Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C01.018: cathepsin F

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, M Mutation, P Specificity, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Zdravkova,K., Mijanovic,O., Brankovic,A., Ilicheva,P.M., Jakovleva,A., Karanovic,J., Pualic,M., Pualic,D., Rubel,A.A., Savvateeva,L.V., Parodi,A. and Zamyatnin,A.A., Jr.
    Unveiling the Roles of Cysteine Proteinases F and W: From Structure to Pathological Implications and Therapeutic Targets
    Cells13, PubMed  Europe PubMed DOI  V
    2. 2023
  2. Tusar,L., Loboda,J., Impens,F., Sosnowski,P., Van Quickelberghe,E., Vidmar,R., Demol,H., Sedeyn,K., Saelens,X., Vizovisek,M., Mihelic,M., Fonovic,M., Horvat,J., Kosec,G., Turk,B., Gevaert,K. and Turk,D.
    Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins
    Commun Biol6, 450-450. PubMed  Europe PubMed DOI
    3. 2020
  3. Maeser,S., Petre,B.A., Ion,L., Rawer,S., Kohlschutter,A., Santorelli,F.M., Simonati,A., Schulz,A. and Przybylski,M.
    Enzymatic diagnosis of neuronal lipofuscinoses in dried blood spots using substrates for concomitant tandem mass spectrometry and fluorimetry
    J Mass Spectrome4675-e4675. PubMed  Europe PubMed DOI
    4. 2018
  4. Ji,C., Zhao,Y., Kou,Y.W., Shao,H., Guo,L., Bao,C.H., Jiang,B.C., Chen,X.Y., Dai,J.W., Tong,Y.X., Yang,R., Sun,W. and Wang,Q.
    Cathepsin F knockdown induces proliferation and inhibits apoptosis in gastric cancer cells
    Oncol Res26, 83-93. PubMed  Europe PubMed DOI  K
    5. 2017
  5. Gao,C., Fu,Q., Su,B., Song,H., Zhou,S., Tan,F. and Li,C.
    The involvement of cathepsin F gene (CTSF) in turbot (Scophthalmus maximus L.) mucosal immunity
    Fish Shellfish Immunol66, 270-279. PubMed  Europe PubMed DOI
  6. Lee,J.R., Park,S.J., Kim,Y.H., Choe,S.H., Cho,H.M., Lee,S.R., Kim,S.U., Kim,J.S., Sim,B.W., Song,B.S., Jeong,K.J., Lee,Y., Jin,Y.B., Kang,P., Huh,J.W. and Chang,K.T.
    Alu-derived alternative splicing events specific to Macaca lineages in CTSF gene
    Mol Cells40, 100-108. PubMed  Europe PubMed DOI
    7. 2015
  7. Ahn,C.S., Na,B.K., Chung,D.L., Kim,J.G., Kim,J.T. and Kong,Y.
    Expression characteristics and specific antibody reactivity of diverse cathepsin F members of Paragonimus westermani
    Parasitol Int64, 37-42. PubMed  Europe PubMed DOI
  8. Carcel-Trullols,J., Kovacs,A.D. and Pearce,D.A.
    Cell biology of the NCL proteins: what they do and don't do
    Biochim Biophys Acta1852, 2242-2255. PubMed  Europe PubMed DOI
  9. Peters,J., Rittger,A., Weisner,R., Knabbe,J., Zunke,F., Rothaug,M., Damme,M., Berkovic,S.F., Blanz,J., Saftig,P. and Schwake,M.
    Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease
    Biochem Biophys Res Commun457, 334-340. PubMed  Europe PubMed DOI  M
  10. Schmitz,J., Furtmann,N., Ponert,M., Frizler,M., Loser,R., Bartz,U., Bajorath,J. and Gutschow,M.
    Active site mapping of human cathepsin F with dipeptide nitrile inhibitors
    ChemMedChem10, 1365-1377. PubMed  Europe PubMed DOI  I
    11. 2013
  11. Jeric,B., Dolenc,I., Mihelic,M., Klaric,M., Zavasnik-Bergant,T., Guncar,G., Turk,B., Turk,V. and Stoka,V.
    N-terminally truncated forms of human cathepsin F accumulate in aggresome-like inclusions
    Biochim Biophys Acta1833, 2254-2266. PubMed  Europe PubMed DOI
  12. Qu,Z.G. and Fu,B.Q.
    [Research progress on cathepsin F of parasitic helminths]
    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi31, 406-409. PubMed  Europe PubMed
  13. Smith,K.R., Dahl,H.H., Canafoglia,L., Andermann,E., Damiano,J., Morbin,M., Bruni,A.C., Giaccone,G., Cossette,P., Saftig,P., Grotzinger,J., Schwake,M., Andermann,F., Staropoli,J.F., Sims,K.B., Mole,S.E., Franceschetti,S., Alexander,N.A., Cooper,J.D., Chapman,H.A., Carpenter,S., Berkovic,S.F. and Bahlo,M.
    Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis
    Hum Mol Genet22, 1417-1423. PubMed  Europe PubMed DOI  M
    14. 2012
  14. Bromme,D.
    Cathepsin F
    [ISSN:978-0-12-407743-0]3, 1792-1795. DOI
    15. 2010
  15. Kim,Y.O., Paik,E.M., Nam,B.H., Kong,H.J., Kim,W.J., Lee,S.J. and Kim,K.K.
    Molecular cloning and characterization of cathepsin F gene from olive flounder Paralichthys olivaceus
    Genes Genomics32, 137-142. DOI
  16. Miyaji,T., Murayama,S., Kouzuma,Y., Kimura,N., Kanost,M.R., Kramer,K.J. and Yonekura,M.
    Molecular cloning of a multidomain cysteine protease and protease inhibitor precursor gene from the tobacco hornworm (Manduca sexta) and functional expression of the cathepsin F-like cysteine protease domain
    Insect Biochem Mol Biol40, 835-846. PubMed  Europe PubMed DOI
    17. 2009
  17. Ahn,S.J., Kim,N.Y., Seo,J.S., Je,J.E., Sung,J.H., Lee,S.H., Kim,M.S., Kim,J.K., Chung,J.K. and Lee,H.H.
    Molecular cloning, mRNA expression and enzymatic characterization of cathepsin F from olive flounder (Paralichthys olivaceus)
    Comp Biochem Physiol B Biochem Mol Biol154, 211-220. PubMed  Europe PubMed DOI
    18. 2008
  18. Maubach,G., Lim,M.C. and Zhuo,L.
    Nuclear cathepsin F regulates activation markers in rat hepatic stellate cells
    Mol Biol Cell19, 4238-4248. PubMed  Europe PubMed DOI
    19. 2007
  19. Joo,H.S., Koo,K.B., Park,K.I., Bae,S.H., Yun,J.W., Chang,C.S. and Choi,J.W.
    Cloning and expression of the cathepsin F-like cysteine protease gene in Escherichia coli and its characterization
    J Microbiol45, 158-167. PubMed  Europe PubMed  E
  20. Kaakinen,R., Lindstedt,K.A., Sneck,M., Kovanen,P.T. and Oorni,K.
    Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: an angiotensin II type 2 receptor-mediated effect
    Atherosclerosis192, 323-327. PubMed  Europe PubMed DOI
  21. Reis,F.C., Costa,T.F., Sulea,T., Mezzetti,A., Scharfstein,J., Bromme,D., Menard,R. and Lima,A.P.
    The propeptide of cruzipain - a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F
    FEBS J274, 1224-1234. PubMed  Europe PubMed DOI
    22. 2006
  22. [YEAR:6-3-2006]Choe,Y., Leonetti,F., Greenbaum,D.C., Lecaille,F., Bogyo,M., Bromme,D., Ellman,J.A. and Craik,C.S.
    Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities
    J Biol Chem281, 12824-12832. PubMed  Europe PubMed DOI  P
  23. Linke,M., Gordon,R.E., Brillard,M., Lecaille,F., Lalmanach,G. and Bromme,D.
    Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins
    Biol Chem387, 1295-1303. PubMed  Europe PubMed DOI  P
  24. Tang,C.H., Lee,J.W., Galvez,M.G., Robillard,L., Mole,S.E. and Chapman,H.A.
    Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease
    Mol Cell Biol26, 2309-2316. PubMed  Europe PubMed DOI  K
  25. [YEAR:28-9-2006]Urbina,H.D., Debaene,F., Jost,B., Bole-Feysot,C., Mason,D.E., Kuzmic,P., Harris,J.L. and Winssinger,N.
