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Literature for peptidase C01.009: cathepsin V

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, M Mutation, P Specificity, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Enneking,A.E., Khorey,M.M. and Edgington-Mitchell,L.E.<br>Nuclear Roles for Canonically Lysosomal Proteases<br>Mol Cell Biol (2025) 45, 343-352. PubMed  Europe PubMed DOI
    2. 2024
  2. He,Y., Xu,M., Zhou,C., Dong,Q., Hu,Z. and Ren,N.<br>The Prognostic Significance of CTSV Expression in Patients with Hepatocellular Carcinoma<br>Int J Gen Med (2024) 17, 4867-4881. PubMed  Europe PubMed DOI  PMC  EPMC  K
  3. Matouskova,Z., Orsaghova,K., Srb,P., Pytelkova,J., Kukacka,Z., Busa,M., Hajdusek,O., Sima,R., Fabry,M., Novak,P., Horn,M., Kopacek,P. and Mares,M.<br>An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans<br>Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2023
  4. Tusar,L., Loboda,J., Impens,F., Sosnowski,P., Van Quickelberghe,E., Vidmar,R., Demol,H., Sedeyn,K., Saelens,X., Vizovisek,M., Mihelic,M., Fonovic,M., Horvat,J., Kosec,G., Turk,B., Gevaert,K. and Turk,D.<br>Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins<br>Commun Biol (2023) 6, 450-450. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2022
  5. Lecaille,F., Chazeirat,T., Saidi,A. and Lalmanach,G.<br>Cathepsin V: Molecular characteristics and significance in health and disease<br>Mol Aspects Med (2022) 88, 101086-101086. PubMed  Europe PubMed DOI  V
  6. Li,C., Liu,Z., Chen,M., Zhang,L., Shi,R. and Zhong,H.<br>Critical Role of Cathepsin L/V in Regulating Endothelial Cell Senescence<br>Biology (Basel) (2022) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  7. Yoon,M.C., Ames,J., Mosier,C., Jiang,Z., Podvin,S., O'Donoghue,A.J. and Hook,V.<br>Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases<br>ACS Chem Neurosci (2022) 13, 245-256. PubMed  Europe PubMed DOI
    8. 2021
  8. Bollavaram,K., Leeman,T.H., Lee,M.W., Kulkarni,A., Upshaw,S.G., Yang,J., Song,H. and Platt,M.O.<br>Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V<br>Protein Sci (2021) PubMed  Europe PubMed DOI
  9. Chazeirat,T., Denamur,S., Bojarski,K.K., Andrault,P.M., Sizaret,D., Zhang,F., Saidi,A., Tardieu,M., Linhardt,R.J., Labarthe,F., Bromme,D., Samsonov,S.A., Lalmanach,G. and Lecaille,F.<br>The abnormal accumulation of heparan sulfate in patients with mucopolysaccharidosis prevents the elastolytic activity of cathepsin V<br>Carbohydr Polym (2021) 253, 117261-117261. PubMed  Europe PubMed DOI
  10. Eckl,K.M., Gruber,R., Brennan,L., Marriott,A., Plank,R., Moosbrugger-Martinz,V., Blunder,S., Schossig,A., Altmuller,J., Thiele,H., Nurnberg,P., Zschocke,J., Hennies,H.C. and Schmuth,M.<br>Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V<br>Front Genet (2021) 12, 689940-689940. PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2020
  11. Leng,Y., Chen,R., Chen,R., He,S., Shi,X., Zhou,X., Zhang,Z. and Chen,A.F.<br>HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway<br>Biochem Biophys Res Commun (2020) 532, 640-646. PubMed  Europe PubMed DOI
  12. Sereesongsaeng,N., McDowell,S.H., Burrows,J.F., Scott,C.J. and Burden,R.E.<br>Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer<br>Breast Cancer Res (2020) 22, 139-139. PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2018
