Literature for peptidase A01.010: cathepsin E

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Deng,T., Lu,X., Jia,X., Du,J., Wang,L., Cao,B., Yang,M., Yin,Y. and Liu,F.
    Cathepsins and cancer risk: a Mendelian randomization study
    Front Endocrinol (Lausanne)15, 1428433-1428433. PubMed  Europe PubMed DOI
  2. 2022
  3. Wu,Y., Zhou,W., Yang,Z., Li,J. and Jin,Y.
    miR-185-5p Represses Cells Growth and Metastasis of Osteosarcoma via Targeting Cathepsin E
    Int J Toxicol41, 115-125. PubMed  Europe PubMed DOI
  4. 2020
  5. Hou,J., Li,R., Qiao,S., Chen,X.X., Xing,G. and Zhang,G.
    The Glycoprotein 5 is cleaved by cathepsin E during porcine reproductive and respiratory virus membrane fusion
    J Virol PubMed  Europe PubMed DOI
  6. Kim,J.W., Cho,J.Y., Kim,J., Kim,D.G., Nam,B.H., Kim,Y.O., An,C.M., Kim,B.S., Park,J.Y. and Kong,H.J.
    First report of cathepsin E in a teleost (Korean rose bitterling, Rhodeus uyekii): molecular characterisation and tissue distribution
    Dev Comp Immunol103607-103607. PubMed  Europe PubMed DOI
  7. Stotz,S., Bleher,D., Kalbacher,H. and Maurer,A.
    Grassystatin-derived peptides selectively inhibit cathepsin E and have low affinity to cathepsin D
    Biochem Biophys Res Commun527, 238-241. PubMed  Europe PubMed DOI  I
  8. 2019
  9. Pontious,C., Kaul,S., Hong,M., Hart,P.A., Krishna,S.G., Lara,L.F., Conwell,D.L. and Cruz-Monserrate,Z.
    Cathepsin E expression and activity: role in the detection and treatment of pancreatic cancer
    Pancreatology19, 951-956. PubMed  Europe PubMed DOI  L
  10. 2018
  11. Bozic,J., Stoka,V. and Dolenc,I.
    Glucosamine prevents polarization of cytotoxic granules in NK-92 cells by disturbing FOXO1/ERK/paxillin phosphorylation
    PLoS ONE13, e0200757-e0200757. PubMed  Europe PubMed DOI
  12. 2017
  13. Al-Awadhi,F.H., Law,B.K., Paul,V.J. and Luesch,H.
    Grassystatins D-F, potent aspartic protease inhibitors from marine cyanobacteria as potential antimetastatic agents targeting invasive breast cancer
    J Nat Prod80, 2969-2986. PubMed  Europe PubMed DOI  I
  14. Harada,Y., Takayama,F., Tanabe,K., Ni,J., Hayashi,Y., Yamamoto,K., Wu,Z. and Nakanishi,H.
    Overexpression of cathepsin E interferes with neuronal differentiation of P19 embryonal teratocarcinoma cells by degradation of N-cadherin
    Cell Mol Neurobiol37, 437-443. PubMed  Europe PubMed DOI
  15. Ivry,S.L., Sharib,J.M., Dominguez,D.A., Roy,N., Hatcher,S.E., Yip-Schneider,M.T., Schmidt,C.M., Brand,R.E., Park,W.G., Hebrok,M., Kim,G.E., O'Donoghue,A.J., Kirkwood,K.S. and Craik,C.S.
    Global protease activity profiling provides differential diagnosis of pancreatic cysts
    Clin Cancer Res23, 4865-4874. PubMed  Europe PubMed DOI
  16. 2016
  17. Al-Awadhi,F.H., Ratnayake,R., Paul,V.J. and Luesch,H.
    Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium
    Bioorg Med Chem24, 3276-3282. PubMed  Europe PubMed DOI  I
  18. Cao,W.J., Li,M.H., Li,J.X., Xu,X., Ren,S.X., Rajbanshi,B. and Xu,J.F.
    High expression of cathepsin E is associated with the severity of airflow limitation in patients with COPD
    COPD13, 160-166. PubMed  Europe PubMed DOI
  19. Nagasawa,T., Sano,K., Kawaguchi,M., Kobayashi,K., Yasumasu,S. and Inokuchi,T.
    Purification and molecular cloning of aspartic proteinases from the stomach of adult Japanese fire belly newts, Cynops pyrrhogaster
    J Biochem159, 449-460. PubMed  Europe PubMed DOI
  20. O'Donoghue,A.J., Ivry,S.L., Chaudhury,C., Hostetter,D.R., Hanahan,D. and Craik,C.S.
    Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors
    Biol Chem397, 871-881. PubMed  Europe PubMed DOI  I
  21. 2015
  22. Fisher,O.M., Levert-Mignon,A.J., Lord,S.J., Botelho,N.K., Freeman,A.K., Thomas,M.L., Falkenback,D., Wettstein,A., Whiteman,D.C., Bobryshev,Y.V. and Lord,R.V.