    Self-assembled small-molecule microarrays for protease screening and profiling
    Chembiochem7, 1790-1797. PubMed  Europe PubMed DOI  I
    26. 2005
  26. Wippersteg,V., Sajid,M., Walshe,D., Khiem,D., Salter,J.P., McKerrow,J.H., Grevelding,C.G. and Caffrey,C.R.
    Biolistic transformation of Schistosoma mansoni with 5' flanking regions of two peptidase genes promotes tissue-specific expression
    Int J Parasitol35, 583-589. PubMed  Europe PubMed DOI
    27. 2004
  27. Bromme,D.
    Cathepsin F
    [ISSN:0-12-079610-4]2, 1087-1088.  V
  28. Dalton,J.P., McKerrow,J.H. and Brindley,P.J.
    Trematode cysteine endopeptidases
    [ISSN:0-12-079610-4]2, 1176-1182.  V
  29. Fonovic,M., Bromme,D., Turk,V. and Turk,B.
    Human cathepsin F: expression in baculovirus system, characterization and inhibition by protein inhibitors
    Biol Chem385, 505-509. PubMed  Europe PubMed DOI
  30. [YEAR:7-6-2004]Oorni,K., Sneck,M., Bromme,D., Pentikainen,M.O., Lindstedt,K.A., Mayranpaa,M., Aitio,H. and Kovanen,P.T.
    Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro
    J Biol Chem279, 34776-34784. PubMed  Europe PubMed DOI
    31. 2003
  31. [YEAR:26-12-2003]Lindstedt,L., Lee,M., Oorni,K., Bromme,D. and Kovanen,P.T.
    Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells
    Biochem Biophys Res Commun312, 1019-1024. PubMed  Europe PubMed DOI
    32. 2002
  32. Ho,J.D., Meltser,Y., Buggy,J.J., Palmer,J.T., Elrod,K.C., Chan,H., Mortara,K.D. and Somoza,J.R.
    Expression, purification, crystallization and preliminary X-ray diffraction studies of human cathepsin F complexed with an irreversible vinyl sulfone inhibitor
    Acta Crystallogr D Biol Crystallogr58, 2187-2190. PubMed  Europe PubMed DOI  I
  33. [YEAR:20-9-2002]Somoza,J.R., Palmer,J.T. and Ho,J.D.
    The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators
    J Mol Biol322, 559-568. PubMed  Europe PubMed DOI  S
    34. 2001
  34. Park,H., Hong,K.M., Sakanari,J.A., Choi,J.H., Park,S.K., Kim,K.Y., Hwang,H.A., Paik,M.K., Yun,K.J., Shin,C.H., Lee,J.B., Ryu,J.S. and Min,D.Y.
    Paragonimus westermani: cloning of a cathepsin F-like cysteine proteinase from the adult worm
    Exp Parasitol98, 223-227. PubMed  Europe PubMed DOI
    35. 2000
  35. [YEAR:27-6-2000]Deussing,J., Tisljar,K., Papazoglou,A. and Peters,C.
    Mouse cathepsin F: cDNA cloning, genomic organization and chromosomal assignment of the gene
    Gene251, 165-173. PubMed  Europe PubMed DOI
  36. [YEAR:3-4-2000]Shi,G.P., Bryant,R.A., Riese,R., Verhelst,S., Driessen,C., Li,Z., Bromme,D., Ploegh,H.L. and Chapman,H.A.
    Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages
    J Exp Med191, 1177-1186. PubMed  Europe PubMed DOI
    37. 1999
  37. [YEAR:13-4-1999]Nagler,D.K., Sulea,T. and Menard,R.
    Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen
    Biochem Biophys Res Commun257, 313-318. PubMed  Europe PubMed DOI
  38. [YEAR:14-5-1999]Santamaria,I., Velasco,G., Pendas,A.M., Paz,A. and Lopez-Otin,C.
    Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain
    J Biol Chem274, 13800-13809. PubMed  Europe PubMed DOI  E  I
  39. Wex,T., Wex,H. and Bromme,D.
    The human cathepsin F gene - a fusion product between an ancestral cathepsin and cystatin gene
    Biol Chem380, 1439-1442. PubMed  Europe PubMed DOI
  40. [YEAR:7-6-1999]Wex,T., Levy,B., Wex,H. and Bromme,D.
    Human cathepsins F and W: A new subgroup of cathepsins
    Biochem Biophys Res Commun259, 401-407. PubMed  Europe PubMed DOI
    41. 1998
  41. [YEAR:27-11-1998]Wang,B., Shi,G.P., Yao,P.M., Li,Z., Chapman,H.A. and Bromme,D.
    Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization
    J Biol Chem273, 32000-32008. PubMed  Europe PubMed DOI  E

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use