Family I36

Family

Summary Holotypes Alignment Genomes Structure Literature Architecture

Summary for family I36

Name	Inhibitor family I36 (SMI family)
Family type peptidase	I36.001 - Streptomyces metallopeptidase inhibitor (Streptomyces nigrescens), MEROPS Accession MER0018465 (inhibitor unit: 30-131)
Content of family	Inhibitor family I36 contains an inhibitor of metalloendopeptidases.
History	Identifier created: MEROPS 6.1 (10 January 2003) The Streptomyces metallopeptidase inhibitor (I36.001) was discovered by Oda et al. (1979).
Peptidases inhibited	Peptidases inhibited are in family M4 (Hiraga et al., 1999). Thermolysin (M04.001) was the first peptidase to be found to be inhibited (Oda et al., 1979), but pseudolysin (M04.005) and griselysin (as Streptomyces griseus metalloproteinase II: M04.017) are inhibited still more potently (Seeram et al., 1997).
Mechanism of inhibition	Streptomyces metallopeptidase inhibitor has been reported to interact with metallopeptidases by the Laskowski mechanism (Seeram et al., 1997; Hiraga et al., 1999) that is normally seen with inhibitors of serine peptidases. The reactive site loop is less flexible than those of many serine peptidase inhibitors (Tate et al., 1998). The way in which the components of the enzyme-inhibitor complex interact has been predicted on the basis of their uncomplexed structures (Tate et al., 1998).
Molecular structure	The protein of 102 amino acid residues contains two small disulfide loops (seven and six residues, respectively: Murai et al., 1985). The reactive site bond is in the second of these (Seeram et al., 1997). A high-resolution solution structure shows that the molecule is composed of two beta-sheets, each consisting of four antiparallel beta-strands (Ohno et al., 1998).
Clan	IU

Distribution of family	Bacteria	details
	Archaea	-
	Protozoa	-
	Fungi	-
	Plants	-
	Animals	-
	Viruses	-

Biological functions
Statistics for family I36	Sequences:	2
	Identifiers:	1
	Identifiers with PDB entries:	1
Downloadable files	Sequence library (FastA format)
	Sequence alignment (FastA format)

Other databases	CATH	2.60.20.30
	INTERPRO	IPR001064
	PFAM	PF03995
	SCOP	49713

Inhibitors and Homologues	MEROPS ID	Structure
Streptomyces metallopeptidase inhibitor	I36.001	Yes
Family I36 unassigned peptidases	unassigned	-