Literature for peptidase A01.010: cathepsin E

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Alzoubi,L., Hamzat,Y., Alqudah,A. and Aljabali,A.A.A. The Cathepsin Family in Disease: From Molecular Mechanisms to Therapeutic Applications Curr Neuropharmacol (2025) PubMed Europe PubMed DOI

2024

Deng,T., Lu,X., Jia,X., Du,J., Wang,L., Cao,B., Yang,M., Yin,Y. and Liu,F. Cathepsins and cancer risk: a Mendelian randomization study Front Endocrinol (Lausanne) (2024) 15, 1428433-1428433. PubMed Europe PubMed DOI PMC EPMC

2022

Wu,Y., Zhou,W., Yang,Z., Li,J. and Jin,Y. miR-185-5p Represses Cells Growth and Metastasis of Osteosarcoma via Targeting Cathepsin E Int J Toxicol (2022) 41, 115-125. PubMed Europe PubMed DOI

2021

Zhu,Z., Wang,Q., Chen,X., Wang,Q., Yan,C., Zhao,X., Zhao,W. and Zhu,W.H. An Enzyme-Activatable Aggregation-Induced-Emission Probe: Intraoperative Pathological Fluorescent Diagnosis of Pancreatic Cancer via Specific Cathepsin E Adv Mater (2021) , e2107444-e2107444. PubMed Europe PubMed DOI

2020

Hou,J., Li,R., Qiao,S., Chen,X.X., Xing,G. and Zhang,G. The Glycoprotein 5 is cleaved by cathepsin E during porcine reproductive and respiratory virus membrane fusion J Virol (2020) PubMed Europe PubMed DOI
Kim,J.W., Cho,J.Y., Kim,J., Kim,D.G., Nam,B.H., Kim,Y.O., An,C.M., Kim,B.S., Park,J.Y. and Kong,H.J. First report of cathepsin E in a teleost (Korean rose bitterling, Rhodeus uyekii): molecular characterisation and tissue distribution Dev Comp Immunol (2020) , 103607-103607. PubMed Europe PubMed DOI
Stotz,S., Bleher,D., Kalbacher,H. and Maurer,A. Grassystatin-derived peptides selectively inhibit cathepsin E and have low affinity to cathepsin D Biochem Biophys Res Commun (2020) 527, 238-241. PubMed Europe PubMed DOI I

2019

Pontious,C., Kaul,S., Hong,M., Hart,P.A., Krishna,S.G., Lara,L.F., Conwell,D.L. and Cruz-Monserrate,Z. Cathepsin E expression and activity: role in the detection and treatment of pancreatic cancer Pancreatology (2019) 19, 951-956. PubMed Europe PubMed DOI L

2018

Bozic,J., Stoka,V. and Dolenc,I. Glucosamine prevents polarization of cytotoxic granules in NK-92 cells by disturbing FOXO1/ERK/paxillin phosphorylation PLoS ONE (2018) 13, e0200757-e0200757. PubMed Europe PubMed DOI PMC EPMC

2017

Al-Awadhi,F.H., Law,B.K., Paul,V.J. and Luesch,H. Grassystatins D-F, potent aspartic protease inhibitors from marine cyanobacteria as potential antimetastatic agents targeting invasive breast cancer J Nat Prod (2017) 80, 2969-2986. PubMed Europe PubMed DOI I
Harada,Y., Takayama,F., Tanabe,K., Ni,J., Hayashi,Y., Yamamoto,K., Wu,Z. and Nakanishi,H. Overexpression of cathepsin E interferes with neuronal differentiation of P19 embryonal teratocarcinoma cells by degradation of N-cadherin Cell Mol Neurobiol (2017) 37, 437-443. PubMed Europe PubMed DOI
Ivry,S.L., Sharib,J.M., Dominguez,D.A., Roy,N., Hatcher,S.E., Yip-Schneider,M.T., Schmidt,C.M., Brand,R.E., Park,W.G., Hebrok,M., Kim,G.E., O'Donoghue,A.J., Kirkwood,K.S. and Craik,C.S. Global protease activity profiling provides differential diagnosis of pancreatic cysts Clin Cancer Res (2017) 23, 4865-4874. PubMed Europe PubMed DOI

2016

Al-Awadhi,F.H., Ratnayake,R., Paul,V.J. and Luesch,H. Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium Bioorg Med Chem (2016) 24, 3276-3282. PubMed Europe PubMed DOI I
Cao,W.J., Li,M.H., Li,J.X., Xu,X., Ren,S.X., Rajbanshi,B. and Xu,J.F. High expression of cathepsin E is associated with the severity of airflow limitation in patients with COPD COPD (2016) 13, 160-166. PubMed Europe PubMed DOI
Nagasawa,T., Sano,K., Kawaguchi,M., Kobayashi,K., Yasumasu,S. and Inokuchi,T. Purification and molecular cloning of aspartic proteinases from the stomach of adult Japanese fire belly newts, Cynops pyrrhogaster J Biochem (2016) 159, 449-460. PubMed Europe PubMed DOI
O'Donoghue,A.J., Ivry,S.L., Chaudhury,C., Hostetter,D.R., Hanahan,D. and Craik,C.S. Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors Biol Chem (2016) 397, 871-881. PubMed Europe PubMed DOI I

