EMD-15025
Leishmania tarentolae proteasome 20S subunit in complex with compound 2
EMD-15025
Single-particle2.7 Å
Deposition: 24/05/2022Map released: 28/09/2022
Last modified: 24/07/2024
Sample Organism:
Leishmania tarentolae
Sample: Proteasome
Fitted models: 7zyj
Deposition Authors: Srinivas H
Sample: Proteasome
Fitted models: 7zyj
Deposition Authors: Srinivas H
Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT).
Koester DC 
,
Marx VM,
Williams S,
Jiricek J,
Dauphinais M,
Rene O,
Miller SL ,
Zhang L,
Patra D,
Chen YL,
Cheung H,
Gable J,
Lakshminarayana SB,
Osborne C,
Galarneau JR,
Kulkarni U,
Richmond W,
Bretz A ,
Xiao L,
Supek F,
Wiesmann C,
Honnappa S,
Be C,
Maser P,
Kaiser M ,
Ritchie R,
Barrett MP,
Diagana TT,
Sarko C,
Rao SPS
(2022) J Med Chem , 65 , 11776 - 11787
,
Marx VM,
Williams S,
Jiricek J,
Dauphinais M,
Rene O,
Miller SL ,
Zhang L,
Patra D,
Chen YL,
Cheung H,
Gable J,
Lakshminarayana SB,
Osborne C,
Galarneau JR,
Kulkarni U,
Richmond W,
Bretz A ,
Xiao L,
Supek F,
Wiesmann C,
Honnappa S,
Be C,
Maser P,
Kaiser M ,
Ritchie R,
Barrett MP,
Diagana TT,
Sarko C,
Rao SPS
(2022) J Med Chem , 65 , 11776 - 11787
Grant Support: