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Literature for peptidase C01.009: cathepsin V

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, M Mutation, P Specificity, I Inhibitor, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. He,Y., Xu,M., Zhou,C., Dong,Q., Hu,Z. and Ren,N.
    The Prognostic Significance of CTSV Expression in Patients with Hepatocellular Carcinoma
    Int J Gen Med17, 4867-4881. PubMed  Europe PubMed DOI  K
  2. Matouskova,Z., Orsaghova,K., Srb,P., Pytelkova,J., Kukacka,Z., Busa,M., Hajdusek,O., Sima,R., Fabry,M., Novak,P., Horn,M., Kopacek,P. and Mares,M.
    An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans
    Int J Mol Sci25, PubMed  Europe PubMed DOI
    3. 2023
  3. Tusar,L., Loboda,J., Impens,F., Sosnowski,P., Van Quickelberghe,E., Vidmar,R., Demol,H., Sedeyn,K., Saelens,X., Vizovisek,M., Mihelic,M., Fonovic,M., Horvat,J., Kosec,G., Turk,B., Gevaert,K. and Turk,D.
    Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins
    Commun Biol6, 450-450. PubMed  Europe PubMed DOI
    4. 2022
  4. Lecaille,F., Chazeirat,T., Saidi,A. and Lalmanach,G.
    Cathepsin V: Molecular characteristics and significance in health and disease
    Mol Aspects Med88, 101086-101086. PubMed  Europe PubMed DOI  V
  5. Li,C., Liu,Z., Chen,M., Zhang,L., Shi,R. and Zhong,H.
    Critical Role of Cathepsin L/V in Regulating Endothelial Cell Senescence
    Biology (Basel)12, PubMed  Europe PubMed DOI
  6. Yoon,M.C., Ames,J., Mosier,C., Jiang,Z., Podvin,S., O'Donoghue,A.J. and Hook,V.
    Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases
    ACS Chem Neurosci13, 245-256. PubMed  Europe PubMed DOI
    7. 2021
  7. Bollavaram,K., Leeman,T.H., Lee,M.W., Kulkarni,A., Upshaw,S.G., Yang,J., Song,H. and Platt,M.O.
    Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V
    Protein Sci PubMed  Europe PubMed DOI
  8. Chazeirat,T., Denamur,S., Bojarski,K.K., Andrault,P.M., Sizaret,D., Zhang,F., Saidi,A., Tardieu,M., Linhardt,R.J., Labarthe,F., Bromme,D., Samsonov,S.A., Lalmanach,G. and Lecaille,F.
    The abnormal accumulation of heparan sulfate in patients with mucopolysaccharidosis prevents the elastolytic activity of cathepsin V
    Carbohydr Polym253, 117261-117261. PubMed  Europe PubMed DOI
  9. Eckl,K.M., Gruber,R., Brennan,L., Marriott,A., Plank,R., Moosbrugger-Martinz,V., Blunder,S., Schossig,A., Altmuller,J., Thiele,H., Nurnberg,P., Zschocke,J., Hennies,H.C. and Schmuth,M.
    Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V
    Front Genet12, 689940-689940. PubMed  Europe PubMed DOI
    10. 2020
  10. Leng,Y., Chen,R., Chen,R., He,S., Shi,X., Zhou,X., Zhang,Z. and Chen,A.F.
    HMGB1 mediates homocysteine-induced endothelial cells pyroptosis via cathepsin V-dependent pathway