2015

Fisher,O.M., Levert-Mignon,A.J., Lord,S.J., Botelho,N.K., Freeman,A.K., Thomas,M.L., Falkenback,D., Wettstein,A., Whiteman,D.C., Bobryshev,Y.V. and Lord,R.V. High expression of cathepsin E in tissues but not blood of patients with Barrett's esophagus and adenocarcinoma Ann Surg Oncol (2015) 22, 2431-2438. PubMed Europe PubMed DOI
Ni,J., Wu,Z., Peterts,C., Yamamoto,K., Qing,H. and Nakanishi,H. The critical role of proteolytic relay through cathepsins B and E in the phenotypic change of microglia/macrophage J Neurosci (2015) 35, 12488-12501. PubMed Europe PubMed DOI T
Zeleznik,T.Z., Puizdar,V. and Dolenc,I. Expression, purification and auto-activation of cathepsin E from insect cells Protein Pept Lett (2015) 22, 525-531. PubMed Europe PubMed E

2014

Kadowaki,T., Kido,M.A., Hatakeyama,J., Okamoto,K., Tsukuba,T. and Yamamoto,K. Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet Biochem Biophys Res Commun (2014) 446, 212-217. PubMed Europe PubMed DOI K
Li,H., Li,Y., Cui,L., Wang,B., Cui,W., Li,M. and Cheng,Y. Monitoring pancreatic carcinogenesis by the molecular imaging of cathepsin E in vivo using confocal laser endomicroscopy PLoS ONE (2014) 9, e106566-e106566. PubMed Europe PubMed DOI PMC EPMC L
Lutz,D., Wolters-Eisfeld,G., Schachner,M. and Kleene,R. Cathepsin E generates a sumoylated intracellular fragment of the cell adhesion molecule L1 to promote neuronal and Schwann cell migration as well as myelination J Neurochem (2014) 128, 713-724. PubMed Europe PubMed DOI
Zhang,X., Shan,P., Homer,R., Zhang,Y., Petrache,I., Mannam,P. and Lee,P.J. Cathepsin E promotes pulmonary emphysema via mitochondrial fission Am J Pathol (2014) 184, 2730-2741. PubMed Europe PubMed DOI

2013

Abd-Elgaliel,W.R., Cruz-Monserrate,Z., Wang,H., Logsdon,C.D. and Tung,C.H. Pancreatic cancer-associated cathepsin E as a drug activator J Control Release (2013) 167, 221-227. PubMed Europe PubMed DOI
Keliher,E.J., Reiner,T., Earley,S., Klubnick,J., Tassa,C., Lee,A.J., Ramaswamy,S., Bardeesy,N., Hanahan,D., DePinho,R.A., Castro,C.M. and Weissleder,R. Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection Neoplasia (2013) 15, 684-693. PubMed Europe PubMed DOI I
Konno-Shimizu,M., Yamamichi,N., Inada,K., Kageyama-Yahara,N., Shiogama,K., Takahashi,Y., Asada-Hirayama,I., Yamamichi-Nishina,M., Nakayama,C., Ono,S., Kodashima,S., Fujishiro,M., Tsutsumi,Y., Ichinose,M. and Koike,K. Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis PLoS ONE (2013) 8, e56766-e56766. PubMed Europe PubMed DOI PMC EPMC
Tsukuba,T., Yanagawa,M., Kadowaki,T., Takii,R., Okamoto,Y., Sakai,E., Okamoto,K. and Yamamoto,K. Cathepsin E deficiency impairs autophagic proteolysis in macrophages PLoS ONE (2013) 8, e82415-e82415. PubMed Europe PubMed DOI PMC EPMC K

2012

Andoh,T., Yoshida,T., Lee,J.B. and Kuraishi,Y. Cathepsin E induces itch-related response through the production of endothelin-1 in mice Eur J Pharmacol (2012) 686, 16-21. PubMed Europe PubMed DOI
Cruz-Monserrate,Z., Abd-Elgaliel,W.R., Grote,T., Deng,D., Ji,B., Arumugam,T., Wang,H., Tung,C.H. and Logsdon,C.D. Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models Gut (2012) 61, 1315-1322. PubMed Europe PubMed DOI
Kitamura,K., Komatsu,M., Biyani,M., Futakami,M., Kawakubo,T., Yamamoto,K. and Nishigaki,K. Proven in vitro evolution of protease cathepsin E-inhibitors and -activators at pH 4.5 using a paired peptide method J Pept Sci (2012) 18, 711-719. PubMed Europe PubMed DOI I
Komatsu,M., Biyani,M., Ghimire Gautam,S. and Nishigaki,K. Peptide-modulated activity enhancement of acidic protease cathepsin E at neutral pH Int J Pept (2012) 2012, 316432-316432. PubMed Europe PubMed DOI PMC EPMC
Pilzner,C., Buhling,F., Reinheckel,T., Chwieralski,C., Rathinasamy,A., Lauenstein,H.D., Wex,T., Welte,T., Braun,A. and Groneberg,D.A. Allergic airway inflammation in mice deficient for the antigen-processing protease cathepsin E Int Arch Allergy Immunol (2012) 159, 367-383. PubMed Europe PubMed DOI K
Puizdar,V., Zajc,T., Zerovnik,E., Renko,M., Pieper,U., Eswar,N., Sali,A., Dolenc,I. and Turk,V. Biochemical characterization and structural modeling of human cathepsin E variant 2 in comparison to the wild-type protein Biol Chem (2012) 393, 177-186. PubMed Europe PubMed DOI
Tsukuba,T., Okamoto,K. and Yamamoto,K. Cathepsin E is critical for proper trafficking of cell surface proteins J Oral Biosci (2012) 54, 48-53. DOI V
Yamamoto,K., Kawakubo,T., Yasukochi,A. and Tsukuba,T. Emerging roles of cathepsin E in host defense mechanisms Biochim Biophys Acta (2012) 1824, 105-112. PubMed Europe PubMed DOI V
Yang,S., Zhang,W., Ding,N., Lo,J., Liu,Y., Clare-Salzler,M.J., Luesch,H. and Li,Y. Total synthesis of grassystatin A, a probe for cathepsin E function Bioorg Med Chem (2012) 20, 4774-4780. PubMed Europe PubMed DOI I
Zaidi,N. and Kalbacher,H. Cathepsin E [ISSN:978-0-12-407744-7] (2012) 3, 42-49. DOI

