Cryo-EM structure of human integrin alpha-E beta-7
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8zjf
Q-score: 0.415
Akasaka H, Sato D, Shihoya W, Nureki O, Kise Y
Biochem Biophys Res Commun (2024) 721 pp. 150121-150121 [ DOI: doi:10.1016/j.bbrc.2024.150121 Pubmed: 38781659 ]
- Integrin alpha-e beta-7 (Complex from Homo sapiens)
- Integrin beta-7 (90 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Integrin alpha-e (132 kDa, Protein from Homo sapiens)
P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent
Resolution: 2.49 Å
EM Method: Single-particle
Fitted PDBs: 8y6h
Q-score: 0.608
Hamaguchi-Suzuki N, Adachi N, Moriya T, Yasuda S, Kawasaki M, Suzuki K, Ogasawara S, Anzai N, Senda T, Murata T
Biochem Biophys Res Commun (2024) 709 pp. 149855-149855 [ DOI: doi:10.1016/j.bbrc.2024.149855 Pubmed: 38579618 ]
- Atp-dependent translocase abcb1,mneongreen (170 kDa, Protein from Homo sapiens)
- Uic2 fab light chain (24 kDa, Protein from Mus musculus)
- Multidrug resistance protein (Complex from Homo sapiens)
- Elacridar (563 Da, Ligand)
- Uic2 fab heavy chain (24 kDa, Protein from Mus musculus)
P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in nanodisc
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 8y6i
Q-score: 0.576
Hamaguchi-Suzuki N, Adachi N, Moriya T, Yasuda S, Kawasaki M, Suzuki K, Ogasawara S, Anzai N, Senda T, Murata T
Biochem Biophys Res Commun (2024) 709 pp. 149855-149855 [ DOI: doi:10.1016/j.bbrc.2024.149855 Pubmed: 38579618 ]
- Atp-dependent translocase abcb1,mneongreen (170 kDa, Protein from Homo sapiens)
- Uic2 fab light chain (24 kDa, Protein from Mus musculus)
- Multidrug resistance protein (Complex from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Elacridar (563 Da, Ligand)
- Uic2 fab heavy chain (24 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
ETB-eGt complex bound to endothelin-1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xgr
Q-score: 0.425
Oshima HS, Sano FK, Akasaka H, Iwama A, Shihoya W, Nureki O
Biochem Biophys Res Commun (2024) 693 pp. 149361-149361 [ DOI: doi:10.1016/j.bbrc.2023.149361 Pubmed: 38128244 ]
- Complex of endothelin-1, etb, egt trimer and nb35* (Complex from Homo sapiens)
- Endothelin-1 (2 kDa, Protein from Homo sapiens)
- Endothelin receptor type b (67 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2,egt-alpha (48 kDa, Protein from Bos taurus)
- Camelid antibody vhh fragment (17 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus rattus)
CryoEM structure of pentameric MotA from Aquifex aeolicus
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8gqy
Q-score: 0.521
Nishikino T, Takekawa N, Tran DP, Kishikawa JI, Hirose M, Onoe S, Kojima S, Homma M, Kitao A, Kato T, Imada K
Biochem Biophys Res Commun (2022) 631 pp. 78-85 [ DOI: doi:10.1016/j.bbrc.2022.09.072 Pubmed: 36179499 ]
- Motility protein a (28 kDa, Protein from Aquifex aeolicus VF5)
- Pentameric mota from aquifex aeolicus (140 kDa, Complex from Aquifex aeolicus)
Solabegron-activated dog beta3 adrenergic receptor
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7xji
Q-score: 0.454
Nureki I, Kobayashi K, Tanaka T, Demura K, Inoue A, Shihoya W, Nureki O
Biochem Biophys Res Commun (2022) 611 pp. 158-164 [ DOI: doi:10.1016/j.bbrc.2022.04.065 Pubmed: 35489202 ]