    High expression of cathepsin E in tissues but not blood of patients with Barrett's esophagus and adenocarcinoma
    Ann Surg Oncol22, 2431-2438. PubMed  Europe PubMed DOI
  23. Ni,J., Wu,Z., Peterts,C., Yamamoto,K., Qing,H. and Nakanishi,H.
    The critical role of proteolytic relay through cathepsins B and E in the phenotypic change of microglia/macrophage
    J Neurosci35, 12488-12501. PubMed  Europe PubMed DOI  T
  24. Zeleznik,T.Z., Puizdar,V. and Dolenc,I.
    Expression, purification and auto-activation of cathepsin E from insect cells
    Protein Pept Lett22, 525-531. PubMed  Europe PubMed  E
  25. 2014
  26. Kadowaki,T., Kido,M.A., Hatakeyama,J., Okamoto,K., Tsukuba,T. and Yamamoto,K.
    Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet
    Biochem Biophys Res Commun446, 212-217. PubMed  Europe PubMed DOI  K
  27. Li,H., Li,Y., Cui,L., Wang,B., Cui,W., Li,M. and Cheng,Y.
    Monitoring pancreatic carcinogenesis by the molecular imaging of cathepsin E in vivo using confocal laser endomicroscopy
    PLoS ONE9, e106566-e106566. PubMed  Europe PubMed DOI  L
  28. Lutz,D., Wolters-Eisfeld,G., Schachner,M. and Kleene,R.
    Cathepsin E generates a sumoylated intracellular fragment of the cell adhesion molecule L1 to promote neuronal and Schwann cell migration as well as myelination
    J Neurochem128, 713-724. PubMed  Europe PubMed DOI
  29. Zhang,X., Shan,P., Homer,R., Zhang,Y., Petrache,I., Mannam,P. and Lee,P.J.
    Cathepsin E promotes pulmonary emphysema via mitochondrial fission
    Am J Pathol184, 2730-2741. PubMed  Europe PubMed DOI
  30. 2013
  31. Abd-Elgaliel,W.R., Cruz-Monserrate,Z., Wang,H., Logsdon,C.D. and Tung,C.H.
    Pancreatic cancer-associated cathepsin E as a drug activator
    J Control Release167, 221-227. PubMed  Europe PubMed DOI
  32. Keliher,E.J., Reiner,T., Earley,S., Klubnick,J., Tassa,C., Lee,A.J., Ramaswamy,S., Bardeesy,N., Hanahan,D., DePinho,R.A., Castro,C.M. and Weissleder,R.
    Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection
    Neoplasia15, 684-693. PubMed  Europe PubMed DOI  I
  33. Konno-Shimizu,M., Yamamichi,N., Inada,K., Kageyama-Yahara,N., Shiogama,K., Takahashi,Y., Asada-Hirayama,I., Yamamichi-Nishina,M., Nakayama,C., Ono,S., Kodashima,S., Fujishiro,M., Tsutsumi,Y., Ichinose,M. and Koike,K.
    Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis
    PLoS ONE8, e56766-e56766. PubMed  Europe PubMed DOI
  34. Tsukuba,T., Yanagawa,M., Kadowaki,T., Takii,R., Okamoto,Y., Sakai,E., Okamoto,K. and Yamamoto,K.
    Cathepsin E deficiency impairs autophagic proteolysis in macrophages
    PLoS ONE8, e82415-e82415. PubMed  Europe PubMed DOI  K
  35. 2012
  36. Andoh,T., Yoshida,T., Lee,J.B. and Kuraishi,Y.
    Cathepsin E induces itch-related response through the production of endothelin-1 in mice
    Eur J Pharmacol686, 16-21. PubMed  Europe PubMed DOI
  37. Cruz-Monserrate,Z., Abd-Elgaliel,W.R., Grote,T., Deng,D., Ji,B., Arumugam,T., Wang,H., Tung,C.H. and Logsdon,C.D.
    Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models
    Gut61, 1315-1322. PubMed  Europe PubMed DOI
  38. Kitamura,K., Komatsu,M., Biyani,M., Futakami,M., Kawakubo,T., Yamamoto,K. and Nishigaki,K.
    Proven in vitro evolution of protease cathepsin E-inhibitors and -activators at pH 4.5 using a paired peptide method
    J Pept Sci18, 711-719. PubMed  Europe PubMed DOI  I
  39. Komatsu,M., Biyani,M., Ghimire Gautam,S. and Nishigaki,K.
    Peptide-modulated activity enhancement of acidic protease cathepsin E at neutral pH
    Int J Pept2012, 316432-316432. PubMed  Europe PubMed DOI
  40. Pilzner,C., Buhling,F., Reinheckel,T., Chwieralski,C., Rathinasamy,A., Lauenstein,H.D., Wex,T., Welte,T., Braun,A. and Groneberg,D.A.
    Allergic airway inflammation in mice deficient for the antigen-processing protease cathepsin E
    Int Arch Allergy Immunol159, 367-383. PubMed  Europe PubMed DOI  K
  41. Puizdar,V., Zajc,T., Zerovnik,E., Renko,M., Pieper,U., Eswar,N., Sali,A., Dolenc,I. and Turk,V.
    Biochemical characterization and structural modeling of human cathepsin E variant 2 in comparison to the wild-type protein
