Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for subfamily S1A

Summary Distribution Literature

(Topics flags: S Structure, I Inhibitor, P Specificity, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Cheng,Y., Su,J., Jiao,Q., Jia,T. and Hu,X.
    Recent advance on the physiological functions of proteases in chloroplast
    Biochem Biophys Res Commun (2025) 765, 151813-151813. PubMed  Europe PubMed DOI  V
  2. Esen,F. and Turner,C.T.
    Editorial: Roles of granzymes in inflammation, aging, and autoimmunity
    Front Immunol (2025) 16, 1672898-1672898. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Morejon,B. and Michel,K.
    The expanded immunoregulatory protease network in mosquitoes is governed by gene coexpression
    Proc Natl Acad Sci U S A (2025) 122, e2425863122-e2425863122. PubMed  Europe PubMed DOI  K
  4. Solomonov,I., Kollet,O. and Sagi,I.
    Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior
    FEBS J (2025) PubMed  Europe PubMed DOI
    5. 2024
  5. Aubert,A., Jung,K., Hiroyasu,S., Pardo,J. and Granville,D.J.
    Granzyme serine proteases in inflammation and rheumatic diseases
    Nat Rev Rheumatol (2024) 20, 361-376. PubMed  Europe PubMed DOI
  6. Cigalotto,L. and Martinvalet,D.
    Granzymes in health and diseases: the good, the bad and the ugly
    Front Immunol (2024) 15, 1371743-1371743. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Daneva,G.N., Tsiakanikas,P., Adamopoulos,P.G. and Scorilas,A.
    Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer
    Expert Opin Ther Targets (2024) , 1-20. PubMed  Europe PubMed DOI  V
  8. Lin,H., Xu,M., Jiang,L., Yuan,C., Jiang,C., Huang,M., Li,J. and Xu,P.
    Water-medicated specifically targeting the S1 pockets among serine proteases using an arginine analogue
    Bioorg Chem (2024) 152, 107734-107734. PubMed  Europe PubMed DOI
  9. Morejon,B. and Michel,K.
    The expanded immunoregulatory protease network in mosquitoes is governed by gene co-expression
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  10. Sun,J., Liu,C., Wang,L. and Song,L.
    The Establishment of Complement System Is from Gene Duplication and Domain Shuffling
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2023
  11. Gul,I., Abbas,M.N., Kausar,S., Luo,J., Gao,X., Mu,Y., Fan,W. and Cui,H.
    Insight into crustacean cathepsins: Structure-evolutionary relationships and functional roles in physiological processes
    Fish Shellfish Immunol (2023) 139, 108852-108852. PubMed  Europe PubMed DOI  V
    12. 2022
  12. Coban,A., Bornberg-Bauer,E. and Kemena,C.
    Domain Evolution of Vertebrate Blood Coagulation Cascade Proteins
    J Mol Evol (2022) 90, 418-428. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Lee,K.Y., Chau,C.H., Price,D.K. and Figg,W.D.
    Drugging the undruggable: activity-based protein profiling offers opportunities for targeting the KLK activome
    Cancer Biol Ther (2022) 23, 136-138. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Matus,C.E., Ehrenfeld,P. and Figueroa,C.D.
    The family of kallikrein-related peptidases and kinin peptides as modulators of epidermal homeostasis
    Am J Physiol Cell Physiol (2022) 323, C1070-C1070. PubMed  Europe PubMed DOI  V
  15. Morizane,S., Sunagawa,K., Nomura,H. and Ouchida,M.
    Aberrant serine protease activities in atopic dermatitis
    J Dermatol Sci (2022) 107, 2-7. PubMed  Europe PubMed DOI
  16. Nussing,S., Sutton,V.R., Trapani,J.A. and Parish,I.A.
    Beyond target cell death - Granzyme serine proteases in health and disease
    Mol Aspects Med (2022) 88, 101152-101152. PubMed  Europe PubMed DOI  V
  17. Song,Y., Ke,Y., Kang,M. and Bao,R.
    Function, molecular mechanisms, and therapeutic potential of bacterial HtrA proteins: An evolving view
    Comput Struct Biotechnol J (2022) 20, 40-49. PubMed  Europe PubMed DOI  PMC  EPMC  V
  18. Sotiropoulou,G., Zingkou,E. and Pampalakis,G.
    Novel specific activity-based probes validate KLK proteases as druggable targets
    Cancer Biol Ther (2022) 23, 401-403. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Tagirasa,R. and Yoo,E.
