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EMD-15025
Leishmania tarentolae proteasome 20S subunit in complex with compound 2
EMD-15025
Single-particle2.7 Å
Deposition: 24/05/2022Map released: 28/09/2022
Last modified: 24/07/2024
Sample Organism:
Leishmania tarentolae
Sample: Proteasome
Fitted models: 7zyj
Deposition Authors: Srinivas H
Sample: Proteasome
Fitted models: 7zyj
Deposition Authors: Srinivas H
Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT).
Koester DC 
,
Marx VM,
Williams S,
Jiricek J,
Dauphinais M,
Rene O,
Miller SL,
Zhang L,
Patra D,
Chen YL,
Cheung H,
Gable J,
Lakshminarayana SB,
Osborne C,
Galarneau JR,
Kulkarni U,
Richmond W,
Bretz A ,
Xiao L,
Supek F,
Wiesmann C,
Honnappa S,
Be C,
Maser P,
Kaiser M ,
Ritchie R,
Barrett MP,
Diagana TT,
Sarko C,
Rao SPS
(2022) J Med Chem , 65 , 11776 - 11787
,
Marx VM,
Williams S,
Jiricek J,
Dauphinais M,
Rene O,
Miller SL,
Zhang L,
Patra D,
Chen YL,
Cheung H,
Gable J,
Lakshminarayana SB,
Osborne C,
Galarneau JR,
Kulkarni U,
Richmond W,
Bretz A ,
Xiao L,
Supek F,
Wiesmann C,
Honnappa S,
Be C,
Maser P,
Kaiser M ,
Ritchie R,
Barrett MP,
Diagana TT,
Sarko C,
Rao SPS
(2022) J Med Chem , 65 , 11776 - 11787
Grant Support: