Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 6x3s
Q-score: 0.531
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with bicuculline (Complex from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- (5s)-6,6-dimethyl-5-[(6r)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium (382 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Gamma-aminobutyric acid type a receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6x3u
Q-score: 0.462
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and flumazenil (Complex)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate (303 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus phenobarbital
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6x3w
Q-score: 0.528
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and phenobarbital (Complex)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- 5-ethyl-5-phenylpyrimidine-2,4,6(1h,3h,5h)-trione (232 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 6x3z
Q-score: 0.497
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba (Complex from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
Human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 6pv7
Q-score: 0.501
Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh Jr RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE
Neuron (2019) 104 pp. 501- [ Pubmed: 31488329 DOI: doi:10.1016/j.neuron.2019.07.030 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- (s)-3-(1-methylpyrrolidin-2-yl)pyridine (162 Da, Ligand)
- Neuronal acetylcholine receptor subunit alpha-3 (Complex)
- Kappa fab light chain (23 kDa, Protein from house mouse)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Igg2b/kappa antibody (Complex)
- Human alpha3beta4 nicotinic acetylcholine receptor (Complex)
- Fusion protein of neuronal acetylcholine receptor subunit alpha-3 and soluble cytochrome b562 (60 kDa, Protein from Homo sapiens)
- Neuronal acetylcholine receptor subunit beta-4 (Complex)
- Fusion protein of neuronal acetylcholine receptor subunit beta-4 and soluble cytochrome b562 (61 kDa, Protein from Homo sapiens)
- Igg2b fab heavy chain (23 kDa, Protein from house mouse)
- Water (18 Da, Ligand)
- Igg2b heavy chain (Complex)
- Human alpha3beta4 nicotinic receptor in complex with fab fragments and bound to nicotine (Complex from Homo sapiens)
- Nonane (128 Da, Ligand)
- Kappa fab light chain (Complex)
Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 6pv8
Q-score: 0.416
Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh Jr RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE
Neuron (2019) 104 pp. 501- [ Pubmed: 31488329 DOI: doi:10.1016/j.neuron.2019.07.030 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Neuronal acetylcholine receptor subunit alpha-3 (Complex)
- Kappa fab light chain (23 kDa, Protein from house mouse)
- Sodium ion (22 Da, Ligand)
- Igg2b/kappa antibody (Complex)
- Human alpha3beta4 nicotinic acetylcholine receptor (Complex)
- Fusion protein of neuronal acetylcholine receptor subunit alpha-3 and soluble cytochrome b562 (60 kDa, Protein from Homo sapiens)
- Neuronal acetylcholine receptor subunit beta-4 (Complex)
- Fusion protein of neuronal acetylcholine receptor subunit beta-4 and soluble cytochrome b562 (61 kDa, Protein from Homo sapiens)
- Igg2b fab heavy chain (23 kDa, Protein from house mouse)
- (3-endo)-n-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine (309 Da, Ligand)
- Human alpha3beta4 nicotinic receptor in complex with fab fragments and bound to at-1001 (Complex from Homo sapiens)
- Igg2b heavy chain (Complex)
- Water (18 Da, Ligand)
- Kappa fab light chain (Complex)