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EMD-17197
Human TPC2 in Complex with Antagonist (S)-SG-094
EMD-17197
Single-particle3.0 Å
Deposition: 24/04/2023Map released: 12/06/2024
Last modified: 02/07/2025
Sample Organism:
Homo sapiens
Sample: Homodimeric complex of human Two-pore channel 2 (TPC2)
Fitted models: 8ouo
Deposition Authors: Chi G
,
Pike ACW,
Maclean EM,
Li H ,
Mukhopadhyay SMM,
Bohstedt T ,
Wang D,
McKinley G,
Fernandez-Cid A,
Duerr K
Sample: Homodimeric complex of human Two-pore channel 2 (TPC2)
Fitted models: 8ouo
Deposition Authors: Chi G
,
Pike ACW,
Maclean EM,
Li H ,
Mukhopadhyay SMM,
Bohstedt T ,
Wang D,
McKinley G,
Fernandez-Cid A,
Duerr K
Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist.
Chi G ,
Jaslan D ,
Kudrina V ,
Bock J,
Li H ,
Pike ACW,
Rautenberg S,
Krogsaeter E,
Bohstedt T ,
Wang D,
McKinley G,
Fernandez-Cid A,
Mukhopadhyay SMM,
Burgess-Brown NA,
Keller M ,
Bracher F,
Grimm C,
Durr KL
(2024) Structure , 32 , 1137 - 1149.e4
,
Jaslan D ,
Kudrina V ,
Bock J,
Li H ,
Pike ACW,
Rautenberg S,
Krogsaeter E,
Bohstedt T ,
Wang D,
McKinley G,
Fernandez-Cid A,
Mukhopadhyay SMM,
Burgess-Brown NA,
Keller M ,
Bracher F,
Grimm C,
Durr KL
(2024) Structure , 32 , 1137 - 1149.e4
Grant Support:
- Wellcome Trust: (United Kingdom)