed Europe PubMed DOI I

2002

Koedel,U., Winkler,F., Angele,B., Fontana,A., Flavell,R.A. and Pfister,H.W.
Role of caspase-1 in experimental pneumococcal meningitis: evidence from pharmacologic caspase inhibition and caspase-1-deficient mice
Ann Neurol (2002) 51, 319-329. PubMed Europe PubMed DOI
[YEAR:15-5-2002]Ming,X., Li,W., Maeda,Y., Blumberg,B., Raval,S., Cook,S.D. and Dowling,P.C.
Caspase-1 expression in multiple sclerosis plaques and cultured glial cells
J Neurol Sci (15-5-2002) 197, 9-18. PubMed Europe PubMed DOI I
[YEAR:1-12-2002]Rowe,S.J., Allen,L., Ridger,V.C., Hellewell,P.G. and Whyte,M.K.
Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury
J Immunol (1-12-2002) 169, 6401-6407. PubMed Europe PubMed K
Shahripour,A.B., Plummer,M.S., Lunney,E.A., Albrecht,H.P., Hays,S.J., Kostlan,C.R., Sawyer,T.K., Walker,N.P., Brady,K.D., Allen,H.J., Talanian,R.V., Wong,W.W. and Humblet,C.
Structure-based design of nonpeptide inhibitors of interleukin-1beta converting enzyme (ICE, caspase-1)
Bioorg Med Chem (2002) 10, 31-40. PubMed Europe PubMed DOI I
[YEAR:1-7-2002]Siegmund,B.
Interleukin-1beta converting enzyme (caspase-1) in intestinal inflammation
Biochem Pharmacol (1-7-2002) 64, 1-8. PubMed Europe PubMed DOI I

2001

[YEAR:6-4-2001]Gupta,S., Radha,V., Furukawa,Y. and Swarup,G.
Direct transcriptional activation of human caspase-1 by tumor suppressor p53
J Biol Chem (6-4-2001) 276, 10585-10588. PubMed Europe PubMed DOI
[YEAR:9-3-2001]Huang,Y.H., Park,Y.C., Rich,R.L., Segal,D., Myszka,D.G. and Wu,H.
Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain
Cell (9-3-2001) 104, 781-790. PubMed Europe PubMed S
Randle,J.C., Harding,M.W., Ku,G., Schonharting,M. and Kurrle,R.
ICE/Caspase-1 inhibitors as novel anti-inflammatory drugs
Expert Opin Investig Drugs (2001) 10, 1207-1209. PubMed Europe PubMed DOI I
Sheng,J.G., Mrak,R.E., Jones,R.A., Brewer,M.M., Zhou,X.Q., McGinness,J., Woodward,S., Bales,K., Paul,S.M., Cordell,B. and Griffin,W.S.
Neuronal DNA damage correlates with overexpression of interleukin-1beta converting enzyme in APPV717F mice
Neurobiol Aging (2001) 22, 895-902. PubMed Europe PubMed DOI

2000

[YEAR:17-7-2000]Monack,D.M., Hersh,D., Ghori,N., Bouley,D., Zychlinsky,A. and Falkow,S.
Salmonella exploits caspase-1 to colonize Peyer's patches in a murine typhoid model
J Exp Med (17-7-2000) 192, 249-258. PubMed Europe PubMed DOI PMC EPMC
[YEAR:15-6-2000]Rabuffetti,M., Sciorati,C., Tarozzo,G., Clementi,E., Manfredi,A.A. and Beltramo,M.
Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines
J Neurosci (15-6-2000) 20, 4398-4404. PubMed Europe PubMed I
Sansonetti,P.J., Phalipon,A., Arondel,J., Thirumalai,K., Banerjee,S., Akira,S., Takeda,K. and Zychlinsky,A.
Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation
Immunity (2000) 12, 581-590. PubMed Europe PubMed
[YEAR:1-9-2000]Stennicke,H.R., Renatus,M., Meldal,M. and Salvesen,G.S.
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8
Biochem J (1-9-2000) 350, 563-568. PubMed Europe PubMed DOI PMC EPMC A P

