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Literature for peptidase C01.074: CPB peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: T Target, K Knockout, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Gini,A.L.R., Joao,E.E., Lopes,J.R., Da Cunha,P.S.T., Velasquez,A.M.A., Graminha,M.A.S., Dos Santos,J.L. and Scarim,C.B.
    Advances in Cysteine Protease B Inhibitors for Leishmaniasis Treatment
    Curr Drug Targets PubMed  Europe PubMed DOI  V
    2. 2021
  2. Aunguldee,T., Gerdprasert,O., Tangteerawatana,P., Jariyapongskul,A., Leelayoova,S. and Wongsatayanon,B.T.
    Immunogenicity and potential protection of DNA vaccine of Leishmania martiniquensis against Leishmania infection in mice
    J Infect Dev Ctries15, 1328-1338. PubMed  Europe PubMed DOI
    3. 2020
  3. Cianni,L., Rocho,F.D.R., Rosini,F., Bonatto,V., Ribeiro,J.F.R., Lameira,J., Leitao,A., Shamim,A. and Montanari,C.A.
    Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases
    Bioorg Chem101, 104039-104039. PubMed  Europe PubMed DOI  I
  4. Fonseca Lameiro,R.D., Shamim,A., Rosini,F., Cendron,R., Jatai Batista,P.H. and Montanari,C.A.
    Synthesis, biochemical evaluation and molecular modeling studies of nonpeptidic nitrile-based fluorinated compounds
    Future Med Chem PubMed  Europe PubMed DOI
  5. Ghosh,S., Verma,A., Kumar,V., Pradhan,D., Selvapandiyan,A., Salotra,P. and Singh,R.
    Genomic and Transcriptomic Analysis for Identification of Genes and Interlinked Pathways Mediating Artemisinin Resistance in Leishmania donovani
    Genes (Basel)11, PubMed  Europe PubMed DOI  I
  6. Matos,T.K.B., Batista,P.H.J., Dos Reis Rocho,F., De Vita,D., Pearce,N., Kellam,B., Montanari,C.A. and Leitao,A.
    Synthesis and matched molecular pair analysis of covalent reversible inhibitors of the cysteine protease CPB
    Bioorg Med Chem Lett30, 127439-127439. PubMed  Europe PubMed DOI  I
  7. Ribeiro,J.F.R., Cianni,L., Li,C., Warwick,T.G., De Vita,D., Rosini,F., Dos Reis Rocho,F., Martins,F.C.P., Kenny,P.W., Lameira,J., Leitao,A., Emsley,J. and Montanari,C.A.
    Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor
    Bioorg Med Chem28, 115743-115743. PubMed  Europe PubMed DOI  I
    8. 2019
  8. Bivona,A.E., Czentner,L., Sanchez Alberti,A., Cerny,N., Cardoso Landaburu,A.C., Nevot,C., Estevez,O., Marco,J.D., Basombrio,M.A., Malchiodi,E.L. and Cazorla,S.I.
    The recombinant cysteine proteinase B (CPB) from Leishmania braziliensis and its domains: promising antigens for serodiagnosis of cutaneous and visceral leishmaniasis in dogs
    J Clin Microbiol57, e00819-19-e00819-19. PubMed  Europe PubMed DOI
    9. 2018
  9. De Luca,L., Ferro,S., Buemi,M.R., Monforte,A.M., Gitto,R., Schirmeister,T., Maes,L., Rescifina,A. and Micale,N.
    Discovery of benzimidazole-based Leishmania mexicana cysteine protease CPB2.8DeltaCTE inhibitors as potential therapeutics for leishmaniasis
    Chem Biol Drug Des92, 1585-1596. PubMed  Europe PubMed DOI  I
  10. Fey,P., Chartomatsidou,R., Kiefer,W., Mottram,J.C., Kersten,C. and Schirmeister,T.
    New aziridine-based inhibitors of cathepsin L-like cysteine proteases with selectivity for the Leishmania cysteine protease LmCPB2.8
