EMD-10462
Leishmania tarentolae proteasome 20S subunit complexed with LXE408
EMD-10462
Single-particle3.4 Å
Deposition: 07/11/2019Map released: 26/08/2020
Last modified: 22/05/2024
Sample Organism:
Leishmania donovani
Sample: Leishmania tarentolae proteasome 20S subunit complex
Fitted models: 6tcz
Deposition Authors: Srinivas H
Sample: Leishmania tarentolae proteasome 20S subunit complex
Fitted models: 6tcz
Deposition Authors: Srinivas H
Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.
Nagle A 
,
Biggart A,
Be C,
Srinivas H,
Hein A,
Caridha D,
Sciotti RJ,
Pybus B,
Kreishman-Deitrick M,
Bursulaya B,
Lai YH,
Gao MY,
Liang F,
Mathison CJN ,
Liu X,
Yeh V,
Smith J,
Lerario I,
Xie Y,
Chianelli D,
Gibney M,
Berman A,
Chen YL,
Jiricek J,
Davis LC,
Liu X,
Ballard J,
Khare S,
Eggimann FK,
Luneau A,
Groessl T,
Shapiro M,
Richmond W,
Johnson K,
Rudewicz PJ,
Rao SPS ,
Thompson C,
Tuntland T,
Spraggon G,
Glynne RJ,
Supek F,
Wiesmann C,
Molteni V
(2020) J Med Chem , 63 , 10773 - 10781
,
Biggart A,
Be C,
Srinivas H,
Hein A,
Caridha D,
Sciotti RJ,
Pybus B,
Kreishman-Deitrick M,
Bursulaya B,
Lai YH,
Gao MY,
Liang F,
Mathison CJN ,
Liu X,
Yeh V,
Smith J,
Lerario I,
Xie Y,
Chianelli D,
Gibney M,
Berman A,
Chen YL,
Jiricek J,
Davis LC,
Liu X,
Ballard J,
Khare S,
Eggimann FK,
Luneau A,
Groessl T,
Shapiro M,
Richmond W,
Johnson K,
Rudewicz PJ,
Rao SPS ,
Thompson C,
Tuntland T,
Spraggon G,
Glynne RJ,
Supek F,
Wiesmann C,
Molteni V
(2020) J Med Chem , 63 , 10773 - 10781