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Literature for peptidase C14.001: caspase-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Shi,Y., Hu,Y., Li,J., Chen,H., Zhong,Q., Ma,X., Li,X., Zhang,S., Zhuang,S. and Liu,N.
    Inhibition of Caspase-1 Suppresses GSDMD-mediated Peritoneal Mesothelial Cell Pyroptosis and Inflammation in Peritoneal Fibrosis
    Smalle2409362-e2409362. PubMed  Europe PubMed DOI  K
  2. Wang,X., Xie,X., Ni,J.Y., Li,J.Y., Sun,X.A., Xie,H.Y., Yang,N.H., Guo,H.J., Lu,L., Ning,M., Zhou,L., Liu,J., Xu,C., Zhang,W., Wen,Y., Shen,Q., Xu,H. and Lu,L.M.
    USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation
    Acta Pharmacol Sin46, 159-170. PubMed  Europe PubMed DOI
  3. Xu,W., Huang,Y. and Zhou,R.
    NLRP3 inflammasome in neuroinflammation and central nervous system diseases
    Cell Mol Immunol PubMed  Europe PubMed DOI  V
    4. 2024
  4. Ai,Y., Meng,Y., Yan,B., Zhou,Q. and Wang,X.
    The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death
    Mol Cell84, 170-179. PubMed  Europe PubMed DOI  V
  5. Azhar,G., Nagano,K., Patyal,P., Zhang,X., Verma,A. and Wei,J.Y.
    Deletion of Interleukin-1beta Converting Enzyme Alters Mouse Cardiac Structure and Function
    Biology (Basel)13, PubMed  Europe PubMed DOI
  6. Babcock,I.W., Sibley,L.A., Labuzan,S.A., Cowan,M.N., Sethi,I., Alemu,S., Kelly,A.G., Kovacs,M.A., Lukens,J.R. and Harris,T.H.
    Caspase-1 in Cx3cr1-expressing cells drives an IL-18-dependent T cell response that promotes parasite control during acute Toxoplasma gondii infection
    PLoS Pathog20, e1012006-e1012006. PubMed  Europe PubMed DOI
  7. Billman,Z.P., Kovacs,S.B., Wei,B., Kang,K., Cisse,O.H. and Miao,E.A.
    Caspase-1 activates gasdermin A in non-mammals
    elife12, PubMed  Europe PubMed DOI
  8. Choudhury,S.M., Sarkar,R., Karki,R. and Kanneganti,T.D.
    A comparative study of apoptosis, pyroptosis, necroptosis, and PANoptosis components in mouse and human cells
    PLoS ONE19, e0299577-e0299577. PubMed  Europe PubMed DOI
  9. Fernandes,J.P., Branton,W.G., Cohen,E.A., Koopman,G., Kondova,I., Gelman,B.B. and Power,C.
    Caspase cleavage of gasdermin E causes neuronal pyroptosis in HIV-associated neurocognitive disorder
    Brain147, 717-734. PubMed  Europe PubMed DOI  K
  10. Imre,G.
    Pyroptosis in health and disease
    Am J Physiol Cell Physiol326, C784-C784. PubMed  Europe PubMed DOI  V
  11. Janin,Y.L.
    On the origins of SARS-CoV-2 main protease inhibitors
    RSC Med Chem15, 81-118. PubMed  Europe PubMed DOI  V  I
  12. Marques-da-Silva,C., Schmidt-Silva,C., Baptista,R.P. and Kurup,S.P.
    Inherently Reduced Expression of ASC Restricts Caspase-1 Processing in Hepatocytes and Promotes Plasmodium Infection
    J Immunol212, 596-606. PubMed  Europe PubMed DOI
  13. Nadella,V. and Kanneganti,T.D.
    Inflammasomes and their role in PANoptosomes
    Curr Opin Immunol91, 102489-102489. PubMed  Europe PubMed DOI  V
  14. Thygesen,S.J., Burgener,S.S., Mudai,P., Monteleone,M., Boucher,D., Sagulenko,V., Schroder,K. and Stacey,K.J.
    Fluorochrome-labeled inhibitors of caspase-1 require membrane permeabilization to efficiently access caspase-1 in macrophages
    Eur J Immunole2350515-e2350515. PubMed  Europe PubMed DOI
  15. Zhang,J., Cai,H., Sun,W., Wu,W., Nan,Y., Ni,Y., Wu,X., Chen,M., Xu,H. and Wang,Y.
    Endoplasmic reticulum aminopeptidase 2 regulates CD4(+) T cells pyroptosis in rheumatoid arthritis
    Arthritis Res Ther26, 36-36. PubMed  Europe PubMed DOI  K
  16. Zhen,H., Hu,Y., Liu,X., Fan,G. and Zhao,S.
    The protease caspase-1: Activation pathways and functions
    Biochem Biophys Res Commun717, 149978-149978. PubMed  Europe PubMed DOI  V
    17. 2023
  17. Alam,M.A., Caocci,M., Ren,M., Chen,Z., Liu,F., Khatun,M.S., Kolls,J.K., Qin,X. and Burdo,T.H.
    Deficiency of Caspase-1 Attenuates HIV-1-Associated Atherogenesis in Mice
    Int J Mol Sci24, PubMed  Europe PubMed DOI
  18. Anderson,M.J., den Hartigh,A.B. and Fink,S.L.
    Molecular Mechanisms of Pyroptosis
    Methods Mol Biol2641, 1-16. PubMed  Europe PubMed DOI  V
  19. Leal,V.N.C. and Pontillo,A.
    Canonical Inflammasomes
    Methods Mol Biol2696, 1-27. PubMed  Europe PubMed DOI  V
  20. Li,X., Jiang,Q., Song,G., Barkestani,M.N., Wang,Q., Wang,S., Fan,M., Fang,C., Jiang,B., Johnson,J., Geirsson,A., Tellides,G., Pober,J.S. and Jane-Wit,D.
    A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells
    Nat Commun14, 3002-3002. PubMed  Europe PubMed DOI
  21. Sahoo,G., Samal,D., Khandayataray,P. and Murthy,M.K.
    A Review on Caspases: Key Regulators of Biological Activities and Apoptosis
    Mol Neurobiol60, 5805-5837. PubMed  Europe PubMed DOI  V
  22. Saller,B.S., Neuwirt,E. and Gross,O.
    Methods to Activate the NLRP3 Inflammasome
    Methods Mol Biol2696, 169-197. PubMed  Europe PubMed DOI
  23. Shi,X., Sun,Q., Hou,Y., Zeng,H., Cao,Y., Dong,M., Ding,J. and Shao,F.
    Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome
    Nature624, 442-450. PubMed  Europe PubMed DOI
  24. Wang,Y., Fang,D., Yang,Q., You,J., Wang,L., Wu,J., Zeng,M. and Luo,M.
    Interactions between PCSK9 and NLRP3 inflammasome signaling in atherosclerosis
    Front Immunol14, 1126823-1126823. PubMed  Europe PubMed DOI  V
  25. Xiao,L., Magupalli,V.G. and Wu,H.
    Cryo-EM structures of the active NLRP3 inflammasome disc
    Nature613, 595-600. PubMed  Europe PubMed DOI
    26. 2022
  26. Banerjee,S.K., Chatterjee,A., Gupta,S. and Nagar,A.
    Activation and Regulation of NLRP3 by Sterile and Infectious Insults
    Front Immunol13, 896353-896353. PubMed  Europe PubMed DOI  V
  27. Bibo-Verdugo,B., Joglekar,I., Karadi Giridhar,M.N., Ramirez,M.L., Snipas,S.J., Clark,A.C., Poreba,M. and Salvesen,G.S.
    Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold
    J Biol Chem298, 101931-101931. PubMed  Europe PubMed DOI
  28. Chen,C. and Xu,P.
    Activation and Pharmacological Regulation of Inflammasomes
    Biomolecules12, PubMed  Europe PubMed DOI  V
  29. Guan,Y., Gu,Y., Li,H., Liang,B., Han,C., Zhang,Y., Liu,Q., Wei,W. and Ma,Y.
    NLRP3 inflammasome activation mechanism and its role in autoimmune liver disease
    Acta Biochim Biophys Sin (Shanghai)54, 1577-1586. PubMed  Europe PubMed DOI  V
  30. Han,L., Hao,Y., Wu,X. and Hu,D.
    PSMB5 Alleviates Ulcerative Colitis by Inhibiting ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis
    Dis Markers2022, 2329904-2329904. PubMed  Europe PubMed DOI
  31. Hu,Y., Jiang,Y., Li,S., Ma,X., Chen,M., Yang,R., Wen,S., Moynagh,P.N., Wang,B., Hu,G. and Yang,S.
    The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1/11
    Proc Natl Acad Sci U S A119, e2210809119-e2210809119. PubMed  Europe PubMed DOI
  32. Liao,Y., Liu,K. and Zhu,L.
    Emerging Roles of Inflammasomes in Cardiovascular Diseases
    Front Immunol13, 834289-834289. PubMed  Europe PubMed DOI  V
  33. Lin,C., Jiang,Z., Cao,L., Zou,H. and Zhu,X.
    Role of NLRP3 inflammasome in systemic sclerosis
    Arthritis Res Ther24, 196-196. PubMed  Europe PubMed DOI  V
  34. Lin,Z., Xia,Y., Guo,J., Xu,G., Liu,Y., Yang,Y., Xie,H., Huang,Y. and Fu,Q.
    Caspase-1 deficiency impairs neutrophils recruitment and bacterial clearance in Streptococcus equi ssp. zooepidemicus infected mice
    Vet Microbiol268, 109411-109411. PubMed  Europe PubMed DOI
  35. Lv,H., Liu,X. and Zhou,H.
    USP25 UPREGULATION BOOSTS GSDMD -MEDIATED PYROPTOSIS OF ACINAR CELLS IN ACUTE PANCREATITIS
    Shock58, 408-416. PubMed  Europe PubMed DOI
  36. Paget,C., Doz-Deblauwe,E., Winter,N. and Briard,B.
    Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases
    Cells11, PubMed  Europe PubMed DOI  V
  37. Ross,C., Chan,A.H., von Pein,J.B., Maddugoda,M.P., Boucher,D. and Schroder,K.
    Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes
    Annu Rev Immunol PubMed  Europe PubMed DOI  V
  38. Sullivan,G.P., Davidovich,P., Munoz-Wolf,N., Ward,R.W., Hernandez Santana,Y.E., Clancy,D.M., Gorman,A., Najda,Z., Turk,B., Walsh,P.T., Lavelle,E.C. and Martin,S.J.
    Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement
    Sci Immunol7, eade5728-eade5728. PubMed  Europe PubMed DOI
  39. Weir,A. and Vince,J.E.
    No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death
    Biochem J479, 1083-1102. PubMed  Europe PubMed DOI  V
  40. Ye,X., Song,G., Huang,S., Liang,Q., Fang,Y., Lian,L. and Zhu,S.
    Caspase-1: A Promising Target for Preserving Blood-Brain Barrier Integrity in Acute Stroke
    Front Mol Neurosci15, 856372-856372. PubMed  Europe PubMed DOI  V
    41. 2021
  41. Bateman,G., Hill,B., Knight,R. and Boucher,D.
    Great balls of fire: activation and signalling of inflammatory caspases
    Biochem Soc Trans49, 1311-1324. PubMed  Europe PubMed DOI  V
  42. Devant,P., Cao,A. and Kagan,J.C.
    Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1beta converting enzyme
    Sci Immunol6, PubMed  Europe PubMed DOI
  43. Huang,Y., Xu,W. and Zhou,R.
    NLRP3 inflammasome activation and cell death
    Cell Mol Immunol PubMed  Europe PubMed DOI  V
  44. Liao,Y., Liu,C., Wang,J., Song,Y., Sabir,N., Hussain,T., Yao,J., Luo,L., Wang,H., Cui,Y., Yang,L., Zhao,D. and Zhou,X.
    Caspase-1 inhibits IFN-beta production via cleavage of cGAS during M. bovis infection
    Vet Microbiol258, 109126-109126. PubMed  Europe PubMed DOI
  45. Lima,C., Falcao,M.A.P., Andrade-Barros,A.I., Seni-Silva,A.C., Grund,L.Z., Balogh,E., Conceicao,K., Queniaux,V.F., Ryffel,B. and Lopes-Ferreira,M.
    Natterin an aerolysin-like fish toxin drives IL-1beta-dependent neutrophilic inflammation mediated by caspase-1 and caspase-11 activated by the inflammasome sensor NLRP6
    Int Immunopharmacol91, 107287-107287. PubMed  Europe PubMed DOI
  46. Wang,J., Wang,L., Zhang,X., Xu,Y., Chen,L., Zhang,W., Liu,E., Xiao,C. and Kou,Q.
    Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis
    Int Immunopharmacol94, 107496-107496. PubMed  Europe PubMed DOI  I
  47. Wu,Z., Tian,Y., Alam,H.B., Li,P., Duan,X., Williams,A.M., Liu,B., Ma,J. and Li,Y.
    PAD2 Mediates Caspase-1 Associated Lethality in Pseudomonas Aeruginosa Pneumonia Induced Sepsis
    J Infect Dis223, 1093-1102. PubMed  Europe PubMed DOI
  48. Yoo,N.J., Park,W.S., Kim,S.Y., Reed,J.C., Son,S.G., Lee,J.Y. and Lee,S.H.
    Corrigendum to "Nod 1, a CARD protein, enhances pro-interleukin-1 beta processing through the interaction with pro-caspase-1" [Biochem. Biophys. Res. Commun. 299(4) (2002) 652-8]
    Biochem Biophys Res Commun543, 97-97. PubMed  Europe PubMed DOI
  49. Zhu,Y., Zhou,J., Niu,P., Chen,H. and Shi,D.
    Cardamonin inhibits cell proliferation by caspase-mediated cleavage of Raptor
    Naunyn Schmiedebergs Arch Pharmacol394, 809-817. PubMed  Europe PubMed DOI  I
  50. Zuo,Y., Chen,L., Gu,H., He,X., Ye,Z., Wang,Z., Shao,Q. and Xue,C.
    GSDMD-mediated pyroptosis: a critical mechanism of diabetic nephropathy
    Expert Rev Mol Med23, e23-e23. PubMed  Europe PubMed DOI  V
    51. 2020
  51. Abu Khweek,A. and Amer,A.O.
    Pyroptotic and non-pyroptotic effector functions of caspase-11
    Immunol Reve12910-e12910. PubMed  Europe PubMed DOI
  52. Barber,G., Anand,A., Katarzyna,O., Phelan,J.J., Heeran,A.B., Flis,E., Clarke,N.E., Watson,J.A., Strangmann,J., Flood,B., O'Neill,H., O'Toole,D., MacCarthy,F., Ravi,N., Reynolds,J.V., Kay,E.W., Quante,M., O'Sullivan,J. and Creagh,E.M.
    Characterizing caspase-1 involvement during esophageal disease progression
    Cancer Immunol Immunother PubMed  Europe PubMed DOI
  53. Cao,R., Zhang,Y., Du,J., Chen,S., Wang,N., Ying,H. and Shen,B.
    Increased FURIN expression in rheumatoid arthritis patients and its anti-inflammatory effect
    J Clin Lab Anale23530-e23530. PubMed  Europe PubMed DOI
  54. Chao,L., Li,Z., Zhou,J., Chen,W., Li,Y., Lv,W., Guo,A., Qu,Q. and Guo,S.
    Shen-Ling-Bai-Zhu-San Improves Dextran Sodium Sulfate-Induced Colitis by Inhibiting Caspase-1/Caspase-11-Mediated Pyroptosis
    Front Pharmacol11, 814-814. PubMed  Europe PubMed DOI
  55. Chen,H., Peng,Y., Wang,L. and Wang,X.
    Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus via upregulation of SIRT1 in a sepsis model
    Arch Physiol Biochem1-8. PubMed  Europe PubMed DOI
  56. Chuang,J.P., Kao,C.Y., Lee,J.C., Ling,P., Maa,M.C. and Leu,T.H.
    EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages
    Biochem Biophys Res Commun PubMed  Europe PubMed DOI
  57. de Vasconcelos,N.M., Van Opdenbosch,N., Van Gorp,H., Martin-Perez,R., Zecchin,A., Vandenabeele,P. and Lamkanfi,M.
    An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
    Cell Rep32, 107959-107959. PubMed  Europe PubMed DOI
  58. Ding,P.H., Yang,M.X., Wang,N.N., Jin,L.J., Dong,Y., Cai,X. and Chen,L.L.
    Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1beta Release Depend on Caspase-4
    Front Microbiol11, 1881-1881. PubMed  Europe PubMed DOI  K
  59. El-Sharkawy,L.Y., Brough,D. and Freeman,S.
    Inhibiting the NLRP3 Inflammasome
    Molecules25, PubMed  Europe PubMed DOI  V
  60. Fagenson,A.M., Xu,K., Saaoud,F., Nanayakkara,G., Jhala,N.C., Liu,L., Drummer,C., Sun,Y., Lau,K.N., Di Carlo,A., Jiang,X., Wang,H., Karhadkar,S.S. and Yang,X.
    Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice
    Pathogens9, PubMed  Europe PubMed DOI
  61. Fisch,D., Clough,B., Domart,M.C., Encheva,V., Bando,H., Snijders,A.P., Collinson,L.M., Yamamoto,M., Shenoy,A.R. and Frickel,E.M.
    Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death
    Cell Rep32, 108008-108008. PubMed  Europe PubMed DOI
  62. Frank,M.G., Baratta,M.V., Zhang,K., Fallon,I.P., Pearson,M.A., Liu,G., Hutchinson,M.R., Watkins,L.R., Goldys,E.M. and Maier,S.F.
    Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1beta protein in dorsal hippocampus
    Brain Behav Immun PubMed  Europe PubMed DOI
  63. Gao,M.R., Wang,M., Jia,Y.Y., Tian,D.D., Liu,A., Wang,W.J., Yang,L., Chen,J.Y., Yang,Q., Liu,R. and Wu,Y.M.
    Echinacoside protects dopaminergic neurons by inhibiting NLRP3/Caspase-1/IL-1beta signaling pathway in MPTP-induced Parkinson's disease model
    Brain Res Bull164, 55-64. PubMed  Europe PubMed DOI
  64. Goh,G., Ahn,M., Zhu,F., Lee,L.B., Luo,D., Irving,A.T. and Wang,L.F.
    Complementary regulation of caspase-1 and IL-1beta reveals additional mechanisms of dampened inflammation in bats
    Proc Natl Acad Sci U S A PubMed  Europe PubMed DOI
  65. Heilig,R., Dilucca,M., Boucher,D., Chen,K.W., Hancz,D., Demarco,B., Shkarina,K. and Broz,P.
    Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD
    Life Sci Alliance3, PubMed  Europe PubMed DOI
  66. Hong,W., Gu,Y., Guan,R., Xie,D., Zhou,H. and Yu,M.
    Pan-cancer analysis of the CASP gene family in relation to survival, tumor-infiltrating immune cells and therapeutic targets
    Genomics PubMed  Europe PubMed DOI
  67. Huang,H., Wang,J., Liu,Z. and Gao,F.
    The angiotensin-converting enzyme 2/angiotensin (1-7)/mas axis protects against pyroptosis in LPS-induced lung injury by inhibiting NLRP3 activation
    Arch Biochem Biophys693, 108562-108562. PubMed  Europe PubMed DOI  I
  68. Israelov,H., Ravid,O., Atrakchi,D., Rand,D., Elhaik,S., Bresler,Y., Twitto-Greenberg,R., Omesi,L., Liraz-Zaltsman,S., Gosselet,F., Schnaider Beeri,M. and Cooper,I.
    Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair
    J Neuroinflammation17, 267-267. PubMed  Europe PubMed DOI  I
  69. Jiao,Y., Wang,L., Lu,L., Liu,J., Li,X., Zhao,H., Hou,Z. and Zheng,B.
    The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors
    Stem Cells Int2020, 8867115-8867115. PubMed  Europe PubMed DOI  K
  70. Kovacs,S.B., Oh,C., Maltez,V.I., McGlaughon,B.D., Verma,A., Miao,E.A. and Aachoui,Y.
    Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium
    Cell Rep32, 107967-107967. PubMed  Europe PubMed DOI
  71. Kumari,P., Russo,A.J., Shivcharan,S. and Rathinam,V.A.
    AIM2 in health and disease: Inflammasome and beyond
    Immunol Rev PubMed  Europe PubMed DOI  V
  72. Leng,Y., Chen,R., Chen,R., He,S., Shi,X., Zhou,X., Zhang,Z. and Chen,A.F.
    HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway
    Biochem Biophys Res Commun532, 640-646. PubMed  Europe PubMed DOI
  73. Li,J., Zhang,Y., Ruan,R., He,W. and Qian,Y.
    The novel interplay between CD44 standard isoform and the caspase-1/IL1B pathway to induce hepatocellular carcinoma progression
    Cell Death Dis11, 961-961. PubMed  Europe PubMed DOI
  74. Li,Y., Ouyang,Y., Jiao,J., Xu,Z. and Zhang,L.
    Exposure to environmental black carbon exacerbates nasal epithelial inflammation via the reactive oxygen species (ROS)-nucleotide-binding, oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3)-caspase-1-interleukin 1beta (IL-1beta) pathway
    Int Forum Allergy Rhinol PubMed  Europe PubMed DOI  I
  75. Liang,H., Li,F., Li,H., Wang,R. and Du,M.
    Overexpression of lncRNA HULC Attenuates Myocardial Ischemia/reperfusion Injury in Rat Models and Apoptosis of Hypoxia/reoxygenation Cardiomyocytes via Targeting miR-377-5p through NLRP3/Caspase1/IL1beta Signaling Pathway Inhibition
    Immunol Invest1-14. PubMed  Europe PubMed DOI  I
  76. Liu,L., Chen,M., Lin,K., Xiang,X., Zheng,Y. and Zhu,S.
    Inhibiting Caspase-12 Mediated Inflammasome Activation protects against Oxygen-Glucose Deprivation Injury in Primary Astrocytes
    Int J Med Sci17, 1936-1945. PubMed  Europe PubMed DOI
  77. Liu,Z., Wang,C., Yang,J., Chen,Y., Zhou,B., Abbott,D.W. and Xiao,T.S.
    Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage
    Immunity53, 106-114. PubMed  Europe PubMed DOI
  78. Lu,J. and Sun,P.D.
    High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity
    J Biol Chem PubMed  Europe PubMed DOI
  79. Ma,S., Wang,Y., Zhou,X., Li,Z., Zhang,Z., Wang,Y., Huang,T., Zhang,Y., Shi,J. and Guan,F.
    MG53 Protects hUC-MSCs against Inflammatory Damage and Synergistically Enhances Their Efficacy in Neuroinflammation Injured Brain through Inhibiting NLRP3/Caspase-1/IL-1beta Axis
    ACS Chem Neurosci11, 2590-2601. PubMed  Europe PubMed DOI
  80. McKenzie,B.A., Fernandes,J.P., Doan,M.A.L., Schmitt,L.M., Branton,W.G. and Power,C.
    Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis
    J Neuroinflammation17, 253-253. PubMed  Europe PubMed DOI  K
  81. Molla,M.D., Ayelign,B., Dessie,G., Geto,Z. and Admasu,T.D.
    Caspase-1 as a regulatory molecule of lipid metabolism
    Lipids Health Dis19, 34-34. PubMed  Europe PubMed DOI
  82. Pang,Y., Zhang,P.C., Lu,R.R., Li,H.L., Li,J.C., Fu,H.X., Cao,Y.W., Fang,G.X., Liu,B.H., Wu,J.B., Zhou,J.Y. and Zhou,Y.
