Sci Adv (2023) 9 [ Pubmed: 37595043 DOI: 10.1126/sciadv.adg8190 ]
Image sets:
- Unalinged multi-frame micrographs of Hypopseudouridylated yeast 80S bound with TSV-IRES RNA [termination complex]
- Unalinged multi-frame micrographs of Hypopseudouridylated yeast 80S bound with TSV-IRES RNA [sordarin bound translocation complex]
- Unalinged multi-frame micrographs of Hypopseudouridylated yeast 80S bound with TSV-IRES RNA [initiation complex]
Cryo-EM structure of guide RNA and target RNA bound Cas7-11
Goswami HN, Rai J, Das A, Li H
eLife (2022) 11 [ DOI: 10.7554/elife.81678 Pubmed: 36190192 ]
Image sets:
Human TPC2 in Complex with Antagonist (S)-SG-094
Chi G, Jaslan D, Kudrina V, Bock J, Li H, Pike ACW, Rautenberg S, Krogsaeter E, Bohstedt T, Wang D, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Keller M, Bracher F, Grimm C, Durr KL
Structure (2024) [ DOI: doi:10.1016/j.str.2024.05.005 Pubmed: 38815576 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Two pore channel protein 2 (85 kDa, Protein from Homo sapiens)
- Homodimeric complex of human two-pore channel 2 (tpc2) (150 kDa, Complex from Homo sapiens)
- Di-heneicosanoyl phosphatidyl choline (875 Da, Ligand)
- 2-{[(4-o-alpha-d-glucopyranosyl-alpha-d-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25r)-spirost-5-en-3-yl]oxy}butyl 4-o-alpha-d-glucopyranosyl-alpha-d-glucopyranoside (1 kDa, Ligand)
- (1s)-6-methoxy-2-methyl-7-phenoxy-1-[(4-phenoxyphenyl)methyl]-3,4-dihydro-1h-isoquinoline (451 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phoshocholine (734 Da, Ligand)
Human TPC2 in Complex withAntagonist (R)-SG-094
Chi G, Jaslan D, Kudrina V, Bock J, Li H, Pike ACW, Rautenberg S, Krogsaeter E, Bohstedt T, Wang D, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Keller M, Bracher F, Grimm C, Durr KL
Structure (2024) [ DOI: doi:10.1016/j.str.2024.05.005 Pubmed: 38815576 ]
Cryo-EM structure of human gamma-secretase in complex with Abeta49
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8x52
Q-score: 0.464
Guo X, Li H, Yan C, Lei J, Zhou R, Shi Y
Science (2024) 384 pp. 1091-1095 [ Pubmed: 38843321 DOI: doi:10.1126/science.adn5820 ]
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Amyloid-beta precursor protein (13 kDa, Protein from Homo sapiens)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Human gamma-secretase in complex with abeta49 (Complex from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human gamma-secretase in complex with Abeta46
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8x53
Q-score: 0.509
Guo X, Li H, Yan C, Lei J, Zhou R, Shi Y
Science (2024) 384 pp. 1091-1095 [ Pubmed: 38843321 DOI: doi:10.1126/science.adn5820 ]
- Nicastrin (78 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Amyloid-beta precursor protein (4 kDa, Protein from Homo sapiens)
- Human gamma-secretase in complex with abeta46 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Gamma-secretase subunit pen-2 (16 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human gamma-secretase in complex with APP-C99
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8x54
Q-score: 0.518
Guo X, Li H, Yan C, Lei J, Zhou R, Shi Y
Science (2024) 384 pp. 1091-1095 [ Pubmed: 38843321 DOI: doi:10.1126/science.adn5820 ]
- Human gamma-secretase in complex with app-c99 (Complex from Homo sapiens)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Amyloid-beta precursor protein (13 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human gamma-secretase in complex with Abeta43
Cryo-EM map of human clmap-clamp loader ATAD5-RFC-gapped PCNA complex in intermediate state 3
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8ui7
Q-score: 0.229
Wang F, He Q, Yao NY, O'Donnel ME, Li H
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01332-4 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Replication factor c subunit 2 (39 kDa, Protein from Homo sapiens)
- Atpase family aaa domain-containing protein 5 (116 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Replication factor c subunit 4 (39 kDa, Protein from Homo sapiens)
- Replication factor c subunit 5 (38 kDa, Protein from Homo sapiens)
- Atad5-rfc-gapped pcna (320 kDa, Complex from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Replication factor c subunit 3 (40 kDa, Protein from Homo sapiens)
Cryo-EM map of human clamp-clamp loader ATAD5-RFC-two PCNAs complex in intermediate state 3
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8ui8
Q-score: 0.464
Wang F, He Q, Yao NY, O'Donnel ME, Li H
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01332-4 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atpase family aaa domain-containing protein 5 (116 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Atad5-rfc-closed pcna (320 kDa, Complex from Homo sapiens)
- Replication factor c subunit 4 (39 kDa, Protein from Homo sapiens)
- Replication factor c subunit 5 (38 kDa, Protein from Homo sapiens)
- Replication factor c subunit 2 (39 kDa, Protein from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Replication factor c subunit 3 (40 kDa, Protein from Homo sapiens)