1999

Bajusz,S., Fauszt,I., Nemeth,K., Barabas,E., Juhasz,A., Patthy,M. and Bauer,P.I.
Peptidyl beta-homo-aspartals (3-amino-4-carboxybutyraldehydes): new specific inhibitors of caspases
Biopolymers (1999) 51, 109-118. PubMed Europe PubMed DOI I
Brady,K.D., Giegel,D.A., Grinnell,C., Lunney,E., Talanian,R.V., Wong,W. and Walker,N.
A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones
Bioorg Med Chem (1999) 7, 621-631. PubMed Europe PubMed DOI S I
Garcia-Calvo,M., Peterson,E.P., Rasper,D.M., Vaillancourt,J.P., Zamboni,R., Nicholson,D.W. and Thornberry,N.A.
Purification and catalytic properties of human caspase family members
Cell Death Differ (1999) 6, 362-369. PubMed Europe PubMed DOI
Lee,D., Adams,J.L., Brandt,M., DeWolf,W.E., Jr., Keller,P.M. and Levy,M.A.
A substrate combinatorial array for caspases
Bioorg Med Chem Lett (1999) 9, 1667-1672. PubMed Europe PubMed DOI P
Liu,X.H., Kwon,D., Schielke,G.P., Yang,G.Y., Silverstein,F.S. and Barks,J.D.
Mice deficient in interleukin-1 converting enzyme are resistant to neonatal hypoxic-ischemic brain damage
J Cereb Blood Flow Metab (1999) 19, 1099-1108. PubMed Europe PubMed DOI K
Okamoto,Y., Anan,H., Nakai,E., Morihira,K., Yonetoku,Y., Kurihara,H., Sakashita,H., Terai,Y., Takeuchi,M., Shibanuma,T. and Isomura,Y.
Peptide based interleukin-1beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex
Chem Pharm Bull (Tokyo) (1999) 47, 11-21. PubMed Europe PubMed I

1998

[YEAR:9-6-1998]Brady,K.D.
Bimodal inhibition of caspase-1 by aryloxymethyl and acyloxymethyl ketones
Biochemistry (9-6-1998) 37, 8508-8515. PubMed Europe PubMed DOI I
[YEAR:28-9-1998]Johnson,A.L., Bridgham,J.T., Munks,M. and Witty,J.P.
Characterization of the chicken interleukin-1beta converting enzyme (caspase-1) cDNA and expression of caspase-1 mRNA in the hen
Gene (28-9-1998) 219, 55-62. PubMed Europe PubMed DOI

1997

Akita,K., Ohtsuki,T., Nukada,Y., Tanimoto,T., Namba,M., Okura,T., Takakura-Yamamoto,R., Torigoe,K., Gu,Y., Su,M.S., Fujii,M., Satoh-Itoh,M., Yamamoto,K., Kohno,K., Ikeda,M. and Kurimoto,M.
Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells
J Biol Chem (1997) 272, 26595-26603. PubMed Europe PubMed DOI I
[YEAR:2-5-1997]Beyaert,R., Kidd,V.J., Cornelis,S., Van de Craen,M., Denecker,G., Lahti,J.M., Gururajan,R., Vandenabeele,P. and Fiers,W.
Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor
J Biol Chem (2-5-1997) 272, 11694-11697. PubMed Europe PubMed DOI
Chen,W., Raybuck,S.A., Fulghum,J.R., Petrillo,R.A., Margolin,N. and Chambers,S.P.
Expression and purification of human interleukin-1 beta converting enzyme from Trichoplusia ni insect cells using a Baculovirus expression system
Protein Expr Purif (1997) 9, 69-75. PubMed Europe PubMed DOI E
[YEAR:15-2-1997]Fantuzzi,G., Ku,G., Harding,M.W., Livingston,D.J., Sipe,J.D., Kuida,K., Flavell,R.A. and Dinarello,C.A.
Response to local inflammation of IL-1 beta-converting enzyme- deficient mice
J Immunol (15-2-1997) 158, 1818-1824. PubMed Europe PubMed K
[YEAR:10-1-1997]Gu,Y., Kuida,K., Tsutsui,H., Ku,G., Hsiao,K., Fleming,M.A., Hayashi,N., Higashino,K., Okamura,H., Nakanishi,K., Kurimoto,M., Tanimoto,T., Flavell,R.A., Sato,V., Harding,M.W., Livingston,D.J. and Su,M.S.
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme
Science (10-1-1997) 275, 206-209. PubMed Europe PubMed DOI K
Li,P., Allen,H., Banerjee,S. and Seshadri,T.
Characterization of mice deficient in interleukin-1beta converting enzyme
J Cell Biochem (1997) 64, 27-32. PubMed Europe PubMed DOI K
Margolin,N., Raybuck,S.A., Wilson,K.P., Chen,W., Fox,T., Gu,Y. and Livingston,D.J.
Substrate and inhibitor specificity of interleukin-1beta-converting enzyme and related caspases
J Biol Chem (1997) 272, 7223-7228. PubMed Europe PubMed DOI S I
Rano,T.A., Timkey,T., Peterson,E.P., Rotonda,J., Nicholson,D.W., Becker,J.W., Chapman,K.T. and Thornberry,N.A.
A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)
Chem Biol (1997) 4, 149-155. PubMed Europe PubMed I
[YEAR:11-4-1997]Talanian,R.V., Quinlan,C., Trautz,S., Hackett,M.C., Mankovich,J.A., Banach,D., Ghayur,T., Brady,K.D. and Wong,W.W.
Substrate specificities of caspase family proteases
J Biol Chem (11-4-1997) 272, 9677-9682. PubMed Europe PubMed DOI P
Van de Craen,M., Vandenabeele,P., Declercq,W., van den Brande,I., Van Loo,G., Molemans,F., Schotte,P., van Criekinge,W., Beyaert,R. and Fiers,W.
Characterization of seven murine caspase family members
FEBS Lett (1997) 403, 61-69. PubMed Europe PubMed DOI