    Biol Chem393, 177-186. PubMed  Europe PubMed DOI
  42. Tsukuba,T., Okamoto,K. and Yamamoto,K.
    Cathepsin E is critical for proper trafficking of cell surface proteins
    J Oral Biosci54, 48-53. DOI  V
  43. Yamamoto,K., Kawakubo,T., Yasukochi,A. and Tsukuba,T.
    Emerging roles of cathepsin E in host defense mechanisms
    Biochim Biophys Acta1824, 105-112. PubMed  Europe PubMed DOI  V
  44. Yang,S., Zhang,W., Ding,N., Lo,J., Liu,Y., Clare-Salzler,M.J., Luesch,H. and Li,Y.
    Total synthesis of grassystatin A, a probe for cathepsin E function
    Bioorg Med Chem20, 4774-4780. PubMed  Europe PubMed DOI  I
  45. Zaidi,N. and Kalbacher,H.
    Cathepsin E
    [ISSN:978-0-12-407744-7]3, 42-49. DOI
  46. 2011
  47. Abd-Elgaliel,W.R., Cruz-Monserrate,Z., Logsdon,C.D. and Tung,C.H.
    Molecular imaging of cathepsin E-positive tumors in mice using a novel protease-activatable fluorescent probe
    Mol Biosyst7, 3207-3213. PubMed  Europe PubMed DOI  L
  48. Biyani,M., Futakami,M., Kitamura,K., Kawakubo,T., Suzuki,M., Yamamoto,K. and Nishigaki,K.
    In vitro selection of cathepsin E-activity-enhancing peptide aptamers at neutral pH
    Int J Pept2011, 834525-834525. PubMed  Europe PubMed DOI  I
  49. Chlabicz,M., Gacko,M., Worowska,A. and Lapinski,R.
    Cathepsin E (EC 3.4.23.34) - a review
    Folia Histochem Cytobiol49, 547-557. PubMed  Europe PubMed DOI  V
  50. Kawakubo,T., Yasukochi,A., Nakamura,S. and Yamamoto,K.
    Cathepsin E as a potent anticancer protease
    J Oral Biosci53, 128-136. DOI  K
  51. Kawakubo,T., Yasukochi,A., Okamoto,K., Okamoto,Y., Nakamura,S. and Yamamoto,K.
    The role of cathepsin E in terminal differentiation of keratinocytes
    Biol Chem392, 571-585. PubMed  Europe PubMed DOI  K
  52. Tulone,C., Sponaas,A.M., Raiber,E.A., Tabor,A.B., Langhorne,J. and Chain,B.M.
    Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1
    PLoS ONE6, e24886-e24886. PubMed  Europe PubMed DOI
  53. 2010
  54. Abd-Elgaliel,W.R. and Tung,C.H.
    Selective detection of cathepsin E proteolytic activity
    Biochim Biophys Acta1800, 1002-1008. PubMed  Europe PubMed DOI  P
  55. Yasukochi,A., Kawakubo,T., Nakamura,S. and Yamamoto,K.
    Cathepsin E enhances anticancer activity of doxorubicin on human prostate cancer cells showing resistance to TRAIL-mediated apoptosis
    Biol Chem391, 947-958. PubMed  Europe PubMed DOI
  56. 2009
  57. Kitamura,K., Yoshida,C., Kinoshita,Y., Kadowaki,T., Takahashi,Y., Tayama,T., Kawakubo,T., Naimuddin,M., Salimullah,M., Nemoto,N., Hanada,K., Husimi,Y., Yamamoto,K. and Nishigaki,K.
    Development of systemic in vitro evolution and its application to generation of peptide-aptamer-based inhibitors of cathepsin E
    J Mol Biol387, 1186-1198. PubMed  Europe PubMed DOI  I
  58. Kwan,J.C., Eksioglu,E.A., Liu,C., Paul,V.J. and Luesch,H.
    Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation
    J Med Chem52, 5732-5747. PubMed  Europe PubMed DOI  I
  59. 2008
  60. Burster,T., Reich,M., Zaidi,N., Voelter,W., Boehm,B.O. and Kalbacher,H.
    Cathepsin E regulates the presentation of tetanus toxin C-fragment in PMA activated primary human B cells
    Biochem Biophys Res Commun377, 1299-1303. PubMed  Europe PubMed DOI
  61. Kawakubo,T., Yasukochi,A., Tsukuba,T., Kadowaki,T. and Yamamoto,K.
    Gene expression profiling of mammary glands of cathepsin E-deficient mice compared with wild-type littermates
    Biochimie90, 396-404. PubMed  Europe PubMed DOI  K
  62. Misinzo,G.M., Delputte,P.L. and Nauwynck,H.J.
    Involvement of proteases in porcine reproductive and respiratory syndrome virus uncoating upon internalization in primary macrophages
    Vet Res39, 55-55. PubMed  Europe PubMed DOI
  63. Ordonez,G.R., Hillier,L.W., Warren,W.C., Grutzner,F., Lopez-Otin,C. and Puente,X.S.
    Loss of genes implicated in gastric function during platypus evolution
    Genome Biol9, R81-R81. PubMed  Europe PubMed DOI
  64. Shigematsu,N., Fukuda,T., Yamamoto,T., Nishioku,T., Yamaguchi,T., Himeno,M., Nakayama,K.I., Tsukuba,T., Kadowaki,T., Okamoto,K., Higuchi,S. and Yamamoto,K.
    Association of cathepsin E deficiency with the increased territorial aggressive response of mice
    J Neurochem105, 1394-1404. PubMed  Europe PubMed DOI  K
  65. Yoshida,C., Kuniwake,A., Naimuddin,M. and Nishigaki,K.
    Molecular design guided by a local map of sequence space: DNA aptamers that inhibit cathepsin E
    Oligonucleotides18, 1-8. PubMed  Europe PubMed DOI  I
  66. Zaidi,N., Hermann,C., Herrmann,T. and Kalbacher,H.
    Emerging functional roles of cathepsin E
    Biochem Biophys Res Commun377, 327-330. PubMed  Europe PubMed DOI  K  V
  67. Zaidi,N. and Kalbacher,H.
    Cathepsin E: a mini review
    Biochem Biophys Res Commun367, 517-522. PubMed  Europe PubMed DOI  V
  68. 2007
  69. Kakehashi,H., Nishioku,T., Tsukuba,T., Kadowaki,T., Nakamura,S. and Yamamoto,K.
    Differential regulation of the nature and functions of dendritic cells and macrophages by cathepsin E
    J Immunol179, 5728-5737. PubMed  Europe PubMed
  70. Kawakubo,T., Okamoto,K., Iwata,J., Shin,M., Okamoto,Y., Yasukochi,A., Nakayama,K.I., Kadowaki,T., Tsukuba,T. and Yamamoto,K.
    Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface
    Cancer Res67, 10869-10878. PubMed  Europe PubMed DOI  U
  71. Naimuddin,M., Kitamura,K., Kinoshita,Y., Honda-Takahashi,Y., Murakami,M., Ito,M., Yamamoto,K., Hanada,K., Husimi,Y. and Nishigaki,K.
    Selection-by-function: efficient enrichment of cathepsin E inhibitors from a DNA library
    J Mol Recognit20, 58-68. PubMed  Europe PubMed DOI  I
  72. Page,J.L., Strom,S.C. and Omiecinski,C.J.
    Regulation of the human cathepsin E gene by the constitutive androstane receptor
    Arch Biochem Biophys467, 132-138. PubMed  Europe PubMed DOI
  73. Shin,M., Kadowaki,T., Iwata,J., Kawakubo,T., Yamaguchi,N., Takii,R., Tsukuba,T. and Yamamoto,K.
    Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses
    Biol Chem388, 1173-1181. PubMed  Europe PubMed DOI
  74. Tulone,C., Tsang,J., Prokopowicz,Z., Grosvenor,N. and Chain,B.
    Natural cathepsin E deficiency in the immune system of C57BL/6J mice
    Immunogenetics59, 927-935. PubMed  Europe PubMed DOI
  75. Yanagawa,M., Tsukuba,T., Nishioku,T., Okamoto,Y., Okamoto,K., Takii,R., Terada,Y., Nakayama,K.I., Kadowaki,T. and Yamamoto,K.
    Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages
    J Biol Chem282, 1851-1862. PubMed  Europe PubMed DOI  K
  76. Zaidi,N., Herrmann,T., Voelter,W. and Kalbacher,H.
    Recombinant cathepsin E has no proteolytic activity at neutral pH
    Biochem Biophys Res Commun360, 51-55. PubMed  Europe PubMed DOI
  77. Zaidi,N., Herrmann,T., Baechle,D., Schleicher,S., Gogel,J., Driessen,C., Voelter,W. and Kalbacher,H.
    A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles
    FEBS J274, 3138-3149. PubMed  Europe PubMed DOI  A
  78. 2006
  79. Busquets,L., Guillen,H., DeFord,M.E., Suckow,M.A., Navari,R.M., Castellino,F.J. and Prorok,M.
    Cathepsin E is a specific marker of dysplasia in APC mouse intestine
    Tumour Biol27, 36-42. PubMed  Europe PubMed DOI
  80. Narita,Y., Oda,S. and Kageyama,T.
    Rodent monophyly deduced from the unique gastric proteinase constitution and molecular phylogenetic analyses using pepsinogen-C cDNA sequences
    Comp Biochem Physiol Part D Genomics Proteomics1, 273-282. PubMed  Europe PubMed DOI
  81. Tsukuba,T., Yamamoto,S., Yanagawa,M., Okamoto,K., Okamoto,Y., Nakayama,K.I., Kadowaki,T. and Yamamoto,K.
    Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface toll-like receptors
    J Biochem140, 57-66. PubMed  Europe PubMed DOI  K
  82. Tsukuba,T., Ikeda,S., Okamoto,K., Yasuda,Y., Sakai,E., Kadowaki,T., Sakai,H. and Yamamoto,K.
    Characterization of rat cathepsin E and mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells
    FEBS J273, 219-229. PubMed  Europe PubMed DOI
  83. [YEAR:21-9-2006]Zhou,W., Scott,S.A., Shelton,S.B. and Crutcher,K.A.
    Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease
    Neuroscience143, 689-701. PubMed  Europe PubMed DOI
  84. 2005
  85. [YEAR:15-2-2005]Chain,B.M., Free,P., Medd,P., Swetman,C., Tabor,A.B. and Terrazzini,N.
    The expression and function of cathepsin E in dendritic cells
    J Immunol174, 1791-1800. PubMed  Europe PubMed
  86. [YEAR:27-5-2005]Chou,K.C.
    Modeling the tertiary structure of human cathepsin-E
    Biochem Biophys Res Commun331, 56-60. PubMed  Europe PubMed DOI  S
  87. [YEAR:1-5-2005]Henningsson,F., Yamamoto,K., Saftig,P., Reinheckel,T., Peters,C., Knight,S.D. and Pejler,G.
    A role for cathepsin E in the processing of mast-cell carboxypeptidase A
    J Cell Sci118, 2035-2042. PubMed  Europe PubMed DOI
  88. Yasuda,Y., Tsukuba,T., Okamoto,K., Kadowaki,T. and Yamamoto,K.
    The role of the cathepsin E propeptide in correct folding, maturation and sorting to the endosome
    J Biochem138, 621-630. PubMed  Europe PubMed DOI
  89. Yasuda,Y., Kohmura,K., Kadowaki,T., Tsukuba,T. and Yamamoto,K.
    A new selective substrate for cathepsin E based on the cleavage site sequence of alpha2-macroglobulin
    Biol Chem386, 299-305. PubMed  Europe PubMed DOI
  90. 2004
  91. Cappiello,M.G., Wu,Z., Scott,B.B., McGeehan,G.M. and Harrison,R.K.
    Purification and characterization of recombinant human cathepsin E expressed in human kidney cell line 293
    Protein Expr Purif37, 53-60. PubMed  Europe PubMed DOI  E
  92. Igarashi,S., Takizawa,T., Takizawa,T., Yasuda,Y., Uchiwa,H., Hayashi,S., Brysk,H., Robinson,J.M., Yamamoto,K., Brysk,M.M. and Horikoshi,T.