    Andrade-Oliveira Salvianolic Acid B Modulates Caspase-1-Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via Nrf2 Pathway
    Front Pharmacol11, 541426-541426. PubMed  Europe PubMed DOI
  83. Pinar,A.A., Yuferov,A., Gaspari,T.A. and Samuel,C.S.
    Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1
    Front Pharmacol11, 1201-1201. PubMed  Europe PubMed DOI  K
  84. Roman-Melendez,G.D., Venkataraman,T., Monaco,D.R. and Larman,H.B.
    Protease Activity Profiling via Programmable Phage Display of Comprehensive Proteome-Scale Peptide Libraries
    Cell Syst11, 375-381. PubMed  Europe PubMed DOI
  85. Sabino,F., Madzharova,E. and auf dem Keller,U.
    Cell density-dependent proteolysis by HtrA1 induces translocation of zyxin to the nucleus and increased cell survival
    Cell Death Dis11, 674-674. PubMed  Europe PubMed DOI
  86. Sachdev,U., Ferrari,R., Cui,X., Pius,A., Sahu,A., Reynolds,M., Liao,H., Sun,P., Shinde,S., Ambrosio,F., Shiva,S., Loughran,P. and Scott,M.
    Caspase1/11 signaling affects muscle regeneration and recovery following ischemia, and can be modulated by chloroquine
    Mol Med26, 69-69. PubMed  Europe PubMed DOI  K
  87. Saito,L.B., Fernandes,J.P., Smith,M.J., Doan,M.A.L., Branton,W.G., Schmitt,L.M., Wuest,M., Monaco,M.C., Major,E.O., Wuest,F. and Power,C.
    Intranasal anti-caspase-1 therapy preserves myelin and glucose metabolism in a model of progressive multiple sclerosis
    Glia PubMed  Europe PubMed DOI  I
  88. Sukhanov,S., Higashi,Y., Yoshida,T., Mummidi,S., Aroor,A.R., Jeffrey Russell,J., Bender,S.B., Demarco,V.G. and Chandrasekar,B.
    The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1beta and IL-18 secretion
    Cell Signal77, 109825-109825. PubMed  Europe PubMed DOI
  89. Sun,X., Zhou,R., Lei,Y., Hu,J. and Li,X.
    The ligand-gated ion channel P2X7 receptor mediates NLRP3/caspase-1-mediated pyroptosis in cerebral cortical neurons of juvenile rats with sepsis
    Brain Res1748, 147109-147109. PubMed  Europe PubMed DOI
  90. Sunderhauf,A., Raschdorf,A., Hicken,M., Schlichting,H., Fetzer,F., Brethack,A.K., Perner,S., Kemper,C., Ghebrehiwet,B., Sina,C. and Derer,S.
    GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells
    Front Oncol10, 575854-575854. PubMed  Europe PubMed DOI
  91. Tang,J., Chen,R., Wang,L., Yu,L., Zuo,D., Cui,G. and Gong,X.
    Melatonin Attenuates Thrombin-induced Inflammation in BV2 Cells and Then Protects HT22 Cells from Apoptosis
    Inflammation43, 1959-1970. PubMed  Europe PubMed DOI
  92. Thorstenberg,M.L., Martins,M.D.A., Figliuolo,V., Silva,C.L.M., Savio,L.E.B. and Coutinho-Silva,R.
    P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1beta Secretion
    Mediators Inflamm2020, 2545682-2545682. PubMed  Europe PubMed DOI
  93. Vande Walle,L. and Lamkanfi,M.
    Snapshot of a Deadly Embrace: The Caspase-1-GSDMD Interface
    Immunity53, 6-8. PubMed  Europe PubMed DOI
  94. Wang,X., Li,X., Liu,S., Brickell,A.N., Zhang,J., Wu,Z., Zhou,S. and Ding,Z.
    PCSK9 regulates pyroptosis via mtDNA damage in chronic myocardial ischemia
    Basic Res Cardiol115, 66-66. PubMed  Europe PubMed DOI
  95. Wang,Y., Zhang,M., Sun,Y., Wang,X., Song,Z., Li,H., Liu,K. and Li,Z.
    Role of short-wavelength blue light in the formation of cataracts and the expression of caspase-1, caspase-11, Gasdermin D in rat lens epithelial cells: insights into a novel pathogenic mmechanism of cataracts
    BMC Ophthalmol20, 289-289. PubMed  Europe PubMed DOI  I
  96. Xiao,Q., Yu,J.S., Wang,Y., Ma,D., Zhou,J. and Lou,X.
    3-Difluoroalkyl Quaternary Oxindoles Inhibit Macrophage Pyroptosis by Blocking Inflammasome Recruitment of Caspase-1
    ACS Med Chem Lett11, 1392-1401. PubMed  Europe PubMed DOI
  97. Yan,C.Y., Ouyang,S.H., Wang,X., Wu,Y.P., Sun,W.Y., Duan,W.J., Liang,L., Luo,X., Kurihara,H., Li,Y.F. and He,R.R.
    Celastrol ameliorates Propionibacterium acnes/LPS-induced liver damage and MSU-induced gouty arthritis via inhibiting K63 deubiquitination of NLRP3
    Phytomedicine80, 153398-153398. PubMed  Europe PubMed DOI  I
  98. Zaslona,Z., Flis,E., Nulty,C., Kearney,J., FitzGerald,R., Douglas,A.R., McNamara,D., Smith,S., O'Neill,L.A.J. and Creagh,E.M.
    Caspase-4: A Therapeutic Target for Peptic Ulcer Disease
    Immunohorizons4, 627-633. PubMed  Europe PubMed DOI
  99. Zhuo,L., Chen,X., Sun,Y., Wang,Y., Shi,Y., Bu,L., Xia,W., Han,J., Chen,D. and Li,X.
    Rapamycin Inhibited Pyroptosis and Reduced the Release of IL-1beta and IL-18 in the Septic Response
    Biomed Res Int2020, 5960375-5960375. PubMed  Europe PubMed DOI
  100. Zu,S.Q., Feng,Y.B., Zhu,C.J., Wu,X.S., Zhou,R.P., Li,G., Dai,B.B., Wang,Z.S., Xie,Y.Y., Li,Y., Ge,J.F. and Chen,F.H.
    Acid-sensing ion channel 1a mediates acid-induced pyroptosis through calpain-2/calcineurin pathway in rat articular chondrocytes
    Cell Biol Int44, 2140-2152. PubMed  Europe PubMed DOI
    101. 2019
  101. Martin,D.D.O., Schmidt,M.E., Nguyen,Y.T., Lazic,N. and Hayden,M.R.
    Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance
    FASEB J33, 3190-3197. PubMed  Europe PubMed DOI
  102. Ramos-Guzman,C.A., Zinovjev,K. and Tunon,I.
    Modeling caspase-1 inhibition: implications for catalytic mechanism and drug design
    Eur J Med Chem169, 159-167. PubMed  Europe PubMed DOI  I
  103. Sandstrom,A., Mitchell,P.S., Goers,L., Mu,E.W., Lesser,C.F. and Vance,R.E.
    Functional degradation: a mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes
    Science364, eaau1330-eaau1330. PubMed  Europe PubMed DOI
  104. Yang,G., Wang,J., Luo,T. and Zhang,X.
    White spot syndrome virus infection activates caspase 1-mediated cell death in crustacean
    Virology528, 37-47. PubMed  Europe PubMed DOI
    105. 2018
  105. Adams,A., Weinman,S.A. and Wozniak,A.L.
    Caspase-1 regulates cellular trafficking via cleavage of the Rab7 adaptor protein RILP
    Biochem Biophys Res Commun503, 2619-2624. PubMed  Europe PubMed DOI  P
  106. Akazawa,K., Sugihara,F., Minoshima,M., Mizukami,S. and Kikuchi,K.
    Sensing caspase-1 activity using activatable (19)F MRI nanoprobes with improved turn-on kinetics
    Chem Commun (Camb)54, 11785-11788. PubMed  Europe PubMed DOI  L
  107. Baker,P.J. and Masters,S.L.
    Caspase substrates won't be defined by a four-letter code
    J Biol Chem293, 7068-7069. PubMed  Europe PubMed DOI  P
  108. Boucher,D., Monteleone,M., Coll,R.C., Chen,K.W., Ross,C.M., Teo,J.L., Gomez,G.A., Holley,C.L., Bierschenk,D., Stacey,K.J., Yap,A.S., Bezbradica,J.S. and Schroder,K.
    Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
    J Exp Med215, 827-840. PubMed  Europe PubMed DOI
  109. Fournier,J.F., Clary,L., Chambon,S., Dumais,L., Harris,C.S., Millois,C., Pierre,R., Talano,S., Thoreau,E., Aubert,J., Aurelly,M., Bouix-Peter,C., Brethon,A., Chantalat,L., Christin,O., Comino,C., El-Bazbouz,G., Ghilini,A.L., Isabet,T., Lardy,C., Luzy,A.P., Mathieu,C., Mebrouk,K., Orfila,D., Pascau,J., Reverse,K., Roche,D., Rodeschini,V. and Hennequin,L.F.
    Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne
    J Med Chem61, 4030-4051. PubMed  Europe PubMed DOI  I
  110. Lin,H., Yang,H., Huang,S., Wang,F., Wang,D.M., Liu,B., Tang,Y.D. and Zhang,C.J.
    Caspase-1 specific light-up probe with aggregation-induced emission characteristics for inhibitor screening of coumarin-originated natural products
    ACS Appl Mater Interfaces10, 12173-12180. PubMed  Europe PubMed DOI  A
  111. Patel,S., Modi,P., Ranjan,V. and Chhabria,M.
    Structure-based design, synthesis and evaluation of 2,4-diaminopyrimidine derivatives as novel caspase-1 inhibitors
    Bioorg Chem78, 258-268. PubMed  Europe PubMed DOI  I
  112. Ramirez,M.L.G., Poreba,M., Snipas,S.J., Groborz,K., Drag,M. and Salvesen,G.S.
    Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1
    J Biol Chem293, 7058-7067. PubMed  Europe PubMed DOI  P
  113. Yang,J., Liu,Z., Wang,C., Yang,R., Rathkey,J.K., Pinkard,O.W., Shi,W., Chen,Y., Dubyak,G.R., Abbott,D.W. and Xiao,T.S.
    Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
    Proc Natl Acad Sci U S A115, 6792-6797. PubMed  Europe PubMed DOI  I
  114. Zheng,Y., Liu,Q., Wu,Y., Ma,L., Zhang,Z., Liu,T., Jin,S., She,Y., Li,Y.P. and Cui,J.
    Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis
    EMBO J37, e99347-e99347. PubMed  Europe PubMed DOI
    115. 2017
  115. Adriaenssens,Y., Jimenez Fernandez,D., Vande Walle,L., Elvas,F., Joossens,J., Lambeir,A., Augustyns,K., Lamkanfi,M. and Van der Veken,P.
    Carboxylate isosteres for caspase inhibitors: the acylsulfonamide case revisited
    Org Biomol Chem15, 7456-7473. PubMed  Europe PubMed DOI  I
  116. Brethon,A., Chantalat,L., Christin,O., Clary,L., Fournier,J.F., Gastreich,M., Harris,C.S., Isabet,T., Pascau,J., Thoreau,E., Roche,D. and Rodeschini,V.
    New caspase-1 inhibitor by scaffold hopping into bio-inspired 3D-fragment space
    Bioorg Med Chem Lett27, 5373-5377. PubMed  Europe PubMed DOI  S  I
  117. O'Brien,M., Moehring,D., Munoz-Planillo,R., Nunez,G., Callaway,J., Ting,J., Scurria,M., Ugo,T., Bernad,L., Cali,J. and Lazar,D.
    A bioluminescent caspase-1 activity assay rapidly monitors inflammasome activation in cells
    J Immunol Methods447, 1-13. PubMed  Europe PubMed DOI  A
  118. Qian,L., Zhang,C.J., Wu,J. and Yao,S.Q.
    Fused bicyclic caspase-1 inhibitors assembled by copper-free strain-promoted alkyne-azide cycloaddition (SPAAC)
    Chemistry23, 360-369. PubMed  Europe PubMed DOI  I
    119. 2016
  119. Guey,B. and Petrilli,V.
    Assessing caspase-1 activation
    Methods Mol Biol1417, 197-206. PubMed  Europe PubMed DOI  A
  120. Julien,O., Zhuang,M., Wiita,A.P., O'Donoghue,A.J., Knudsen,G.M., Craik,C.S. and Wells,J.A.
    Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
    Proc Natl Acad Sci U S A113, E2001-E2010. PubMed  Europe PubMed DOI  P
  121. Kent,C.R., Bryja,M., Gustafson,H.A., Kawarski,M.Y., Lenti,G., Pierce,E.N., Knopp,R.C., Ceja,V., Pati,B., Walters,D.E. and Karver,C.E.
    Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases
    Bioorg Med Chem Lett26, 5476-5480. PubMed  Europe PubMed DOI  I
  122. Lu,A., Li,Y., Schmidt,F.I., Yin,Q., Chen,S., Fu,T.M., Tong,A.B., Ploegh,H.L., Mao,Y. and Wu,H.
    Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism
    Nat Struct Mol Biol23, 416-425. PubMed  Europe PubMed DOI  S
    123. 2015
  123. Caution,K., Gavrilin,M.A., Tazi,M., Kanneganti,A., Layman,D., Hoque,S., Krause,K. and Amer,A.O.
    Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance
    Sci Rep5, 18479-18479. PubMed  Europe PubMed DOI
  124. Cerqueira,D.M., Pereira,M.S., Silva,A.L., Cunha,L.D. and Zamboni,D.S.
    Caspase-1 but not caspase-11 is required for NLRC4-mediated pyroptosis and restriction of infection by flagellated Legionella species in mouse macrophages and in vivo
    J Immunol195, 2303-2311. PubMed  Europe PubMed DOI
  125. Hendrikx,T., Jeurissen,M.L., van Gorp,P.J., Gijbels,M.J., Walenbergh,S.M., Houben,T., van Gorp,R., Pottgens,C.C., Stienstra,R., Netea,M.G., Hofker,M.H., Donners,M.M. and Shiri-Sverdlov,R.
    Bone marrow-specific caspase-1/11 deficiency inhibits atherosclerosis development in Ldlr(-/-) mice
    FEBS J282, 2327-2338. PubMed  Europe PubMed DOI  K
  126. Kawarski,M., Hagerman,T.K. and Karver,C.E.
    Lazaroids U83836E and U74389G are potent, time-dependent inhibitors of caspase-1
    Chem Biol Drug Des86, 1049-1054. PubMed  Europe PubMed DOI  I
  127. Moriwaki,K., Bertin,J., Gough,P.J. and Chan,F.K.
    A RIPK3-caspase 8 complex mediates atypical pro-IL-1beta processing
    J Immunol194, 1938-1944. PubMed  Europe PubMed DOI
  128. Rahman,M.A., Mitra,S., Sarkar,A. and Wewers,M.D.
    Alpha 1-antitrypsin does not inhibit human monocyte caspase-1
    PLoS ONE10, e0117330-e0117330. PubMed  Europe PubMed DOI
  129. Shi,J., Zhao,Y., Wang,K., Shi,X., Wang,Y., Huang,H., Zhuang,Y., Cai,T., Wang,F. and Shao,F.
    Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
    Nature526, 660-665. PubMed  Europe PubMed DOI
  130. Shim,Y.R. and Lee,H.K.
    Caspase-1 independent viral clearance and adaptive immunity against mucosal respiratory syncytial virus infection
    Immune Netw15, 73-82. PubMed  Europe PubMed DOI
  131. Sollberger,G., Strittmatter,G.E., Grossi,S., Garstkiewicz,M., auf dem Keller,U., French,L.E. and Beer,H.D.
    Caspase-1 activity is required for UVB-induced apoptosis of human keratinocytes
    J Invest Dermatol135, 1395-1404. PubMed  Europe PubMed DOI
  132. Wu,Y. and Nie,F.
    Caspase-1 assay based on peptide and luminol labeled gold nanoparticle as chemiluminescence probe coupling magnetic separation technology
    Sens Actuators, B Chem220, 481-484. DOI  A
    133. 2014
  133. Guey,B., Bodnar,M., Manie,S.N., Tardivel,A. and Petrilli,V.
    Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function
    Proc Natl Acad Sci U S A111, 17254-17259. PubMed  Europe PubMed DOI
  134. Heymann,M.C., Winkler,S., Luksch,H., Flecks,S., Franke,M., Ru,S., Ozen,S., Yilmaz,E., Klein,C., Kallinich,T., Lindemann,D., Brenner,S., Ganser,G., Roesler,J., Rosen-Wolff,A. and Hofmann,S.R.
    Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-kappaB signaling
    J Immunol192, 4379-4385. PubMed  Europe PubMed DOI  M
  135. Sollberger,G., Strittmatter,G.E., Garstkiewicz,M., Sand,J. and Beer,H.D.
    Caspase-1: The inflammasome and beyond
    Innate Immun20, 115-125. PubMed  Europe PubMed DOI  V
  136. Wang,H., Capell,W., Yoon,J.H., Faubel,S. and Eckel,R.H.
    Obesity development in caspase-1-deficient mice
    Int J Obes (Lond)38, 152-155. PubMed  Europe PubMed DOI  K
    137. 2013
  137. Bartok,E., Bauernfeind,F., Khaminets,M.G., Jakobs,C., Monks,B., Fitzgerald,K.A., Latz,E. and Hornung,V.
    iGLuc: a luciferase-based inflammasome and protease activity reporter
    Nat Methods10, 147-154. PubMed  Europe PubMed DOI  L
  138. Case,C.L. and Roy,C.R.
    Analyzing caspase-1 activation during Legionella pneumophila infection in macrophages
    Methods Mol Biol954, 479-491. PubMed  Europe PubMed DOI  A
  139. Datta,D., McClendon,C.L., Jacobson,M.P. and Wells,J.A.
    Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3
    J Biol Chem288, 9971-9981. PubMed  Europe PubMed DOI  I
  140. Jakobs,C., Bartok,E., Kubarenko,A., Bauernfeind,F. and Hornung,V.
    Immunoblotting for active caspase-1
    Methods Mol Biol1040, 103-115. PubMed  Europe PubMed DOI  A
  141. Jin,T., Curry,J., Smith,P., Jiang,J. and Xiao,T.S.
    Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1
    Proteins81, 1266-1270. PubMed  Europe PubMed DOI
  142. Juruj,C., Lelogeais,V., Pierini,R., Perret,M., Py,B.F., Jamilloux,Y., Broz,P., Ader,F., Faure,M. and Henry,T.
    Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop
    Front Cell Infect Microbiol3, 14-14. PubMed  Europe PubMed DOI
  143. Luksch,H., Romanowski,M.J., Chara,O., Tungler,V., Caffarena,E.R., Heymann,M.C., Lohse,P., Aksentijevich,I., Remmers,E.F., Flecks,S., Quoos,N., Gramatte,J., Petzold,C., Hofmann,S.R., Winkler,S., Pessler,F., Kallinich,T., Ganser,G., Nimtz-Talaska,A., Baumann,U., Runde,V., Grimbacher,B., Birmelin,J., Gahr,M., Roesler,J. and Rosen-Wolff,A.
    Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1beta
    Hum Mutat34, 122-131. PubMed  Europe PubMed DOI  M
  144. Xiao,J., Broz,P., Puri,A.W., Deu,E., Morell,M., Monack,D.M. and Bogyo,M.
    A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases
    J Am Chem Soc135, 9130-9138. PubMed  Europe PubMed DOI  L
    145. 2012
  145. Denes,A., Lopez-Castejon,G. and Brough,D.
    Caspase-1: is IL-1 just the tip of the ICEberg?
    Cell Death Dis3, e338-e338. PubMed  Europe PubMed DOI
  146. Jorgensen,I. and Miao,E.A.
    YopM puts caspase-1 on ice
    Cell Host Microbe12, 737-738. PubMed  Europe PubMed DOI
  147. Puri,A.W., Broz,P., Shen,A., Monack,D.M. and Bogyo,M.
    Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection
    Nat Chem Biol8, 745-747. PubMed  Europe PubMed DOI  L
  148. Roschitzki-Voser,H., Schroeder,T., Lenherr,E.D., Frolich,F., Schweizer,A., Donepudi,M., Ganesan,R., Mittl,P.R., Baici,A. and Grutter,M.G.