1996

Ku,G., Faust,T., Lauffer,L.L., Livingston,D.J. and Harding,M.W.
Interleukin-1 beta converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice
Cytokine (1996) 8, 377-386. PubMed Europe PubMed DOI
Talanian,R.V., Dang,L.C., Ferenz,C.R., Hackett,M.C., Mankovich,J.A., Welch,J.P., Wong,W.W. and Brady,K.D.
Stability and oligomeric equilibria of refolded interleukin-1beta converting enzyme
J Biol Chem (1996) 271, 21853-21858. PubMed Europe PubMed DOI

1995

Elford,P.R., Heng,R., Revesz,L. and MacKenzie,A.R.
Reduction of inflammation and pyrexia in the rat by oral administration of SDZ 224-015, an inhibitor of the interleukin- 1beta converting enzyme
Br J Pharmacol (1995) 115, 601-606. PubMed Europe PubMed PMC EPMC I
Fletcher,D.S., Agarwal,L., Chapman,K.T., Chin,J., Egger,L.A., Limjuco,G., Luell,S., MacIntyre,D.E., Peterson,E.P., Thornberry,N.A. and Kostura,M.J.
A synthetic inhibitor of interleukin-1beta converting enzyme prevents endotoxin-induced interleukin-1beta production in vitro and in vivo
J Interferon Res (1995) 15, 243-248. I
[YEAR:1-3-1995]Howard,A.D., Palyha,O.C., Griffin,P.R., Peterson,E.P., Lenny,A.B., Ding,G.J., Pickup,D.J., Thornberry,N.A., Schmidt,J.A. and Tocci,M.J.
Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA
J Immunol (1-3-1995) 154, 2321-2332. PubMed Europe PubMed
Kuida,K., Lippke,J.A., Ku,G., Harding,M.W., Livingston,D.J., Su,M.S. and Flavell,R.A.
Altered cytokine export and apoptosis in mice deficient in interleukin-1beta converting enzyme
Science (1995) 267, 2000-2003. PubMed Europe PubMed K
Li,P., Allen,H., Banerjee,S., Franklin,S., Herzog,L., Johnston,C., McDowell,J., Paskind,M., Rodman,L., Salfeld,J., Towne,E., Tracey,D., Wardwell,S., Wei,F.Y., Wong,W., Kamen,R. and Seshadri,T.
Mice deficient in IL-1beta-converting enzyme are defective in production of mature IL-1beta and resistant to endotoxic shock
Cell (1995) 80, 401-411. PubMed Europe PubMed
Malinowski,J.J., Grasberger,B.L., Trakshel,G., Huston,E.E., Helaszek,C.T., Smallwood,A.M., Ator,M.A., Banks,T.M., Brake,P.G., Ciccarelli,R.B., Jones,B.N., Koehn,J.A., Kratz,D., Lundberg,N., Stams,T., Rubin,B., Alexander,R.S. and Stevis,P.E.
Production, purification, and crystallization of human interleukin- 1 beta converting enzyme derived from an Escherichia coli expression system
Protein Sci (1995) 4, 2149-2155. PubMed Europe PubMed DOI PMC EPMC E
Miller,B.E., Krasney,P.A., Gauvin,D.M., Holbrook,K.B., Koonz,D.J., Abruzzese,R.V., Miller,R.E., Pagani,K.A., Dolle,R.E., Ator,M.A. and Gilman,S.C.
Inhibition of mature IL-1 beta production in murine macrophages and a murine model of inflammation by WIN 67694, an inhibitor of IL-1beta converting enzyme
J Immunol (1995) 154, 1331-1338. PubMed Europe PubMed I
Prasad,C.V.C., Prouty,C.P., Hoyer,D., Ross,T.M., Salvino,J.M., Awas,M., Graybill,T.L., Schmidt,S.J., Osifo,I.K., Dolle,R.E., Helaszek,C.T., Miller,E. and Ator,M.A.
Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1beta converting enzyme
Bioorg Med Chem Lett (1995) 5, 315-318. DOI I
Quan,L.T., Caputo,A., Bleackley,R.C., Pickup,D.J. and Salvesen,G.S.
Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A
J Biol Chem (1995) 270, 10377-10379. PubMed Europe PubMed DOI
Thornberry,N.A. and Molineaux,S.M.
Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell death
Protein Sci (1995) 4, 3-12. PubMed Europe PubMed DOI PMC EPMC