    Cathepsin D, but not cathepsin E, degrades desmosomes during epidermal desquamation
    Br J Dermatol151, 355-361. PubMed  Europe PubMed DOI
  93. Kay,J. and Tatnell,P.J.
    Cathepsin E
    [ISSN:0-12-079610-4]2, 33-38.  V
  94. [YEAR:17-9-2004]Ostermann,N., Gerhartz,B., Worpenberg,S., Trappe,J. and Eder,J.
    Crystal structure of an activation intermediate of cathepsin E
    J Mol Biol342, 889-899. PubMed  Europe PubMed DOI  S
  95. [YEAR:1-5-2004]Yee,C.S., Yao,Y., Li,P., Klemsz,M.J., Blum,J.S. and Chang,C.H.
    Cathepsin E: a novel target for regulation by class II transactivator
    J Immunol172, 5528-5534. PubMed  Europe PubMed
  96. 2003
  97. Ikuzawa,M., Yasumasu,S., Inokuchi,T., Kobayashi,K., Nomura,K. and Iuchi,I.
    Differential expression of two cathepsin Es during metamorphosis-associated remodeling of the larval to adult type epithelium in Xenopus stomach
    J Biochem134, 385-394. PubMed  Europe PubMed DOI
  98. Inokuchi,T., Ikuzawa,M., Mineta,T., Yasumasu,S. and Kobayashi,K.
    Molecular cloning of preprocathepsin E cDNA from the stomach of bullfrog Rana catesbeiana
    Comp Biochem Physiol B Biochem Mol Biol135, 647-655. PubMed  Europe PubMed DOI
  99. Shibata,M., Sakai,H., Sakai,E., Okamoto,K., Nishishita,K., Yasuda,Y., Kato,Y. and Yamamoto,K.
    Disruption of structural and functional integrity of alpha2-macroglobulin by cathepsin E
    Eur J Biochem270, 1189-1198. PubMed  Europe PubMed DOI
  100. [YEAR:27-1-2003]Tatnell,P.J., Cook,M. and Kay,J.
    An alternatively spliced variant of cathepsin E in human gastric adenocarcinoma cells
    Biochim Biophys Acta1625, 203-206. PubMed  Europe PubMed DOI  R
  101. Tsukuba,T., Okamoto,K., Okamoto,Y., Yanagawa,M., Kohmura,K., Yasuda,Y., Uchi,H., Nakahara,T., Furue,M., Nakayama,K., Kadowaki,T., Yamamoto,K. and Nakayama,K.I.
    Association of cathepsin E deficiency with development of atopic dermatitis
    J Biochem134, 893-902. PubMed  Europe PubMed DOI  K
  102. 2002
  103. Athauda,S.B. and Takahashi,K.
    Distinct cleavage specificity of human cathepsin E at neutral pH with special preference for Arg-Arg bonds
    Protein Pept Lett9, 15-22. PubMed  Europe PubMed DOI
  104. [YEAR:1-9-2002]Liu,J., Tsukuba,T., Okamoto,K., Ohishi,M. and Yamamoto,K.
    Mutational analysis of residues in two consensus motifs in the active sites of cathepsin E
    J Biochem132, 493-499. PubMed  Europe PubMed
  105. [YEAR:15-2-2002]Nishioku,T., Hashimoto,K., Yamashita,K., Liou,S.Y., Kagamiishi,Y., Maegawa,H., Katsube,N., Peters,C., von Figura,K., Saftig,P., Katunuma,N., Yamamoto,K. and Nakanishi,H.
    Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia
    J Biol Chem277, 4816-4822. PubMed  Europe PubMed DOI
  106. 2001
  107. Cook,M., Caswell,R.C., Richards,R.J., Kay,J. and Tatnell,P.J.
    Regulation of human and mouse procathepsin E gene expression
    Eur J Biochem268, 2658-2668. PubMed  Europe PubMed DOI
  108. 2000
  109. [YEAR:31-12-2000]Tsukuba,T., Okamoto,K., Yasuda,Y., Morikawa,W., Nakanishi,H. and Yamamoto,K.
    New functional aspects of cathepsin D and cathepsin E
    Mol Cells10, 601-611. PubMed  Europe PubMed  V
  110. Uno,K., Azuma,T., Nakajima,M., Yasuda,K., Hayakumo,T., Mukai,H., Sakai,T. and Kawai,K.
    Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma
    J Gastroenterol Hepatol15, 1333-1338. PubMed  Europe PubMed DOI
  111. 1999
  112. Yasuda,Y., Ikeda,S., Sakai,H., Tsukuba,T., Okamoto,K., Nishishita,K., Akamine,A., Kato,Y. and Yamamoto,K.
    Role of N-glycosylation in cathepsin E. A comparative study of cathepsin E with distinct N-linked oligosaccharides and its nonglycosylated mutant