2011

Abd-Elgaliel,W.R., Cruz-Monserrate,Z., Logsdon,C.D. and Tung,C.H. Molecular imaging of cathepsin E-positive tumors in mice using a novel protease-activatable fluorescent probe Mol Biosyst (2011) 7, 3207-3213. PubMed Europe PubMed DOI L
Biyani,M., Futakami,M., Kitamura,K., Kawakubo,T., Suzuki,M., Yamamoto,K. and Nishigaki,K. In vitro selection of cathepsin E-activity-enhancing peptide aptamers at neutral pH Int J Pept (2011) 2011, 834525-834525. PubMed Europe PubMed DOI PMC EPMC I
Chlabicz,M., Gacko,M., Worowska,A. and Lapinski,R. Cathepsin E (EC 3.4.23.34) - a review Folia Histochem Cytobiol (2011) 49, 547-557. PubMed Europe PubMed DOI V
Kawakubo,T., Yasukochi,A., Nakamura,S. and Yamamoto,K. Cathepsin E as a potent anticancer protease J Oral Biosci (2011) 53, 128-136. DOI K
Kawakubo,T., Yasukochi,A., Okamoto,K., Okamoto,Y., Nakamura,S. and Yamamoto,K. The role of cathepsin E in terminal differentiation of keratinocytes Biol Chem (2011) 392, 571-585. PubMed Europe PubMed DOI K
Tulone,C., Sponaas,A.M., Raiber,E.A., Tabor,A.B., Langhorne,J. and Chain,B.M. Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1 PLoS ONE (2011) 6, e24886-e24886. PubMed Europe PubMed DOI PMC EPMC

2010

Abd-Elgaliel,W.R. and Tung,C.H. Selective detection of cathepsin E proteolytic activity Biochim Biophys Acta (2010) 1800, 1002-1008. PubMed Europe PubMed DOI P
Yasukochi,A., Kawakubo,T., Nakamura,S. and Yamamoto,K. Cathepsin E enhances anticancer activity of doxorubicin on human prostate cancer cells showing resistance to TRAIL-mediated apoptosis Biol Chem (2010) 391, 947-958. PubMed Europe PubMed DOI

2009

Kitamura,K., Yoshida,C., Kinoshita,Y., Kadowaki,T., Takahashi,Y., Tayama,T., Kawakubo,T., Naimuddin,M., Salimullah,M., Nemoto,N., Hanada,K., Husimi,Y., Yamamoto,K. and Nishigaki,K. Development of systemic in vitro evolution and its application to generation of peptide-aptamer-based inhibitors of cathepsin E J Mol Biol (2009) 387, 1186-1198. PubMed Europe PubMed DOI I
Kwan,J.C., Eksioglu,E.A., Liu,C., Paul,V.J. and Luesch,H. Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation J Med Chem (2009) 52, 5732-5747. PubMed Europe PubMed DOI PMC EPMC I

2008

Burster,T., Reich,M., Zaidi,N., Voelter,W., Boehm,B.O. and Kalbacher,H. Cathepsin E regulates the presentation of tetanus toxin C-fragment in PMA activated primary human B cells Biochem Biophys Res Commun (2008) 377, 1299-1303. PubMed Europe PubMed DOI
Kawakubo,T., Yasukochi,A., Tsukuba,T., Kadowaki,T. and Yamamoto,K. Gene expression profiling of mammary glands of cathepsin E-deficient mice compared with wild-type littermates Biochimie (2008) 90, 396-404. PubMed Europe PubMed DOI K
Misinzo,G.M., Delputte,P.L. and Nauwynck,H.J. Involvement of proteases in porcine reproductive and respiratory syndrome virus uncoating upon internalization in primary macrophages Vet Res (2008) 39, 55-55. PubMed Europe PubMed DOI
Ordonez,G.R., Hillier,L.W., Warren,W.C., Grutzner,F., Lopez-Otin,C. and Puente,X.S. Loss of genes implicated in gastric function during platypus evolution Genome Biol (2008) 9, R81-R81. PubMed Europe PubMed DOI PMC EPMC
Shigematsu,N., Fukuda,T., Yamamoto,T., Nishioku,T., Yamaguchi,T., Himeno,M., Nakayama,K.I., Tsukuba,T., Kadowaki,T., Okamoto,K., Higuchi,S. and Yamamoto,K. Association of cathepsin E deficiency with the increased territorial aggressive response of mice J Neurochem (2008) 105, 1394-1404. PubMed Europe PubMed DOI K
Yoshida,C., Kuniwake,A., Naimuddin,M. and Nishigaki,K. Molecular design guided by a local map of sequence space: DNA aptamers that inhibit cathepsin E Oligonucleotides (2008) 18, 1-8. PubMed Europe PubMed DOI I
Zaidi,N. and Kalbacher,H. Cathepsin E: a mini review Biochem Biophys Res Commun (2008) 367, 517-522. PubMed Europe PubMed DOI V
Zaidi,N., Hermann,C., Herrmann,T. and Kalbacher,H. Emerging functional roles of cathepsin E Biochem Biophys Res Commun (2008) 377, 327-330. PubMed Europe PubMed DOI K V

