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grant_code:"R01 AI136680"

Filter By

Current Database

  • EMDB [11]

Current status

  • REL [11]

Sample type

  • Complex [11]
  • Protein [11]
  • DNA [8]
  • Ligand [8]

Organism

  • Human immunodeficiency virus 1 [5]
  • Human immunodeficiency virus 1 [3]
  • Streptomyces griseus [3]
  • Mouse mammary tumor virus [2]
  • Synthetic construct [1]
  • Visna-maedi virus [1]

EM Method

  • Single-particle [11]

Resolution

  • ≥ 2Å and < 3Å [4]
  • ≥ 3Å and < 4Å [6]
  • ≥ 8Å and < 12Å [1]

Model molecular weight

  • 100-250 kDa [2]
  • 250-500 kDa [6]
  • 500-1000 kDa [2]

Release Date

  • 2022 [6]
  • 2020 [5]

Author by name

  • Lyumkis D [11]
  • Passos DO [8]
  • Jozwik IK [7]
  • Passos D [7]
  • Burke Jr Tr [5]
  • Craigie R [5]
  • Forli S [5]
  • Hughes SH [5]
  • Jeon Y [5]
  • Li M [5]
  • Santos-martins D [5]
  • Smith SJ [5]
  • Yang R [5]
  • Zhao XZ [5]
  • Arnold E [3]
  • Ballandras-colas A [3]
  • Bauman JD [3]
  • Bruhn JF [3]
  • Cherepanov P [3]
  • Destefano JJ [3]
  • Engelman AN [3]
  • Harrison JJEK [3]
  • Li W [3]
  • Ruiz FX [3]
  • Tuberty L [3]
  • Aiyer S [2]
  • Grawenhoff J [2]
  • Jozwik I [2]
  • Wong D [2]
  • Zhang DW [2]
  • Bedwell GJ [1]
  • Chivukula V [1]
  • Cook NJ [1]
  • Fadel HJ [1]
  • Griffiths DJ [1]
  • Gruszka DT [1]
  • Harrison J [1]
  • Mclean RK [1]
  • Nans A [1]
  • Poeschla EM [1]
  • Pye VE [1]
  • Shan Z [1]
  • Singh PK [1]
  • Taylor IA [1]
  • Vargas J [1]
  • Yardimci H [1]

Author by ORCID

  • Lyumkis D [11]
  • Passos DO [8]
  • Jozwik IK [7]
  • Jeon Y [5]
  • Craigie R [5]
  • Yang R [5]
  • Burke Jr Tr [5]
  • Forli S [5]
  • Zhao XZ [5]
  • Santos-martins D [5]
  • Ruiz FX [3]
  • Cherepanov P [3]
  • Harrison JJEK [3]
  • Bruhn JF [3]
  • Tuberty L [3]
  • Destefano JJ [3]
  • Engelman AN [3]
  • Arnold E [3]
  • Ballandras-colas A [3]
  • Grawenhoff J [2]
  • Yardimci H [1]
  • Chivukula V [1]
  • Griffiths DJ [1]
  • Pye VE [1]
  • Cook NJ [1]
  • Nans A [1]
  • Mclean RK [1]
  • Taylor IA [1]
  • Singh PK [1]
  • Poeschla EM [1]
  • Gruszka DT [1]
  • Shan Z [1]

Journal

  • SCIENCE [5]
  • SCI ADV [3]
  • NUCLEIC ACIDS RES [2]
  • NAT COMMUN [1]

Software

  • CISTEM [7]
  • CRYOSPARC [6]
  • WARP [1]

Microscope

  • FEI TITAN KRIOS [10]
  • FEI TALOS ARCTICA [1]

Electron Source

  • FIELD EMISSION GUN [11]

Film or detector model

  • GATAN K2 SUMMIT 4K X 4K [11]

External links

  • UniProt [11]
  • PDB [10]
  • PDBe-Kb [9]
  • ChEBI [8]
  • ChEMBL [8]
  • DrugBank [8]
  • Gene Ontology [3]
  • InterPro [3]
  • Pfam [3]
  • EMPIAR [1]
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Showing 1 - 10 of 11. Page 1 of 2
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EMD-26737
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3D View
Mouse mammary tumor virus strand transfer complex intasome
Release date: Aug. 24, 2022
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7usf
Q-score: 0.403

Jozwik IK, Li W, Zhang DW, Wong D, Grawenhoff J, Ballandras-Colas A, Aiyer S, Cherepanov P, Engelman AN, Lyumkis D

Nucleic Acids Res (2022) 50 pp. 8898-8918 [ Pubmed: 35947647 DOI: doi:10.1093/nar/gkac644 ]

