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initial_angle_assignment_type:"MAXIMUM LIKELIHOOD" AND xref_links:"pdb" AND citation_journal_name:"TO BE PUBLISHED" AND author_orcid:"0000-0001-9237-9887"
Release date: Feb. 7, 2024
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 8ssz
Q-score: 0.537
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 8ssz
Q-score: 0.537
Kang G, Mazzaferro S, Natarajan K, Sine S, Hibbs RE
To Be Published
Sample:
- Calcium ion (40 Da, Ligand)
- N-octane (114 Da, Ligand)
- Acetylcholine (146 Da, Ligand)
- Igg1 kappa light chain (26 kDa, Protein from Mus musculus)
- Igg1 heavy chain (51 kDa, Protein from Mus musculus)
- A complex of three fab fragments with the 2alpha3beta stoichiometry of the full-length human alpha4beta2 nicotinic receptor bound to acetylcholine and calcium (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Neuronal acetylcholine receptor subunit alpha-4 (67 kDa, Protein from Homo sapiens)
- Neuronal acetylcholine receptor subunit beta-2 (55 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Release date: Feb. 7, 2024
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8st0
Q-score: 0.567
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8st0
Q-score: 0.567
Kang G, Mazzaferro S, Natarajan K, Sine S, Hibbs RE
To Be Published
Sample:
- N-octane (114 Da, Ligand)
- Acetylcholine (146 Da, Ligand)
- Water (18 Da, Ligand)
- Igg1 kappa light chain (26 kDa, Protein from Mus musculus)
- Igg1 heavy chain (51 kDa, Protein from Mus musculus)
- A complex of three fab fragments with the 2alpha3beta stoichiometry of the full-length human alpha4beta2 nicotinic receptor bound to acetylcholine (Complex from Homo sapiens)
- Neuronal acetylcholine receptor subunit alpha-4 (67 kDa, Protein from Homo sapiens)
- Neuronal acetylcholine receptor subunit beta-2 (55 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Release date: Feb. 7, 2024
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8st1
Q-score: 0.496
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8st1
Q-score: 0.496
Kang G, Mazzaferro S, Natarajan K, Sine S, Hibbs RE
To Be Published
Sample:
- Calcium ion (40 Da, Ligand)
- Neuronal acetylcholine receptor subunit alpha-4 (44 kDa, Protein from Homo sapiens)
- A complex of two fab fragments with the 3alpha2beta stoichiometry of human alpha4beta2 nicotinic receptor bound to acetylcholine and calcium (Complex from Homo sapiens)
- Acetylcholine (146 Da, Ligand)
- Igg1 kappa light chain (26 kDa, Protein from Mus musculus)
- Neuronal acetylcholine receptor subunit beta-2 (46 kDa, Protein from Homo sapiens)
- Igg1 heavy chain (51 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Release date: Feb. 7, 2024
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8st2
Q-score: 0.545
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8st2
Q-score: 0.545
Kang G, Mazzaferro S, Natarajan K, Sine S, Hibbs RE
To Be Published
Sample:
- A complex of two fab fragments with the 3alpha2beta stoichiometry of human alpha4beta2 nicotinic receptor bound to acetylcholine (Complex from Homo sapiens)
- Neuronal acetylcholine receptor subunit alpha-4 (44 kDa, Protein from Homo sapiens)
- Acetylcholine (146 Da, Ligand)
- Igg1 kappa light chain (26 kDa, Protein from Mus musculus)
- Neuronal acetylcholine receptor subunit beta-2 (46 kDa, Protein from Homo sapiens)
- Igg1 heavy chain (51 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Release date: Feb. 7, 2024
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8st3
Q-score: 0.533
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8st3
Q-score: 0.533
Kang G, Mazzaferro S, Natarajan K, Sine S, Hibbs RE
To Be Published
Sample:
- Calcium ion (40 Da, Ligand)
- Neuronal acetylcholine receptor subunit alpha-4 (44 kDa, Protein from Homo sapiens)
- Acetylcholine (146 Da, Ligand)
- Igg1 kappa light chain (26 kDa, Protein from Mus musculus)
- Neuronal acetylcholine receptor subunit beta-2 (46 kDa, Protein from Homo sapiens)
- Igg1 heavy chain (51 kDa, Protein from Mus musculus)
- A complex of three fab fragments with the 2alpha3beta stoichiometry of human alpha4beta2 nicotinic receptor bound to acetylcholine and calcium (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Release date: Feb. 7, 2024
Resolution: 2.35 Å
EM Method: Single-particle
Fitted PDBs: 8st4
Q-score: 0.597
Resolution: 2.35 Å
EM Method: Single-particle
Fitted PDBs: 8st4
Q-score: 0.597
Kang G, Mazzaferro S, Natarajan K, Sine S, Hibbs RE
To Be Published
Sample:
- Neuronal acetylcholine receptor subunit alpha-4 (44 kDa, Protein from Homo sapiens)
- Acetylcholine (146 Da, Ligand)
- Igg1 kappa light chain (26 kDa, Protein from Mus musculus)
- Neuronal acetylcholine receptor subunit beta-2 (46 kDa, Protein from Homo sapiens)
- Igg1 heavy chain (51 kDa, Protein from Mus musculus)
- A complex of three fab fragments with the 2alpha3beta stoichiometry of human alpha4beta2 nicotinic receptor bound to acetylcholine (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium ion (22 Da, Ligand)