    Eur J Biochem266, 383-391. PubMed  Europe PubMed DOI
  113. Yasuda,Y., Kageyama,T., Akamine,A., Shibata,M., Kominami,E., Uchiyama,Y. and Yamamoto,K.
    Characterization of new fluorogenic substrates for the rapid and sensitive assay of cathepsin E and cathepsin D
    J Biochem125, 1137-1143. PubMed  Europe PubMed  A
  114. 1998
  115. Bernstein,H.G., Reichenbach,A. and Wiederanders,B.
    Cathepsin E immunoreactivity in human ocular tissues: influence of aging and pathological states
    Neurosci Lett240, 135-138. PubMed  Europe PubMed DOI
  116. Bukhtiyarova,M., Rao-Naik,C., Tatnell,P.J., White,P.C., Kay,J. and Dunn,B.M.
    Detailed analysis of human cathepsin E prime region specificity
    Adv Exp Med Biol436, 219-222. PubMed  Europe PubMed
  117. Kageyama,T., Tatematsu,M., Ichinose,M., Yahagi,N., Miki,K., Moriyama,A. and Yonezawa,S.
    Development-dependent expression of cathepsins D and E in various rat tissues, with special reference to the high expression of cathepsin E in fetal liver
    Zoolog Sci15, 517-523. PubMed  Europe PubMed DOI
  118. Mineta,T., Inokuchi,T., Kobayashi,K. and Horiuchi,S.
    Distribution of cathepsin E in the larval and adult organs of the bullfrog with special reference to the mature form in the larval fore-gut
    Comp Biochem Physiol B Biochem Mol Biol121, 333-340. PubMed  Europe PubMed DOI
  119. [YEAR:29-5-1998]Tatnell,P.J., Roth,W., Deussing,J., Peters,C. and Kay,J.
    Mouse procathepsin E gene: molecular organisation and chromosomal localisation
    Biochim Biophys Acta1398, 57-66. PubMed  Europe PubMed DOI
  120. Tominaga,K., Nakanishi,H., Yasuda,Y. and Yamamoto,K.
    Excitotoxin-induced neuronal death is associated with response of a unique intracellular aspartic proteinase, cathepsin E
    J Neurochem71, 2574-2584. PubMed  Europe PubMed
  121. Yonezawa,S., Masaki,S., Hanai,A., Ono,T., Sonta,S., Hirai,H., Ichinose,M., Miki,K., Takahashi,K. and Kageyama,T.
    Cathepsin E gene in mouse
    Biomed Res19, 327-334.
  122. 1997
  123. Arnold,D., Keilholz,W., Schild,H., Dumrese,T., Stevanovic,S. and Rammensee,H.G.
    Substrate specificity of cathepsins D and E determined by N-terminal and C-terminal sequencing of peptide pools
    Eur J Biochem249, 171-179. PubMed  Europe PubMed
  124. Arnold,D., Keilholz,W., Schild,H., Dumrese,T., Stevanovic,S. and Rammensee,H.G.
    Evolutionary conserved cathepsin E substrate specificity as defined by N-terminal and C-terminal sequencing of peptide pools
    Biol Chem378, 883-891. PubMed  Europe PubMed
  125. [YEAR:15-11-1997]Hewitt,E.W., Treumann,A., Morrice,N., Tatnell,P.J., Kay,J. and Watts,C.
    Natural processing sites for human cathepsin E and cathepsin D in tetanus toxin: implications for T cell epitope generation
    J Immunol159, 4693-4699. PubMed  Europe PubMed
  126. Mackay,E.A., Ehrhard,A., Moniatte,M., Guenet,C., Tardif,C., Tarnus,C., Sorokine,O., Heintzelmann,B., Nay,C., Remy,J.M., Higaki,J., Van Dorsselaer,A., Wagner,J., Danzin,C. and Mamont,P.
    A possible role for cathepsins D, E, and B in the processing of beta-amyloid precursor protein in Alzheimer's disease
    Eur J Biochem244, 414-425. PubMed  Europe PubMed
  127. Tatnell,P.J., Lees,W.E. and Kay,J.
    Cloning, expression and characterisation of murine procathepsin E
    FEBS Lett408, 62-66. PubMed  Europe PubMed DOI
  128. 1996
  129. Kageyama,T., Yonezawa,S., Ichinose,M., Miki,K. and Moriyama,A.
    Potential sites for processing of the human invariant chain by cathepsins D and E
    Biochem Biophys Res Commun223, 549-553. PubMed  Europe PubMed DOI
  130. Tsukuba,T., Sakai,H., Yamada,M., Maeda,H., Hori,H., Azuma,T., Akamine,A. and Yamamoto,K.
    Biochemical properties of the monomeric mutant of human cathepsin E expressed in Chinese hamster ovary cells: Comparison with dimeric forms of the natural and recombinant cathepsin E