    Biochem Biophys Res Commun532, 640-646. PubMed  Europe PubMed DOI
  11. Sereesongsaeng,N., McDowell,S.H., Burrows,J.F., Scott,C.J. and Burden,R.E.
    Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer
    Breast Cancer Res22, 139-139. PubMed  Europe PubMed DOI
    12. 2018
  12. Homma,T., Kageyama,S., Nishikawa,A. and Nagata,K.
    Melanosome degradation in epidermal keratinocytes related to lysosomal protease cathepsin V
    Biochem Biophys Res Commun500, 339-343. PubMed  Europe PubMed DOI
  13. Leng,Y.P., Ma,Y.S., Li,X.G., Chen,R.F., Zeng,P.Y., Li,X.H., Qiu,C.F., Li,Y.P., Zhang,Z. and Chen,A.F.
    l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia
    Br J Pharmacol175, 1157-1172. PubMed  Europe PubMed DOI
  14. Podvin,S., Wojnicz,A. and Hook,V.
    Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production
    Heliyon4, e00673-e00673. PubMed  Europe PubMed DOI
  15. Sarria,A.L.F., Silva,T.L., de Oliveira,J.M., de Oliveira,M.A.R., Fernandes,J.B., da Silva,M.F.D.G.F., Vieira,P.C., Venancio,T., Alves Filho,E.G., Batista JM Jr and Guido,R.V.C.
    Dimeric chalcones derivatives from Myracrodruon urundeuva act as cathepsin V inhibitors
    Phytochemistry154, 31-38. PubMed  Europe PubMed DOI  I
    16. 2017
  16. Huang,K., Gao,L., Yang,M., Wang,J., Wang,Z., Wang,L., Wang,G. and Li,H.
    Exogenous cathepsin V protein protects human cardiomyocytes HCM from angiotensin -Induced hypertrophy
    Int J Biochem Cell Biol89, 6-15. PubMed  Europe PubMed DOI
    17. 2015
  17. Pribis,J.P., Al-Abed,Y., Yang,H., Gero,D., Xu,H., Montenegro,M.F., Bauer,E.M., Kim,S., Chavan,S.S., Cai,C., Li,T., Szoleczky,P., Szabo,C., Tracey,K.J. and Billiar,T.R.
    The HIV protease inhibitor saquinavir inhibits HMGB1-driven inflammation by targeting the interaction of cathepsin V with TLR4/MyD88
    Mol Med21, 749-757. PubMed  Europe PubMed DOI  I
    18. 2013
  18. Brocklehurst,K. and Philpott,M.P.
    Cysteine proteases: mode of action and role in epidermal differentiation
    Cell Tissue Res351, 237-244. PubMed  Europe PubMed DOI
  19. Du,X., Chen,N.L., Wong,A., Craik,C.S. and Bromme,D.
    Elastin degradation by cathepsin V requires two exosites
    J Biol Chem288, 34871-34881. PubMed  Europe PubMed DOI
    20. 2012
  20. Bromme,D.
    Cathepsin V
    [ISSN:978-0-12-407743-0]3, 1831-1834. DOI
  21. Funkelstein,L., Lu,W.D., Koch,B., Mosier,C., Toneff,T., Taupenot,L., O'Connor,D.T., Reinheckel,T., Peters,C. and Hook,V.
    Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters
    J Biol Chem287, 15232-15241. PubMed  Europe PubMed DOI
  22. Marques,E.F., Bueno,M.A., Duarte,P.D., Silva,L.R., Martinelli,A.M., Dos Santos,C.Y., Severino,R.P., Bromme,D., Vieira,P.C. and Correa,A.G.
    Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V
    Eur J Med Chem54, 10-21. PubMed  Europe PubMed DOI  I
  23. Niwa,Y., Suzuki,T., Dohmae,N., Umezawa,K. and Simizu,S.
    Determination of cathepsin V activity and intracellular trafficking by N-glycosylation
    FEBS Lett586, 3601-3607. PubMed  Europe PubMed DOI
  24. Novinec,M., Pavsic,M. and Lenarcic,B.
    A simple and efficient protocol for the production of recombinant cathepsin V and other cysteine cathepsins in soluble form in Escherichia coli
    Protein Expr Purif82, 1-5. PubMed  Europe PubMed DOI  E
    25. 2011
  25. Severino,R.P., Guido,R.V., Marques,E.F., Bromme,D., da Silva,M.F., Fernandes,J.B., Andricopulo,A.D. and Vieira,P.C.
    Acridone alkaloids as potent inhibitors of cathepsin V
    Bioorg Med Chem19, 1477-1481. PubMed  Europe PubMed DOI  I
    26. 2010
  26. Alvim,J., Severino,R.P., Marques,E.F., Martinelli,A.M., Vieira,P.C., Fernandes,J.B., da Silva,M.F. and Correa,A.G.
    Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors
    J Comb Chem12, 687-695. PubMed  Europe PubMed DOI  I
  27. Coppini,L.P., Barros,N.M., Oliveira,M., Hirata,I.Y., Alves,M.F., Paschoalin,T., Assis,D.M., Juliano,M.A., Puzer,L., Bromme,D. and Carmona,A.K.
