› 7lwd

Electron Microscopy
3.65Å resolution

Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15B8 Fab

Released:
DOI: 10.2210/pdb7lwd/pdb
PDB entry 7lwd coloured by chain, front view.
PDB entry 7lwd coloured by chain, side view.
PDB entry 7lwd coloured by chain, top view.
Source organisms:
Primary publication:
The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.
Plenge P, Yang D, Salomon K, Laursen L, Kalenderoglou IE, Newman AH, Gouaux E, Coleman JA, Loland CJ
Nat Commun 12 5063 (2021)
PMID: 34417466
Related structures: EMD-23545

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211049 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Sodium-dependent serotonin transporter Chain: A
Molecule details ›
Chain: A
Length: 541 amino acids
Theoretical weight: 61.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P31645 (Residues: 77-617; Coverage: 86%)
Gene names: HTT, SERT, SLC6A4
Sequence domains: Sodium:neurotransmitter symporter family
heavy chain antibody fragment Chain: H
Molecule details ›
Chain: H
Length: 118 amino acids
Theoretical weight: 12.98 KDa
Source organism: Mus musculus
light chain antibody fragment Chain: L
Molecule details ›
Chain: L
Length: 110 amino acids
Theoretical weight: 11.78 KDa
Source organism: Mus musculus

Ligands and Environments

3 bound ligands:
Ligand IXX 1 x IXX
Ligand YG7 1 x YG7
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.65Å
Relevant EMDB volumes: EMD-23545
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas.
Semple et al. (2022)
4 more

6 mentions without citation

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.
Plenge et al. (2021)
5 more