    Eur J Med Chem156, 587-597. PubMed  Europe PubMed DOI  I
    11. 2017
  11. Beyzay,F., Zavaran Hosseini,A. and Soudi,S.
    Alpha alumina nanoparticle conjugation to cysteine peptidase A and B: an efficient method for autophagy induction
    Avicenna J Med Biotechnol9, 71-81. PubMed  Europe PubMed
    12. 2016
  12. Casgrain,P.A., Martel,C., McMaster,W.R., Mottram,J.C., Olivier,M. and Descoteaux,A.
    Cysteine peptidase B regulates Leishmania mexicana virulence through the modulation of GP63 expression
    PLoS Pathog12, e1005658-e1005658. PubMed  Europe PubMed DOI
  13. Santos,D.A., de Souza Costa,M.G., Alves,C.R. and Caffarena,E.R.
    Structural and dynamic insights into the C-terminal extension of cysteine proteinase B from Leishmania amazonensis
    J Mol Graph Model70, 30-39. PubMed  Europe PubMed DOI
  14. Scala,A., Micale,N., Piperno,A., Rescifina,A., Schirmeister,T., Kesselring,J. and Grassi,G.
    Targeting of the Leishmania mexicana cysteine protease CPB2.8DCTE by decorated fused benzo[b] thiophene scaffold
    RSC Adv6, 30628-30635. DOI  I
    15. 2015
  15. De Sousa,L.R., Wu,H., Nebo,L., Fernandes,J.B., da Silva,M.F., Kiefer,W., Schirmeister,T. and Vieira,P.C.
    Natural products as inhibitors of recombinant cathepsin L of Leishmania mexicana
    Exp Parasitol156, 42-48. PubMed  Europe PubMed DOI  I
  16. Gontijo,V.S., Espuri,P.F., Alves,R.B., de Camargos,L.F., Santos,F.V., de Souza Judice,W.A., Marques,M.J. and Freitas,R.P.
    Leishmanicidal, antiproteolytic, and mutagenic evaluation of alkyltriazoles and alkylphosphocholines
    Eur J Med Chem101, 24-33. PubMed  Europe PubMed DOI  I
  17. Shahbazi,M., Zahedifard,F., Taheri,T., Taslimi,Y., Jamshidi,S., Shirian,S., Mahdavi,N., Hassankhani,M., Daneshbod,Y., Zarkesh-Esfahani,S.H., Papadopoulou,B. and Rafati,S.
    Evaluation of live recombinant nonpathogenic Leishmania tarentolae expressing cysteine proteinase and A2 Genes as a candidate vaccine against experimental canine visceral leishmaniasis
    PLoS ONE10, e0132794-e0132794. PubMed  Europe PubMed DOI
    18. 2013
  18. Chaouch,M., Fathallah-Mili,A., Driss,M., Lahmadi,R., Ayari,C., Guizani,I., Ben Said,M. and Benabderrazak,S.
    Identification of Tunisian Leishmania spp. by PCR amplification of cysteine proteinase B (cpb) genes and phylogenetic analysis
    Acta Trop125, 357-365. PubMed  Europe PubMed DOI
  19. Judice,W.A., Manfredi,M.A., Souza,G.P., Sansevero,T.M., Almeida,P.C., Shida,C.S., Gesteira,T.F., Juliano,L., Westrop,G.D., Sanderson,S.J., Coombs,G.H. and Tersariol,I.L.
    Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-like rCPB2.8
    PLoS ONE8, e80153-e80153. PubMed  Europe PubMed DOI
  20. Schroder,J., Noack,S., Marhofer,R.J., Mottram,J.C., Coombs,G.H. and Selzer,P.M.
    Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB
    PLoS ONE8, e77460-e77460. PubMed  Europe PubMed DOI  I
  21. Unciti-Broceta,J.D., Maceira,J., Morales,S., Garcia-Perez,A., Munoz-Torres,M.E. and Garcia-Salcedo,J.A.
    Nicotinamide inhibits the lysosomal cathepsin B-like protease and kills African trypanosomes
    J Biol Chem288, 10548-10557. PubMed  Europe PubMed DOI  I
    22. 2012
  22. Myburgh,E., Coombs,G.H. and Mottram,J.C.
    Leishmania CPA, CPB and CPC cysteine proteases
    [ISSN:978-0-12-407743-0]3, 1923-1928. DOI
  23. Rana,S., Dikhit,M.R., Rani,M., Moharana,K.C., Sahoo,G.C. and Das,P.
    CPDB: cysteine protease annotation database in Leishmania species
    Integr Biol (Camb)4, 1351-1357. PubMed  Europe PubMed DOI
    24. 2011
  24. Caffrey,C.R., Lima,A.P. and Steverding,D.
    Cysteine peptidases of kinetoplastid parasites
    Adv Exp Med Biol712, 84-99. PubMed  Europe PubMed DOI  V
  25. Doroud,D., Zahedifard,F., Vatanara,A., Najafabadi,A.R., Taslimi,Y., Vahabpour,R., Torkashvand,F., Vaziri,B. and Rafati,S.