  13. Homma,T., Kageyama,S., Nishikawa,A. and Nagata,K.<br>Melanosome degradation in epidermal keratinocytes related to lysosomal protease cathepsin V<br>Biochem Biophys Res Commun (2018) 500, 339-343. PubMed  Europe PubMed DOI
  14. Leng,Y.P., Ma,Y.S., Li,X.G., Chen,R.F., Zeng,P.Y., Li,X.H., Qiu,C.F., Li,Y.P., Zhang,Z. and Chen,A.F.<br>l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia<br>Br J Pharmacol (2018) 175, 1157-1172. PubMed  Europe PubMed DOI
  15. Podvin,S., Wojnicz,A. and Hook,V.<br>Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production<br>Heliyon (2018) 4, e00673-e00673. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Sarria,A.L.F., Silva,T.L., de Oliveira,J.M., de Oliveira,M.A.R., Fernandes,J.B., da Silva,M.F.D.G.F., Vieira,P.C., Venancio,T., Alves Filho,E.G., Batista JM Jr and Guido,R.V.C.<br>Dimeric chalcones derivatives from Myracrodruon urundeuva act as cathepsin V inhibitors<br>Phytochemistry (2018) 154, 31-38. PubMed  Europe PubMed DOI  I
    17. 2017
  17. Huang,K., Gao,L., Yang,M., Wang,J., Wang,Z., Wang,L., Wang,G. and Li,H.<br>Exogenous cathepsin V protein protects human cardiomyocytes HCM from angiotensin -Induced hypertrophy<br>Int J Biochem Cell Biol (2017) 89, 6-15. PubMed  Europe PubMed DOI
    18. 2015
  18. Pribis,J.P., Al-Abed,Y., Yang,H., Gero,D., Xu,H., Montenegro,M.F., Bauer,E.M., Kim,S., Chavan,S.S., Cai,C., Li,T., Szoleczky,P., Szabo,C., Tracey,K.J. and Billiar,T.R.<br>The HIV protease inhibitor saquinavir inhibits HMGB1-driven inflammation by targeting the interaction of cathepsin V with TLR4/MyD88<br>Mol Med (2015) 21, 749-757. PubMed  Europe PubMed DOI  I
    19. 2013
  19. Brocklehurst,K. and Philpott,M.P.<br>Cysteine proteases: mode of action and role in epidermal differentiation<br>Cell Tissue Res (2013) 351, 237-244. PubMed  Europe PubMed DOI
  20. Du,X., Chen,N.L., Wong,A., Craik,C.S. and Bromme,D.<br>Elastin degradation by cathepsin V requires two exosites<br>J Biol Chem (2013) 288, 34871-34881. PubMed  Europe PubMed DOI
    21. 2012
  21. Bromme,D.<br>Cathepsin V<br>[ISSN:978-0-12-407743-0] (2012) 3, 1831-1834. DOI
  22. Funkelstein,L., Lu,W.D., Koch,B., Mosier,C., Toneff,T., Taupenot,L., O'Connor,D.T., Reinheckel,T., Peters,C. and Hook,V.<br>Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters<br>J Biol Chem (2012) 287, 15232-15241. PubMed  Europe PubMed DOI
  23. Marques,E.F., Bueno,M.A., Duarte,P.D., Silva,L.R., Martinelli,A.M., Dos Santos,C.Y., Severino,R.P., Bromme,D., Vieira,P.C. and Correa,A.G.<br>Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V<br>Eur J Med Chem (2012) 54, 10-21. PubMed  Europe PubMed DOI  I
  24. Niwa,Y., Suzuki,T., Dohmae,N., Umezawa,K. and Simizu,S.<br>Determination of cathepsin V activity and intracellular trafficking by N-glycosylation<br>FEBS Lett (2012) 586, 3601-3607. PubMed  Europe PubMed DOI
  25. Novinec,M., Pavsic,M. and Lenarcic,B.<br>A simple and efficient protocol for the production of recombinant cathepsin V and other cysteine cathepsins in soluble form in Escherichia coli<br>Protein Expr Purif (2012) 82, 1-5. PubMed  Europe PubMed DOI  E
    26. 2011
  26. Severino,R.P., Guido,R.V., Marques,E.F., Bromme,D., da Silva,M.F., Fernandes,J.B., Andricopulo,A.D. and Vieira,P.C.<br>Acridone alkaloids as potent inhibitors of cathepsin V<br>Bioorg Med Chem (2011) 19, 1477-1481. PubMed  Europe PubMed DOI  I