    Plasminogen hydrolysis by cathepsin S and identification of derived peptides as selective substrate for cathepsin V and cathepsin L inhibitor
    Biol Chem391, 561-570. PubMed  Europe PubMed DOI  P
  28. Piovan,L., Alves,M.F.M., Juliano,L., Bromme,D., Cunha,R.L.O.R. and Andrade,L.H.
    Chemoenzymatic synthesis of organoselenium(IV) compounds and their evaluation as cysteine protease inhibitors
    J Braz Chem Soc21, 2108-2118.  I
  29. Sevenich,L., Hagemann,S., Stoeckle,C., Tolosa,E., Peters,C. and Reinheckel,T.
    Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice
    Biochimie92, 1674-1680. PubMed  Europe PubMed DOI
    30. 2009
  30. Bethel,P.A., Gerhardt,S., Jones,E.V., Kenny,P.W., Karoutchi,G.I., Morley,A.D., Oldham,K., Rankine,N., Augustin,M., Krapp,S., Simader,H. and Steinbacher,S.
    Design of selective cathepsin inhibitors
    Bioorg Med Chem Lett19, 4622-4625. PubMed  Europe PubMed DOI  I
    31. 2008
  31. Puzer,L., Barros,N.M., Paschoalin,T., Hirata,I.Y., Tanaka,A.S., Oliveira,M.C., Bromme,D. and Carmona,A.K.
    Cathepsin V, but not cathepsins L, B and K, may release angiostatin-like fragments from plasminogen
    Biol Chem389, 195-200. PubMed  Europe PubMed DOI
    32. 2007
  32. Burden,R.E., Snoddy,P., Jefferies,C.A., Walker,B. and Scott,C.J.
    Inhibition of cathepsin L-like proteases by cathepsin V propeptide
    Biol Chem388, 541-545. PubMed  Europe PubMed DOI
  33. Ong,P.C., McGowan,S., Pearce,M.C., Irving,J.A., Kan,W.T., Grigoryev,S.A., Turk,B., Silverman,G.A., Brix,K., Bottomley,S.P., Whisstock,J.C. and Pike,R.N.
    DNA accelerates the inhibition of human cathepsin V by serpins
    J Biol Chem282, 36980-36986. PubMed  Europe PubMed DOI
  34. Viken,M.K., Sollid,H.D., Joner,G., Dahl-Jorgensen,K., Ronningen,K.S., Undlien,D.E., Flato,B., Selvaag,A.M., Forre,O., Kvien,T.K., Thorsby,E., Melms,A., Tolosa,E. and Lie,B.A.
    Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis
    Hum Immunol68, 748-755. PubMed  Europe PubMed DOI  M
  35. Zeeuwen,P.L., Ishida-Yamamoto,A., van Vlijmen-Willems,I.M., Cheng,T., Bergers,M., Iizuka,H. and Schalkwijk,J.
    Colocalization of cystatin M/E and cathepsin V in lamellar granules and corneodesmosomes suggests a functional role in epidermal differentiation
    J Invest Dermatol127, 120-128. PubMed  Europe PubMed DOI
    36. 2006
  36. [YEAR:24-3-2006]Cheng,T., Hitomi,K., van Vlijmen-Willems,I.M., de Jongh,G.J., Yamamoto,K., Nishi,K., Watts,C., Reinheckel,T., Schalkwijk,J. and Zeeuwen,P.L.
    Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification
    J Biol Chem281, 15893-15899. PubMed  Europe PubMed DOI
  37. [YEAR:6-3-2006]Choe,Y., Leonetti,F., Greenbaum,D.C., Lecaille,F., Bogyo,M., Bromme,D., Ellman,J.A. and Craik,C.S.
    Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities
    J Biol Chem281, 12824-12832. PubMed  Europe PubMed DOI  P
  38. Linke,M., Gordon,R.E., Brillard,M., Lecaille,F., Lalmanach,G. and Bromme,D.
    Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins
    Biol Chem387, 1295-1303. PubMed  Europe PubMed DOI  P
    39. 2005
  39. Kenney,M.C., Chwa,M., Atilano,S.R., Tran,A., Carballo,M., Saghizadeh,M., Vasiliou,V., Adachi,W. and Brown,D.J.
    Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder
    Invest Ophthalmol Vis Sci46, 823-832. PubMed  Europe PubMed DOI
    40. 2004
  40. Bromme,D.
    Cathepsin V
    [ISSN:0-12-079610-4]2, 1107-1109.  V
  41. Hagemann,S., Gunther,T., Dennemarker,J., Lohmuller,T., Bromme,D., Schule,R., Peters,C. and Reinheckel,T.
    The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles
    Eur J Cell Biol83, 775-780. PubMed  Europe PubMed DOI
  42. [YEAR:15-10-2004]Puzer,L., Cotrin,S.S., Alves,M.F., Egborge,T., Araujo,M.S., Juliano,M.A., Juliano,L., Bromme,D. and Carmona,A.K.
    Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L
    Arch Biochem Biophys430, 274-283. PubMed  Europe PubMed DOI
  43. [YEAR:10-6-2004]Yasuda,Y., Li,Z., Greenbaum,D., Bogyo,M., Weber,E. and Bromme,D.
    Cathepsin V, A novel and potent elastolytic activity expressed in activated macrophages
    J Biol Chem279, 36761-36770. PubMed  Europe PubMed DOI
    44. 2003
  44. Bernard,D., Mehul,B., Thomas-Collignon,A., Simonetti,L., Remy,V., Bernard,M.A. and Schmidt,R.
    Analysis of proteins with caseinolytic activity in a human stratum corneum extract revealed a yet unidentified cysteine protease and identified the so-called "stratum corneum thiol protease" as cathepsin L2
    J Invest Dermatol120, 592-600. PubMed  Europe PubMed DOI
  45. Tolosa,E., Li,W., Yasuda,Y., Wienhold,W., Denzin,L.K., Lautwein,A., Driessen,C., Schnorrer,P., Weber,E., Stevanovic,S., Kurek,R., Melms,A. and Bromme,D.
    Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis
    J Clin Invest112, 517-526. PubMed  Europe PubMed DOI
    46. 2000
  46. [YEAR:17-10-2000]Somoza,J.R., Zhan,H., Bowman,K.K., Yu,L., Mortara,K.D., Palmer,J.T., Clark,J.M. and McGrath,M.E.
    Crystal structure of human cathepsin V
    Biochemistry39, 12543-12551. PubMed  Europe PubMed DOI  S  I
    47. 1999
  47. [YEAR:23-2-1999]Bromme,D., Li,Z., Barnes,M. and Mehler,E.
    Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization
    Biochemistry38, 2377-2385. PubMed  Europe PubMed DOI  E
  48. [YEAR:30-4-1999]Itoh,R., Kawamoto,S., Adachi,W., Kinoshita,S. and Okubo,K.
    Genomic organization and chromosomal localization of the human cathepsin L2 gene
    DNA Res6, 137-140. PubMed  Europe PubMed
    49. 1998
  49. Adachi,W., Kawamoto,S., Ohno,I., Nishida,K., Kinoshita,S., Matsubara,K. and Okubo,K.
    Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium
    Invest Ophthalmol Vis Sci39, 1789-1796. PubMed  Europe PubMed
  50. [YEAR:15-4-1998]Santamaria,I., Velasco,G., Cazorla,M., Fueyo,A., Campo,E. and Lopez-Otin,C.
    Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas
    Cancer Res58, 1624-1630. PubMed  Europe PubMed

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