    J Biochem119, 126-134. PubMed  Europe PubMed
  131. 1995
  132. Aoki,T., Takasaki,T., Furukawa,T., Morikawa,J., Yano,T. and Watabe,H.
    Conversion of cathepsin E to enzymatic unstable form in gastric cancer cells
    Biol Pharm Bull18, 1522-1525. PubMed  Europe PubMed
  133. Athauda,S.B., Kageyama,T., Takahashi,T., Inoue,H., Ichinose,M., Ukai,M. and Takahashi,K.
    Isolation and characterization of human gastric procathepsin E and cathepsin E
    Adv Exp Med Biol362, 201-210. PubMed  Europe PubMed
  134. Fowler,S.D., Kay,J., Dunn,B.M. and Tatnell,P.J.
    Monomeric human cathepsin E
    FEBS Lett366, 72-74. PubMed  Europe PubMed DOI
  135. Hill,J., Montgomery,D. and Kay,J.
    Recombinant human cathepsin E
    Adv Exp Med Biol362, 315-318. PubMed  Europe PubMed
  136. Iida,H., Matsuba,T., Yamada,M., Azuma,T., Suzuki,H., Yamamoto,K. and Hori,H.
    Purification and characterization of recombinant human cathepsin E
    Adv Exp Med Biol362, 325-330. PubMed  Europe PubMed
  137. Kageyama,T., Ichinose,M. and Yonezawa,S.
    Processing of the precursors to neurotensin and other bioactive peptides by cathepsin E
    J Biol Chem270, 19135-19140. PubMed  Europe PubMed DOI
  138. Kageyama,T.
    Procathepsin E and cathepsin E
    Methods Enzymol248, 120-136. PubMed  Europe PubMed DOI  V
  139. Okamoto,K., Yu,H., Misumi,Y., Ikehara,Y. and Yamamoto,K.
    Isolation and sequencing of two cDNA clones encoding rat spleen cathepsin E and analysis of the activation of purified procathepsin E
    Arch Biochem Biophys322, 103-111. PubMed  Europe PubMed DOI
  140. Rao-Naik,C., Guruprasad,K., Batley,B., Rapundalo,S., Hill,J., Blundell,T., Kay,J. and Dunn,B.M.
    Exploring the binding preferences/specificity in the active site of human cathepsin E
    Proteins22, 168-181. PubMed  Europe PubMed DOI
  141. Tsukada,S., Ichinose,M., Miki,K., Kakei,N., Matsushima,M., Yahagi,N., Ishihama,S., Shimizu,Y., Kido,M., Fukamachi,H., Kurokawa,K., Yonezawa,S., Kageyama,T. and Takahashi,K.
    Tissue- and cell-specific control of guinea pig cathepsin E gene expression
    Adv Exp Med Biol362, 349-355. PubMed  Europe PubMed
  142. Tsukuba,T., Masayuki,Y., Hori,H., Azuma,T. and Yamamoto,K.
    Comparison of biochemical properties of natural and recombinant cathepsin E
    Adv Exp Med Biol362, 331-334. PubMed  Europe PubMed
  143. Yamada,M., Matsuba,T., Azuma,T., Suzuki,H., Yamamoto,K. and Hori,H.
    Expression of human cathepsin E in methylotrophic yeast, Pichia pastoris
    Adv Exp Med Biol362, 319-324. PubMed  Europe PubMed  E
  144. Yonezawa,S., Ichinose,M., Tsukada,S., Miki,K. and Kageyama,T.
    Functional aspects of cathepsin E: is it an embryonic or fetal type of aspartic proteinase?
    Adv Exp Med Biol362, 345-348. PubMed  Europe PubMed
  145. 1994
  146. Inokuchi,T., Kobayashi,K. and Horiuchi,S.
    Purification and characterization of cathepsin E type acid proteinase from gastric mucosa of bullfrog, Rana catesbeiana
    J Biochem115, 76-81. PubMed  Europe PubMed
  147. Maric,M.A., Taylor,M.D. and Blum,J.S.
    Endosomal aspartic proteinases are required for invariant-chain processing
    Proc Natl Acad Sci U S A91, 2171-2175. PubMed  Europe PubMed
  148. 1993
  149. Athauda,S.B., Arakawa,H., Nishigai,M., Takahashi,T., Ikai,A. and Takahashi,K.
    Inhibition of cathepsin E by alpha2-macroglobulin and the resulting structural changes in the inhibitor
    J Biochem113, 526-530. PubMed  Europe PubMed
  150. Kageyama,T.
    Rabbit procathepsin E and cathepsin E. Nucleotide sequence of cDNA, hydrolytic specificity for biologically active peptides and gene expression during development
    Eur J Biochem216, 717-728. PubMed  Europe PubMed
  151. Rao,C., Scarborough,P.E., Lowther,W.T., Kay,J., Batley,B., Rapundalo,S., Klutchko,S., Taylor,M.D. and Dunn,B.M.
    Structure-function database for active site binding to the aspartic proteinases
    Adv Exp Med Biol306, 143-147.
  152. Solcia,E., Paulli,M., Silini,E., Fiocca,R., Finzi,G., Kindl,S., Boveri,E., Bosi,F., Cornaggia,M. and Capella,C.
    Cathepsin E in antigen-presenting Langerhans and interdigitating reticulum cells. Its possible role in antigen processing
    Eur J Histochem37, 19-26. PubMed  Europe PubMed
  153. Takeda-Ezaki,M. and Yamamoto,K.
    Isolation and biochemical characterization of procathepsin E from human erythrocyte membranes
    Arch Biochem Biophys304, 352-358. PubMed  Europe PubMed DOI
  154. Tsukuba,T., Hori,H., Azuma,T., Takahashi,T., Taggart,R.T., Akamine,A., Ezaki,M., Nakanishi,H., Sakai,H. and Yamamoto,K.
    Isolation and characterization of recombinant human cathepsin E expressed in Chinese hamster ovary cells
    J Biol Chem268, 7276-7282. PubMed  Europe PubMed
  155. 1992
  156. Azuma,T., Liu,W.G., Vander Laan,D.J., Bowcock,A.M. and Taggart,R.T.
    Human gastric cathepsin E gene. Multiple transcripts result from alternative polyadenylation of the primary transcripts of a single gene locus at 1q31-q32
    J Biol Chem267, 1609-1614. PubMed  Europe PubMed
  157. Bennett,K., Levine,T., Ellis,J.S., Peanasky,R.J., Samloff,I.M., Kay,J. and Chain,B.M.
    Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E
    Eur J Immunol22, 1519-1524. PubMed  Europe PubMed DOI
  158. Kageyama,T., Ichinose,M., Tsukada,S., Miki,K., Kurokawa,K., Koiwai,O., Tanji,M., Yakabe,E., Athauda,S.B. and Takahashi,K.