    27. 2010
  27. Alvim,J., Severino,R.P., Marques,E.F., Martinelli,A.M., Vieira,P.C., Fernandes,J.B., da Silva,M.F. and Correa,A.G.<br>Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors<br>J Comb Chem (2010) 12, 687-695. PubMed  Europe PubMed DOI  I
  28. Coppini,L.P., Barros,N.M., Oliveira,M., Hirata,I.Y., Alves,M.F., Paschoalin,T., Assis,D.M., Juliano,M.A., Puzer,L., Bromme,D. and Carmona,A.K.<br>Plasminogen hydrolysis by cathepsin S and identification of derived peptides as selective substrate for cathepsin V and cathepsin L inhibitor<br>Biol Chem (2010) 391, 561-570. PubMed  Europe PubMed DOI  P
  29. Piovan,L., Alves,M.F.M., Juliano,L., Bromme,D., Cunha,R.L.O.R. and Andrade,L.H.<br>Chemoenzymatic synthesis of organoselenium(IV) compounds and their evaluation as cysteine protease inhibitors<br>J Braz Chem Soc (2010) 21, 2108-2118.  I
  30. Sevenich,L., Hagemann,S., Stoeckle,C., Tolosa,E., Peters,C. and Reinheckel,T.<br>Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice<br>Biochimie (2010) 92, 1674-1680. PubMed  Europe PubMed DOI
    31. 2009
  31. Bethel,P.A., Gerhardt,S., Jones,E.V., Kenny,P.W., Karoutchi,G.I., Morley,A.D., Oldham,K., Rankine,N., Augustin,M., Krapp,S., Simader,H. and Steinbacher,S.<br>Design of selective cathepsin inhibitors<br>Bioorg Med Chem Lett (2009) 19, 4622-4625. PubMed  Europe PubMed DOI  I
    32. 2008
  32. Puzer,L., Barros,N.M., Paschoalin,T., Hirata,I.Y., Tanaka,A.S., Oliveira,M.C., Bromme,D. and Carmona,A.K.<br>Cathepsin V, but not cathepsins L, B and K, may release angiostatin-like fragments from plasminogen<br>Biol Chem (2008) 389, 195-200. PubMed  Europe PubMed DOI
    33. 2007
  33. Burden,R.E., Snoddy,P., Jefferies,C.A., Walker,B. and Scott,C.J.<br>Inhibition of cathepsin L-like proteases by cathepsin V propeptide<br>Biol Chem (2007) 388, 541-545. PubMed  Europe PubMed DOI
  34. Ong,P.C., McGowan,S., Pearce,M.C., Irving,J.A., Kan,W.T., Grigoryev,S.A., Turk,B., Silverman,G.A., Brix,K., Bottomley,S.P., Whisstock,J.C. and Pike,R.N.<br>DNA accelerates the inhibition of human cathepsin V by serpins<br>J Biol Chem (2007) 282, 36980-36986. PubMed  Europe PubMed DOI
  35. Viken,M.K., Sollid,H.D., Joner,G., Dahl-Jorgensen,K., Ronningen,K.S., Undlien,D.E., Flato,B., Selvaag,A.M., Forre,O., Kvien,T.K., Thorsby,E., Melms,A., Tolosa,E. and Lie,B.A.<br>Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis<br>Hum Immunol (2007) 68, 748-755. PubMed  Europe PubMed DOI  M
  36. Zeeuwen,P.L., Ishida-Yamamoto,A., van Vlijmen-Willems,I.M., Cheng,T., Bergers,M., Iizuka,H. and Schalkwijk,J.<br>Colocalization of cystatin M/E and cathepsin V in lamellar granules and corneodesmosomes suggests a functional role in epidermal differentiation<br>J Invest Dermatol (2007) 127, 120-128. PubMed  Europe PubMed DOI
    37. 2006
  37. [YEAR:24-3-2006]Cheng,T., Hitomi,K., van Vlijmen-Willems,I.M., de Jongh,G.J., Yamamoto,K., Nishi,K., Watts,C., Reinheckel,T., Schalkwijk,J. and Zeeuwen,P.L.<br>Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification<br>J Biol Chem (24-3-2006) 281, 15893-15899. PubMed  Europe PubMed DOI
  38. [YEAR:6-3-2006]Choe,Y., Leonetti,F., Greenbaum,D.C., Lecaille,F., Bogyo,M., Bromme,D., Ellman,J.A. and Craik,C.S.<br>Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities<br>J Biol Chem (6-3-2006) 281, 12824-12832. PubMed  Europe PubMed DOI  P