- 3-[3-[2-[[(2~{s})-2-(3-chlorophenyl)-2-oxidanyl-ethyl]amino]ethylamino]phenyl]benzoic acid (410 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Rattus norvegicus)
- Beta-3 adrenergic receptor (42 kDa, Protein from Canis lupus familiaris)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Beta-3 adrenergic receptor (Complex from Canis lupus familiaris)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Nanobody-35 (15 kDa, Protein from unidentified)
- Dog beta3 adrenergic receptor bound to mirabegron in complex with a minigs heterotrimer (Complex)
- Nanobody nb35 (Complex from unidentified)
LptB2FG-LPS from Klebsiella pneumoniae in nanodiscs
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 7efo
Q-score: 0.393
Biochem Biophys Res Commun (2021) 571 pp. 20-25 [ Pubmed: 34303191 DOI: doi:10.1016/j.bbrc.2021.07.049 ]
- Lipopolysaccharide export system atp-binding protein lptb (26 kDa, Protein from Klebsiella pneumoniae subsp. pneumoniae)
- Lptb2fg from klebsiella pneumoniae with bound lps (Complex from Klebsiella pneumoniae subsp. pneumoniae 1158)
- (2~{r},4~{r},5~{r},6~{r})-6-[(1~{r})-1,2-bis(oxidanyl)ethyl]-2-[(2~{r},4~{r},5~{r},6~{r})-6-[(1~{r})-1,2-bis(oxidanyl)ethyl]-5-[(2~{s},3~{s},4~{r},5~{r},6~{r})-6-[(1~{s})-1,2-bis(oxidanyl)ethyl]-4-[(2~{r},3~{s},4~{r},5~{s},6~{r})-6-[(1~{s})-2-[(2~{s},3~{s},4~{s},5~{s},6~{r})-6-[(1~{s})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-1-oxidanyl-ethyl]-3,4-bis(oxidanyl)-5-phosphonooxy-oxan-2-yl]oxy-3-oxidanyl-5-phosphonooxy-oxan-2-yl]oxy-2-carboxy-2-[[(2~{r},3~{s},4~{r},5~{r},6~{r})-5-[[(3~{r})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{r},3~{s},4~{r},5~{r},6~{r})-3-oxidanyl-5-[[(3~{r})-3-oxidanyltetradecanoyl]amino]-4-[(3~{r})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{r})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid (2 kDa, Ligand)
- Lipopolysaccharide export system permease protein lptf (40 kDa, Protein from Klebsiella pneumoniae subsp. pneumoniae)
- Lps export abc transporter permease lptg (39 kDa, Protein from Klebsiella pneumoniae subsp. pneumoniae)
Peptide-19 bound to the Glucagon-Like Peptide-1 Receptor (GLP-1R)
Resolution: 2.14 Å
EM Method: Single-particle
Fitted PDBs: 7rtb
Q-score: 0.533
Johnson RM, Zhang X, Piper SJ, Nettleton TJ, Vandekolk TH, Langmead CJ, Danev R, Sexton PM, Wootten D
Biochem Biophys Res Commun (2021) 578 pp. 84-90 [ DOI: doi:10.1016/j.bbrc.2021.09.016 Pubmed: 34547628 ]
- Peptide-19 (4 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Glucagon-like peptide 1 receptor (56 kDa, Protein from Homo sapiens)
- Nb35 (13 kDa, Protein from Lama glama)
- Peptide-19-glp-1r-gs complex (Complex from Homo sapiens)
Human SECR in complex with an engineered Gs heterotrimer
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7d3s
Q-score: 0.552
Fukuhara S, Kobayashi K, Kusakizako T, Iida W, Kato M, Shihoya W, Nureki O
Biochem Biophys Res Commun (2020) 533 pp. 861-866 [ DOI: doi:10.1016/j.bbrc.2020.08.042 Pubmed: 33008599 ]
- Secr-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex)
- Secretin receptor (49 kDa, Protein from Homo sapiens)
- Secretin receptor (Complex)
- Nanobody nb35 (15 kDa, Protein from unidentified)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Nanobody nb35 (Complex)
- Secretin (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex)
- Secretin (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)