1994

Dolle,R.E., Hoyer,D., Prasad,C.V., Schmidt,S.J., Helaszek,C.T., Miller,R.E. and Ator,M.A.
P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1beta-converting enzyme
J Med Chem (1994) 37, 563-564. PubMed Europe PubMed I
[YEAR:11-11-1994]Dolle,R.E., Singh,J., Rinker,J., Hoyer,D., Prasad,C.V., Graybill,T.L., Salvino,J.M., Helaszek,C.T., Miller,R.E. and Ator,M.A.
Aspartyl alpha-((1-phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl ketones as interleukin-1 beta converting enzyme inhibitors. Significance of the P1 and P3 amido nitrogens for enzyme-peptide inhibitor binding
J Med Chem (11-11-1994) 37, 3863-3866. PubMed Europe PubMed DOI I
Graybill,T.L., Dolle,R.E., Helaszek,C.T., Miller,R.E. and Ator,M.A.
Preparation and evaluation of peptidic aspartyl hemiacetals as reversible inhibitors of interleukin-1 beta converting enzyme (ICE)
Int J Pept Protein Res (1994) 44, 173-182. PubMed Europe PubMed I
[YEAR:29-7-1994]Komiyama,T., Ray,C.A., Pickup,D.J., Howard,A.D., Thornberry,N.A., Peterson,E.P. and Salvesen,G.
Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition
J Biol Chem (29-7-1994) 269, 19331-19337. PubMed Europe PubMed
Mjalli,A.M.M., Chapman,K.T., MacCoss,M., Thornberry,N.A. and Peterson,E.P.
Activated ketones as potent reversible inhibitors of interleukin-1beta converting enzyme
Bioorg Med Chem Lett (1994) 4, 1965-1968. DOI I
Mullican,M.D., Lauffer,D.J., Gillespie,R.J., Martharu,S.S., Kay,D., Porritt,G.M., Evans,P.L., Golec,J.M., Murcko,M.A., Luong,Y.P., Raybuck,S.A. and Livingston,D.J.
The synthesis and evaluation of peptidyl aspartyl aldehydes as inhibitors of ice
Bioorg Med Chem Lett (1994) 4, 2359-2364. DOI I
Revesz,L., Briswalter,C., Heng,R., Leutwiller,A., Mueller,R. and Wuethrich,H.J.
Synthesis of P1-apartyl-based peptide acyloxymethyl and fluoromethyl ketones as inhibitors of interleukin-1-beta converting enzyme
Tetrahedron Lett (1994) 35, 9693-9696. DOI I
Thornberry,N.A., Peterson,E.P., Zhao,J.J., Howard,A.D., Griffin,P.R. and Chapman,K.T.
Inactivation of interleukin-1beta converting enzyme by peptide (acyloxy)methyl ketones
Biochemistry (1994) 33, 3934-3940. PubMed Europe PubMed I
Thornberry,N.A.
Interleukin-1 beta converting enzyme
Methods Enzymol (1994) 244, 615-631. PubMed Europe PubMed DOI V
[YEAR:29-7-1994]Walker,N.P.C., Talanian,R.V., Brady,K.D., Dang,L.C., Bump,N.J., Ferenz,C.R., Franklin,S., Ghayur,T., Hackett,M.C., Hammill,L.D., Herzog,L., Hugunin,M., Houy,W., Mankovich,J.A., McGuiness,L., Orlewicz,E., Paskind,M., Pratt,C.A., Reis,P., Summani,A., Terranova,M., Welch,J.P., Xiong,L. and Moller,A.
Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer
Cell (29-7-1994) 78, 343-352. PubMed Europe PubMed DOI S
Wang,X.M., Helaszek,C.T., Winter,L.A., Lirette,R.P., Dixon,D.C., Ciccarelli,R.B., Kelley,M.M., Malinowski,J.J., Simmons,S.J., Huston,E.E., Koehn,J.A., Kratz,D., Bruckner,R.C., Graybill,T., Ator,M.A., Lehr,R.V. and Stevis,P.E.
Production of active human interleukin-1beta-converting enzyme in a baculovirus expression system
Gene (1994) 145, 273-277. PubMed Europe PubMed DOI
Wilson,K.P., Black,J.F., Thomson,J.A., Kim,E.E., Griffith,J.P., Navia,M.A., Murcko,M.A., Chambers,S.P., Aldape,R.A., Raybuck,S.A. and Livingston,D.J.
Structure and mechanism of interleukin-1beta converting enzyme
Nature (1994) 370, 270-275. PubMed Europe PubMed DOI S