    Role of Serine Proteases at the Tumor-Stroma Interface
    Front Immunol (2022) 13, 832418-832418. PubMed  Europe PubMed DOI  PMC  EPMC  V
  20. Zupanic,N., Pocic,J., Leonardi,A., Sribar,J., Kordis,D. and Krizaj,I.
    Serine pseudoproteases in physiology and disease
    FEBS J (2022) PubMed  Europe PubMed DOI  V
    21. 2021
  21. Weiss,S.A.I., Rehm,S.R.T., Perera,N.C., Biniossek,M.L., Schilling,O. and Jenne,D.E.
    Origin and Expansion of the Serine Protease Repertoire in the Myelomonocyte Lineage
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
    22. 2019
  22. Goettig,P., Brandstetter,H. and Magdolen,V.
    Surface loops of trypsin-like serine proteases as determinants of function
    Biochimie (2019) 166, 52-76. PubMed  Europe PubMed DOI  P
    23. 2018
  23. Iqbal,M., Dubey,M., Gudmundsson,M., Viketoft,M., Jensen,D.F. and Karlsson,M.
    Comparative evolutionary histories of fungal proteases reveal gene gains in the mycoparasitic and nematode-parasitic fungus Clonostachys rosea
    BMC Evol Biol (2018) 18, 171-171. PubMed  Europe PubMed DOI  PMC  EPMC
    24. 2017
  24. Premzl,M.
    Comparative genomic analysis of eutherian kallikrein genes
    Mol Genet Metab Rep (2017) 10, 96-99. PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2016
  25. Waldner,B.J., Fuchs,J.E., Huber,R.G., von Grafenstein,S., Schauperl,M., Kramer,C. and Liedl,K.R.
    Quantitative correlation of conformational binding enthalpy with substrate specificity of serine proteases
    J Phys Chem B (2016) 120, 299-308. PubMed  Europe PubMed DOI
    26. 2015
  26. Akula,S., Thorpe,M., Boinapally,V. and Hellman,L.
    Granule associated serine proteases of hematopoietic cells - an analysis of their appearance and diversification during vertebrate evolution
    PLoS ONE (2015) 10, 0143091- PubMed  Europe PubMed DOI
  27. Cao,X., He,Y., Hu,Y., Zhang,X., Wang,Y., Zou,Z., Chen,Y., Blissard,G.W., Kanost,M.R. and Jiang,H.
    Sequence conservation, phylogenetic relationships, and expression profiles of nondigestive serine proteases and serine protease homologs in Manduca sexta
    Insect Biochem Mol Biol (2015) 62, 51-63. PubMed  Europe PubMed DOI
  28. Dias,R.O., Via,A., Brandao,M.M., Tramontano,A. and Silva-Filho,M.C.
    Digestive peptidase evolution in holometabolous insects led to a divergent group of enzymes in Lepidoptera
    Insect Biochem Mol Biol (2015) 58, 1-11. PubMed  Europe PubMed DOI
    29. 2014
  29. Ahmad,J., Bird,P.I. and Kaiserman,D.
    Analysis of the evolution of granule associated serine proteases of immune defence (GASPIDs) suggests a revised nomenclature
    Biol Chem (2014) 395, 1253-1262. PubMed  Europe PubMed DOI
  30. Douaiher,J., Succar,J., Lancerotto,L., Gurish,M.F., Orgill,D.P., Hamilton,M.J., Krilis,S.A. and Stevens,R.L.
    Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing
    Adv Immunol (2014) 122, 211-252. PubMed  Europe PubMed DOI  V
  31. Pustelny,K., Zdzalik,M., Stach,N., Stec-Niemczyk,J., Cichon,P., Czarna,A., Popowicz,G., Mak,P., Drag,M., Salvesen,G.S., Wladyka,B., Potempa,J., Dubin,A. and Dubin,G.
    Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation
    J Biol Chem (2014) 289, 15544-15553. PubMed  Europe PubMed DOI
    32. 2013
  32. Koumandou,V.L. and Scorilas,A.
    Evolution of the plasma and tissue kallikreins, and their alternative splicing isoforms
    PLoS ONE (2013) 8, e68074-e68074. PubMed  Europe PubMed DOI  PMC  EPMC
    33. 2011
  33. Gohara,D.W. and Di Cera,E.
    Allostery in trypsin-like proteases suggests new therapeutic strategies
    Trends Biotechnol (2011) 29, 577-585. PubMed  Europe PubMed DOI
  34. Wahlgren,W.Y., Pal,G., Kardos,J., Porrogi,P., Szenthe,B., Patthy,A., Graf,L. and Katona,G.
    The catalytic aspartate is protonated in the Michaelis complex formed between trypsin and an in vitro evolved substrate-like inhibitor: a refined mechanism of serine protease action
    J Biol Chem (2011) 286, 3587-3596. PubMed  Europe PubMed DOI  S
    35. 2010
  35. Antalis,T.M., Buzza,M.S., Hodge,K.M., Hooper,J.D. and Netzel-Arnett,S.
    The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment
    Biochem J (2010) 428, 325-346. PubMed  Europe PubMed DOI  V
  36. Anthony,D.A., Andrews,D.M., Watt,S.V., Trapani,J.A. and Smyth,M.J.
    Functional dissection of the granzyme family: cell death and inflammation
    Immunol Rev (2010) 235, 73-92. PubMed  Europe PubMed DOI  V
  37. Trivedi,N.N. and Caughey,G.H.
    Mast cell peptidases: chameleons of innate immunity and host defense
    Am J Respir Cell Mol Biol (2010) 42, 257-267. PubMed  Europe PubMed DOI
    38. 2009
  38. Bugge,T.H., Antalis,T.M. and Wu,Q.
    Type II transmembrane serine proteases
    J Biol Chem (2009) 284, 23177-23181. PubMed  Europe PubMed DOI  PMC  EPMC  V
    39. 2008
  39. Jang,I.H., Nam,H.J. and Lee,W.J.
    CLIP-domain serine proteases in Drosophila innate immunity
    BMB Rep (2008) 41, 102-107. PubMed  Europe PubMed
  40. Lundwall,A. and Brattsand,M.
    Kallikrein-related peptidases
    Cell Mol Life Sci (2008) 65, 2019-2038. PubMed  Europe PubMed DOI
  41. Schmidt,A.E., Sun,M.F., Ogawa,T., Bajaj,S.P. and Gailani,D.
    Functional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa
    Biochemistry (2008) 47, 1326-1335. PubMed  Europe PubMed DOI
  42. Shah,P.K., Tripathi,L.P., Jensen,L.J., Gahnim,M., Mason,C., Furlong,E.E., Rodrigues,V., White,K.P., Bork,P. and Sowdhamini,R.
    Enhanced function annotations for Drosophila serine proteases: a case study for systematic annotation of multi-member gene families
    Gene (2008) 407, 199-215. PubMed  Europe PubMed DOI
    43. 2007
  43. [YEAR:1-2-2007]Xu,H., Shan,J., Jurukovski,V., Yuan,L., Li,J. and Tian,K.
    TSP50 encodes a testis-specific protease and is negatively regulated by p53
    Cancer Res (1-2-2007) 67, 1239-1245. PubMed  Europe PubMed DOI
    44. 2006
  44. Srinivasan,A., Giri,A.P. and Gupta,V.S.
    Structural and functional diversities in lepidopteran serine proteases
    Cell Mol Biol Lett (2006) 11, 132-154. PubMed  Europe PubMed DOI
    45. 2005
  45. Page,M.J., MacGillivray,R.T. and Di Cera,E.
    Determinants of specificity in coagulation proteases
    J Thromb Haemost (2005) 3, 2401-2408. PubMed  Europe PubMed DOI
  46. Zamolodchikova,T.S., Smirnova,E.V., Andrianov,A.N., Kashparov,I.V., Kotsareva,O.D., Sokolova,E.A., Ignatov,K.B. and Pemberton,A.D.
    Cloning and molecular modeling of duodenase with respect to evolution of substrate specificity within mammalian serine proteases that have lost a conserved active-site disulfide bond
    Biochemistry (Mosc) (2005) 70, 672-684. PubMed  Europe PubMed DOI
    47. 2004
  47. Castro,H.C., Zingali,R.B., Albuquerque,M.G., Pujol-Luz,M. and Rodrigues,C.R.
    Snake venom thrombin-like enzymes: from reptilase to now
    Cell Mol Life Sci (2004) 61, 843-856. PubMed  Europe PubMed DOI
  48. Clements,J.A., Willemsen,N.M., Myers,S.A. and Dong,Y.
    The tissue kallikrein family of serine proteases: functional roles in human disease and potential as clinical biomarkers
    Crit Rev Clin Lab Sci (2004) 41, 265-312. PubMed  Europe PubMed DOI
  49. Olsson,A.Y., Lilja,H. and Lundwall,A.
    Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen
    Genomics (2004) 84, 147-156. PubMed  Europe PubMed DOI
    50. 2003
  50. [YEAR:13-5-2003]Bergstrom,R.C., Coombs,G.S., Ye,S., Madison,E.L., Goldsmith,E.J. and Corey,D.R.