    Human caspases in vitro: expression, purification and kinetic characterization
    Protein Expr Purif84, 236-246. PubMed  Europe PubMed DOI  E
  149. Scheer,J.M.
    Caspase-1
    [ISSN:978-0-12-407743-0]3, 2237-2243. DOI
  150. Sun,L., Wu,Z., Hayashi,Y., Peters,C., Tsuda,M., Inoue,K. and Nakanishi,H.
    Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain
    J Neurosci32, 11330-11342. PubMed  Europe PubMed DOI
    151. 2011
  151. Bergheanu,S.C., Pons,D., Van Der Hoeven,B.L., Liem,S.S., Siegerink,B., Schalij,M.J., Van Der Bom,J.G. and Jukema,J.W.
    The 5352 a allele of the pro-inflammatory caspase-1 gene predicts late-acquired stent malapposition in STEMI patients treated with sirolimus stents
    Heart Vessels26, 235-241. PubMed  Europe PubMed DOI  M
  152. Lee,G., Wang,Z., Sehgal,R., Chen,C.H., Kikuno,K., Hay,B. and Park,J.H.
    Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis
    J Comp Neurol519, 34-48. PubMed  Europe PubMed DOI
  153. Pei-Yu,S., Geng-Liang,Y., Hua,Z., Xin-Hua,L. and Shao-Jing,L.
    High-throughput screening for interleukin-1beta converting enzyme inhibitors
    Chin J Antibiot36, 346-350.  I
  154. Vande Walle,L. and Lamkanfi,M.
    Inflammasomes: caspase-1-activating platforms with critical roles in host defense
    Front Microbiol2, 3-3. PubMed  Europe PubMed DOI
  155. Walsh,J.G., Logue,S.E., Luthi,A.U. and Martin,S.J.
    Caspase-1 promiscuity is counterbalanced by rapid inactivation of processed enzyme
    J Biol Chem286, 32513-32524. PubMed  Europe PubMed DOI  P
    156. 2010
  156. Agard,N.J., Maltby,D. and Wells,J.A.
    Inflammatory stimuli regulate caspase substrate profiles
    Mol Cell Proteomics9, 880-893. PubMed  Europe PubMed DOI  P
  157. Boxer,M.B., Quinn,A.M., Shen,M., Jadhav,A., Leister,W., Simeonov,A., Auld,D.S. and Thomas,C.J.
    A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety
    ChemMedChem5, 730-738. PubMed  Europe PubMed DOI  I
  158. Boxer,M.B., Shen,M., Auld,D.S., Wells,J.A. and Thomas,C.J.
    A small molecule inhibitor of caspase 1
     PubMed  Europe PubMed  I
  159. Galatsis,P., Caprathe,B., Downing,D., Gilmore,J., Harter,W., Hays,S., Kostlan,C., Linn,K., Lunney,E., Para,K., Thomas,A., Warmus,J., Allen,H., Brady,K., Talanian,R. and Walker,N.
    Inhibition of interleukin-1beta converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones
    Bioorg Med Chem Lett20, 5089-5094. PubMed  Europe PubMed DOI  I
  160. Galatsis,P., Caprathe,B., Gilmore,J., Thomas,A., Linn,K., Sheehan,S., Harter,W., Kostlan,C., Lunney,E., Stankovic,C., Rubin,J., Brady,K., Allen,H. and Talanian,R.
    Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1)
    Bioorg Med Chem Lett20, 5184-5190. PubMed  Europe PubMed DOI  I
  161. Kindermann,M., Roschitzki-Voser,H., Caglic,D., Repnik,U., Miniejew,C., Mittl,P.R., Kosec,G., Grutter,M.G., Turk,B. and Wendt,K.U.
    Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe
    Chem Biol17, 999-1007. PubMed  Europe PubMed DOI  A
  162. Loser,R., Abbenante,G., Madala,P.K., Halili,M., Le,G.T. and Fairlie,D.P.
    Noncovalent tripeptidyl benzyl- and cyclohexyl-amine inhibitors of the cysteine protease caspase-1
    J Med Chem53, 2651-2655. PubMed  Europe PubMed DOI  I
  163. Muller,A.J., Hoffmann,C. and Hardt,W.D.
    Caspase-1 activation via Rho GTPases: a common theme in mucosal infections?
    PLoS Pathog6, e1000795-e1000795. PubMed  Europe PubMed DOI
  164. Ulrichts,P., Bovijn,C., Lievens,S., Beyaert,R., Tavernier,J. and Peelman,F.
    Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site
    J Cell Sci123, 256-265. PubMed  Europe PubMed DOI  P
  165. Vezzani,A., Balosso,S., Maroso,M., Zardoni,D., Noe,F. and Ravizza,T.
    ICE/caspase 1 inhibitors and IL-1beta receptor antagonists as potential therapeutics in epilepsy
    Curr Opin Investig Drugs11, 43-50. PubMed  Europe PubMed  T
  166. Weigert,A., Cremer,S., Schmidt,M.V., von Knethen,A., Angioni,C., Geisslinger,G. and Brune,B.
    Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells
    Blood115, 3531-3540. PubMed  Europe PubMed DOI
  167. Wu,B., Ma,Q., Khatibi,N., Chen,W., Sozen,T., Cheng,O. and Tang,J.
    Ac-YVAD-CMK decreases blood-brain barrier degradation by inhibiting caspase-1 activation of interleukin-1beta in intracerebral hemorrhage mouse model
    Transl Stroke Res1, 57-64. PubMed  Europe PubMed DOI  I
  168. Yazdi,A.S., Guarda,G., D'Ombrain,M.C. and Drexler,S.K.
    Inflammatory caspases in innate immunity and inflammation
    J Innate Immun2, 228-237. PubMed  Europe PubMed DOI
    169. 2009
  169. Benkova,B., Lozanov,V., Ivanov,I.P. and Mitev,V.
    Evaluation of recombinant caspase specificity by competitive substrates
    Anal Biochem394, 68-74. PubMed  Europe PubMed DOI  A  P
  170. Cayrol,C. and Girard,J.P.
    The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
    Proc Natl Acad Sci U S A106, 9021-9026. PubMed  Europe PubMed DOI
  171. Elliott,J.M., Rouge,L., Wiesmann,C. and Scheer,J.M.
    Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation
    J Biol Chem284, 6546-6553. PubMed  Europe PubMed DOI  S
  172. Guma,M., Ronacher,L., Liu-Bryan,R., Takai,S., Karin,M. and Corr,M.
    Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation
    Arthritis Rheum60, 3642-3650. PubMed  Europe PubMed DOI
  173. Lan,Q., Morton,L.M., Armstrong,B., Hartge,P., Menashe,I., Zheng,T., Purdue,M.P., Cerhan,J.R., Zhang,Y., Grulich,A., Cozen,W., Yeager,M., Holford,T.R., Vajdic,C.M., Davis,S., Leaderer,B., Kricker,A., Schenk,M., Zahm,S.H., Chatterjee,N., Chanock,S.J., Rothman,N. and Wang,S.S.
    Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies
    Blood114, 264-267. PubMed  Europe PubMed DOI  M
    174. 2008
  174. Chae,J.J., Wood,G., Richard,K., Jaffe,H., Colburn,N.T., Masters,S.L., Gumucio,D.L., Shoham,N.G. and Kastner,D.L.
    The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment
    Blood112, 1794-1803. PubMed  Europe PubMed DOI
  175. Datta,D., Scheer,J.M., Romanowski,M.J. and Wells,J.A.
    An allosteric circuit in caspase-1
    J Mol Biol381, 1157-1167. PubMed  Europe PubMed DOI
  176. Lamkanfi,M., Kanneganti,T.D., Van Damme,P., Vanden Berghe,T., Vanoverberghe,I., Vandekerckhove,J., Vandenabeele,P., Gevaert,K. and Nunez,G.
    Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes
    Mol Cell Proteomics7, 2350-2363. PubMed  Europe PubMed DOI  P
  177. Pereira,N.A. and Song,Z.
    Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity
    Biochem Biophys Res Commun377, 873-877. PubMed  Europe PubMed DOI  P  I
  178. Soung,Y.H., Jeong,E.G., Ahn,C.H., Kim,S.S., Song,S.Y., Yoo,N.J. and Lee,S.H.
    Mutational analysis of caspase 1, 4, and 5 genes in common human cancers
    Hum Pathol39, 895-900. PubMed  Europe PubMed DOI  M
  179. Wickliffe,K.E., Leppla,S.H. and Moayeri,M.
    Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome
    Cell Microbiol10, 332-343. PubMed  Europe PubMed DOI
    180. 2007
  180. Boost,K.A., Hoegl,S., Hofstetter,C., Flondor,M., Stegewerth,K., Platacis,I., Pfeilschifter,J., Muhl,H. and Zwissler,B.
    Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia
    Intensive Care Med33, 863-871. PubMed  Europe PubMed DOI  I
  181. Brodsky,M., Yosef,S., Galit,R., Albeck,M., Longo,D.L., Albeck,A. and Sredni,B.
    The synthetic tellurium compound, AS101, is a novel inhibitor of IL-1beta converting enzyme
    J Interferon Cytokine Res27, 453-462. PubMed  Europe PubMed DOI  I
  182. Edelstein,C.L., Hoke,T.S., Somerset,H., Fang,W., Klein,C.L., Dinarello,C.A. and Faubel,S.
    Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury
    Nephrol Dial Transplant22, 1052-1061. PubMed  Europe PubMed DOI  K  I
  183. Hsu,S., Qin,H., Dickinson,D., Xie,D., Bollag,W.B., Stoppler,H., Pearl,H., Vu,A., Watkins,M., Koehler,M. and Schuster,G.
    Expression of caspase-14 reduces tumorigenicity of skin cancer cells
    In Vivo21, 279-283. PubMed  Europe PubMed  U
  184. Kersse,K., Vanden Berghe,T., Lamkanfi,M. and Vandenabeele,P.
    A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins
    Biochem Soc Trans35, 1508-1511. PubMed  Europe PubMed DOI
  185. Ma,X.Q., Zhang,H.J., Zhang,Y.H., Chen,Y.H., Wu,F., Du,J.Q., Yu,H.P., Zhou,Z.L., Li,J.Y., Nan,F.J. and Li,J.
    Novel irreversible caspase-1 inhibitor attenuates the maturation of intracellular interleukin-1beta
    Biochem Cell Biol85, 56-65. PubMed  Europe PubMed DOI  I
  186. Martinon,F. and Tschopp,J.
    Inflammatory caspases and inflammasomes: master switches of inflammation
    Cell Death Differ14, 10-22. PubMed  Europe PubMed DOI
  187. Mastronardi,C., Whelan,F., Yildiz,O.A., Hannestad,J., Elashoff,D., McCann,S.M., Licinio,J. and Wong,M.L.
    Caspase 1 deficiency reduces inflammation-induced brain transcription
    Proc Natl Acad Sci U S A104, 7205-7210. PubMed  Europe PubMed DOI  K
  188. Ross,J., Brough,D., Gibson,R.M., Loddick,S.A. and Rothwell,N.J.
    A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat
    Neuropharmacology53, 638-642. PubMed  Europe PubMed DOI  I
  189. Scott,A.M. and Saleh,M.
    The inflammatory caspases: guardians against infections and sepsis
    Cell Death Differ14, 23-31. PubMed  Europe PubMed DOI
  190. Shao,W., Yeretssian,G., Doiron,K., Hussain,S.N. and Saleh,M.
    The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock
    J Biol Chem282, 36321-36329. PubMed  Europe PubMed DOI
  191. Wang,Y., O'Neil,S.V., Wos,J.A., Oppong,K.A., Laufersweiler,M.C., Soper,D.L., Ellis,C.D., Baize,M.W., Fancher,A.N., Lu,W., Suchanek,M.K., Wang,R.L., Schwecke,W.P., Cruze,C.A., Buchalova,M., Belkin,M., De,B. and Demuth,T.P., Jr.
    Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors
    Bioorg Med Chem15, 1311-1322. PubMed  Europe PubMed DOI  I
  192. Wannamaker,W., Davies,R., Namchuk,M., Pollard,J., Ford,P., Ku,G., Decker,C., Charifson,P., Weber,P., Germann,U.A., Kuida,K. and Randle,J.C.
    (S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl- butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18
    J Pharmacol Exp Ther321, 509-516. PubMed  Europe PubMed DOI  I
    193. 2006
  193. [YEAR:15-6-2006]Blankenberg,S., Godefroy,T., Poirier,O., Rupprecht,H.J., Barbaux,S., Bickel,C., Nicaud,V., Schnabel,R., Kee,F., Morrison,C., Evans,A., Lackner,K.J., Cambien,F., Munzel,T. and Tiret,L.
    Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk
    Circ Res99, 102-108. PubMed  Europe PubMed DOI  M
  194. [YEAR:29-8-2006]Clark,A.K., D'Aquisto,F., Gentry,C., Marchand,F., McMahon,S.B. and Malcangio,M.
    Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation
    J Neurochem99, 868-880. PubMed  Europe PubMed DOI
  195. [YEAR:24-7-2006]Ellis,C.D., Oppong,K.A., Laufersweiler,M.C., O'Neil,S.V., Soper,D.L., Wang,Y., Wos,J.A., Fancher,A.N., Lu,W., Suchanek,M.K., Wang,R.L., De,B. and Demuth,T.P., Jr.
    Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors
    Bioorg Med Chem Lett16, 4728-4732. PubMed  Europe PubMed DOI  I
  196. [YEAR:22-9-2006]Gurcel,L., Abrami,L., Girardin,S., Tschopp,J. and van der Goot,F.G.
    Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
    Cell126, 1135-1145. PubMed  Europe PubMed DOI
  197. [YEAR:22-6-2006]Kleinke,A.S., Li,C., Rabasso,N. and Porco,J.A., Jr.
    Total synthesis of the interleukin-1beta converting enzyme inhibitor EI-1941-2 using tandem oxa-electrocyclization/oxidation
    Org Lett8, 2847-2850. PubMed  Europe PubMed DOI  I
  198. [YEAR:1-10-2006]Nadiri,A., Wolinski,M.K. and Saleh,M.
    The inflammatory caspases: key players in the host response to pathogenic invasion and sepsis
    J Immunol177, 4239-4245. PubMed  Europe PubMed  V
  199. Ravizza,T., Lucas,S.M., Balosso,S., Bernardino,L., Ku,G., Noe,F., Malva,J., Randle,J.C., Allan,S. and Vezzani,A.
    Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy
    Epilepsia47, 1160-1168. PubMed  Europe PubMed DOI  I
  200. [YEAR:22-9-2006]Saleh,M.
    Caspase-1 builds a new barrier to infection
    Cell126, 1028-1030. PubMed  Europe PubMed DOI
  201. [YEAR:14-8-2006]Sarkar,A., Hall,M.W., Exline,M., Hart,J., Knatz,N., Gatson,N.T. and Wewers,M.D.
    Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18
    Am J Respir Crit Care Med174, 1003-1010. PubMed  Europe PubMed DOI  I
  202. [YEAR:16-5-2006]Scheer,J.M., Romanowski,M.J. and Wells,J.A.
    A common allosteric site and mechanism in caspases
    Proc Natl Acad Sci U S A103, 7595-7600. PubMed  Europe PubMed DOI  I
  203. [YEAR:12-8-2006]Soper,D.L., Sheville,J.X., O'Neil,S.V., Wang,Y., Laufersweiler,M.C., Oppong,K.A., Wos,J.A., Ellis,C.D., Baize,M.W., Chen,J.J., Fancher,A.N., Lu,W., Suchanek,M.K., Wang,R.L., Schwecke,W.P., Cruze,C.A., Buchalova,M., Belkin,M., Wireko,F., Ritter,A., De,B., Wang,D. and Demuth,T.P., Jr.
    Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme (ICE) inhibitors
    Bioorg Med Chem14, 7880-7892. PubMed  Europe PubMed DOI  I
  204. [YEAR:15-6-2006]Soper,D.L., Sheville,J., O'Neil,S.V., Wang,Y., Laufersweiler,M.C., Oppong,K.A., Wos,J.A., Ellis,C.D., Fancher,A.N., Lu,W., Suchanek,M.K., Wang,R.L., De,B. and Demuth,T.P., Jr.
    Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors
    Bioorg Med Chem Lett16, 4233-4236. PubMed  Europe PubMed DOI  I
    205. 2005
  205. [YEAR:22-4-2005]Corasaniti,M.T., Russo,R., Amantea,D., Gliozzi,M., Siviglia,E., Stringaro,A.R., Malorni,W., Melino,G. and Bagetta,G.
    Neuroprotection by the caspase-1 inhibitor Ac-YVAD-(acyloxy)mk in experimental neuroAIDS is independent from IL-1beta generation
    Cell Death Differ12 Suppl 1, 999-1001. PubMed  Europe PubMed DOI  I
  206. Dinarello,C.A.
    An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor
    Immunity23, 461-462. PubMed  Europe PubMed DOI
  207. Gemma,C., Fister,M., Hudson,C. and Bickford,P.C.
    Improvement of memory for context by inhibition of caspase-1 in aged rats
    Eur J Neurosci22, 1751-1756. PubMed  Europe PubMed DOI  I
  208. [YEAR:1-5-2005]O'Brien,T., Fahr,B.T., Sopko,M.M., Lam,J.W., Waal,N.D., Raimundo,B.C., Purkey,H.E., Pham,P. and Romanowski,M.J.
    Structural analysis of caspase-1 inhibitors derived from tethering
    Acta Crystallograph Sect F Struct Biol Cryst Commun61, 451-458. PubMed  Europe PubMed DOI  S
  209. [YEAR:7-10-2005]O'Neil,S.V., Wang,Y., Laufersweiler,M.C., Oppong,K.A., Soper,D.L., Wos,J.A., Ellis,C.D., Baize,M.W., Bosch,G.K., Fancher,A.N., Lu,W., Suchanek,M.K., Wang,R.L., De,B. and Demuth,T.P., Jr.
    Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme inhibitors
    Bioorg Med Chem Lett15, 5434-5438. PubMed  Europe PubMed DOI  I
  210. Scheer,J.M., Wells,J.A. and Romanowski,M.J.
    Malonate-assisted purification of human caspases
    Protein Expr Purif41, 148-153. PubMed  Europe PubMed DOI  E
  211. [YEAR:15-8-2005]Stack,J.H., Beaumont,K., Larsen,P.D., Straley,K.S., Henkel,G.W., Randle,J.C. and Hoffman,H.M.
    IL-Converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients
    J Immunol175, 2630-2634. PubMed  Europe PubMed  I
  212. [YEAR:1-12-2005]Verhoef,P.A., Kertesy,S.B., Lundberg,K., Kahlenberg,J.M. and Dubyak,G.R.
    Inhibitory effects of chloride on the activation of caspase-1, Il-1beta secretion, and cytolysis by the p2x7 receptor
    J Immunol175, 7623-7634. PubMed  Europe PubMed
    213. 2004
  213. Faubel,S., Ljubanovic,D., Reznikov,L., Somerset,H., Dinarello,C.A. and Edelstein,C.L.
    Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis
    Kidney Int66, 2202-2213. PubMed  Europe PubMed DOI  K
  214. Feng,Q., Li,P., Leung,P.C. and Auersperg,N.
    Caspase-1zeta, a new splice variant of the caspase-1 gene
    Genomics84, 587-591. PubMed  Europe PubMed DOI  R
  215. [YEAR:23-3-2004]Lamkanfi,M., Kalai,M., Saelens,X., Declercq,W. and Vandenabeele,P.
    Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity
    J Biol Chem279, 24785-24793. PubMed  Europe PubMed DOI
  216. Loher,F., Bauer,C., Landauer,N., Schmall,K., Siegmund,B., Lehr,H.A., Dauer,M., Schoenharting,M., Endres,S. and Eigler,A.
    The interleukin-1 beta-converting enzyme inhibitor pralnacasan reduces dextran sulfate sodium-induced murine colitis and T helper 1 T-cell activation
    J Pharmacol Exp Ther308, 583-590. PubMed  Europe PubMed DOI  I
  217. [YEAR:8-7-2004]Mariathasan,S., Newton,K., Monack,D.M., Vucic,D., French,D.M., Lee,W.P., Roose-Girma,M., Erickson,S. and Dixit,V.M.
    Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    Nature430, 213-218. PubMed  Europe PubMed DOI
  218. Romanowski,M.J., Scheer,J.M., O'Brien,T. and McDowell,R.S.
    Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding
    Structure12, 1361-1371. PubMed  Europe PubMed DOI  S
  219. Thakur,A., Barrett,R.P., Hobden,J.A. and Hazlett,L.D.
    Caspase-1 inhibitor reduces severity of Pseudomonas aeruginosa keratitis in mice
    Invest Ophthalmol Vis Sci45, 3177-3184. PubMed  Europe PubMed DOI  I
  220. Thornberry,N.A.
    Caspase-1
    [ISSN:0-12-079610-4]2, 1287-1292.  V
    221. 2003
  221. Frantz,S., Ducharme,A., Sawyer,D., Rohde,L.E., Kobzik,L., Fukazawa,R., Tracey,D., Allen,H., Lee,R.T. and Kelly,R.A.
    Targeted deletion of caspase-1 reduces early mortality and left ventricular dilatation following myocardial infarction
    J Mol Cell Cardiol35, 685-694. PubMed  Europe PubMed DOI  K
  222. Hentze,H., Lin,X.Y., Choi,M.S. and Porter,A.G.
    Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin
    Cell Death Differ10, 956-968. PubMed  Europe PubMed DOI
  223. Rudolphi,K., Gerwin,N., Verzijl,N., Van der Kraan,P. and Van den Berg,W.
    Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis
    Osteoarthritis Cartilage11, 738-746. PubMed  Europe PubMed DOI  I
    224. 2002
  224. Koedel,U., Winkler,F., Angele,B., Fontana,A., Flavell,R.A. and Pfister,H.W.
    Role of caspase-1 in experimental pneumococcal meningitis: evidence from pharmacologic caspase inhibition and caspase-1-deficient mice
    Ann Neurol51, 319-329. PubMed  Europe PubMed DOI
  225. [YEAR:15-5-2002]Ming,X., Li,W., Maeda,Y., Blumberg,B., Raval,S., Cook,S.D. and Dowling,P.C.