    Delivery of a cocktail DNA vaccine encoding cysteine proteinases type I, II and III with solid lipid nanoparticles potentiate protective immunity against Leishmania major infection
    J Control Release153, 154-162. PubMed  Europe PubMed DOI
    26. 2010
  26. Steert,K., Berg,M., Mottram,J.C., Westrop,G.D., Coombs,G.H., Cos,P., Maes,L., Joossens,J., Van der Veken,P., Haemers,A. and Augustyns,K.
    alpha-Ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB
    ChemMedChem5, 1734-1748. PubMed  Europe PubMed DOI  I
    27. 2009
  27. Caffrey,C.R. and Steverding,D.
    Kinetoplastid papain-like cysteine peptidases
    Mol Biochem Parasitol167, 12-19. PubMed  Europe PubMed DOI  I
  28. Rebello,K.M., Cortes,L.M., Pereira,B.A., Pascarelli,B.M., Corte-Real,S., Finkelstein,L.C., Pinho,R.T., D'Avila-Levy,C.M. and Alves,C.R.
    Cysteine proteinases from promastigotes of Leishmania (Viannia) braziliensis
    Parasitol Res106, 95-104. PubMed  Europe PubMed DOI
  29. Saffari,B. and Mohabatkar,H.
    Computational analysis of cysteine proteases (Clan CA, Family C1) of Leishmania major to find potential epitopic regions
    Genomics Proteomics Bioinformatics7, 87-95. PubMed  Europe PubMed DOI
    30. 2008
  30. Lanfranco,M.F., Loayza-Muro,R., Clark,D., Nunez,R., Zavaleta,A.I., Jimenez,M., Meldal,M., Coombs,G.H., Mottram,J.C., Izidoro,M., Juliano,M.A., Juliano,L. and Arevalo,J.
    Expression and substrate specificity of a recombinant cysteine proteinase B of Leishmania braziliensis
    Mol Biochem Parasitol161, 91-100. PubMed  Europe PubMed DOI
  31. Marin-Villa,M., Vargas-Inc, Chaves,S.P., Tempone,A.J., Dutra,J.M., Soares,M.J., Ueda-Nakamura,T., Mendonca,S.C., Rossi-Bergmann,B., Soong,L. and Traub-Cseko,Y.M.
    The C-terminal extension of Leishmania pifanoi amastigote-specific cysteine proteinase Lpcys2: a putative function in macrophage infection
    Mol Biochem Parasitol162, 52-59. PubMed  Europe PubMed DOI
    32. 2007
  32. Kuru,T., Jirata,D., Genetu,A., Barr,S., Mengistu,Y., Aseffa,A. and Gedamu,L.
    Leishmania aethiopica: identification and characterization of cathepsin L-like cysteine protease genes
    Exp Parasitol115, 283-290. PubMed  Europe PubMed DOI
    33. 2006
  33. [YEAR:27-6-2006]Williams,R.A., Tetley,L., Mottram,J.C. and Coombs,G.H.
    Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana
    Mol Microbiol61, 655-674. PubMed  Europe PubMed DOI  T
    34. 2005
  34. Judice,W.A., Mottram,J.C., Coombs,G.H., Juliano,M.A. and Juliano,L.
    Specific negative charges in cysteine protease isoforms of Leishmania mexicana are highly influential on the substrate binding and hydrolysis
    Mol Biochem Parasitol144, 36-43. PubMed  Europe PubMed DOI  P
  35. [YEAR:3-2-2005]Mundodi,V., Kucknoor,A.S. and Gedamu,L.
    Role of Leishmania (Leishmania) chagasi amastigote cysteine protease in intracellular parasite survival: studies by gene disruption and antisense mRNA inhibition
    BMC Mol Biol6, 3-3. PubMed  Europe PubMed DOI
    36. 2004
  36. [YEAR:1-9-2004]Cameron,P., McGachy,A., Anderson,M., Paul,A., Coombs,G.H., Mottram,J.C., Alexander,J. and Plevin,R.
    Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway
    J Immunol173, 3297-3304. PubMed  Europe PubMed
  37. Judice,W.A., Puzer,L., Cotrin,S.S., Carmona,A.K., Coombs,G.H., Juliano,L. and Juliano,M.A.
    Carboxydipeptidase activities of recombinant cysteine peptidases. Cruzain of Trypanosoma cruzi and CPB of Leishmania mexicana
    Eur J Biochem271, 1046-1053. PubMed  Europe PubMed DOI  P
  38. Juliano,M.A., Brooks,D.R., Selzer,P.M., Pandolfo,H.L., Judice,W.A., Juliano,L., Meldal,M., Sanderson,S.J., Mottram,J.C. and Coombs,G.H.
    Differences in substrate specificities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes
    Eur J Biochem271, 3704-3714. PubMed  Europe PubMed DOI  P
  39. Mottram,J.C., Coombs,G.H. and Alexander,J.
    Cysteine peptidases as virulence factors of Leishmania
    Curr Opin Microbiol7, 375-381. PubMed  Europe PubMed DOI
  40. Mottram,J.C. and Coombs,G.H.
    Leishmania CPA, CPB and CPC cysteine proteases
    [ISSN:0-12-079610-4]2, 1166-1169.  V
  41. [YEAR:7-5-2004]Zadeh-Vakili,A., Taheri,T., Taslimi,Y., Doustdari,F., Salmanian,A.H. and Rafati,S.
    Immunization with the hybrid protein vaccine, consisting of Leishmania major cysteine proteinases Type I (CPB) and Type II (CPA), partially protects against leishmaniasis
    Vaccine22, 1930-1940. PubMed  Europe PubMed DOI
    42. 2003
  42. [YEAR:1-10-2003]Buxbaum,L.U., Denise,H., Coombs,G.H., Alexander,J., Mottram,J.C. and Scott,P.
    Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity
    J Immunol171, 3711-3717. PubMed  Europe PubMed
  43. Chibale,K. and Musonda,C.C.
    The synthesis of parasitic cysteine protease and trypanothione reductase inhibitors
    Curr Med Chem10, 1863-1889. PubMed  Europe PubMed DOI  I
  44. Denise,H., McNeil,K., Brooks,D.R., Alexander,J., Coombs,G.H. and Mottram,J.C.
    Expression of multiple CPB genes encoding cysteine proteases is required for Leishmania mexicana virulence in vivo
    Infect Immun71, 3190-3195. PubMed  Europe PubMed DOI
  45. Pascalis,H., Lavergne,A., Bourreau,E., Prevot-Linguet,G., Kariminia,A., Pradinaud,R., Rafati,S. and Launois,P.
    Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis
    Infect Immun71, 2924-2926. PubMed  Europe PubMed DOI
  46. [YEAR:15-2-2003]Pollock,K.G., McNeil,K.S., Mottram,J.C., Lyons,R.E., Brewer,J.M., Scott,P., Coombs,G.H. and Alexander,J.
    The Leishmania mexicana cysteine protease, CPB2.8, induces potent Th2 responses
    J Immunol170, 1746-1753. PubMed  Europe PubMed
  47. Rafati,S., Nakhaee,A., Taheri,T., Ghashghaii,A., Salmanian,A.H., Jimenez,M., Mohebali,M., Masina,S. and Fasel,N.
    Expression of cysteine proteinase type I and II of Leishmania infantum and their recognition by sera during canine and human visceral leishmaniasis
    Exp Parasitol103, 143-151. PubMed  Europe PubMed DOI
    48. 2002
  48. Sajid,M. and McKerrow,J.H.
    Cysteine proteases of parasitic organisms
    Mol Biochem Parasitol120, 1-21. PubMed  Europe PubMed
  49. [YEAR:9-5-2002]St Hilaire,P.M., Alves,L.C., Herrera,F., Renil,M., Sanderson,S.J., Mottram,J.C., Coombs,G.H., Juliano,M.A., Juliano,L., Arevalo,J. and Meldal,M.
    Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B
    J Med Chem45, 1971-1982. PubMed  Europe PubMed DOI  I
    50. 2001
  50. Alves,L.C., Melo,R.L., Sanderson,S.J., Mottram,J.C., Coombs,G.H., Caliendo,G., Santagada,V., Juliano,L. and Juliano,M.A.
    S1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids
    Eur J Biochem268, 1206-1212. PubMed  Europe PubMed DOI  P
  51. [YEAR:25-4-2001]Alves,L.C., St Hilaire,P.M., Meldal,M., Sanderson,S.J., Mottram,J.C., Coombs,G.H., Juliano,L. and Juliano,M.A.
    Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicana
    Mol Biochem Parasitol114, 81-88. PubMed  Europe PubMed DOI
  52. Alves,L.C., Judice,W.A., St Hilaire,P.M., Meldal,M., Sanderson,S.J., Mottram,J.C., Coombs,G.H., Juliano,L. and Juliano,M.A.
    Substrate specificity of recombinant cysteine proteinase, CPB, of Leishmania mexicana
    Mol Biochem Parasitol116, 1-9. PubMed  Europe PubMed DOI  P
  53. Alves,L.C., Melo,R.L., Cezari,M.H., Sanderson,S.J., Mottram,J.C., Coombs,G.H., Juliano,L. and Juliano,M.A.
    Analysis of the S(2) subsite specificities of the recombinant cysteine proteinases CPB of Leishmania mexicana, and cruzain of Trypanosoma cruzi, using fluorescent substrates containing non-natural basic amino acids
    Mol Biochem Parasitol117, 137-143. PubMed  Europe PubMed DOI  P
  54. [YEAR:14-12-2001]Brooks,D.R., Denise,H., Westrop,G.D., Coombs,G.H. and Mottram,J.C.
    The stage-regulated expression of Leishmania mexicana CPB cysteine proteases is mediated by an intercistronic sequence element
    J Biol Chem276, 47061-47069. PubMed  Europe PubMed DOI
  55. [YEAR:15-3-2001]Das,L., Datta,N., Bandyopadhyay,S. and Das,P.K.
    Successful therapy of lethal murine visceral leishmaniasis with cystatin involves up-regulation of nitric oxide and a favorable T cell response
    J Immunol166, 4020-4028. PubMed  Europe PubMed
  56. Graven,A., St,H.P.M., Sanderson,S.J., Mottram,J.C., Coombs,G.H. and Meldal,M.
    Combinatorial library of peptide isosters based on Diels-Alder reactions: identification of novel inhibitors against a recombinant cysteine protease from Leishmania mexicana
    J Comb Chem3, 441-452. PubMed  Europe PubMed DOI  I
  57. [YEAR:14-5-2001]Rafati,S., Salmanian,A.H., Taheri,T., Vafa,M. and Fasel,N.
    A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major
    Vaccine19, 3369-3375. PubMed  Europe PubMed DOI
  58. Rafati,S., Salmanian,A.H., Hashemi,K., Schaff,C., Belli,S. and Fasel,N.
    Identification of Leishmania major cysteine proteinases as targets of the immune response in humans
    Mol Biochem Parasitol113, 35-43. PubMed  Europe PubMed DOI
    59. 2000
  59. Brooks,D.R., Tetley,L., Coombs,G.H. and Mottram,J.C.
    Processing and trafficking of cysteine proteases in Leishmania mexicana
    J Cell Sci113, 4035-4041. PubMed  Europe PubMed  K
  60. Frame,M.J., Mottram,J.C. and Coombs,G.H.
    Analysis of the roles of cysteine proteinases of Leishmania mexicana in the host-parasite interaction
    Parasitology121, 367-377. PubMed  Europe PubMed DOI  K
  61. [YEAR:15-4-2000]Sanderson,S.J., Pollock,K.G., Hilley,J.D., Meldal,M., St Hilaire,P., Juliano,M.A., Juliano,L., Mottram,J.C. and Coombs,G.H.
    Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana
    Biochem J347, 383-388. PubMed  Europe PubMed DOI  E
  62. [YEAR:18-8-2000]St Hilaire,P.M., Alves,L.C., Sanderson,S.J., Mottram,J.C., Juliano,M.A., Juliano,L., Coombs,G.H. and Meldal,M.