2007

Kakehashi,H., Nishioku,T., Tsukuba,T., Kadowaki,T., Nakamura,S. and Yamamoto,K. Differential regulation of the nature and functions of dendritic cells and macrophages by cathepsin E J Immunol (2007) 179, 5728-5737. PubMed Europe PubMed
Kawakubo,T., Okamoto,K., Iwata,J., Shin,M., Okamoto,Y., Yasukochi,A., Nakayama,K.I., Kadowaki,T., Tsukuba,T. and Yamamoto,K. Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface Cancer Res (2007) 67, 10869-10878. PubMed Europe PubMed DOI U
Naimuddin,M., Kitamura,K., Kinoshita,Y., Honda-Takahashi,Y., Murakami,M., Ito,M., Yamamoto,K., Hanada,K., Husimi,Y. and Nishigaki,K. Selection-by-function: efficient enrichment of cathepsin E inhibitors from a DNA library J Mol Recognit (2007) 20, 58-68. PubMed Europe PubMed DOI I
Page,J.L., Strom,S.C. and Omiecinski,C.J. Regulation of the human cathepsin E gene by the constitutive androstane receptor Arch Biochem Biophys (2007) 467, 132-138. PubMed Europe PubMed DOI
Shin,M., Kadowaki,T., Iwata,J., Kawakubo,T., Yamaguchi,N., Takii,R., Tsukuba,T. and Yamamoto,K. Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses Biol Chem (2007) 388, 1173-1181. PubMed Europe PubMed DOI
Tulone,C., Tsang,J., Prokopowicz,Z., Grosvenor,N. and Chain,B. Natural cathepsin E deficiency in the immune system of C57BL/6J mice Immunogenetics (2007) 59, 927-935. PubMed Europe PubMed DOI
Yanagawa,M., Tsukuba,T., Nishioku,T., Okamoto,Y., Okamoto,K., Takii,R., Terada,Y., Nakayama,K.I., Kadowaki,T. and Yamamoto,K. Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages J Biol Chem (2007) 282, 1851-1862. PubMed Europe PubMed DOI K
Zaidi,N., Herrmann,T., Baechle,D., Schleicher,S., Gogel,J., Driessen,C., Voelter,W. and Kalbacher,H. A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles FEBS J (2007) 274, 3138-3149. PubMed Europe PubMed DOI A
Zaidi,N., Herrmann,T., Voelter,W. and Kalbacher,H. Recombinant cathepsin E has no proteolytic activity at neutral pH Biochem Biophys Res Commun (2007) 360, 51-55. PubMed Europe PubMed DOI

2006

Busquets,L., Guillen,H., DeFord,M.E., Suckow,M.A., Navari,R.M., Castellino,F.J. and Prorok,M. Cathepsin E is a specific marker of dysplasia in APC mouse intestine Tumour Biol (2006) 27, 36-42. PubMed Europe PubMed DOI
Narita,Y., Oda,S. and Kageyama,T. Rodent monophyly deduced from the unique gastric proteinase constitution and molecular phylogenetic analyses using pepsinogen-C cDNA sequences Comp Biochem Physiol Part D Genomics Proteomics (2006) 1, 273-282. PubMed Europe PubMed DOI
Tsukuba,T., Ikeda,S., Okamoto,K., Yasuda,Y., Sakai,E., Kadowaki,T., Sakai,H. and Yamamoto,K. Characterization of rat cathepsin E and mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells FEBS J (2006) 273, 219-229. PubMed Europe PubMed DOI
Tsukuba,T., Yamamoto,S., Yanagawa,M., Okamoto,K., Okamoto,Y., Nakayama,K.I., Kadowaki,T. and Yamamoto,K. Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface toll-like receptors J Biochem (2006) 140, 57-66. PubMed Europe PubMed DOI K
[YEAR:21-9-2006]Zhou,W., Scott,S.A., Shelton,S.B. and Crutcher,K.A. Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease Neuroscience (21-9-2006) 143, 689-701. PubMed Europe PubMed DOI

2005

[YEAR:15-2-2005]Chain,B.M., Free,P., Medd,P., Swetman,C., Tabor,A.B. and Terrazzini,N. The expression and function of cathepsin E in dendritic cells J Immunol (15-2-2005) 174, 1791-1800. PubMed Europe PubMed
[YEAR:27-5-2005]Chou,K.C. Modeling the tertiary structure of human cathepsin-E Biochem Biophys Res Commun (27-5-2005) 331, 56-60. PubMed Europe PubMed DOI S
[YEAR:1-5-2005]Henningsson,F., Yamamoto,K., Saftig,P., Reinheckel,T., Peters,C., Knight,S.D. and Pejler,G. A role for cathepsin E in the processing of mast-cell carboxypeptidase A J Cell Sci (1-5-2005) 118, 2035-2042. PubMed Europe PubMed DOI
Yasuda,Y., Kohmura,K., Kadowaki,T., Tsukuba,T. and Yamamoto,K. A new selective substrate for cathepsin E based on the cleavage site sequence of alpha2-macroglobulin Biol Chem (2005) 386, 299-305. PubMed Europe PubMed DOI
Yasuda,Y., Tsukuba,T., Okamoto,K., Kadowaki,T. and Yamamoto,K. The role of the cathepsin E propeptide in correct folding, maturation and sorting to the endosome J Biochem (2005) 138, 621-630. PubMed Europe PubMed DOI