1993

Mjalli,A.M.M., Chapman,K.T., MacCoss,M. and Thornberry,N.A.
Phenylalkyl ketones as potent reversible inhibitors of interleukin-1beta converting enzyme
Bioorg Med Chem Lett (1993) 3, 2689-2692. DOI I
Mjalli,A.M.M., Chapman,K.T. and MacCoss,M.
Synthesis of a peptidyl 2,2-difluoro-4-phenylbutyl ketone and its evaluation as an inhibitor of interleukin-1beta converting enzyme
Bioorg Med Chem Lett (1993) 3, 2693-2698. DOI I
Molineaux,S.M., Casano,F.J., Rolando,A.M., Peterson,E.P., Limjuco,G., Chin,J., Griffin,P.R., Calaycay,J.R., Ding,G.J. and Yamin,T.T.
Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme
Proc Natl Acad Sci U S A (1993) 90, 1809-1813. PubMed Europe PubMed PMC EPMC I

1992

Cerretti,D.P., Kozlosky,C.J., Mosley,B., Nelson,N., Van Ness,K., Greenstreet,T.A., March,C.J., Kronheim,S.R., Druck,T., Cannizzaro,L.A., Huebner,K. and Black,R.A.
Molecular cloning of the interleukin-1beta converting enzyme
Science (1992) 256, 97-100. PubMed Europe PubMed
Chapman,K.T.
Synthesis of a potent, reversible inhibitor of interleukin-1beta converting enzyme
Bioorg Med Chem Lett (1992) 2, 613-618. DOI I
Nett,M.A., Cerretti,D.P., Berson,D.R., Seavitt,J., Gilbert,D.J., Jenkins,N.A., Copeland,N.G., Black,R.A. and Chaplin,D.D.
Molecular cloning of the murine IL-1beta converting enzyme cDNA
J Immunol (1992) 149, 3254-3259. PubMed Europe PubMed
[YEAR:15-5-1992]Ray,C.A., Black,R.A., Kronheim,S.R., Greenstreet,T.A., Sleath,P.R., Salvesen,G.S. and Pickup,D.J.
Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme
Cell (15-5-1992) 69, 597-604. PubMed Europe PubMed DOI
Robinson,R.P. and Donahue,K.M.
Synthesis of a peptidyl difluoro ketone bearing the aspartic acid side chain: an inhibitor of interleukin-1beta converting enzyme
J Org Chem (1992) 57, 7309-7314. DOI I
Thornberry,N.A., Bull,H.G., Calaycay,J.R., Chapman,K.T., Howard,A.D., Kostura,M.J., Miller,D.K., Molineaux,S.M., Weidner,J.R., Aunins,J., Elliston,K.O., Ayala,J.M., Casano,F.J., Chin,J., Ding,G.J.F., Egger,L.A., Gaffney,E.P., Limjuco,G., Palyha,O.C., Raju,S.M., Rolando,A.M., Salley,J.P., Yamin,T.T. and Tocci,M.J.
A novel heterodimeric cysteine protease is required for interleukin-1beta processing in monocytes
Nature (1992) 356, 768-774. PubMed Europe PubMed DOI I

1991

Howard,A., Kostura,M.J., Thornberry,N., Ding,G.J., Limjuco,G., Weidner,J., Salley,J.P., Hogquist,K.A., Chaplin,D.D., Mumford,R.A., Schmidt,J.A. and Tocci,M.J.
IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha
J Immunol (1991) 147, 2964-2969. PubMed Europe PubMed

1989

Black,R.A., Kronheim,S.R. and Sleath,P.R.
Activation of interleukin-1beta by a co-induced protease
FEBS Lett (1989) 247, 386-390. PubMed Europe PubMed
Kostura,M.J., Tocci,M.J., Limjuco,G., Chin,J., Cameron,P., Hillman,A.G., Chartrain,N.A. and Schmidt,J.A.
Identification of a monocyte specific pre-interleukin 1 beta convertase activity
Proc Natl Acad Sci U S A (1989) 86, 5227-5231. PubMed Europe PubMed PMC EPMC