Ligand-free Lassa GPC Trimer with C3 Symmetry
Gorman J, Cheung CS, Duan Z, Ou L, Wang M, Chen X, Cheng C, Biju A, Sun Y, Wang P, Yang Y, Zhang B, Boyington JC, Bylund T, Charaf S, Chen SJ, Du H, Henry AR, Liu T, Sarfo EK, Schramm CA, Shen CH, Stephens T, Teng IT, Todd JP, Tsybovsky Y, Verardi R, Wang D, Wang S, Wang Z, Zheng CY, Zhou T, Douek DC, Mascola JR, Ho DD, Ho M, Kwong PD
Nat Commun (2024) 15 pp. 285-285 [ Pubmed: 38177144 DOI: doi:10.1038/s41467-023-44534-y ]
- Lassa gpc (Protein from Lassa virus Josiah)
- Lassa gpc trimer (Complex from Lassa virus Josiah)
Ligand-free Lassa GPC Trimer with C1 Symmetry
Gorman J, Cheung CS, Duan Z, Ou L, Wang M, Chen X, Cheng C, Biju A, Sun Y, Wang P, Yang Y, Zhang B, Boyington JC, Bylund T, Charaf S, Chen SJ, Du H, Henry AR, Liu T, Sarfo EK, Schramm CA, Shen CH, Stephens T, Teng IT, Todd JP, Tsybovsky Y, Verardi R, Wang D, Wang S, Wang Z, Zheng CY, Zhou T, Douek DC, Mascola JR, Ho DD, Ho M, Kwong PD
Nat Commun (2024) 15 pp. 285-285 [ Pubmed: 38177144 DOI: doi:10.1038/s41467-023-44534-y ]
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 7l2d
Q-score: 0.425
Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Cell Host Microbe (2021) 29 pp. 819- [ DOI: doi:10.1016/j.chom.2021.03.005 Pubmed: 33789084 ]
- 1-87 light chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 1-87 heavy chain (25 kDa, Protein from Homo sapiens)
- Prefusion sars-cov-2 spike glycoprotein in complex with 1-87 fab (Complex from Homo sapiens)
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7l2e
Q-score: 0.505
Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Cell Host Microbe (2021) 29 pp. 819- [ DOI: doi:10.1016/j.chom.2021.03.005 Pubmed: 33789084 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 4-18 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Prefusion sars-cov-2 spike glycoprotein in complex with 4-18 fab (Complex from Homo sapiens)
- 4-18 heavy chain (24 kDa, Protein from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7l2f
Q-score: 0.332
Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Cell Host Microbe (2021) 29 pp. 819- [ DOI: doi:10.1016/j.chom.2021.03.005 Pubmed: 33789084 ]
- 5-24 heavy chain (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 5-24 light chain (23 kDa, Protein from Homo sapiens)
- Prefusion sars-cov-2 spike glycoprotein in complex with 5-24 fab (Complex from Homo sapiens)
Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Cell Host Microbe (2021) 29 pp. 819-833.e7 [ DOI: doi:10.1016/j.chom.2021.03.005 Pubmed: 33789084 ]
Resolution: 4.47 Å
EM Method: Single-particle
Fitted PDBs: 7lqw
Q-score: 0.222
Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Cell Host Microbe (2021) 29 pp. 819-833.e7 [ DOI: doi:10.1016/j.chom.2021.03.005 Pubmed: 33789084 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-17 fab in complex with sars-cov-2 s2p spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-17 light chain (23 kDa, Protein from Homo sapiens)
- 2-17 heavy chain (24 kDa, Protein from Homo sapiens)
Cryo-EM structure of single ACE2-bound SARS-CoV-2 trimer spike at pH 5.5
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 7kne
Q-score: 0.253
Zhou T, Tsybovsky Y, Gorman J, Rapp M, Cerutti G, Chuang GY, Katsamba PS, Sampson JM, Schon A, Bimela J, Boyington JC, Nazzari A, Olia AS, Shi W, Sastry M, Stephens T, Stuckey J, Teng IT, Wang P, Wang S, Zhang B, Friesner RA, Ho DD, Mascola JR, Shapiro L, Kwong PD
Cell Host Microbe (2020) 28 pp. 867-879.e5 [ Pubmed: 33271067 DOI: doi:10.1016/j.chom.2020.11.004 ]
- Angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Single ace2-bound sars-cov-2 trimer spike at ph 5.5 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of double ACE2-bound SARS-CoV-2 trimer Spike at pH 7.4
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 7kmz
Q-score: 0.285
Zhou T, Tsybovsky Y, Gorman J, Rapp M, Cerutti G, Chuang GY, Katsamba PS, Sampson JM, Schon A, Bimela J, Boyington JC, Nazzari A, Olia AS, Shi W, Sastry M, Stephens T, Stuckey J, Teng IT, Wang P, Wang S, Zhang B, Friesner RA, Ho DD, Mascola JR, Shapiro L, Kwong PD
Cell Host Microbe (2020) 28 pp. 867-879.e5 [ Pubmed: 33271067 DOI: doi:10.1016/j.chom.2020.11.004 ]
- Angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cryo-em structure of double ace2-bound sars-cov-2 trimer spike at ph 7.4 (Complex from Severe acute respiratory syndrome coronavirus 2)