    Binding of nonphysiological protein and peptide substrates to proteases: differences between urokinase-type plasminogen activator and trypsin and contributions to the evolution of regulated proteolysis
    Biochemistry (13-5-2003) 42, 5395-5402. PubMed  Europe PubMed DOI
  51. Grossman,W.J., Revell,P.A., Lu,Z.H., Johnson,H., Bredemeyer,A.J. and Ley,T.J.
    The orphan granzymes of humans and mice
    Curr Opin Immunol (2003) 15, 544-552. PubMed  Europe PubMed DOI  V
  52. Netzel-Arnett,S., Hooper,J.D., Szabo,R., Madison,E.L., Quigley,J.P., Bugge,T.H. and Antalis,T.M.
    Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer
    Cancer Metastasis Rev (2003) 22, 237-258. PubMed  Europe PubMed DOI  V
  53. Szabo,R., Wu,Q., Dickson,R.B., Netzel-Arnett,S., Antalis,T.M. and Bugge,T.H.
    Type II transmembrane serine proteases
    Thromb Haemost (2003) 90, 185-193. PubMed  Europe PubMed DOI  V
    54. 2002
  54. [YEAR:25-10-2002]Krem,M.M., Prasad,S. and Di Cera,E.
    Ser(214) is crucial for substrate binding to serine proteases
    J Biol Chem (25-10-2002) 277, 40260-40264. PubMed  Europe PubMed DOI
    55. 2001
  55. Nakao,M., Osaka,K., Kato,Y., Fujiki,K. and Yano,T.
    Molecular cloning of the complement C1r/C1s/MASP2-like serine proteases from the common carp (Cyprinus carpio)
    Immunogenetics (2001) 52, 255-263. PubMed  Europe PubMed DOI
    56. 2000
  56. [YEAR:17-10-2000]Gan,L., Lee,I., Smith,R., Argonza-Barrett,R., Lei,H., McCuaig,J., Moss,P., Paeper,B. and Wang,K.
    Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region
    Gene (17-10-2000) 257, 119-130. PubMed  Europe PubMed DOI
  57. [YEAR:1-12-2000]Harvey,T.J., Hooper,J.D., Myers,S.A., Stephenson,S.A., Ashworth,L.K. and Clements,J.A.
    Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4
    J Biol Chem (1-12-2000) 275, 37397-37406. PubMed  Europe PubMed DOI
  58. Jiang,H. and Kanost,M.R.
    The clip-domain family of serine proteinases in arthropods
    Insect Biochem Mol Biol (2000) 30, 95-105. PubMed  Europe PubMed DOI
  59. [YEAR:7-3-2000]Kam,C.M., Hudig,D. and Powers,J.C.
    Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors
    Biochim Biophys Acta (7-3-2000) 1477, 307-323. PubMed  Europe PubMed DOI  V
  60. Krem,M.M., Rose,T. and Di Cera,E.
    Sequence determinants of function and evolution in serine proteases
    Trends Cardiovasc Med (2000) 10, 171-176. PubMed  Europe PubMed DOI
  61. [YEAR:7-3-2000]Matsui,T., Fujimura,Y. and Titani,K.
    Snake venom proteases affecting hemostasis and thrombosis
    Biochim Biophys Acta (7-3-2000) 1477, 146-156. PubMed  Europe PubMed DOI
  62. Poorafshar,M., Aveskogh,M., Munday,B. and Hellman,L.
    Identification and structural analysis of four serine proteases in a monotreme, the platypus, Ornithorhynchus anatinus
    Immunogenetics (2000) 52, 19-28. PubMed  Europe PubMed DOI
  63. [YEAR:16-9-2000]Yousef,G.M., Chang,A., Scorilas,A. and Diamandis,E.P.
    Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4
    Biochem Biophys Res Commun (16-9-2000) 276, 125-133. PubMed  Europe PubMed DOI
    64. 1998
  64. Baptista,A.M., Jonson,P.H., Hough,E. and Petersen,S.B.
    The origin of trypsin: Evidence for multiple gene duplications in trypsins
    J Mol Evol (1998) 47, 353-362. PubMed  Europe PubMed DOI
  65. Matsushita,M., Endo,Y., Nonaka,M. and Fujita,T.
    Complement-related serine proteases in tunicates and vertebrates
    Curr Opin Immunol (1998) 10, 29-35. PubMed  Europe PubMed DOI
  66. Takeda-Shitaka,M. and Umeyama,H.
    Effect of exceptional valine replacement for highly conserved alanine-55 on the catalytic site structure of chymotrypsin-like serine protease
    Chem Pharm Bull (Tokyo) (1998) 46, 1343-1348. PubMed  Europe PubMed
  67. [YEAR:3-4-1998]Takeda-Shitaka,M. and Umeyama,H.
    Elucidation of the cause for reduced activity of abnormal human plasmin containing an Ala55-Thr mutation: Importance of highly conserved Ala55 in serine proteases
    FEBS Lett (3-4-1998) 425, 448-452. PubMed  Europe PubMed DOI
    68. 1997
  68. Chen,L., DeVries,A.L. and Cheng,C.H.
    Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish
    Proc Natl Acad Sci U S A (1997) 94, 3811-3816. PubMed  Europe PubMed DOI  PMC  EPMC
  69. Ji,X., Azumi,K., Sasaki,M. and Nonaka,M.
    Ancient origin of the complement lectin pathway revealed by molecular cloning of mannan binding protein-associated serine protease from a urochordate, the Japanese ascidian, Halocynthia roretzi
    Proc Natl Acad Sci U S A (1997) 94, 6340-6345. PubMed  Europe PubMed DOI  PMC  EPMC
  70. Roach,J.C., Wang,K., Gan,L. and Hood,L.
    The molecular evolution of the vertebrate trypsinogens
    J Mol Evol (1997) 45, 640-652. PubMed  Europe PubMed DOI
    71. 1996
  71. [YEAR:1-10-1996]Dang,Q.D. and Di Cera,E.
    Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases
    Proc Natl Acad Sci U S A (1-10-1996) 93, 10653-10656. PubMed  Europe PubMed DOI  PMC  EPMC
    72. 1995
  72. Male,R., Lorens,J.B., Smalas,A.O. and Torrissen,K.R.
    Molecular cloning and characterization of anionic and cationic variants of trypsin from Atlantic salmon
    Eur J Biochem (1995) 232, 677-685. PubMed  Europe PubMed DOI
    73. 1994
  73. Huang,R. and Hellman,L.
    Genes for mast-cell serine protease and their molecular evolution
    Immunogenetics (1994) 40, 397-414. PubMed  Europe PubMed
  74. Rypniewski,W.R., Perrakis,A., Vorgias,C.E. and Wilson,K.S.
    Evolutionary divergence and conservation of trypsin
    Protein Eng (1994) 7, 57-64. PubMed  Europe PubMed
    75. 1993
  75. Patthy,L.
    Modular design of proteases of coagulation, fibrinolysis, and complement activation: implications for protein engineering and structure-function studies
    Methods Enzymol (1993) 222, 10-21. PubMed  Europe PubMed DOI  V
  76. [YEAR:1-10-1993]Perkins,S.J. and Smith,K.F.
    Identity of the putative serine-proteinase fold in proteins of the complement system with nine relevant crystal structures
    Biochem J (1-10-1993) 295, 109-114. PubMed  Europe PubMed  PMC  EPMC  S
    77. 1991
  77. Klemm,U., Flake,A. and Engel,W.
    Rat sperm acrosin: cDNA sequence, derived primary structure and phylogenetic origin
    Biochim Biophys Acta (1991) 1090, 270-272. PubMed  Europe PubMed DOI
  78. Salvesen,G. and Enghild,J.J.
    Zymogen activation specificity and genomic structures of human neutrophil elastase and cathepsin G reveal a new branch of the chymotrypsinogen superfamily of serine proteinases
    Biomed Biochim Acta (1991) 50, 665-671. PubMed  Europe PubMed
    79. 1960
  79. Sanger,F. and Shaw,D.C.
    Amino-acid sequence about the reactive serine of a proteolytic enzyme from Bacillus subtilis
    Nature (1960) 187, 872-873. PubMed  Europe PubMed DOI  I

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use