  39. Linke,M., Gordon,R.E., Brillard,M., Lecaille,F., Lalmanach,G. and Bromme,D.<br>Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins<br>Biol Chem (2006) 387, 1295-1303. PubMed  Europe PubMed DOI  P
    40. 2005
  40. Kenney,M.C., Chwa,M., Atilano,S.R., Tran,A., Carballo,M., Saghizadeh,M., Vasiliou,V., Adachi,W. and Brown,D.J.<br>Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder<br>Invest Ophthalmol Vis Sci (2005) 46, 823-832. PubMed  Europe PubMed DOI
    41. 2004
  41. Bromme,D.<br>Cathepsin V<br>[ISSN:0-12-079610-4] (2004) 2, 1107-1109.  V
  42. Hagemann,S., Gunther,T., Dennemarker,J., Lohmuller,T., Bromme,D., Schule,R., Peters,C. and Reinheckel,T.<br>The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles<br>Eur J Cell Biol (2004) 83, 775-780. PubMed  Europe PubMed DOI
  43. [YEAR:15-10-2004]Puzer,L., Cotrin,S.S., Alves,M.F., Egborge,T., Araujo,M.S., Juliano,M.A., Juliano,L., Bromme,D. and Carmona,A.K.<br>Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L<br>Arch Biochem Biophys (15-10-2004) 430, 274-283. PubMed  Europe PubMed DOI
  44. [YEAR:10-6-2004]Yasuda,Y., Li,Z., Greenbaum,D., Bogyo,M., Weber,E. and Bromme,D.<br>Cathepsin V, A novel and potent elastolytic activity expressed in activated macrophages<br>J Biol Chem (10-6-2004) 279, 36761-36770. PubMed  Europe PubMed DOI
    45. 2003
  45. Bernard,D., Mehul,B., Thomas-Collignon,A., Simonetti,L., Remy,V., Bernard,M.A. and Schmidt,R.<br>Analysis of proteins with caseinolytic activity in a human stratum corneum extract revealed a yet unidentified cysteine protease and identified the so-called "stratum corneum thiol protease" as cathepsin L2<br>J Invest Dermatol (2003) 120, 592-600. PubMed  Europe PubMed DOI
  46. Tolosa,E., Li,W., Yasuda,Y., Wienhold,W., Denzin,L.K., Lautwein,A., Driessen,C., Schnorrer,P., Weber,E., Stevanovic,S., Kurek,R., Melms,A. and Bromme,D.<br>Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis<br>J Clin Invest (2003) 112, 517-526. PubMed  Europe PubMed DOI  PMC  EPMC
    47. 2000
  47. [YEAR:17-10-2000]Somoza,J.R., Zhan,H., Bowman,K.K., Yu,L., Mortara,K.D., Palmer,J.T., Clark,J.M. and McGrath,M.E.<br>Crystal structure of human cathepsin V<br>Biochemistry (17-10-2000) 39, 12543-12551. PubMed  Europe PubMed DOI  S  I
    48. 1999
  48. [YEAR:23-2-1999]Bromme,D., Li,Z., Barnes,M. and Mehler,E.<br>Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization<br>Biochemistry (23-2-1999) 38, 2377-2385. PubMed  Europe PubMed DOI  E
  49. [YEAR:30-4-1999]Itoh,R., Kawamoto,S., Adachi,W., Kinoshita,S. and Okubo,K.<br>Genomic organization and chromosomal localization of the human cathepsin L2 gene<br>DNA Res (30-4-1999) 6, 137-140. PubMed  Europe PubMed
    50. 1998
  50. Adachi,W., Kawamoto,S., Ohno,I., Nishida,K., Kinoshita,S., Matsubara,K. and Okubo,K.<br>Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium<br>Invest Ophthalmol Vis Sci (1998) 39, 1789-1796. PubMed  Europe PubMed
  51. [YEAR:15-4-1998]Santamaria,I., Velasco,G., Cazorla,M., Fueyo,A., Campo,E. and Lopez-Otin,C.<br>Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas<br>Cancer Res (15-4-1998) 58, 1624-1630. PubMed  Europe PubMed

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