EMD-26744
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Higher-order assembly of multiple MMTV strand transfer complex intasomes
Release date: Aug. 24, 2022
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7ut1
Q-score: 0.39

Jozwik IK, Li W, Zhang DW, Wong D, Grawenhoff J, Ballandras-Colas A, Aiyer S, Cherepanov P, Engelman AN, Lyumkis D

Nucleic Acids Res (2022) 50 pp. 8898-8918 [ Pubmed: 35947647 DOI: doi:10.1093/nar/gkac644 ]

EMD-25075
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PR-RT portion of HIV-1 Pol
Release date: Aug. 10, 2022
Resolution: 3.74 Å
EM Method: Single-particle

Harrison JJEK, Passos DO, Bruhn JF, Bauman JD, Tuberty L, DeStefano JJ, Ruiz FX, Lyumkis D, Arnold E

Sci Adv (2022) 8 pp. eabn9874-eabn9874 [ Pubmed: 35857464 DOI: doi:10.1126/sciadv.abn9874 ]

EMD-25074
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Cryo-EM Structure of the RT component of the HIV-1 Pol Polyprotein
Release date: July 27, 2022
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7sep
Q-score: 0.346

Harrison JJEK, Passos DO, Bruhn JF, Bauman JD, Tuberty L, DeStefano JJ, Ruiz FX, Lyumkis D, Arnold E

Sci Adv (2022) 8 pp. eabn9874-eabn9874 [ Pubmed: 35857464 DOI: doi:10.1126/sciadv.abn9874 ]

EMD-25165
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Cryo-EM Structure of the PR-RT components of the HIV-1 Pol Polyprotein
Release date: July 27, 2022
Resolution: 8.2 Å
EM Method: Single-particle
Fitted PDBs: 7sjx
Q-score: 0.188

Harrison JJEK, Passos DO, Bruhn JF, Bauman JD, Tuberty L, DeStefano JJ, Ruiz FX, Lyumkis D, Arnold E

Sci Adv (2022) 8 pp. eabn9874-eabn9874 [ Pubmed: 35857464 DOI: doi:10.1126/sciadv.abn9874 ]

EMD-26322
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3D View
MVV cleaved synaptic complex CSC intasome at 3.4 A resolution
Release date: May 11, 2022
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 7u32
Q-score: 0.256

Ballandras-Colas A, Chivukula V, Gruszka DT, Shan Z, Singh PK, Pye VE, McLean RK, Bedwell GJ, Li W, Nans A, Cook NJ, Fadel HJ, Poeschla EM, Griffiths DJ, Vargas J, Taylor IA, Lyumkis D, Yardimci H, Engelman AN, Cherepanov P

Nat Commun (2022) 13 pp. 2416-2416 [ DOI: doi:10.1038/s41467-022-29928-8 Pubmed: 35504909 ]

EMD-20481
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Structure of HIV cleaved synaptic complex CSC intasome bound with calcium
Release date: Feb. 12, 2020
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6put
Q-score: 0.579

Passos DO, Li M, Jozwik IK, Zhao XZ, Santos-Martins D, Yang R, Smith SJ, Jeon Y, Forli S, Hughes SH, Burke Jr TR, Craigie R, Lyumkis D

Science (2020) 367 pp. 810-814 [ Pubmed: 32001521 DOI: doi:10.1126/science.aay8015 ]

EMD-20483
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3D View
Structure of HIV cleaved synaptic complex CSC intasome bound with magnesium and Bictegravir BIC
Release date: Feb. 12, 2020
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6puw
Q-score: 0.573

Passos DO, Li M, Jozwik IK, Zhao XZ, Santos-Martins D, Yang R, Smith SJ, Jeon Y, Forli S, Hughes SH, Burke Jr TR, Craigie R, Lyumkis D

Science (2020) 367 pp. 810-814 [ Pubmed: 32001521 DOI: doi:10.1126/science.aay8015 ]

EMD-20484
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Raw data
EMPIAR-10387
Structure of HIV cleaved synaptic complex CSC intasome bound with magnesium and INSTI XZ426 compound 4d
Release date: Feb. 12, 2020
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6puy
Q-score: 0.591

Passos DO, Li M, Jozwik IK, Zhao XZ, Santos-Martins D, Yang R, Smith SJ, Jeon Y, Forli S, Hughes SH, Burke Jr TR, Craigie R, Lyumkis D

Science (2020) 367 pp. 810-814 [ Pubmed: 32001521 DOI: doi:10.1126/science.aay8015 ]

EMD-20485
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3D View
Structure of HIV cleaved synaptic complex CSC intasome bound with magnesium and INSTI XZ446 compound 4f
Release date: Feb. 12, 2020
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6puz
Q-score: 0.589

Passos DO, Li M, Jozwik IK, Zhao XZ, Santos-Martins D, Yang R, Smith SJ, Jeon Y, Forli S, Hughes SH, Burke Jr TR, Craigie R, Lyumkis D

Science (2020) 367 pp. 810-814 [ Pubmed: 32001521 DOI: doi:10.1126/science.aay8015 ]

Sort by: Download
Showing 1 - 10 of 11. Page 1 of 2
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [11]

Current status

  • REL [11]

Sample type

  • Complex [11]
  • Protein [11]
  • DNA [8]
  • Ligand [8]

Organism

  • Human immunodeficiency virus 1 [5]
  • Human immunodeficiency virus 1 [3]
  • Streptomyces griseus [3]
  • Mouse mammary tumor virus [2]
  • Synthetic construct [1]
  • Visna-maedi virus [1]

EM Method

  • Single-particle [11]

Resolution

  • ≥ 2Å and < 3Å [4]
  • ≥ 3Å and < 4Å [6]
  • ≥ 8Å and < 12Å [1]

Model molecular weight

  • 100-250 kDa [2]
  • 250-500 kDa [6]
  • 500-1000 kDa [2]

Release Date

  • 2022 [6]
  • 2020 [5]

Author by name

  • Lyumkis D [11]
  • Passos DO [8]
  • Jozwik IK [7]
  • Passos D [7]
  • Burke Jr Tr [5]
  • Craigie R [5]
  • Forli S [5]
  • Hughes SH [5]
  • Jeon Y [5]
  • Li M [5]
  • Santos-martins D [5]
  • Smith SJ [5]
  • Yang R [5]
  • Zhao XZ [5]
  • Arnold E [3]
  • Ballandras-colas A [3]
  • Bauman JD [3]
  • Bruhn JF [3]
  • Cherepanov P [3]
  • Destefano JJ [3]
  • Engelman AN [3]
  • Harrison JJEK [3]
  • Li W [3]
  • Ruiz FX [3]
  • Tuberty L [3]
  • Aiyer S [2]
  • Grawenhoff J [2]
  • Jozwik I [2]
  • Wong D [2]
  • Zhang DW [2]
  • Bedwell GJ [1]
  • Chivukula V [1]
  • Cook NJ [1]
  • Fadel HJ [1]
  • Griffiths DJ [1]
  • Gruszka DT [1]
  • Harrison J [1]
  • Mclean RK [1]
  • Nans A [1]
  • Poeschla EM [1]
  • Pye VE [1]
  • Shan Z [1]
  • Singh PK [1]
  • Taylor IA [1]
  • Vargas J [1]
  • Yardimci H [1]

Author by ORCID

  • Lyumkis D [11]
  • Passos DO [8]
  • Jozwik IK [7]
  • Jeon Y [5]
  • Craigie R [5]
  • Yang R [5]
  • Burke Jr Tr [5]
  • Forli S [5]
  • Zhao XZ [5]
  • Santos-martins D [5]
  • Ruiz FX [3]
  • Cherepanov P [3]
  • Harrison JJEK [3]
  • Bruhn JF [3]
  • Tuberty L [3]
  • Destefano JJ [3]
  • Engelman AN [3]
  • Arnold E [3]
  • Ballandras-colas A [3]
  • Grawenhoff J [2]
  • Yardimci H [1]
  • Chivukula V [1]
  • Griffiths DJ [1]
  • Pye VE [1]
  • Cook NJ [1]
  • Nans A [1]
  • Mclean RK [1]
  • Taylor IA [1]
  • Singh PK [1]
  • Poeschla EM [1]
  • Gruszka DT [1]
  • Shan Z [1]

Journal

  • SCIENCE [5]
  • SCI ADV [3]
  • NUCLEIC ACIDS RES [2]
  • NAT COMMUN [1]

Software

  • CISTEM [7]
  • CRYOSPARC [6]
  • WARP [1]

Microscope

  • FEI TITAN KRIOS [10]
  • FEI TALOS ARCTICA [1]

Electron Source

  • FIELD EMISSION GUN [11]

Film or detector model

  • GATAN K2 SUMMIT 4K X 4K [11]

External links

  • UniProt [11]
  • PDB [10]
  • PDBe-Kb [9]
  • ChEBI [8]
  • ChEMBL [8]
  • DrugBank [8]
  • Gene Ontology [3]
  • InterPro [3]
  • Pfam [3]
  • EMPIAR [1]