    Caspase-1 expression in multiple sclerosis plaques and cultured glial cells
    J Neurol Sci197, 9-18. PubMed  Europe PubMed DOI  I
  226. [YEAR:1-12-2002]Rowe,S.J., Allen,L., Ridger,V.C., Hellewell,P.G. and Whyte,M.K.
    Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury
    J Immunol169, 6401-6407. PubMed  Europe PubMed  K
  227. Shahripour,A.B., Plummer,M.S., Lunney,E.A., Albrecht,H.P., Hays,S.J., Kostlan,C.R., Sawyer,T.K., Walker,N.P., Brady,K.D., Allen,H.J., Talanian,R.V., Wong,W.W. and Humblet,C.
    Structure-based design of nonpeptide inhibitors of interleukin-1beta converting enzyme (ICE, caspase-1)
    Bioorg Med Chem10, 31-40. PubMed  Europe PubMed DOI  I
  228. [YEAR:1-7-2002]Siegmund,B.
    Interleukin-1beta converting enzyme (caspase-1) in intestinal inflammation
    Biochem Pharmacol64, 1-8. PubMed  Europe PubMed DOI  I
    229. 2001
  229. [YEAR:6-4-2001]Gupta,S., Radha,V., Furukawa,Y. and Swarup,G.
    Direct transcriptional activation of human caspase-1 by tumor suppressor p53
    J Biol Chem276, 10585-10588. PubMed  Europe PubMed DOI
  230. [YEAR:9-3-2001]Huang,Y.H., Park,Y.C., Rich,R.L., Segal,D., Myszka,D.G. and Wu,H.
    Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain
    Cell104, 781-790. PubMed  Europe PubMed  S
  231. Randle,J.C., Harding,M.W., Ku,G., Schonharting,M. and Kurrle,R.
    ICE/Caspase-1 inhibitors as novel anti-inflammatory drugs
    Expert Opin Investig Drugs10, 1207-1209. PubMed  Europe PubMed DOI  I
  232. Sheng,J.G., Mrak,R.E., Jones,R.A., Brewer,M.M., Zhou,X.Q., McGinness,J., Woodward,S., Bales,K., Paul,S.M., Cordell,B. and Griffin,W.S.
    Neuronal DNA damage correlates with overexpression of interleukin-1beta converting enzyme in APPV717F mice
    Neurobiol Aging22, 895-902. PubMed  Europe PubMed DOI
    233. 2000
  233. [YEAR:17-7-2000]Monack,D.M., Hersh,D., Ghori,N., Bouley,D., Zychlinsky,A. and Falkow,S.
    Salmonella exploits caspase-1 to colonize Peyer's patches in a murine typhoid model
    J Exp Med192, 249-258. PubMed  Europe PubMed DOI
  234. [YEAR:15-6-2000]Rabuffetti,M., Sciorati,C., Tarozzo,G., Clementi,E., Manfredi,A.A. and Beltramo,M.
    Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines
    J Neurosci20, 4398-4404. PubMed  Europe PubMed  I
  235. Sansonetti,P.J., Phalipon,A., Arondel,J., Thirumalai,K., Banerjee,S., Akira,S., Takeda,K. and Zychlinsky,A.
    Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation
    Immunity12, 581-590. PubMed  Europe PubMed
  236. [YEAR:1-9-2000]Stennicke,H.R., Renatus,M., Meldal,M. and Salvesen,G.S.
    Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8
    Biochem J350, 563-568. PubMed  Europe PubMed DOI  A  P
    237. 1999
  237. Bajusz,S., Fauszt,I., Nemeth,K., Barabas,E., Juhasz,A., Patthy,M. and Bauer,P.I.
    Peptidyl beta-homo-aspartals (3-amino-4-carboxybutyraldehydes): new specific inhibitors of caspases
    Biopolymers51, 109-118. PubMed  Europe PubMed DOI  I
  238. Brady,K.D., Giegel,D.A., Grinnell,C., Lunney,E., Talanian,R.V., Wong,W. and Walker,N.
    A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones
    Bioorg Med Chem7, 621-631. PubMed  Europe PubMed DOI  S  I
  239. Garcia-Calvo,M., Peterson,E.P., Rasper,D.M., Vaillancourt,J.P., Zamboni,R., Nicholson,D.W. and Thornberry,N.A.
    Purification and catalytic properties of human caspase family members
    Cell Death Differ6, 362-369. PubMed  Europe PubMed DOI
  240. Lee,D., Adams,J.L., Brandt,M., DeWolf,W.E., Jr., Keller,P.M. and Levy,M.A.
    A substrate combinatorial array for caspases
    Bioorg Med Chem Lett9, 1667-1672. PubMed  Europe PubMed DOI  P
  241. Liu,X.H., Kwon,D., Schielke,G.P., Yang,G.Y., Silverstein,F.S. and Barks,J.D.
    Mice deficient in interleukin-1 converting enzyme are resistant to neonatal hypoxic-ischemic brain damage
    J Cereb Blood Flow Metab19, 1099-1108. PubMed  Europe PubMed DOI  K
  242. Okamoto,Y., Anan,H., Nakai,E., Morihira,K., Yonetoku,Y., Kurihara,H., Sakashita,H., Terai,Y., Takeuchi,M., Shibanuma,T. and Isomura,Y.
    Peptide based interleukin-1beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex
    Chem Pharm Bull (Tokyo)47, 11-21. PubMed  Europe PubMed  I
    243. 1998
  243. [YEAR:9-6-1998]Brady,K.D.
    Bimodal inhibition of caspase-1 by aryloxymethyl and acyloxymethyl ketones
    Biochemistry37, 8508-8515. PubMed  Europe PubMed DOI  I
  244. [YEAR:28-9-1998]Johnson,A.L., Bridgham,J.T., Munks,M. and Witty,J.P.
    Characterization of the chicken interleukin-1beta converting enzyme (caspase-1) cDNA and expression of caspase-1 mRNA in the hen
    Gene219, 55-62. PubMed  Europe PubMed DOI
    245. 1997
  245. Akita,K., Ohtsuki,T., Nukada,Y., Tanimoto,T., Namba,M., Okura,T., Takakura-Yamamoto,R., Torigoe,K., Gu,Y., Su,M.S., Fujii,M., Satoh-Itoh,M., Yamamoto,K., Kohno,K., Ikeda,M. and Kurimoto,M.
    Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells
    J Biol Chem272, 26595-26603. PubMed  Europe PubMed DOI  I
  246. [YEAR:2-5-1997]Beyaert,R., Kidd,V.J., Cornelis,S., Van de Craen,M., Denecker,G., Lahti,J.M., Gururajan,R., Vandenabeele,P. and Fiers,W.
    Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor
    J Biol Chem272, 11694-11697. PubMed  Europe PubMed DOI
  247. Chen,W., Raybuck,S.A., Fulghum,J.R., Petrillo,R.A., Margolin,N. and Chambers,S.P.
    Expression and purification of human interleukin-1 beta converting enzyme from Trichoplusia ni insect cells using a Baculovirus expression system
    Protein Expr Purif9, 69-75. PubMed  Europe PubMed DOI  E
  248. [YEAR:15-2-1997]Fantuzzi,G., Ku,G., Harding,M.W., Livingston,D.J., Sipe,J.D., Kuida,K., Flavell,R.A. and Dinarello,C.A.
    Response to local inflammation of IL-1 beta-converting enzyme- deficient mice
    J Immunol158, 1818-1824. PubMed  Europe PubMed  K
  249. [YEAR:10-1-1997]Gu,Y., Kuida,K., Tsutsui,H., Ku,G., Hsiao,K., Fleming,M.A., Hayashi,N., Higashino,K., Okamura,H., Nakanishi,K., Kurimoto,M., Tanimoto,T., Flavell,R.A., Sato,V., Harding,M.W., Livingston,D.J. and Su,M.S.
    Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme
    Science275, 206-209. PubMed  Europe PubMed DOI  K
  250. Li,P., Allen,H., Banerjee,S. and Seshadri,T.
    Characterization of mice deficient in interleukin-1beta converting enzyme
    J Cell Biochem64, 27-32. PubMed  Europe PubMed DOI  K
  251. Margolin,N., Raybuck,S.A., Wilson,K.P., Chen,W., Fox,T., Gu,Y. and Livingston,D.J.
    Substrate and inhibitor specificity of interleukin-1beta-converting enzyme and related caspases
    J Biol Chem272, 7223-7228. PubMed  Europe PubMed DOI  S  I
  252. Rano,T.A., Timkey,T., Peterson,E.P., Rotonda,J., Nicholson,D.W., Becker,J.W., Chapman,K.T. and Thornberry,N.A.
    A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)
    Chem Biol4, 149-155. PubMed  Europe PubMed  I
  253. [YEAR:11-4-1997]Talanian,R.V., Quinlan,C., Trautz,S., Hackett,M.C., Mankovich,J.A., Banach,D., Ghayur,T., Brady,K.D. and Wong,W.W.
    Substrate specificities of caspase family proteases
    J Biol Chem272, 9677-9682. PubMed  Europe PubMed DOI  P
  254. Van de Craen,M., Vandenabeele,P., Declercq,W., van den Brande,I., Van Loo,G., Molemans,F., Schotte,P., van Criekinge,W., Beyaert,R. and Fiers,W.
    Characterization of seven murine caspase family members
    FEBS Lett403, 61-69. PubMed  Europe PubMed DOI
    255. 1996
  255. Ku,G., Faust,T., Lauffer,L.L., Livingston,D.J. and Harding,M.W.
    Interleukin-1 beta converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice
    Cytokine8, 377-386. PubMed  Europe PubMed DOI
  256. Talanian,R.V., Dang,L.C., Ferenz,C.R., Hackett,M.C., Mankovich,J.A., Welch,J.P., Wong,W.W. and Brady,K.D.
    Stability and oligomeric equilibria of refolded interleukin-1beta converting enzyme
    J Biol Chem271, 21853-21858. PubMed  Europe PubMed DOI
    257. 1995
  257. Elford,P.R., Heng,R., Revesz,L. and MacKenzie,A.R.
    Reduction of inflammation and pyrexia in the rat by oral administration of SDZ 224-015, an inhibitor of the interleukin- 1beta converting enzyme
    Br J Pharmacol115, 601-606. PubMed  Europe PubMed  I
  258. Fletcher,D.S., Agarwal,L., Chapman,K.T., Chin,J., Egger,L.A., Limjuco,G., Luell,S., MacIntyre,D.E., Peterson,E.P., Thornberry,N.A. and Kostura,M.J.
    A synthetic inhibitor of interleukin-1beta converting enzyme prevents endotoxin-induced interleukin-1beta production in vitro and in vivo
    J Interferon Res15, 243-248.  I
  259. [YEAR:1-3-1995]Howard,A.D., Palyha,O.C., Griffin,P.R., Peterson,E.P., Lenny,A.B., Ding,G.J., Pickup,D.J., Thornberry,N.A., Schmidt,J.A. and Tocci,M.J.
    Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA
    J Immunol154, 2321-2332. PubMed  Europe PubMed
  260. Kuida,K., Lippke,J.A., Ku,G., Harding,M.W., Livingston,D.J., Su,M.S. and Flavell,R.A.
    Altered cytokine export and apoptosis in mice deficient in interleukin-1beta converting enzyme
    Science267, 2000-2003. PubMed  Europe PubMed  K
  261. Li,P., Allen,H., Banerjee,S., Franklin,S., Herzog,L., Johnston,C., McDowell,J., Paskind,M., Rodman,L., Salfeld,J., Towne,E., Tracey,D., Wardwell,S., Wei,F.Y., Wong,W., Kamen,R. and Seshadri,T.
    Mice deficient in IL-1beta-converting enzyme are defective in production of mature IL-1beta and resistant to endotoxic shock
    Cell80, 401-411. PubMed  Europe PubMed
  262. Malinowski,J.J., Grasberger,B.L., Trakshel,G., Huston,E.E., Helaszek,C.T., Smallwood,A.M., Ator,M.A., Banks,T.M., Brake,P.G., Ciccarelli,R.B., Jones,B.N., Koehn,J.A., Kratz,D., Lundberg,N., Stams,T., Rubin,B., Alexander,R.S. and Stevis,P.E.
    Production, purification, and crystallization of human interleukin- 1 beta converting enzyme derived from an Escherichia coli expression system
    Protein Sci4, 2149-2155. PubMed  Europe PubMed DOI  E
  263. Miller,B.E., Krasney,P.A., Gauvin,D.M., Holbrook,K.B., Koonz,D.J., Abruzzese,R.V., Miller,R.E., Pagani,K.A., Dolle,R.E., Ator,M.A. and Gilman,S.C.
    Inhibition of mature IL-1 beta production in murine macrophages and a murine model of inflammation by WIN 67694, an inhibitor of IL-1beta converting enzyme
    J Immunol154, 1331-1338. PubMed  Europe PubMed  I
  264. Prasad,C.V.C., Prouty,C.P., Hoyer,D., Ross,T.M., Salvino,J.M., Awas,M., Graybill,T.L., Schmidt,S.J., Osifo,I.K., Dolle,R.E., Helaszek,C.T., Miller,E. and Ator,M.A.
    Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1beta converting enzyme
    Bioorg Med Chem Lett5, 315-318. DOI  I
  265. Quan,L.T., Caputo,A., Bleackley,R.C., Pickup,D.J. and Salvesen,G.S.
    Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A
    J Biol Chem270, 10377-10379. PubMed  Europe PubMed DOI
  266. Thornberry,N.A. and Molineaux,S.M.
    Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell death
    Protein Sci4, 3-12. PubMed  Europe PubMed DOI
    267. 1994
  267. [YEAR:11-11-1994]Dolle,R.E., Singh,J., Rinker,J., Hoyer,D., Prasad,C.V., Graybill,T.L., Salvino,J.M., Helaszek,C.T., Miller,R.E. and Ator,M.A.
    Aspartyl alpha-((1-phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl ketones as interleukin-1 beta converting enzyme inhibitors. Significance of the P1 and P3 amido nitrogens for enzyme-peptide inhibitor binding
    J Med Chem37, 3863-3866. PubMed  Europe PubMed DOI  I
  268. Dolle,R.E., Hoyer,D., Prasad,C.V., Schmidt,S.J., Helaszek,C.T., Miller,R.E. and Ator,M.A.
    P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1beta-converting enzyme
    J Med Chem37, 563-564. PubMed  Europe PubMed  I
  269. Graybill,T.L., Dolle,R.E., Helaszek,C.T., Miller,R.E. and Ator,M.A.
    Preparation and evaluation of peptidic aspartyl hemiacetals as reversible inhibitors of interleukin-1 beta converting enzyme (ICE)
    Int J Pept Protein Res44, 173-182. PubMed  Europe PubMed  I
  270. [YEAR:29-7-1994]Komiyama,T., Ray,C.A., Pickup,D.J., Howard,A.D., Thornberry,N.A., Peterson,E.P. and Salvesen,G.
    Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition
    J Biol Chem269, 19331-19337. PubMed  Europe PubMed
  271. Mjalli,A.M.M., Chapman,K.T., MacCoss,M., Thornberry,N.A. and Peterson,E.P.
    Activated ketones as potent reversible inhibitors of interleukin-1beta converting enzyme
    Bioorg Med Chem Lett4, 1965-1968. DOI  I
  272. Mullican,M.D., Lauffer,D.J., Gillespie,R.J., Martharu,S.S., Kay,D., Porritt,G.M., Evans,P.L., Golec,J.M., Murcko,M.A., Luong,Y.P., Raybuck,S.A. and Livingston,D.J.
    The synthesis and evaluation of peptidyl aspartyl aldehydes as inhibitors of ice
    Bioorg Med Chem Lett4, 2359-2364. DOI  I
  273. Revesz,L., Briswalter,C., Heng,R., Leutwiller,A., Mueller,R. and Wuethrich,H.J.
    Synthesis of P1-apartyl-based peptide acyloxymethyl and fluoromethyl ketones as inhibitors of interleukin-1-beta converting enzyme
    Tetrahedron Lett35, 9693-9696. DOI  I
  274. Thornberry,N.A.
    Interleukin-1 beta converting enzyme
    Methods Enzymol244, 615-631. PubMed  Europe PubMed DOI  V
  275. Thornberry,N.A., Peterson,E.P., Zhao,J.J., Howard,A.D., Griffin,P.R. and Chapman,K.T.
    Inactivation of interleukin-1beta converting enzyme by peptide (acyloxy)methyl ketones
    Biochemistry33, 3934-3940. PubMed  Europe PubMed  I
  276. [YEAR:29-7-1994]Walker,N.P.C., Talanian,R.V., Brady,K.D., Dang,L.C., Bump,N.J., Ferenz,C.R., Franklin,S., Ghayur,T., Hackett,M.C., Hammill,L.D., Herzog,L., Hugunin,M., Houy,W., Mankovich,J.A., McGuiness,L., Orlewicz,E., Paskind,M., Pratt,C.A., Reis,P., Summani,A., Terranova,M., Welch,J.P., Xiong,L. and Moller,A.
    Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer
    Cell78, 343-352. PubMed  Europe PubMed DOI  S
  277. Wang,X.M., Helaszek,C.T., Winter,L.A., Lirette,R.P., Dixon,D.C., Ciccarelli,R.B., Kelley,M.M., Malinowski,J.J., Simmons,S.J., Huston,E.E., Koehn,J.A., Kratz,D., Bruckner,R.C., Graybill,T., Ator,M.A., Lehr,R.V. and Stevis,P.E.
    Production of active human interleukin-1beta-converting enzyme in a baculovirus expression system
    Gene145, 273-277. PubMed  Europe PubMed DOI
  278. Wilson,K.P., Black,J.F., Thomson,J.A., Kim,E.E., Griffith,J.P., Navia,M.A., Murcko,M.A., Chambers,S.P., Aldape,R.A., Raybuck,S.A. and Livingston,D.J.
    Structure and mechanism of interleukin-1beta converting enzyme
    Nature370, 270-275. PubMed  Europe PubMed DOI  S
    279. 1993
  279. Mjalli,A.M.M., Chapman,K.T. and MacCoss,M.
    Synthesis of a peptidyl 2,2-difluoro-4-phenylbutyl ketone and its evaluation as an inhibitor of interleukin-1beta converting enzyme
    Bioorg Med Chem Lett3, 2693-2698. DOI  I
  280. Mjalli,A.M.M., Chapman,K.T., MacCoss,M. and Thornberry,N.A.
    Phenylalkyl ketones as potent reversible inhibitors of interleukin-1beta converting enzyme
    Bioorg Med Chem Lett3, 2689-2692. DOI  I
  281. Molineaux,S.M., Casano,F.J., Rolando,A.M., Peterson,E.P., Limjuco,G., Chin,J., Griffin,P.R., Calaycay,J.R., Ding,G.J. and Yamin,T.T.
    Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme
    Proc Natl Acad Sci U S A90, 1809-1813. PubMed  Europe PubMed  I
    282. 1992
  282. Cerretti,D.P., Kozlosky,C.J., Mosley,B., Nelson,N., Van Ness,K., Greenstreet,T.A., March,C.J., Kronheim,S.R., Druck,T., Cannizzaro,L.A., Huebner,K. and Black,R.A.
    Molecular cloning of the interleukin-1beta converting enzyme
    Science256, 97-100. PubMed  Europe PubMed
  283. Chapman,K.T.
    Synthesis of a potent, reversible inhibitor of interleukin-1beta converting enzyme
    Bioorg Med Chem Lett2, 613-618. DOI  I
  284. Nett,M.A., Cerretti,D.P., Berson,D.R., Seavitt,J., Gilbert,D.J., Jenkins,N.A., Copeland,N.G., Black,R.A. and Chaplin,D.D.
    Molecular cloning of the murine IL-1beta converting enzyme cDNA
    J Immunol149, 3254-3259. PubMed  Europe PubMed
  285. [YEAR:15-5-1992]Ray,C.A., Black,R.A., Kronheim,S.R., Greenstreet,T.A., Sleath,P.R., Salvesen,G.S. and Pickup,D.J.
    Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme
    Cell69, 597-604. PubMed  Europe PubMed DOI
  286. Robinson,R.P. and Donahue,K.M.
    Synthesis of a peptidyl difluoro ketone bearing the aspartic acid side chain: an inhibitor of interleukin-1beta converting enzyme
    J Org Chem57, 7309-7314. DOI  I
  287. Thornberry,N.A., Bull,H.G., Calaycay,J.R., Chapman,K.T., Howard,A.D., Kostura,M.J., Miller,D.K., Molineaux,S.M., Weidner,J.R., Aunins,J., Elliston,K.O., Ayala,J.M., Casano,F.J., Chin,J., Ding,G.J.F., Egger,L.A., Gaffney,E.P., Limjuco,G., Palyha,O.C., Raju,S.M., Rolando,A.M., Salley,J.P., Yamin,T.T. and Tocci,M.J.
    A novel heterodimeric cysteine protease is required for interleukin-1beta processing in monocytes
    Nature356, 768-774. PubMed  Europe PubMed DOI  I
    288. 1991
  288. Howard,A., Kostura,M.J., Thornberry,N., Ding,G.J., Limjuco,G., Weidner,J., Salley,J.P., Hogquist,K.A., Chaplin,D.D., Mumford,R.A., Schmidt,J.A. and Tocci,M.J.
    IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha
    J Immunol147, 2964-2969. PubMed  Europe PubMed
    289. 1989
  289. Black,R.A., Kronheim,S.R. and Sleath,P.R.
    Activation of interleukin-1beta by a co-induced protease
    FEBS Lett247, 386-390. PubMed  Europe PubMed
  290. Kostura,M.J., Tocci,M.J., Limjuco,G., Chin,J., Cameron,P., Hillman,A.G., Chartrain,N.A. and Schmidt,J.A.
    Identification of a monocyte specific pre-interleukin 1 beta convertase activity
    Proc Natl Acad Sci U S A86, 5227-5231. PubMed  Europe PubMed

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