2004

Cappiello,M.G., Wu,Z., Scott,B.B., McGeehan,G.M. and Harrison,R.K. Purification and characterization of recombinant human cathepsin E expressed in human kidney cell line 293 Protein Expr Purif (2004) 37, 53-60. PubMed Europe PubMed DOI E
Igarashi,S., Takizawa,T., Takizawa,T., Yasuda,Y., Uchiwa,H., Hayashi,S., Brysk,H., Robinson,J.M., Yamamoto,K., Brysk,M.M. and Horikoshi,T. Cathepsin D, but not cathepsin E, degrades desmosomes during epidermal desquamation Br J Dermatol (2004) 151, 355-361. PubMed Europe PubMed DOI
Kay,J. and Tatnell,P.J. Cathepsin E [ISSN:0-12-079610-4] (2004) 2, 33-38. V
[YEAR:17-9-2004]Ostermann,N., Gerhartz,B., Worpenberg,S., Trappe,J. and Eder,J. Crystal structure of an activation intermediate of cathepsin E J Mol Biol (17-9-2004) 342, 889-899. PubMed Europe PubMed DOI S
[YEAR:1-5-2004]Yee,C.S., Yao,Y., Li,P., Klemsz,M.J., Blum,J.S. and Chang,C.H. Cathepsin E: a novel target for regulation by class II transactivator J Immunol (1-5-2004) 172, 5528-5534. PubMed Europe PubMed

2003

Ikuzawa,M., Yasumasu,S., Inokuchi,T., Kobayashi,K., Nomura,K. and Iuchi,I. Differential expression of two cathepsin Es during metamorphosis-associated remodeling of the larval to adult type epithelium in Xenopus stomach J Biochem (2003) 134, 385-394. PubMed Europe PubMed DOI
Inokuchi,T., Ikuzawa,M., Mineta,T., Yasumasu,S. and Kobayashi,K. Molecular cloning of preprocathepsin E cDNA from the stomach of bullfrog Rana catesbeiana Comp Biochem Physiol B Biochem Mol Biol (2003) 135, 647-655. PubMed Europe PubMed DOI
Shibata,M., Sakai,H., Sakai,E., Okamoto,K., Nishishita,K., Yasuda,Y., Kato,Y. and Yamamoto,K. Disruption of structural and functional integrity of alpha2-macroglobulin by cathepsin E Eur J Biochem (2003) 270, 1189-1198. PubMed Europe PubMed DOI
[YEAR:27-1-2003]Tatnell,P.J., Cook,M. and Kay,J. An alternatively spliced variant of cathepsin E in human gastric adenocarcinoma cells Biochim Biophys Acta (27-1-2003) 1625, 203-206. PubMed Europe PubMed DOI R
Tsukuba,T., Okamoto,K., Okamoto,Y., Yanagawa,M., Kohmura,K., Yasuda,Y., Uchi,H., Nakahara,T., Furue,M., Nakayama,K., Kadowaki,T., Yamamoto,K. and Nakayama,K.I. Association of cathepsin E deficiency with development of atopic dermatitis J Biochem (2003) 134, 893-902. PubMed Europe PubMed DOI K

2002

Athauda,S.B. and Takahashi,K. Distinct cleavage specificity of human cathepsin E at neutral pH with special preference for Arg-Arg bonds Protein Pept Lett (2002) 9, 15-22. PubMed Europe PubMed DOI
[YEAR:1-9-2002]Liu,J., Tsukuba,T., Okamoto,K., Ohishi,M. and Yamamoto,K. Mutational analysis of residues in two consensus motifs in the active sites of cathepsin E J Biochem (1-9-2002) 132, 493-499. PubMed Europe PubMed
[YEAR:15-2-2002]Nishioku,T., Hashimoto,K., Yamashita,K., Liou,S.Y., Kagamiishi,Y., Maegawa,H., Katsube,N., Peters,C., von Figura,K., Saftig,P., Katunuma,N., Yamamoto,K. and Nakanishi,H. Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia J Biol Chem (15-2-2002) 277, 4816-4822. PubMed Europe PubMed DOI

2001

Cook,M., Caswell,R.C., Richards,R.J., Kay,J. and Tatnell,P.J. Regulation of human and mouse procathepsin E gene expression Eur J Biochem (2001) 268, 2658-2668. PubMed Europe PubMed DOI

2000

[YEAR:31-12-2000]Tsukuba,T., Okamoto,K., Yasuda,Y., Morikawa,W., Nakanishi,H. and Yamamoto,K. New functional aspects of cathepsin D and cathepsin E Mol Cells (31-12-2000) 10, 601-611. PubMed Europe PubMed V
Uno,K., Azuma,T., Nakajima,M., Yasuda,K., Hayakumo,T., Mukai,H., Sakai,T. and Kawai,K. Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma J Gastroenterol Hepatol (2000) 15, 1333-1338. PubMed Europe PubMed DOI

