EMD-23545

Single-particle
3.65 Å
EMD-23545
3D View Gallery
Deposition: 01/03/2021
Map released: 11/08/2021
Last modified: 23/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-23545

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-7lwd summary report (pdf.gz) Map-7lwd FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15B8 Fab

EMD-23545

Single-particle
3.65 Å
EMD-23545
3D View Gallery
Deposition: 01/03/2021
Map released: 11/08/2021
Last modified: 23/10/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens
Sample: serotonin transporter 8B6 Fab complex
Fitted models: 7lwd

Deposition Authors: Yang D, Kalenderoglou IE
The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.
Plenge P, Yang D, Salomon K , Laursen L , Kalenderoglou IE , Newman AH , Gouaux E , Coleman JA, Loland CJ
(2021) Nat Commun , 12 , 5063 - 5063
PUBMED: 34417466
DOI: doi:10.1038/s41467-021-25363-3
ISSN: 2041-1723