    The substrate specificity of a recombinant cysteine protease from Leishmania mexicana: application of a combinatorial peptide library approach
    Chembiochem1, 115-122. PubMed  Europe PubMed  P
    63. 1999
  63. [YEAR:28-9-1999]Selzer,P.M., Pingel,S., Hsieh,I., Ugele,B., Chan,V.J., Engel,J.C., Bogyo,M., Russell,D.G., Sakanari,J.A. and McKerrow,J.H.
    Cysteine protease inhibitors as chemotherapy: lessons from a parasite target
    Proc Natl Acad Sci U S A96, 11015-11022. PubMed  Europe PubMed DOI
    64. 1998
  64. [YEAR:15-12-1998]Alexander,J., Coombs,G.H. and Mottram,J.C.
    Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a TH1 response
    J Immunol161, 6794-6801. PubMed  Europe PubMed  K
  65. Mottram,J.C., Brooks,D.R. and Coombs,G.H.
    Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions
    Curr Opin Microbiol1, 455-460. PubMed  Europe PubMed
    66. 1997
  66. Mottram,J.C., Frame,M.J., Brooks,D.R., Tetley,L., Hutchison,J.E., Souza,A.E. and Coombs,G.H.
    The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences
    J Biol Chem272, 14285-14293. PubMed  Europe PubMed DOI
  67. [YEAR:1-12-1997]Omara-Opyene,A.L. and Gedamu,L.
    Molecular cloning, characterization and overexpression of two distinct cysteine protease cDNAs from Leishmania donovani chagasi
    Mol Biochem Parasitol90, 247-267. PubMed  Europe PubMed DOI
  68. Sakanari,J.A., Nadler,S.A., Chan,V.J., Engel,J.C., Leptak,C. and Bouvier,J.
    Leishmania major: Comparison of the cathepsin L- and B-like cysteine protease genes with those of other trypanosomatids
    Exp Parasitol85, 63-76. PubMed  Europe PubMed DOI
  69. Selzer,P.M., Chen,X., Chan,V.J., Cheng,M., Kenyon,G.L., Kuntz,I.D., Sakanari,J.A., Cohen,F.E. and McKerrow,J.H.
    Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors
    Exp Parasitol87, 212-221. PubMed  Europe PubMed DOI
    70. 1996
  70. Mottram,J.C., Souza,A.E., Hutchison,J.E., Carter,R., Frame,M.J. and Coombs,G.H.
    Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors
    Proc Natl Acad Sci U S A93, 6008-6013. PubMed  Europe PubMed DOI  K
    71. 1995
  71. De Souza Leao,S., Lang,T., Prina,E., Hellio,R. and Antoine,J.C.
    Intracellular Leishmania amazonensis amastigotes internalize and degrade MHC class II molecules of their host cells
    J Cell Sci108, 3219-3231. PubMed  Europe PubMed
    72. 1994
  72. Duboise,S.M., Vannier-Santos,M.A., Costa-Pinto,D., Rivas,L., Pan,A.A., Traub-Cseko,Y., de Souza,W. and McMahon-Pratt,D.
    The biosynthesis, processing, and immunolocalization of Leishmania pifanoi amastigote cysteine proteinases
    Mol Biochem Parasitol68, 119-132. PubMed  Europe PubMed DOI
  73. Robertson,C.D. and Coombs,G.H.
    Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the Imcpb gene array
    Microbiology (Reading, Engl )140, 417-424. PubMed  Europe PubMed
    74. 1993
  74. Traub-Cseko,Y.M., Duboise,M., Boukai,L.K. and McMahon-Pratt,D.
    Identification of two distinct cysteine proteinase genes of Leishmania pifanoi axenic amastigotes using the polymerase chain reaction
    Mol Biochem Parasitol57, 101-115. PubMed  Europe PubMed DOI
    75. 1992
  75. [YEAR:19-10-1992]Souza,A.E., Waugh,S., Coombs,G.H. and Mottram,J.C.
    Characterization of a multi-copy gene for a major stage-specific cysteine proteinase of Leishmania mexicana
    FEBS Lett311, 124-127. PubMed  Europe PubMed DOI
    76. 1990
  76. Robertson,C.D. and Coombs,G.H.
    Characterisation of three groups of cysteine proteinases in the amastigotes of Leishmania mexicana mexicana
    Mol Biochem Parasitol42, 269-276. PubMed  Europe PubMed DOI

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