1999

Yasuda,Y., Kageyama,T., Akamine,A., Shibata,M., Kominami,E., Uchiyama,Y. and Yamamoto,K. Characterization of new fluorogenic substrates for the rapid and sensitive assay of cathepsin E and cathepsin D J Biochem (1999) 125, 1137-1143. PubMed Europe PubMed A
Yasuda,Y., Ikeda,S., Sakai,H., Tsukuba,T., Okamoto,K., Nishishita,K., Akamine,A., Kato,Y. and Yamamoto,K. Role of N-glycosylation in cathepsin E. A comparative study of cathepsin E with distinct N-linked oligosaccharides and its nonglycosylated mutant Eur J Biochem (1999) 266, 383-391. PubMed Europe PubMed DOI

1998

Bernstein,H.G., Reichenbach,A. and Wiederanders,B. Cathepsin E immunoreactivity in human ocular tissues: influence of aging and pathological states Neurosci Lett (1998) 240, 135-138. PubMed Europe PubMed DOI
Bukhtiyarova,M., Rao-Naik,C., Tatnell,P.J., White,P.C., Kay,J. and Dunn,B.M. Detailed analysis of human cathepsin E prime region specificity Adv Exp Med Biol (1998) 436, 219-222. PubMed Europe PubMed
Kageyama,T., Tatematsu,M., Ichinose,M., Yahagi,N., Miki,K., Moriyama,A. and Yonezawa,S. Development-dependent expression of cathepsins D and E in various rat tissues, with special reference to the high expression of cathepsin E in fetal liver Zoolog Sci (1998) 15, 517-523. PubMed Europe PubMed DOI
Mineta,T., Inokuchi,T., Kobayashi,K. and Horiuchi,S. Distribution of cathepsin E in the larval and adult organs of the bullfrog with special reference to the mature form in the larval fore-gut Comp Biochem Physiol B Biochem Mol Biol (1998) 121, 333-340. PubMed Europe PubMed DOI
[YEAR:29-5-1998]Tatnell,P.J., Roth,W., Deussing,J., Peters,C. and Kay,J. Mouse procathepsin E gene: molecular organisation and chromosomal localisation Biochim Biophys Acta (29-5-1998) 1398, 57-66. PubMed Europe PubMed DOI
Tominaga,K., Nakanishi,H., Yasuda,Y. and Yamamoto,K. Excitotoxin-induced neuronal death is associated with response of a unique intracellular aspartic proteinase, cathepsin E J Neurochem (1998) 71, 2574-2584. PubMed Europe PubMed
Yonezawa,S., Masaki,S., Hanai,A., Ono,T., Sonta,S., Hirai,H., Ichinose,M., Miki,K., Takahashi,K. and Kageyama,T. Cathepsin E gene in mouse Biomed Res (1998) 19, 327-334.

1997

Arnold,D., Keilholz,W., Schild,H., Dumrese,T., Stevanovic,S. and Rammensee,H.G. Substrate specificity of cathepsins D and E determined by N-terminal and C-terminal sequencing of peptide pools Eur J Biochem (1997) 249, 171-179. PubMed Europe PubMed
Arnold,D., Keilholz,W., Schild,H., Dumrese,T., Stevanovic,S. and Rammensee,H.G. Evolutionary conserved cathepsin E substrate specificity as defined by N-terminal and C-terminal sequencing of peptide pools Biol Chem (1997) 378, 883-891. PubMed Europe PubMed
[YEAR:15-11-1997]Hewitt,E.W., Treumann,A., Morrice,N., Tatnell,P.J., Kay,J. and Watts,C. Natural processing sites for human cathepsin E and cathepsin D in tetanus toxin: implications for T cell epitope generation J Immunol (15-11-1997) 159, 4693-4699. PubMed Europe PubMed
Mackay,E.A., Ehrhard,A., Moniatte,M., Guenet,C., Tardif,C., Tarnus,C., Sorokine,O., Heintzelmann,B., Nay,C., Remy,J.M., Higaki,J., Van Dorsselaer,A., Wagner,J., Danzin,C. and Mamont,P. A possible role for cathepsins D, E, and B in the processing of beta-amyloid precursor protein in Alzheimer's disease Eur J Biochem (1997) 244, 414-425. PubMed Europe PubMed
Tatnell,P.J., Lees,W.E. and Kay,J. Cloning, expression and characterisation of murine procathepsin E FEBS Lett (1997) 408, 62-66. PubMed Europe PubMed DOI

1996

Kageyama,T., Yonezawa,S., Ichinose,M., Miki,K. and Moriyama,A. Potential sites for processing of the human invariant chain by cathepsins D and E Biochem Biophys Res Commun (1996) 223, 549-553. PubMed Europe PubMed DOI
Tsukuba,T., Sakai,H., Yamada,M., Maeda,H., Hori,H., Azuma,T., Akamine,A. and Yamamoto,K. Biochemical properties of the monomeric mutant of human cathepsin E expressed in Chinese hamster ovary cells: Comparison with dimeric forms of the natural and recombinant cathepsin E J Biochem (1996) 119, 126-134. PubMed Europe PubMed