    Gastric procathepsin E and progastricsin from guinea pig. Purification, molecular cloning of cDNAs, and characterization of enzymatic properties, with special reference to procathepsin E
    J Biol Chem267, 16450-16459. PubMed  Europe PubMed
  159. Robinson,P.S., Lees,W.E., Kay,J. and Cook,N.D.
    Kinetic parameters for the generation of endothelin-1, -2 and -3 by human cathepsin E
    Biochem J284, 407-409. PubMed  Europe PubMed
  160. 1990
  161. Athauda,S.B., Matsuzaki,O., Kageyama,T. and Takahashi,K.
    Structural evidence for two isozymic forms and the carbohydrate attachment site of human gastric cathepsin E
    Biochem Biophys Res Commun168, 878-885. PubMed  Europe PubMed DOI
  162. [YEAR:1-5-1990]Baxter,A., Campbell,C.J., Grinham,C.J., Keane,R.M., Lawton,B.C. and Pendlebury,J.E.
    Substrate and inhibitor studies with human gastric aspartic proteinases
    Biochem J267, 665-669. PubMed  Europe PubMed
  163. [YEAR:29-10-1990]Lees,W.E., Kalinka,S., Meech,J., Capper,S.J., Cook,N.D. and Kay,J.
    Generation of human endothelin by cathepsin E
    FEBS Lett273, 99-102. PubMed  Europe PubMed DOI
  164. 1989
  165. Azuma,T., Pals,G., Mohandas,T.K., Couvreur,J.M. and Taggart,R.T.
    Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases
    J Biol Chem264, 16748-16753. PubMed  Europe PubMed
  166. 1988
  167. Jupp,R.A., Richards,A.D., Kay,J., Dunn,B.M., Wyckoff,J.B., Samloff,I.M. and Yamamoto,K.
    Identification of the aspartic proteinases from human erythrocyte membranes and gastric mucosa (slow-moving proteinase) as catalytically equivalent to cathepsin E
    Biochem J254, 895-898. PubMed  Europe PubMed
  168. Matsuzaki,O. and Takahashi,K.
    Improved purification of slow moving protease from gastric mucosa and its action on the B chain of oxidized bovine insulin
    Biomed Res9, 515-523.
  169. Yamamoto,K., Yamamoto,H., Takeda,M. and Kato,Y.
    An aspartic proteinase of erythrocyte membranes. Proposed mechanism for activation and further molecular properties
    Biol Chem Hoppe Seyler369 Suppl, 315-322. PubMed  Europe PubMed
  170. Yonezawa,S., Fujii,K., Maejima,Y., Tamoto,K., Mori,Y. and Muto,N.
    Further studies on rat cathepsin E: subcellular localization and existence of the active subunit form
    Arch Biochem Biophys267, 176-183. PubMed  Europe PubMed
  171. 1987
  172. Samloff,I.M., Taggart,R.T., Shiraishi,T., Branch,T., Reid,W.A., Heath,R., Lewis,R.W., Valler,M.J. and Kay,J.
    Slow moving proteinase. Isolation, characterization, and immunohistochemical localization in gastric mucosa
    Gastroenterology93, 77-84. PubMed  Europe PubMed
  173. [YEAR:14-10-1987]Yamamoto,K., Ueno,E., Uemura,H. and Kato,Y.
    Biochemical and immunochemical similarity between erythrocyte membrane aspartic proteinase and cathepsin E
    Biochem Biophys Res Commun148, 267-272. PubMed  Europe PubMed
  174. 1986
  175. Takeda,M., Ueno,E., Kato,Y. and Yamamoto,K.
    Isolation, and catalytic and immunochemical properties of cathepsin D-like acid proteinase from rat erythrocytes
    J Biochem100, 1269-1277. PubMed  Europe PubMed
  176. [YEAR:15-1-1986]Tarasova,N.I., Szecsi,P.B. and Foltmann,B.
    An aspartic proteinase from human erythrocytes is immunochemically indistinguishable from a non-pepsin, electrophoretically slow moving proteinase from gastric mucosa
    Biochim Biophys Acta880, 96-100. PubMed  Europe PubMed
  177. 1977
  178. Bowers,W.E., Beyer,C.F. and Yago,N.
    Cathepsin D of mouse leukemia L1210 cells: unusual intracellular localization and biochemical properties
    Biochim Biophys Acta497, 272-279. PubMed  Europe PubMed
  179. 1975
  180. Yago,N. and Bowers,W.E.
    Unique cathepsin D-type proteases in rat thoracic duct lymphocytes and in rat lymphoid tissues
    J Biol Chem250, 4749-4754. PubMed  Europe PubMed
  181. 1970
  182. Keilova,H. and Lapresle,C.
    Inhibition of cathepsin E by diazoacetyl-norleucine methyl ester
    FEBS Lett9, 348-350. PubMed  Europe PubMed  I
  183. 1960
  184. Lapresle,C. and Webb,T.
    Study of a proteolytic enzyme from rabbit spleen
    Biochem J76, 538-543. PubMed  Europe PubMed
  185. 1931
  186. [YEAR:20-9-1931]Northrop,J.H.
    The presence of a gelatin-liquefying enzyme in crude pepsin preparations
    J Gen Physiol15, 29-43. PubMed  Europe PubMed DOI