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Yang Y, Shi Y, Schweighauser M, Zhang X, Kotecha A, Murzin AG, Garringer HJ, Cullinane PW, Saito Y, Foroud T, Warner TT, Hasegawa K, Vidal R, Murayama S, Revesz T, Ghetti B, Hasegawa M, Lashley T, Scheres SHW, Goedert M
Nature (2022) 610 pp. 791-795 [ Pubmed: 36108674 DOI: 10.1038/s41586-022-05319-3 ]
Image sets:
Resolution: 2.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 8a9l
Q-score: 0.653
Yang Y, Shi Y, Schweighauser M, Zhang X, Kotecha A, Murzin AG, Garringer HJ, Cullinane PW, Saito Y, Foroud T, Warner TT, Hasegawa K, Vidal R, Murayama S, Revesz T, Ghetti B, Hasegawa M, Lashley T, Scheres SHW, Goedert M
Nature (2022) 610 pp. 791-795 [ DOI: doi:10.1038/s41586-022-05319-3 Pubmed: 36108674 ]
- Alpha-synuclein filaments extracted from the human brain with pd, pdd, and dlb (Tissue from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from human)
- Unknown fragment (627 Da, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Unknown fragment (783 Da, Protein from Homo sapiens)
Cryo-EM reconstruction of TMEM106B fold I-d filaments from case 18 with multiple system atrophy
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lövestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ Pubmed: 35344985 DOI: 10.1038/s41586-022-04650-z ]
Image sets:
TMEM106B filaments with Fold I from Alzheimer's disease (case 1)
Resolution: 2.64 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qvc
Q-score: 0.617
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ DOI: doi:10.1038/s41586-022-04650-z Pubmed: 35344985 ]
- Tmem106b (Tissue from Homo sapiens)
- Transmembrane protein 106b (31 kDa, Protein from human)
TMEM106B filaments with Fold I-d from Multiple system atrophy (case 18)
Resolution: 3.64 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qvf
Q-score: 0.469
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ DOI: doi:10.1038/s41586-022-04650-z Pubmed: 35344985 ]
- Tmem106b (Tissue from Homo sapiens)
- Transmembrane protein 106b (31 kDa, Protein from human)
TMEM106B filaments with Fold IIa from Multiple system atrophy (case 19)
Resolution: 3.38 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qwg
Q-score: 0.53
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ DOI: doi:10.1038/s41586-022-04650-z Pubmed: 35344985 ]
- Tmem106b (Tissue from Homo sapiens)
- Transmembrane protein 106b (31 kDa, Protein from human)
TMEM106B filaments with Fold IIb from Multiple system atrophy (case 19)
Resolution: 3.47 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qwl
Q-score: 0.513
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ DOI: doi:10.1038/s41586-022-04650-z Pubmed: 35344985 ]
- Tmem106b (Tissue from Homo sapiens)
- Transmembrane protein 106b (31 kDa, Protein from human)
TMEM106B filaments with Fold III from Multiple system atrophy (case 17)
Resolution: 2.76 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qwm
Q-score: 0.671
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ DOI: doi:10.1038/s41586-022-04650-z Pubmed: 35344985 ]
- Tmem106b (Tissue from Homo sapiens)
- Transmembrane protein 106b (31 kDa, Protein from human)
Resolution: 3.47 Å
EM Method: Helical reconstruction
Fitted PDBs: 7nca
Q-score: 0.559
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ Pubmed: 33548114 DOI: doi:10.1002/2211-5463.13110 ]
- Alpha synuclein filament (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
Resolution: 3.43 Å
EM Method: Helical reconstruction
Fitted PDBs: 7ncg
Q-score: 0.494
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ Pubmed: 33548114 DOI: doi:10.1002/2211-5463.13110 ]
- Alpha synuclein filament (Complex from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)