1995

Aoki,T., Takasaki,T., Furukawa,T., Morikawa,J., Yano,T. and Watabe,H. Conversion of cathepsin E to enzymatic unstable form in gastric cancer cells Biol Pharm Bull (1995) 18, 1522-1525. PubMed Europe PubMed
Athauda,S.B., Kageyama,T., Takahashi,T., Inoue,H., Ichinose,M., Ukai,M. and Takahashi,K. Isolation and characterization of human gastric procathepsin E and cathepsin E Adv Exp Med Biol (1995) 362, 201-210. PubMed Europe PubMed
Fowler,S.D., Kay,J., Dunn,B.M. and Tatnell,P.J. Monomeric human cathepsin E FEBS Lett (1995) 366, 72-74. PubMed Europe PubMed DOI
Hill,J., Montgomery,D. and Kay,J. Recombinant human cathepsin E Adv Exp Med Biol (1995) 362, 315-318. PubMed Europe PubMed
Iida,H., Matsuba,T., Yamada,M., Azuma,T., Suzuki,H., Yamamoto,K. and Hori,H. Purification and characterization of recombinant human cathepsin E Adv Exp Med Biol (1995) 362, 325-330. PubMed Europe PubMed
Kageyama,T., Ichinose,M. and Yonezawa,S. Processing of the precursors to neurotensin and other bioactive peptides by cathepsin E J Biol Chem (1995) 270, 19135-19140. PubMed Europe PubMed DOI
Kageyama,T. Procathepsin E and cathepsin E Methods Enzymol (1995) 248, 120-136. PubMed Europe PubMed DOI V
Okamoto,K., Yu,H., Misumi,Y., Ikehara,Y. and Yamamoto,K. Isolation and sequencing of two cDNA clones encoding rat spleen cathepsin E and analysis of the activation of purified procathepsin E Arch Biochem Biophys (1995) 322, 103-111. PubMed Europe PubMed DOI
Rao-Naik,C., Guruprasad,K., Batley,B., Rapundalo,S., Hill,J., Blundell,T., Kay,J. and Dunn,B.M. Exploring the binding preferences/specificity in the active site of human cathepsin E Proteins (1995) 22, 168-181. PubMed Europe PubMed DOI
Tsukada,S., Ichinose,M., Miki,K., Kakei,N., Matsushima,M., Yahagi,N., Ishihama,S., Shimizu,Y., Kido,M., Fukamachi,H., Kurokawa,K., Yonezawa,S., Kageyama,T. and Takahashi,K. Tissue- and cell-specific control of guinea pig cathepsin E gene expression Adv Exp Med Biol (1995) 362, 349-355. PubMed Europe PubMed
Tsukuba,T., Masayuki,Y., Hori,H., Azuma,T. and Yamamoto,K. Comparison of biochemical properties of natural and recombinant cathepsin E Adv Exp Med Biol (1995) 362, 331-334. PubMed Europe PubMed
Yamada,M., Matsuba,T., Azuma,T., Suzuki,H., Yamamoto,K. and Hori,H. Expression of human cathepsin E in methylotrophic yeast, Pichia pastoris Adv Exp Med Biol (1995) 362, 319-324. PubMed Europe PubMed E
Yonezawa,S., Ichinose,M., Tsukada,S., Miki,K. and Kageyama,T. Functional aspects of cathepsin E: is it an embryonic or fetal type of aspartic proteinase? Adv Exp Med Biol (1995) 362, 345-348. PubMed Europe PubMed

1994

Inokuchi,T., Kobayashi,K. and Horiuchi,S. Purification and characterization of cathepsin E type acid proteinase from gastric mucosa of bullfrog, Rana catesbeiana J Biochem (1994) 115, 76-81. PubMed Europe PubMed
Maric,M.A., Taylor,M.D. and Blum,J.S. Endosomal aspartic proteinases are required for invariant-chain processing Proc Natl Acad Sci U S A (1994) 91, 2171-2175. PubMed Europe PubMed PMC EPMC

1993

Athauda,S.B., Arakawa,H., Nishigai,M., Takahashi,T., Ikai,A. and Takahashi,K. Inhibition of cathepsin E by alpha2-macroglobulin and the resulting structural changes in the inhibitor J Biochem (1993) 113, 526-530. PubMed Europe PubMed
Kageyama,T. Rabbit procathepsin E and cathepsin E. Nucleotide sequence of cDNA, hydrolytic specificity for biologically active peptides and gene expression during development Eur J Biochem (1993) 216, 717-728. PubMed Europe PubMed
Rao,C., Scarborough,P.E., Lowther,W.T., Kay,J., Batley,B., Rapundalo,S., Klutchko,S., Taylor,M.D. and Dunn,B.M. Structure-function database for active site binding to the aspartic proteinases Adv Exp Med Biol (1993) 306, 143-147.
Solcia,E., Paulli,M., Silini,E., Fiocca,R., Finzi,G., Kindl,S., Boveri,E., Bosi,F., Cornaggia,M. and Capella,C. Cathepsin E in antigen-presenting Langerhans and interdigitating reticulum cells. Its possible role in antigen processing Eur J Histochem (1993) 37, 19-26. PubMed Europe PubMed
Takeda-Ezaki,M. and Yamamoto,K. Isolation and biochemical characterization of procathepsin E from human erythrocyte membranes Arch Biochem Biophys (1993) 304, 352-358. PubMed Europe PubMed DOI
Tsukuba,T., Hori,H., Azuma,T., Takahashi,T., Taggart,R.T., Akamine,A., Ezaki,M., Nakanishi,H., Sakai,H. and Yamamoto,K. Isolation and characterization of recombinant human cathepsin E expressed in Chinese hamster ovary cells J Biol Chem (1993) 268, 7276-7282. PubMed Europe PubMed

