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grant_code:"CF19-0527"

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EMD-23545
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Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15B8 Fab
Release date: Aug. 11, 2021
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 7lwd
Q-score: 0.466

Plenge P, Yang D, Salomon K, Laursen L, Kalenderoglou IE, Newman AH, Gouaux E, Coleman JA, Loland CJ

Nat Commun (2021) 12 pp. 5063-5063 [ Pubmed: 34417466 DOI: doi:10.1038/s41467-021-25363-3 ]

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Filter By

Current Database

  • EMDB [1]

Current status

  • REL [1]

Sample type

  • Complex [1]
  • Ligand [1]
  • Protein [1]

Organism

  • Mus musculus [1]
  • Homo sapiens [1]

EM Method

  • Single-particle [1]

Resolution

  • ≥ 3Å and < 4Å [1]

Model molecular weight

  • 50-100 kDa [1]

Release Date

  • 2021 [1]

Author by name

  • Coleman JA [1]
  • Gouaux E [1]
  • Kalenderoglou IE [1]
  • Laursen L [1]
  • Loland CJ [1]
  • Newman AH [1]
  • Plenge P [1]
  • Salomon K [1]
  • Yang D [1]

Author by ORCID

  • Laursen L [1]
  • Kalenderoglou IE [1]
  • Gouaux E [1]
  • Newman AH [1]
  • Coleman JA [1]
  • Loland CJ [1]
  • Salomon K [1]

Journal

  • NAT COMMUN [1]

Software

  • CISTEM [1]
  • CRYOSPARC [1]
  • RELION [1]

Microscope

  • FEI TITAN KRIOS [1]

Electron Source

  • FIELD EMISSION GUN [1]

Film or detector model

  • GATAN K3 BIOQUANTUM 6K X 4K [1]

External links

  • AlphaFold DB [1]
  • ChEBI [1]
  • ChEMBL [1]
  • DrugBank [1]
  • InterPro [1]
  • PDB [1]
  • PDBe-Kb [1]
  • Pfam [1]
  • UniProt [1]