T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor CT1
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8gcc
Q-score: 0.574
Rao SPS, Gould MK, Noeske J, Saldivia M, Jumani RS, Ng PS, Rene O, Chen YL, Kaiser M, Ritchie R, Francisco AF, Johnson N, Patra D, Cheung H, Deniston C, Schenk AD, Cortopassi WA, Schmidt RS, Wiedemar N, Thomas B, Palkar R, Ghafar NA, Manoharan V, Luu C, Gable JE, Wan KF, Myburgh E, Mottram JC, Barnes W, Walker J, Wartchow C, Aziz N, Osborne C, Wagner J, Sarko C, Kelly JM, Manjunatha UH, Maeser P, Jiricek J, Lakshminarayana SB, Barrett MP, Diagana TT
Science (2023) 380 pp. 1349-1356 [ Pubmed: 37384702 DOI: doi:10.1126/science.adh0614 ]
- Topoisomerase ii alpha bound to dsdna and inhibitor ct1 (Complex from Trypanosoma cruzi)
- 2-{3-[(z)-iminomethyl]-1h-1,2,4-triazol-1-yl}-1-{(3m)-3-[2-(trifluoromethyl)phenyl]-6h-pyrrolo[3,4-b]pyridin-6-yl}ethan-1-one (398 Da, Ligand)
- Dna topoisomerase 2 (89 kDa, Protein from Trypanosoma cruzi strain CL Brener)
- Topoisomerase ii alpha (Complex from Trypanosoma cruzi)
- Dna (28-mer) (8 kDa, DNA from Escherichia coli)
- Dsdna (Complex from Escherichia coli)
Leishmania tarentolae proteasome 20S subunit in complex with compound 2
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7zyj
Q-score: 0.565
Koester DC, Marx VM, Williams S, Jiricek J, Dauphinais M, Rene O, Miller SL, Zhang L, Patra D, Chen YL, Cheung H, Gable J, Lakshminarayana SB, Osborne C, Galarneau JR, Kulkarni U, Richmond W, Bretz A, Xiao L, Supek F, Wiesmann C, Honnappa S, Be C, Maser P, Kaiser M, Ritchie R, Barrett MP, Diagana TT, Sarko C, Rao SPS
J Med Chem (2022) 65 pp. 11776-11787 [ DOI: doi:10.1021/acs.jmedchem.2c00791 Pubmed: 35993839 ]
- Proteasome alpha 7 subunit, putative (25 kDa, Protein from Leishmania tarentolae)
- Proteasome alpha 5 subunit, putative (38 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (22 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (22 kDa, Protein from Leishmania tarentolae)
- ~{n}-cyclopentyl-6-methyl-4-phenylazanyl-quinoline-2-carboxamide (345 Da, Ligand)
- Proteasome (840 kDa, Complex from Leishmania tarentolae)
- Proteasome subunit beta (23 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
- Proteasome alpha 1 subunit, putative (47 kDa, Protein from Leishmania tarentolae)
- Proteasome beta 6 subunit, putative (37 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
ACE2 -Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7v61
Q-score: 0.366
Chen Y, Zhang YN, Yan R, Wang G, Zhang Y, Zhang ZR, Li Y, Ou J, Chu W, Liang Z, Wang Y, Chen YL, Chen G, Wang Q, Zhou Q, Zhang B, Wang C
Signal Transduct Target Ther (2021) 6 pp. 315-315 [ DOI: doi:10.1038/s41392-021-00740-y Pubmed: 34433803 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 3e8 (49 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sodium-dependent neutral amino acid transporter b(0)at1 (73 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2 (93 kDa, Protein from Homo sapiens)
- Ace2-b0at1 complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- 3e8 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of the B dENE construct complexed with a 28-mer poly(A)
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 7ljy
Q-score: 0.13
Torabi SF, Chen YL, Zhang K, Wang J, DeGregorio SJ, Vaidya AT, Su Z, Pabit SA, Chiu W, Pollack L, Steitz JA
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2026656118 Pubmed: 33785601 ]
- Poly(a) (9 kDa, RNA from synthetic construct)
- B dene construct (24 kDa, RNA from Oryza sativa)
- Dene construct complexed with a 28-mer poly(a) (33 kDa, Complex from Oryza sativa)
Leishmania tarentolae proteasome 20S subunit complexed with LXE408
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6tcz
Q-score: 0.514
Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, Sciotti RJ, Pybus B, Kreishman-Deitrick M, Bursulaya B, Lai YH, Gao MY, Liang F, Mathison CJN, Liu X, Yeh V, Smith J, Lerario I, Xie Y, Chianelli D, Gibney M, Berman A, Chen YL, Jiricek J, Davis LC, Liu X, Ballard J, Khare S, Eggimann FK, Luneau A, Groessl T, Shapiro M, Richmond W, Johnson K, Rudewicz PJ, Rao SPS, Thompson C, Tuntland T, Spraggon G, Glynne RJ, Supek F, Wiesmann C, Molteni V
J Med Chem (2020) 63 pp. 10773-10781 [ DOI: doi:10.1021/acs.jmedchem.0c00499 Pubmed: 32667203 ]
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (30 kDa, Protein from Leishmania donovani)
- ~{n}-[4-fluoranyl-3-[6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide (443 Da, Ligand)
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (38 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (37 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (33 kDa, Protein from Leishmania donovani)
- Proteasome subunit family protein (23 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (47 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (27 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (22 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (27 kDa, Protein from Leishmania donovani)
- Leishmania tarentolae proteasome 20s subunit complex (Complex from Leishmania donovani)
Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6td5
Q-score: 0.512
Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, Sciotti RJ, Pybus B, Kreishman-Deitrick M, Bursulaya B, Lai YH, Gao MY, Liang F, Mathison CJN, Liu X, Yeh V, Smith J, Lerario I, Xie Y, Chianelli D, Gibney M, Berman A, Chen YL, Jiricek J, Davis LC, Liu X, Ballard J, Khare S, Eggimann FK, Luneau A, Groessl T, Shapiro M, Richmond W, Johnson K, Rudewicz PJ, Rao SPS, Thompson C, Tuntland T, Spraggon G, Glynne RJ, Supek F, Wiesmann C, Molteni V
J Med Chem (2020) 63 pp. 10773-10781 [ DOI: doi:10.1021/acs.jmedchem.0c00499 Pubmed: 32667203 ]
- ~{n}-[4-fluoranyl-3-[6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide (443 Da, Ligand)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (38 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (22 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania donovani)
- Leishmania tarentolae proteasome 20s subunit complexed with lxe408 and bortezomib (Complex from Leishmania donovani)
- Proteasome endopeptidase complex (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit family protein (23 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (37 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (47 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (27 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (22 kDa, Protein from Leishmania donovani)
- N-[(1r)-1-(dihydroxyboryl)-3-methylbutyl]-n-(pyrazin-2-ylcarbonyl)-l-phenylalaninamide (384 Da, Ligand)