1992

Azuma,T., Liu,W.G., Vander Laan,D.J., Bowcock,A.M. and Taggart,R.T. Human gastric cathepsin E gene. Multiple transcripts result from alternative polyadenylation of the primary transcripts of a single gene locus at 1q31-q32 J Biol Chem (1992) 267, 1609-1614. PubMed Europe PubMed
Bennett,K., Levine,T., Ellis,J.S., Peanasky,R.J., Samloff,I.M., Kay,J. and Chain,B.M. Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E Eur J Immunol (1992) 22, 1519-1524. PubMed Europe PubMed DOI
Kageyama,T., Ichinose,M., Tsukada,S., Miki,K., Kurokawa,K., Koiwai,O., Tanji,M., Yakabe,E., Athauda,S.B. and Takahashi,K. Gastric procathepsin E and progastricsin from guinea pig. Purification, molecular cloning of cDNAs, and characterization of enzymatic properties, with special reference to procathepsin E J Biol Chem (1992) 267, 16450-16459. PubMed Europe PubMed
Robinson,P.S., Lees,W.E., Kay,J. and Cook,N.D. Kinetic parameters for the generation of endothelin-1, -2 and -3 by human cathepsin E Biochem J (1992) 284, 407-409. PubMed Europe PubMed PMC EPMC

1990

Athauda,S.B., Matsuzaki,O., Kageyama,T. and Takahashi,K. Structural evidence for two isozymic forms and the carbohydrate attachment site of human gastric cathepsin E Biochem Biophys Res Commun (1990) 168, 878-885. PubMed Europe PubMed DOI
[YEAR:1-5-1990]Baxter,A., Campbell,C.J., Grinham,C.J., Keane,R.M., Lawton,B.C. and Pendlebury,J.E. Substrate and inhibitor studies with human gastric aspartic proteinases Biochem J (1-5-1990) 267, 665-669. PubMed Europe PubMed PMC EPMC
[YEAR:29-10-1990]Lees,W.E., Kalinka,S., Meech,J., Capper,S.J., Cook,N.D. and Kay,J. Generation of human endothelin by cathepsin E FEBS Lett (29-10-1990) 273, 99-102. PubMed Europe PubMed DOI

1989

Azuma,T., Pals,G., Mohandas,T.K., Couvreur,J.M. and Taggart,R.T. Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases J Biol Chem (1989) 264, 16748-16753. PubMed Europe PubMed

1988

Jupp,R.A., Richards,A.D., Kay,J., Dunn,B.M., Wyckoff,J.B., Samloff,I.M. and Yamamoto,K. Identification of the aspartic proteinases from human erythrocyte membranes and gastric mucosa (slow-moving proteinase) as catalytically equivalent to cathepsin E Biochem J (1988) 254, 895-898. PubMed Europe PubMed PMC EPMC
Matsuzaki,O. and Takahashi,K. Improved purification of slow moving protease from gastric mucosa and its action on the B chain of oxidized bovine insulin Biomed Res (1988) 9, 515-523.
Yamamoto,K., Yamamoto,H., Takeda,M. and Kato,Y. An aspartic proteinase of erythrocyte membranes. Proposed mechanism for activation and further molecular properties Biol Chem Hoppe Seyler (1988) 369 Suppl, 315-322. PubMed Europe PubMed
Yonezawa,S., Fujii,K., Maejima,Y., Tamoto,K., Mori,Y. and Muto,N. Further studies on rat cathepsin E: subcellular localization and existence of the active subunit form Arch Biochem Biophys (1988) 267, 176-183. PubMed Europe PubMed

1987

Samloff,I.M., Taggart,R.T., Shiraishi,T., Branch,T., Reid,W.A., Heath,R., Lewis,R.W., Valler,M.J. and Kay,J. Slow moving proteinase. Isolation, characterization, and immunohistochemical localization in gastric mucosa Gastroenterology (1987) 93, 77-84. PubMed Europe PubMed
[YEAR:14-10-1987]Yamamoto,K., Ueno,E., Uemura,H. and Kato,Y. Biochemical and immunochemical similarity between erythrocyte membrane aspartic proteinase and cathepsin E Biochem Biophys Res Commun (14-10-1987) 148, 267-272. PubMed Europe PubMed

1986

Takeda,M., Ueno,E., Kato,Y. and Yamamoto,K. Isolation, and catalytic and immunochemical properties of cathepsin D-like acid proteinase from rat erythrocytes J Biochem (1986) 100, 1269-1277. PubMed Europe PubMed
[YEAR:15-1-1986]Tarasova,N.I., Szecsi,P.B. and Foltmann,B. An aspartic proteinase from human erythrocytes is immunochemically indistinguishable from a non-pepsin, electrophoretically slow moving proteinase from gastric mucosa Biochim Biophys Acta (15-1-1986) 880, 96-100. PubMed Europe PubMed

1977

Bowers,W.E., Beyer,C.F. and Yago,N. Cathepsin D of mouse leukemia L1210 cells: unusual intracellular localization and biochemical properties Biochim Biophys Acta (1977) 497, 272-279. PubMed Europe PubMed

1975

Yago,N. and Bowers,W.E. Unique cathepsin D-type proteases in rat thoracic duct lymphocytes and in rat lymphoid tissues J Biol Chem (1975) 250, 4749-4754. PubMed Europe PubMed

1970

Keilova,H. and Lapresle,C. Inhibition of cathepsin E by diazoacetyl-norleucine methyl ester FEBS Lett (1970) 9, 348-350. PubMed Europe PubMed I

1960

Lapresle,C. and Webb,T. Study of a proteolytic enzyme from rabbit spleen Biochem J (1960) 76, 538-543. PubMed Europe PubMed PMC EPMC

1931

[YEAR:20-9-1931]Northrop,J.H. The presence of a gelatin-liquefying enzyme in crude pepsin preparations J Gen Physiol (20-9-1931) 15, 29-43. PubMed Europe PubMed DOI